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Application of the modified vaccination technique for the prevention and cure of chronic ailments

Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 160-166页

作者： Arpad Z Barabas Chad D Cole Arpad D Barabas Richard M Graeff rene lafreniere Donald M Weir Department of Surgery University of Calgary Department of Neurosurgery University of Utah Department of Pharmacology University of Minnesota University of Edinburgh Medical School

Over the years vaccination has proven to be the most successful health protection program for large populations,to prevent them from acquiring serious infectious and contagious diseases caused by exogenous antigens(ags) such as bacteria and *** is generally achieved by an active immunization program,though passive immunization has also been employed, especially in the past,to combat diseases caused by certain bacterial infections(***, diphtheria,etc.). Most recently,encouraging research data suggests that therapeutic approaches employing vaccination techniques can also be used to correct or deal with mishaps induced by or involving endogenous ***,most attempts at employing conventional vaccination techniques to do so have proven less than *** the case of cancer,one of the reasons for this is that the presentation of cancer related ags in presently available immunization frameworks is unable to evoke a powerful,specific cancer killing ***,drug treatments have been required in order to achieve additional beneficial effects. Recently,the Barabas group has developed a new vaccination technique(the third vaccination method,after active and passive immunization) called Modified Vaccination Technique(MVT). In experiments the MVT has been able to prevent-and with equal effectiveness,terminatemishaps induced by or involving endogenous ags,*** an experimental autoimmune kidney disease called slowly progressive Heymann nephritis(SPHN). The MVT is safe,and is able to initiate a specific immune response in the injected host(provided the injected components are in pure form).The MVT promises to provide the next generation of vaccines for the prevention,treatment,and termination of chronic disorders in humans,such as autoimmune diseases,cancer,and chronic infections.

关键词： Autoimmunity Modified vaccination technique Prophylactic Therapeutic

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