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免疫检查点抑制剂相关抗神经元抗体阳性副肿瘤神经综合征临床特征分析

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中国现代神经疾病杂志 2024年第5期24卷 346-351页

作者：张乐范思远任海涛徐燕柏琳关鸿志中国医学科学院北京协和医学院北京协和医院神经科 100730 中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科 100730

目的分析抗神经元抗体阳性免疫检查点抑制剂相关副肿瘤神经综合征(ICI-PNS)的临床特征。方法与结果纳入2012年1月至2024年3月中国医学科学院北京协和医院诊断与治疗的5例抗神经元抗体阳性ICI-PNS患者,肿瘤类型包括小细胞肺癌(2例)、... 详细信息

目的分析抗神经元抗体阳性免疫检查点抑制剂相关副肿瘤神经综合征(ICI-PNS)的临床特征。方法与结果纳入2012年1月至2024年3月中国医学科学院北京协和医院诊断与治疗的5例抗神经元抗体阳性ICI-PNS患者,肿瘤类型包括小细胞肺癌(2例)、恶性黑色素瘤(1例)、霍奇金淋巴瘤(1例)、宫颈癌(1例),免疫检查点抑制剂包括程序性死亡蛋白-1抑制剂(3例)、程序性死亡蛋白配体-1抑制剂(1例)、程序性死亡蛋白-1/细胞毒性T细胞相关抗原4双抑制剂(1例)。5例患者均出现副肿瘤神经综合征的高风险表型,其中4例表现为边缘性脑炎,1例表现为快速进展的小脑综合征。血清和(或)脑脊液中检出的抗神经元抗体包括抗Hu、γ-氨基丁酸B型受体、Y染色体性别决定区相关高迁移率组盒蛋白1、代谢型谷氨酸受体5型、Yo抗体。4例神经系统症状出现在应用免疫检查点抑制剂2周内。4例病情达峰时改良Rankin量表评分为3分,1例为5分。5例患者常见不良事件评价标准分级(CTCAE)均为3级。治疗方面,停用免疫检查点抑制剂,给予糖皮质激素联合静脉注射免疫球蛋白治疗,神经系统症状均有改善。结论中高风险抗神经元抗体是ICI-PNS的诊断标志物,可依据ICI-PNS临床表型及CTCAE分级等综合制定免疫治疗方案,停用免疫检查点抑制剂,应用糖皮质激素、静脉注射免疫球蛋白可以改善患者预后。

关键词：副肿瘤综合征神经系统免疫检查点抑制剂(非MeSH词) 神经元自身抗体药物相关性副作用和不良反应

Fabrication strategies of porous precious-metal-free bifunctional electrocatalysts for overall water splitting:Recent advances

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Green Energy & Environment 2021年第5期6卷 620-643页

作者： Jin-tao ren Yali Yao Zhong-Yong Yuan Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Institute of New Catalytic Materials ScienceSchool of Materials Science and EngineeringNankai UniversityTianjin300350China Institute for the Development of Energy for African Sustainability College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburgSouth Africa

Electrocatalytic water splitting using power generated from renewable energy to produce hydrogen has been considered as one of the more attractive approach to alleviate the problems of energy crisis and environmental *** of the biggest challenges for the large-scale application of water electrolysis is the searching of the low cost electrocatalysts with high and stable activity toward both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The well-developed porous features of materials synthesized from the earth abundant elements endow them with the enhanced mass transfer and improved electronic interconnection during electrochemical reactions,resulting in the excellent electrocatalytic performance for both OER and ***,this review focuses on the recent development of innovation strategies for the fabrication of porous non-noble-metal materials including heteroatom-doped carbon-based and transition metal(mainly Co,Ni,and Fe)-based materials as efficient electrocatalysts for overall water ***,a detailed discussion of the structure–activity correlation gives an insight on the origin of the high electrocatalytic performance of porous materials obtained from different strategies,and provides guidance for future design and preparation of highly efficient electocatalysts based on non-precious carbon or metal materials for overall water splitting.

关键词： Electrocatalysis Porous materials Hydrogen evolution Oxygen evolution Overall water splitting

A 3-D numerical simulation of the characteristics of open channel flows with submerged rigid vegetation

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Journal of Hydrodynamics 2021年第4期33卷 833-843页

作者： Jun-tao ren Xue-fei Wu Ting Zhang School of Environment and Resource Southwest University of Science and TechnologyMianyang621010China

This paper applies the Flow-3D to investigate the impacts of different flow discharge and vegetation scenarios on the flow velocity (including the longitudinal, transverse and vertical velocities). After the verification by using experimental measurements, a sensitivity analysis is conducted for the vegetation diameter, the vegetation height and the flow discharge. For the longitudinal velocity, the greatest impact on the flow structure originates from the vegetation diameter, rather than the discharge. The vegetation height, however, determines the inflection point of the vertical distribution. Comparing the transverse velocities at two positions in the vegetated area, i.e., the upstream and the downstream, a symmetric pattern is identified along the water depth. The same pattern is also observed for the vertical velocity regardless of the flow or vegetation scenario, including both transverse and vertical fluid circulation patterns in the vegetated area. Moreover, the larger the vegetation diameter is, the more evident these patterns become. The upper circulation occurs near the vegetation canopy. These findings regarding the circulations along the transverse and vertical directions in the vegetated region shed light on the 3-D flow structure through the submerged vegetation.

