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Postmarketing safety evaluation: depside salt injection made from Danshen(Radix Salviae Miltiorrhizae)

Journal of Traditional Chinese Medicine 2014年第6期34卷 749-753页

作者： Yanpeng Chang Wen Zhang Yanming Xie Xiangyang Xu rendi sun Zheng Wang Ruihua Yan Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Intensive Care Unit of Shenyang Orthopedic Hospital Shanghai Green Valley Pharmaceutical Ltd.

OBJECTIVE: To systematically examine the postmarketing safety of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),identifythe potential risk factors, and ensure its clinical ***: We examined a comprehensive series of studies on the production process, quality standards, pharmacology, population pharmacokinetics, and safety evaluation of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae). Data from Ⅰ-Ⅳ clinical drug trials, hospital information systems(HIS), and spontaneous reporting systems(SRS) were also ***: The effective components of salvianolic acid salt content reached almost 100%, and the magnesium lithospermate B content reached morethan 80%. The median lethal dose(LD50) calculated by the Bliss method was 1.49 g/kg, with 95%confidence intervals of 1.29-1.72 g/kg. Long-term tests on Beagle dogs indicated that doses of less than 80 mg/kg were safe and doses of 320 mg/kg were toxic. Adverse drug reactions(ADRs) included digestive disorders; drug-induced erythrocyte deformation in lung, liver, spleen, kidney, bone marrow, intestinal mucosa, lymph nodes, and other tissues; megakaryocytes in lung, liver, and spleen resulting from mild hemolysis; and mild hyperplasia in bone marrow hematopoietic tissue. Other studies indicated no irritative effect of the injection on local tissues and blood vessels, and no allergic reactions, erythrocyte coagulation, or hemolysis. SRS data showed that the most common ADRs were headache, head distention, dizziness, facial flushing, skin itching, thrombocytopenia, and the reversibility of elevated Aspartate transaminase. HIS data indicated no damage to renal function from using depside salt injection made from Danshen(Radix Salviae Miltiorrhizae) at a dosage higher than the recommended ***: This study analyzes the clinical characteristics of ADRs from depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),and discusses the factors influencing s

关键词： Product surveillance, postmarketingChinese medicine Safety Danshen (Radix SalviaeMiltiorrhizae) Depside salt injection

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Characteristics of the anti-dementia drug system of Zisu Fang preparations based on pharmacokinetic and pharmacodynamic analysis

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Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 207-215页

作者： Jianye Quan Shujuan Yang Fang Zhang Li Tan Jing Kong Yanyan Jiang rendi sun Renbing Shi School of Chinese Pharmacy Key Unit of Exploring Effective Substances of Classical and Famous Formulas of State Administration of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 100102China Quality Control Technology and Engineering Center of Chinese Medicine Beijing Municipal Commission of EducationBeijing 100102China Shanghai Green Valley Pharmaceutical Life Park Shanghai 201707China

Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu Fang preparations and additionally analysis the anti-dementia drug system ***:A PK-PD-drug interaction (DI) method was applied to determine the characteristics of index components of Zisu Fong preparations in ***:In the PK study,maximum plasma concentration,area under the plasma concentration-time curve,and mean residence time of index components of Zisu Fang preparations were higher in the memory-deficit model group than in the control *** suggested that the index components of Zisu Fang preparations had an affinity for the state of dementia in this *** the PD study,at the peak time points of anti-dementia efficacy (0.17 h and 1 h),the plasma concentrations of index components of Zisu Fang preparations reached the first or second largest plasma concentration peak or were close to the plasma concentration peak,and showed positive correlation between these two peaks,indicating that the index components of Zisu Fang synergistically exerted an anti-dementia *** to the association analysis of PK-PD-DI,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA were the main active ingredients of the anti-dementia drug system of Zisu Fang preparations in vivo,but were only efficacious against dementia when all five components were present at a specific concentration and ***:Based on the PK and PD correlation analysis,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA are the main active ingredients of Zisu Fang preparations with regard to its anti-dementia effects,and represent the basic characteristics of drug system:natures,synergy,and affinity.

