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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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Liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine Karvellas David L.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-LatAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(P<0.001,0.007,and 0.031,respectively).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,<0.001,0.003,and 0.043,respectively)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,and<0.001,respectively).Levels of the pro-inflammatory cyto-kines,particularly interleukin(IL)-1β,IL-2,IL-4,IL-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

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新媒体时代学术期刊编辑素养提升策略探究

艺术科技 2024年第13期37卷 85-87页

作者：热娜·阿不拉合提新疆警察学院科研处新疆乌鲁木齐830013

目的:作为传播知识、推动学术进步的重要媒介,学术期刊的发展质量受到广大读者广泛关注。提升学术期刊编辑素养成为推动学术期刊高质量发展的关键因素。提升学术期刊编辑素养,可以确保编辑具备更专业的知识背景和更敏锐的洞察力,推动学... 详细信息

目的:作为传播知识、推动学术进步的重要媒介,学术期刊的发展质量受到广大读者广泛关注。提升学术期刊编辑素养成为推动学术期刊高质量发展的关键因素。提升学术期刊编辑素养,可以确保编辑具备更专业的知识背景和更敏锐的洞察力,推动学术交流与传播,从而适应新的发展需求,为更好地培养专业化的编辑队伍服务,推动学术期刊高质量发展,提高学术期刊的竞争力。基于此,文章主要分析学术期刊编辑素养提升策略。方法:文章从新媒体时代学术期刊编辑应具备的素养入手,认为学术期刊编辑应提升自身的政治素养、学术素养、编辑业务素养、服务素养。同时提出,学术期刊编辑应不断丰富专业知识储备,提升专业素养,强化责任心与职业道德,提升创新能力,顺应时代发展潮流,主动适应新的学术环境,以推动学术期刊高质量发展,为各领域的发展与进步提供理论支撑。结果:学术期刊编辑应加强对信息技术、互联网技术的学习,熟练掌握新媒体工具;加强与编辑同人交流;订阅专业期刊,研究期刊行业发展的最新动向。结论:新媒体时代,提升学术期刊编辑素养对推动学术期刊高质量发展具有重要意义。只有不断提升编辑素养,才能更好地推动学术交流与进步,提高学术期刊的质量和影响力,为学科发展作出更大贡献。

关键词：学术期刊编辑素养提升策略

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抑郁症自杀行为发生机制及预测研究新进展

首都医科大学学报 2024年第1期45卷 88-96页

作者：任艳萍吴涵王雯金文青李人首都医科大学附属北京安定医院国家精神疾病医学中心国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室北京100088 人脑保护高精尖创新中心首都医科大学北京100069

自杀是个体蓄意或自愿采取各种手段结束自己生命的行为。全球年自杀病死率约为16/100000,即每年大约有703000人死于自杀,是人类死亡的首位原因。自杀多发生于精神疾病患者中,最常见的为抑郁症。研究抑郁症自杀行为发生的机制对于制定从... 详细信息

自杀是个体蓄意或自愿采取各种手段结束自己生命的行为。全球年自杀病死率约为16/100000,即每年大约有703000人死于自杀,是人类死亡的首位原因。自杀多发生于精神疾病患者中,最常见的为抑郁症。研究抑郁症自杀行为发生的机制对于制定从自杀意念到自杀行为的预防措施可提供重要的数据支持。自杀行为发生的相关因素包括社会、心理、生物遗传等多种相关因素,本文旨在针对抑郁症自杀行为的生物学机制包括与自杀行为相关的磁共振研究、与自杀行为相关的神经认知研究、机器学习、生态瞬时评价及数字表型研究进展进行综述,以期为开发自杀风险早期识别指标提供借鉴。

关键词：自杀行为抑郁机制

Women's health in exercise and aging:What do we know?

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Journal of Sport and Health Science 2014年第3期3卷 153-154,248页

作者： rena Li Center for Hormone Advanced Science and Education Roskamp Institute

Recent articles published in Nature point out how sex bias,primarily concerning male-exclusivity,in biological research result in misleading and ambiguous science.1-4 For example,the majority of animal studies published in academic journals used only males,while only very limited studies were investigated in females or both *** consequences of such male-favored sex bias in biomedical studies had lead to a huge cost in the biomedical industry including drug *** 1997and 2001,eight out of 10 prescription drugs were withdrawn from the market by the US FDA because they showed more side

关键词：公共健康女性老龄化生物医药产业科学基础运动美国FDA 学术刊物

Troubleshooting of reinterventions after stent-by-stent placement for malignant hilar biliary obstruction(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 500-502页

作者： Tadahisa Inoue rena Kitano Masashi Yoneda Department of Gastroenterology Aichi Medical University1-1 YazakokarimataNagakuteAichi 480-1195Japan

To the Editor:Biliary drainage is essential for controlling cholangitis and/or jaundice in patients with malignant hilar biliary obstruction,and endoscopy is the first choice of approach due to its less *** unresectable cases,placement of self-expandable metal stents(SEMSs)has been recommended over that of plastic stents due to their longer patency,and bilateral placement is also recommended to achieve higher clinical success and patency rates[1].

