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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei ren-lin li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(li and Jia,2023).

关键词： death specialized barrier

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Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China life Sciences 2025年第1期 309-310页

作者： Tao Zhou lin li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

lithium-sulfur （li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （liPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes li2S dissolution and nucleation ***,the li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： lithium sulfur batteries

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Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li Hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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势阱深度对双稳态电磁发电系统发电性能的影响研究

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应用数学和力学 2017年第6期38卷 622-632页

作者：张小静刘丽兰任博林李淑超西安理工大学机械与精密仪器工程学院西安710048

电磁式振动能量捕获技术从单稳态系统发展到多稳态系统,拓宽了响应频带,增大了输出电压,能够获得较好的发电性能.以附加线性振子的双稳态电磁式振动能量捕获器为研究对象,主要研究了势阱深度对双稳态系统发电性能的影响,并基于最优发电... 详细信息

电磁式振动能量捕获技术从单稳态系统发展到多稳态系统,拓宽了响应频带,增大了输出电压,能够获得较好的发电性能.以附加线性振子的双稳态电磁式振动能量捕获器为研究对象,主要研究了势阱深度对双稳态系统发电性能的影响,并基于最优发电性能下的势阱深度,研究了双稳态系统结构参数中质量比与调频比对系统发电性能的影响.通过数值仿真结果说明,在外部激励频率为低频时:势阱深度较大时,双稳态系统的振子只能在一个阱内发生小幅振动运动;当势阱深度小到一定程度时,双稳态系统的振子跨过势垒在两个阱间内发生大幅混沌运动或周期运动,其优于小幅振动运动时的平均输出功率.通过数值模拟,得到双稳态系统具有较高的发电性能下的最优质量比、调频比以及阻尼比参数.

关键词：双稳态系统势阱深度质量比调频比平均输出功率

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上消化道出血患者的临床护理探析

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医学食疗与健康 2019年第15期17卷 21-21,23页

作者：任琳莉绵阳市中心医院

目的:分析上消化道出血患者的临床护理情况。方法:选取我院收治的上消化道出血患者92例,将其分为观察组和对照组各46例,观察组患者应用优质护理,对照组应用常规护理,对比两组护理效果。结果:观察组患者护理满意度明显高于对照组,差异具... 详细信息

目的:分析上消化道出血患者的临床护理情况。方法:选取我院收治的上消化道出血患者92例,将其分为观察组和对照组各46例,观察组患者应用优质护理,对照组应用常规护理,对比两组护理效果。结果:观察组患者护理满意度明显高于对照组,差异具有统计学意义(P<0.05)。结论:上消化道出血患者的临床护理中选择优质护理方式,给予患者综合、高效的护理干预能够更好的缓解患者临床症状,促进上消化道出血患者病情好转,临床应用效果良好,值得推广使用。

关键词：上消化道出血临床护理护理分析

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急诊科护士职业性肌肉骨骼损伤与工作能力的关系

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工业卫生与职业病 2019年第1期45卷 21-23页

作者：任琳莉绵阳市中心医院四川绵阳621000

目的了解急诊科护士职业性肌肉骨骼损伤和工作能力情况,分析职业性肌肉骨骼损伤与工作能力的关系。方法整群抽样法对绵阳市5所三级综合医院260名急诊科护理人员进行调查,采用工作能力指数量表、职业性肌肉骨骼疾患调查量表进行调查分析... 详细信息

目的了解急诊科护士职业性肌肉骨骼损伤和工作能力情况,分析职业性肌肉骨骼损伤与工作能力的关系。方法整群抽样法对绵阳市5所三级综合医院260名急诊科护理人员进行调查,采用工作能力指数量表、职业性肌肉骨骼疾患调查量表进行调查分析,分析急诊科护士的工作能力与职业性肌肉骨骼疾患的关系。结果不同工作能力级别护士的工作能力指数之间比较,差异有统计学意义(P<0.05)。不同工作能力级别的护士职业性肌肉骨骼疾患的患病率比较,差异有统计学意义(P<0.05)。其中,工作能力差的护士发生职业性肌肉骨骼疾患的患病率最高,差异有统计学意义(P<0.05)。两组护士工作能力级别构成比之间存在明显差异(χ~2=198.452,P<0.05)。两组护士工作能力级别之间存在明显差异(Z=-12.857,P<0.05),其中患病者"中""差"比例明显高于非患病组,而"优""良"比例明显低于非患病组。结论急诊科护士工作能力处于中良状态,职业性肌肉骨骼疾患是导致工作能力下降的危险因素。

关键词：职业性肌肉骨骼疾患急诊科工作能力

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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui ren Tian li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion batteries(liBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(liBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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