关键词： Index components Pharmacokinetics Pharmacodynamics Characteristics of anti-dementia drug system

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顶空毛细管气相色谱法测定丹参多酚酸盐原料中乙醇残留量

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中国药师 2013年第8期16卷 1127-1128页

作者：孙仁弟杨瑞花上海绿谷制药有限公司上海201203

目的:建立丹参多酚酸盐原料中乙醇残留量的测定方法,并测定其残留量。方法:采用顶空毛细管气相色谱法,以水为溶剂,色谱柱为HP-5(5%苯基～95%甲基聚硅氧烷固定液)石英毛细管柱(30 m×0.32 mm,0.5μm),载气为氮气。进样口温度为220℃,FID... 详细信息

目的:建立丹参多酚酸盐原料中乙醇残留量的测定方法,并测定其残留量。方法:采用顶空毛细管气相色谱法,以水为溶剂,色谱柱为HP-5(5%苯基～95%甲基聚硅氧烷固定液)石英毛细管柱(30 m×0.32 mm,0.5μm),载气为氮气。进样口温度为220℃,FID检测器温度为260℃,柱温为50℃;顶空进样,平衡温度为80℃,平衡时间为30 min,分流比2:1。结果:被测物能得到很好的分离,峰面积与浓度呈良好的线性关系,精密度和回收率良好。结论:该法可用于丹参多酚酸盐原料中乙醇残留量的检测。

关键词：丹参多酚酸盐乙醇残留量毛细管气相色谱

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响应面法优化紫苏子中迷迭香酸超声提取工艺的研究

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上海医药 2017年第7期38卷 75-78页

作者：张玥莉孙仁弟上海绿谷制药有限公司上海复方中药(绿谷)工程技术研究中心上海201707

目的 :优选紫苏子中迷迭香酸的超声提取工艺。方法 :在单因素试验基础上,以超声功率、乙醇浓度、提取时间为考察因素,以迷迭香酸提取率为考察指标,利用Design-Expert 7.0进行三因素三水平响应面分析优选工艺条件。结果 :最佳提取工艺为... 详细信息

目的 :优选紫苏子中迷迭香酸的超声提取工艺。方法 :在单因素试验基础上,以超声功率、乙醇浓度、提取时间为考察因素,以迷迭香酸提取率为考察指标,利用Design-Expert 7.0进行三因素三水平响应面分析优选工艺条件。结果 :最佳提取工艺为:超声功率380 W、乙醇浓度60%、提取时间85 min,模型相关系数R^2=0.960 2,该条件下迷迭香酸平均提取率为0.59%。结论 :该提取工艺可为进一步开发紫苏子药用价值提供依据。

关键词：紫苏子迷迭香酸响应面超声提取

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Engineering nanoparticle structure at synergistic Ru-Na interface for integrated CO2 capture and hydrogenation

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Journal of Energy Chemistry 2025年第1期100卷 779-791页

作者： Hanzi Liu Ling Cen Xinlin Xie Lei Liu Zhao sun Zhiqiang sun Hunan Engineering Research Center of Clean and Low-Carbon Energy Technology School of Energy Science and Engineering Central South University

The development of dual functional material for cyclic CO2capture and hydrogenation is of great significance for converting diluted CO2into valuable fuels,but suffers from kinetic limitation and deactivation of adsorbent and ***,we engineered a series of RuNa/γ-Al2O3materials,varying the size of ruthenium from single atoms to clusters/*** coordination environment and structure sensitivity of ruthenium were quantitatively investigated at atomic *** findings reveal that the reduced Ru nanoparticles,approximately 7.1 nm in diameter with a Ru-Ru coordination number of 5.9,exhibit high methane formation activity and selectivity at 340°*** Ru-Na interfacial sites facilitate CO2migration through a deoxygenation pathway,involving carbonate dissociation,carbonyl formation,and ***-situ experiments and theoretical calculations show that stable carbonyl intermediates on metallic Ru nanoparticles facilitate heterolytic C–O scission and C–H bonding,significantly lowering the energy barrier for activating stored CO2.

关键词： Carbon capture and utilization

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基于灰色关联度和偏最小二乘回归分析的芩苏胶囊抑菌谱效关系研究

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药物评价研究 2022年第6期45卷 1060-1069页

作者：黄广伟陈淮臣刘渝孙仁弟杨素德上海绿谷生命园医药有限公司上海201707 上海复方中药(绿谷)工程技术研究中心上海201707

目的基于灰色关联度法和偏最小二乘法研究芩苏胶囊抑菌作用的谱效关系。方法使用高效液相色谱(HPLC)法建立10批芩苏胶囊的指纹图谱,采用管碟法测定芩苏胶囊(0.3 g·mL^(−1))对5种常见致病菌(金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌... 详细信息