关键词： obstruction malignant stent

Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease

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World Journal of Clinical Cases 2022年第7期10卷 2095-2105页

作者： Lian Qin rena Rehemuding Aikeliyaer Ainiwaer Xiang Ma Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous regionChina

BACKGROUND The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid ***,there are still differences studies on the correlation and interaction mechanism between betatrophin,angiogenin-likeprotein3(ANGPTL3)and lipoprotein lipase(LPL).In our previous studies,we found an increase in serum ANGPTL3 Levels in Chinese patients with coronary heart disease(CHD).Therefore,we retrospectively studied Kazakh CHD *** To explore the correlation between the betatrophin/ANGPTL3/LPL pathway and severity of coronary artery disease(CAD)in patients with *** Nondiabetic patients diagnosed with CHD were selected as the case group;79 were of Kazakh descent and 72 were of Han *** control groups comprised of 61 Kazakh and 65 Han *** serum levels of betatrophin and LPL were detected by enzyme-linked immunosorbent assay(ELISA),and the double antibody sandwich ELISA was used to detect serum level of *** levels of triglycerides,total cholesterol,and fasting blood glucose in each group were determined by an automatic biochemical *** the same time,the clinical baseline data of patients in each group were *** Betatrophin,ANGPTL3 and LPL levels of Kazakh patients were significantly higher than those of Han patients(P=0.031,0.038,0.021 respectively).There was a positive correlation between the Gensini score and total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),betatrophin,and LPL in Kazakh patients(r=0.204,0.453,0.352,0.471,and 0.382 respectively),(P=0.043,0.009,0.048,0.001,and P<0.001 respectively).A positive correlation was found between the Gensini score and body mass index(BMI),TC,TG,LDL-C,LPL,betatrophin in Han patients(r=0.438,0.195,0.296,0.357,0.328,and 0.446 respectively),(P=0.044,0.026,0.003,0.20,0.004,and P<0.001).TG and betatrophin were the risk factors of coronary artery disease in Kaza

关键词： Betatrophin/angiogenin-likeprotein3/Lipoprotein lipase pathway Coronary heart disease Gensini integral Coronary artery disease

What does complement do in Alzheimer’s disease? Old molecules with new insights

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Translational Neurodegeneration 2013年第1期2卷 143-153页

作者： Yong Shen Libang Yang rena Li Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute2040 Whitfield AvenueSarasotaUSA Department of Pediatrics School of MedicineUniversity of MinnesotaMinneapolisMN 55455USA Department of Neurology College of MedicineUniversity of FloridaGainesvilleFL 32610USA Center for Hormones Advanced Science and Education Roskamp Institute2040 Whitfield AvenueSarasotaFloridaUSA

Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease(AD)and anti-inflammatory and immunotherapeutic approaches may be amenable to AD *** is known that complement activation occurs in the brain of patients with AD,and contributes to a local inflammatory state development which is correlated with cognitive *** addition to the complement’s critical role in the innate immune system recognizing and killing,or targeting for destruction,complement proteins can also interact with cell surface receptors to promote a local inflammatory response and contributes to the protection and healing of the *** the other hand,complement activation also causes inflammation and cell damage as an essential immune function to eliminate cell debris and potentially toxic protein *** is the balance of these seemingly competing events that influences the ultimate state of neuronal *** mini review will be focusing on the unique molecular interactions happening in the AD development,the functional outcomes of those interactions,as well as the contribution of each element to AD.

关键词： Alzheimer healing inflammation

Why women see differently from the way men see? A review of sex differences in cognition and sports

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Journal of Sport and Health Science 2014年第3期3卷 155-162页

作者： rena Li Center for Hormone Advanced Science and Education.Roskamp Institute

The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal development and last through entire lifespan. The major biological basis of the gender-dependent cognitive activity includes two major components： sex hormone and sex-related characteristics, such as sex- determining region of the Y chromosome （SRY） protein. However, the knowledge of how much biology of sex contributes to normal cogni- tive function and elite athletes in various sports are still pretty limited. In this review, we will be focusing on sex differences in spatial learning and memory -- especially the role of male- and female-type cognitive behaviors in sports.

关键词： Brain Hormones Learning and memory in sports Sex-specific cognition

Mini review: linkage between α-Synuclein protein and cognition

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Translational Neurodegeneration 2015年第1期4卷 33-38页

作者： Huda Saleh Ayeh Saleh Hailan Yao Jie Cui Yong Shen rena Li Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute SarasotaFL 34243USA Center for Hormone Advanced Science and Education Roskamp InstituteSarasotaFL 34243USA Neurodegenerative Disease Research Center School of Life SciencesUniversity of Science and Technology of ChinaAnhui 230027China Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalBeijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China

α-synuclein is a protein that plays important roles in cognitive function in the normal brain,although its exact role is not fully ***,current studies reveal that defects inα-synuclein function could contribute to various neurodegenerative disorders,such as Parkinson’s disease(PD),a disease with symptomatic progression of deterioration in motor and cognitive *** studies show that the level ofα-synuclein in cerebrospinal fluid(CSF)is highly correlated with speed of cognitive decline,suggesting a potential role ofα-synuclein in cognitive *** this mini review,we will be focus on literatures ofα-synuclein in cognitive function in the non-diseased brain,as well as the impact that defectiveα-synuclein has on cognition in disease *** will be accomplished by assessing the effects of solubleα-synuclein,α-synuclein oligomers,and extracellularα-synuclein transport,on neurodegeneration.

关键词： α-Synuclein Parkinson’s disease Cognition Memory Learning Alzheimer’s disease