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浅谈癌症免疫治疗中的新型免疫细胞接合器

医学研究前沿

医学研究前沿 2024年第4期2卷 13-18页

作者：任红利刘芳芳赣南医科大学江西赣州341000

免疫疗法是治疗癌症的一种革命性方法,包括基于细胞的疗法、疫苗、检查点抑制剂和靶向抗体,以及涉及免疫细胞接合器的最新方法。免疫细胞接合器是一种基于生物工程抗体的分子,旨在将免疫细胞重定向至肿瘤。大多数免疫细胞接合器是具有... 详细信息

免疫疗法是治疗癌症的一种革命性方法,包括基于细胞的疗法、疫苗、检查点抑制剂和靶向抗体,以及涉及免疫细胞接合器的最新方法。免疫细胞接合器是一种基于生物工程抗体的分子,旨在将免疫细胞重定向至肿瘤。大多数免疫细胞接合器是具有多个臂的抗体,通过靶向肿瘤抗原和效应细胞表面分子来桥接肿瘤细胞和效应细胞。效应细胞分子必须触发激活免疫效应细胞杀伤机制的信号通路。因此,这些分子的作用模式是在肿瘤细胞和免疫细胞之间形成免疫突触。第一代双特异性免疫细胞接合器被设计成靶向T细胞上CD3和白血病B细胞上的肿瘤抗原如CD19。这些药物在治疗血液系统恶性肿瘤患者方面已显示出良好的疗效,但仍存在许多挑战。特别是,细胞因子释放综合征(CRS)和免疫效应细胞相关的神经毒性,以及治疗后复发和实体瘤疗效不佳,都是严重的挑战。目前,人们正在努力提高T细胞接合器的安全性和有效性,包括开发对CD3具有较低亲和力的分子,靶向共刺激T细胞分子,并且可以在肿瘤微环境中被条件激活。此外,还正在探索靶向具有内在肿瘤细胞杀伤能力的其他类型的免疫效应细胞,如γδT细胞、自然杀伤(NK)细胞和髓系细胞。

关键词：癌症免疫治疗免疫细胞接合器

Representation of the ENSO Combination Mode and its Asymmetric SST Response in Different Resolutions of HadGEM3

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Advances in Atmospheric Sciences 2018年第8期35卷 167-180页

作者： Jianghua WAN hongli ren Peili WU Laboratory for Climate Studies and CMA-NJU Joint Laboratory for Climate Prediction Studies National Climate Center China Meteorological Administration Beijing 100081 China Department of Atmospheric Sciences School of Environment Studies University of Geoscience Wuhan 430074 China Met Office Hadley Center Exeter EX1 3PB UK

Previous studies have revealed a combination mode （C-mode） occurring in the Indo-Pacific region, arising from nonlinear interactions between ENSO and the western Pacific warm pool annual cycle. This paper evaluates the simulation of this C-mode and its asymmetric SST response in HadGEM3 and its resolution sensitivity using three sets of simulations at horizontal resolutions of N96, N216 and N512. The results show that HadGEM3 can capture well the spatial pattern of the C-mode associated surface wind anomalies, as well as the asymmetric response of SST in the tropical Pacific, but it strongly overestimates the explained variability of the C-mode compared to the ENSO mode. The model with the three resolutions is able to reproduce the distinct spectral peaks of the C-mode at the near annual combination frequencies, but the performance in simulating the longer periods is not satisfactory, presumably due to the unrealistic simulation of the ENSO mode. Increasing the horizontal resolution can improve the consistency between atmospheric and oceanic representations of the C-mode, but not necessarily enhance the accuracy of C-mode simulation compared with observation.

关键词： ENSO combination mode asymmetric response Nifio-A index HadGEM3 horizontal resolution

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反省与弥补:新时代中医师承教育事业探讨

中医文献杂志 2024年第1期42卷 73-80,95页

作者：章林任宏丽段逸山上海中医药大学上海201203

师承教育在历代中医药人才培养过程中发挥了重要作用。1949年以来,党和国家出台了一系列政策措施以加强师承教育,培养高层次中医药人才。中医界围绕如何融合中医院校教育和师承教育展开了深入讨论,明确了以院校教育为主体、师承教育为... 详细信息

师承教育在历代中医药人才培养过程中发挥了重要作用。1949年以来,党和国家出台了一系列政策措施以加强师承教育,培养高层次中医药人才。中医界围绕如何融合中医院校教育和师承教育展开了深入讨论,明确了以院校教育为主体、师承教育为辅助的新型中医高等教育培养模式。中医高等院校就如何融合院校教育和师承教育进行了大量改革,探索出诸多具有特色的人才培养模式。一系列学术争鸣和改革实践证明,尽管师承教育存在天然缺陷,但它仍是独具特色、符合中医药人才成长和学术传承规律的教育模式之一,是中医药人才培养的重要途径。发展中医药师承教育,对发挥中医药特色优势、加强中医药人才队伍建设、提高中医药学术水平和服务能力具有重要意义。