目的基于灰色关联度法和偏最小二乘法研究芩苏胶囊抑菌作用的谱效关系。方法使用高效液相色谱(HPLC)法建立10批芩苏胶囊的指纹图谱,采用管碟法测定芩苏胶囊(0.3 g·mL^(−1))对5种常见致病菌(金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、肺炎链球菌)的抑菌活性,使用灰色关联度分析法结合偏最小二乘法构建谱效关系。结果10批样品指纹图谱中有37个共有峰,芩苏胶囊对5种致病菌均具有一定的抑菌作用,对金黄色葡萄球菌有较好的抑菌作用。6、10(迷迭香酸)、14、17(丹酚酸B)号峰为芩苏胶囊抑制金黄色葡萄球菌的主要成分;10(迷迭香酸)、17(丹酚酸B)、35(苦参碱)、37(氧化苦参碱)号峰为抑制大肠埃希菌的主要成分;6、7、8、9、10(迷迭香酸)、14、17(丹酚酸B)、27、31(丹参酮Ⅰ)、37(氧化苦参碱)号峰为抑制铜绿假单胞菌的主要成分;8、9、10(迷迭香酸)、14、17(丹酚酸B)、37(氧化苦参碱)为抑制肺炎克雷伯菌的主要成分;5、23(汉黄芩素)、27、30、31(丹参酮Ⅰ)、32、33(丹参酮ⅡA)、34(槐果碱)、36(氧化槐定碱)、37(氧化苦参碱)号峰为抑制肺炎链球菌的主要成分。结论通过谱效关系研究明确了芩苏胶囊抑菌药效作用是多种成分共同作用的结果,可为芩苏胶囊的药效物质基础研究与质量控制提供参考。

关键词：芩苏胶囊抑菌活性指纹图谱谱效关系迷迭香酸丹酚酸B 苦参碱氧化苦参碱汉黄芩素

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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： Shi Li Didi sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

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Traffic safety helmet wear detection based on improved YOLOv5 network

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Optoelectronics Letters 2025年第1期21卷 35-42页

作者： GUI Dongdong sun Bo College of Software Southeast University Quanzhou Equipment Research Centre Haixi Institute Chinese Academy of Sciences

Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model, a method based on improving you only look once version 5(YOLOv5) is proposed. By incorporating the lightweight Ghost Net module into the YOLOv5 backbone network, we effectively reduce the model size. The addition of the receptive fields block(RFB) module enhances feature extraction and improves the feature acquisition capability of the lightweight model. Subsequently, the high-performance lightweight convolution, GSConv, is integrated into the neck structure for further model size compression. Moreover, the baseline model's loss function is substituted with efficient insertion over union(EIoU), accelerating network convergence and enhancing detection precision. Experimental results corroborate the effectiveness of this improved algorithm in real-world traffic scenarios.

关键词： Traffic control

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Microstructure and Wear/corrosion Resistance of Stainless Steel Laser-alloyed with Mn+W_(2)C, Mn+NiWC and Mn+SiC

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 283-294页

作者： ZHOU Rui DIAO Xiaogang sun Yixin School of Metallurgical Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China CITIC Heavy Cast Iron Industry Co. Ltd.Luoyang 417039China

In-situ formed high Mn steel coating reinforced by carbides was formed by laser surface alloying(LSA).Laser alloyed layers on 1Cr18Ni9Ti steel with Mn+W_(2)C(specimen A),Mn+NiWC(specimen B)and Mn+SiC(specimen C)powders were fabricated to improve the wear and corrosion behavior of 1Cr18Ni9Ti steel blades in high speed *** evolution,phases,element distribution,microhardness,wear and corrosion behavior of the laser alloyed layers were *** indicated that high Mn steel matrix composites with undissolved W_(2)C,WC and other in-situ formed carbides were formed by LSA with Mn+W_(2)C and Mn+NiWC while SiC totally dissolved into the high Mn matrix when adding Mn+*** as the binding phase in Ni-WC powder decreased the crack sensitivity of the alloyed layer as compared with the addition of W_(2)C *** improvement in average microhardness was achieved in the matrix in specimen A,B and C,with the value of 615,602 and 277 HV_(0.5),while that of the substrate was 212 HV_(0.5).The increase of microhardness,wear and corrosion resistance is highly corelated to microstructure,formed phases,type and content of carbides,micro-hardness and toughness of the alloyed layers.

关键词： laser surface alloying stainless steel carbide type microstructure wear and corrosion resistance

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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang Shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

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