关键词：中医高等教育师承教育院校教育人才培养模式中医史

The Boreal Summer Intraseasonal Oscillation Simulated by Four Chinese AGCMs Participating in the CMIP5 Project

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Advances in Atmospheric Sciences 2014年第5期31卷 1167-1180页

作者： ZHAO Chongbo ZHOU Tianjun SONG Lianchun ren hongli Laboratory for Climate Studies National Climate Center China Meteorological Administration State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences National Climate Center China Meteorological Administration

The performances of four Chinese AGCMs participating in the Coupled Model Intercomparison Project Phase 5 （CMIP5） in the simulation of the boreal summer intraseasonal oscillation （BSISO） are assessed. The authors focus on the major characteristics of BSISO： the intensity, significant period, and propagation. The results show that the four AGCMs can reproduce boreal summer intraseasonal signals of precipitation; however their limitations are also evident. Compared with the Climate Prediction Center Merged Analysis of Precipitation （CMAP） data, the models underestimate the strength of the intraseasonal oscillation （ISO） over the eastern equatorial Indian Ocean （IO） during the boreal summer （May to October）, but overestimate the intraseasonal variability over the western Pacific （WP）. In the model results, the westward propagation dominates, whereas the eastward propagation dominates in the CMAP data. The northward propagation in these models is tilted southwest-northeast, which is also different from the CMAP result. Thus, there is not a northeast-southwest tilted rain belt revolution off the equator during the BSISO＇s eastward journey in the models. The biases of the BSISO are consistent with the summer mean state, especially the vertical shear. Analysis also shows that there is a positive feedback between the intraseasonal precipitation and the summer mean precipitation. The positive feedback processes may amplify the models＇ biases in the BSISO simulation.

关键词： boreal summer intraseasonal oscillation AGCM simulation feedback

Subtropical Air-Sea Interaction and Development of Central Pacific El Nio

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Journal of Ocean University of China 2013年第2期12卷 260-271页

作者： XIE Ruihuang HUANG Fei ren hongli Department of Marine Meteorology Physical Oceanography Laboratory and Key Laboratory of Ocean-Atmosphere Interaction and Climate in Universities of ShandongOcean University of China Department of Meteorology School of Ocean and Earth Science and TechnologyUniversity of Hawaii Laboratory for Climate Studies National Climate CenterChina Meteorological Administration

The standard deviation of the central Pacific sea surface temperature anomaly （SSTA） during the period from October to February shows that the central Pacific SSTA variation is primarily due to the occurrence of the Central Pacific E1 Nifio （CP-E1 Nifio） and has a connection with the subtropical air-sea interaction in the northeastern Pacific. After removing the influence of the Eastern Pacific E1 Nifio, an S-EOF analysis is conducted and the leading mode shows a clear seasonal SSTA evolving from the subtropical northeastern Pacific to the tropical central Pacific with a quasi-biennial period. The initial subtropical SSTA is generated by the wind speed decrease and surface heat flux increase due to a north Pacific anomalous cyclone. Such subtropical SSTA can further influence the establishment of the SSTA in the tropical central Pacific via the wind-evaporation-SST （WES） feedback. After established, the central equatorial Pacific SSTA can be strengthened by the zonal advective feedback and thermocline feedback, and develop into CP-E1 Nifio. However, as the thermocline feedback increases the SSTA cooling after the mature phase, the heat flux loss and the reversed zonal advective feedback can cause the phase transition of CP-EI Nifio. Along with the wind stress variability, the recharge （discharge） process occurs in the central （eastern） equatorial Pacific and such a process causes the phase consistency between the thermocline depth and SST anomalies, which presents a contrast to the original recharge/discharge theory.

关键词： CP-E1 Nifio subtropical forcing recharge/discharge process phase consistency thermocline depth

中医药产业高质量发展的内涵、评价体系与基本路径探析

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新中医 2024年第15期56卷 181-188页

作者：章林任宏丽刘红宁上海中医药大学上海201203 江西中医药大学江西南昌330004

实现中医药产业高质量发展是构建现代中医药产业体系、推动中医药整体事业高质量发展的基本命题和重要支撑。文章通过梳理中医药产业高质量发展的内涵与评价体系,认为中医药产业高质量发展仍面临着技术升级和科技创新、产业集群打造、... 详细信息

实现中医药产业高质量发展是构建现代中医药产业体系、推动中医药整体事业高质量发展的基本命题和重要支撑。文章通过梳理中医药产业高质量发展的内涵与评价体系,认为中医药产业高质量发展仍面临着技术升级和科技创新、产业集群打造、产业融合发展、龙头企业带动辐射、国际市场占领、产业服务平台完善等压力。为此,实现中医药产业高质量发展的政策导向和基本路径在于:建设产业基地、产业集群和产业园,完善产业链和产业体系;开发道地品牌中药材优势,打造富民兴业支柱产业;发挥特色脱贫致富模式效应,推进经济社会可持续发展;实施科技创新驱动战略,推动创造性转化创新性发展;构建“中医药+”融合发展新格局,推进现代化产业化;建设服务出口基地,促进对外贸易高速发展;聚焦发展瓶颈,探索产学研医政企协同共建新模式。

关键词：中医药产业新发展格局高质量发展基本路径评价体系

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乡村振兴战略下农村基层中医药事业发展研究

中医药管理杂志 2024年第15期32卷 226-229页

作者：谭峰浪章林任宏丽上海中医药大学科技人文研究院上海201203

新时代推动农村基层中医药事业发展是推进乡村振兴战略的题中之义,同时也为乡村振兴战略的实施提供了有力的支持和保障。虽然农村基层中医药事业历经脱贫攻坚、致富增收、健康保障等考验,但在推动农村基层中医药事业发展中依然存在人才... 详细信息

新时代推动农村基层中医药事业发展是推进乡村振兴战略的题中之义,同时也为乡村振兴战略的实施提供了有力的支持和保障。虽然农村基层中医药事业历经脱贫攻坚、致富增收、健康保障等考验,但在推动农村基层中医药事业发展中依然存在人才、产业、制度保障和物资基础等多维度困境。为此要持续培养农村基层中医药人才队伍,大力发展农村中医药一二三产业,努力提升中医药文化进农村的工作覆盖水平,着力增强农村吸引社会资本发展“中医药+”格局的能力,为顺利推进乡村振兴战略保驾护航。

关键词：乡村振兴农村中医药

Large-scale low-frequency rainfall regimes and their transition modes in summertime over China

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Chinese Science Bulletin 2006年第11期51卷 1355-1367页

作者： ren hongli ZHANG Peiqun CHOU Jifan LI Weijing GAO Li College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China Laboratory for Climate Studies National Climate Centre China Meteorological Administration Beijing 100081 China LASG Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

Seven large-scale low-frequency rainfall regimes (LFRRs) in summertime are identified for China in a 10-dimensional phase space by using a 40-year daily precipitation dataset. Corresponding to the local extrema of observed probability density in phase space, the LFRRs are characterized by the persistence and transitions that reflect the spread and jump features of low-frequency rainfall centers. The LFRRs are generally consistent with summer monsoon rainbelts on the intraseasonal timescale, and there exist the preferred transition relationships between the LFRRs. Four LFRRs’ transition modes (LFRRTMs), which are the dominant components of the interannual and intraseasonal variability of sum- mer rainfall in China, are further induced. Analyses of atmospheric circulation system show that the anomalies of the subtropical high over the western Pacific (SHWP) and blockings in mid-high latitudes, the low-latitude circulation anomalies, and the wavetrains over the East Asia-Pacific region (EAPWs), play crucial roles in the occurrence and transitions of the LFRRs. Moreover, the evolution of the SHWP and blockings, the distribution and movement of the EAPWs, and the intraseasonal variability of the East Asian-Pacific jet stream may be principal factors of the formations of the LFRRTMs.

关键词：夏季降雨相空间低频降雨体系大尺度预报

Predictor-based error correction method in short-term climate prediction

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Progress in Natural Science:Materials International 2008年第1期18卷 129-135页

作者： hongli ren Laboratory for Climate Studies,National Climate Center,China Meteorological Administration,Beijing 100081,China Laboratory for Climate Studies National Climate Center China Meteorological Administration

In terms of the basic idea of combining dynamical and statistical methods in short-term climate prediction,a new prediction method of predictor-based error correction(PREC)is put forward in order to effectively use statistical experiences in dynamical ***- yses show that the PREC can reasonably utilize the significant correlations between predictors and model prediction errors and correct prediction errors by establishing statistical prediction ***,the PREC is further applied to the cross-validation experiments of dynamical seasonal prediction on the operational atmosphere-ocean coupled general circulation model of China Meteorological Admin- istration/National Climate Center by selecting the sea surface temperature index in Ninflo3 region as the physical predictor that represents the prevailing ENSO-cycle mode of interannual variability in climate *** is shown from the prediction results of summer mean circulation and total precipitation that the PREC can improve predictive skills to some *** the PREC provides a new approach for improving short-term climate prediction.

关键词： Short-term climate prediction Seasonal prediction Predictor Error correction