关键词： Submerged rigid vegetation longitudinal velocity transverse velocity vertical velocity open channel

单元尺寸自密实混凝土抗压强度Weibull分布研究

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宁波工程学院学报 2024年第3期36卷 41-48页

作者：赵应洪任涛陈巧林杨韬贵州大学土木工程学院贵州贵阳550025

为了研究骨料组成对自密实混凝土抗压强度Weibull分布的影响,对自密实混凝土的砂子和碎石进行粒径筛选,并通过人工控制材料的均匀程度,浇筑了大量具有不同粒径特征的试件。根据500个试件的单轴抗压强度数据,利用数理统计方法得出Weibul... 详细信息

为了研究骨料组成对自密实混凝土抗压强度Weibull分布的影响,对自密实混凝土的砂子和碎石进行粒径筛选,并通过人工控制材料的均匀程度,浇筑了大量具有不同粒径特征的试件。根据500个试件的单轴抗压强度数据,利用数理统计方法得出Weibull分布中的均质度系数,随后将该系数赋值到数值软件中进行建模分析。通过物理试验发现:随着粒径增加,抗压强度呈先降低后上升的趋势;均质度系数的取值范围为4.67~7.99。数值模拟结果显示:均质度系数越小,损伤单元数量越多,模型产生较多裂缝,破坏较为碎片化;随着均质度增大,损伤单元变少,应力集中现象减弱,局部损伤和裂缝减少。

关键词：自密实混凝土抗压强度 Weibull分布均质度系数取值范围

Ore genesis of Badi copper deposit, northwest Yunnan Province, China： evidence from geology, fluid inclusions, and sulfur, hydrogen and oxygen isotopes

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Acta Geochimica 2018年第4期37卷 559-570页

作者： Hejun Yin Jianguo Huang tao ren Kunming University of Science and Technology Kunming 650093 China

The Badi copper deposit is located in Shangjiang town, Shangri-La County, Yunnan Province. Tectonically, it belongs to the Sanjiang Block. Vapor-liquid two-phase fluid inclusions, CO2-bearing fluid inclusions, and daugh- ter-beating inclusions were identified in sulfide-rich quartz veins. Microthermometric and Raman spectroscopy studies revealed their types of ore-forming fluids：（1） low-tem- perature, low-salinity fluid; （2） medium-temperature, low salinity CO2-bearing; and （3） high-temperature, Fe-rich, high sulfur fugacity. The δ^18O values of chalcopyrite- bearing quartz ranged from 4.96‰ to 5.86%0, with an average of 5.40%0. The δD values of ore-forming fluid in equilibrium with the sulfide-bearing quartz were from - 87‰ to - 107‰, with an average of - 97.86%0. These isotopic features indicate that the ore-forming fluid is a mixing fluid between magmatic fluid and meteoric water. The δ^34S values of chalcopyrite ranged from 13.3‰ to 15.5‰, with an average of 14.3‰. Sulfur isotope values suggest that the sulfur in the deposit most likely derived from seawater. Various fluid inclusions coexisted in the samples; similar homogenization temperature to different phases suggests that the Badi fluid inclusions might have been captured under a boiling system. Fluid boiling caused by fault activity could be the main reason for the mineral precipitation in the Badi deposit.

关键词： Badi copper deposit Fluid inclusion Sulfurisotope Hydrogen and oxygen isotope Ore genesis

Genesis of Xinzhai Sandstone-Type Copper Deposit in Northern Laos: Geological and Geochemical Evidences

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Journal of Earth Science 2019年第1期30卷 95-108页

作者： Jianguo Huang tao ren Haijun Zou Faculty of Land Resources Engineering Kunming University of Science and Technology State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences

Xinzhai sandstone-type copper deposit located in northern Laos lies in the Jiangcheng-Phongsaly-Phrae Mesozoic basin(JPMB), which is regarded as southern extension of the Lanping-Simao Mesozoic basin in China. The copper deposit belt is bounded by the AilaoshanHeishui River fault and the Dian Bien Phu-Luang Prabang fault at the east and Lancang RiverBannankan faults at the west. Two types of orebodies are identified in the Xinzhai area based on geological investigation. One is lamellar copper orebody hosted by the fine lithic feldspar sandstones and feldspar lithic sandstones; another is vein-type orebody. The sulfur isotopic compositions of the chalcopyrite and tetrahedrite are from -11.6‰ to -1.8‰, indicating that sulfur is derived from bacterial sulfate reduction(BSR). δD values of fluid inclusions in ore-bearing quartz samples are from -99‰ to -78‰. The calculated δ^(18)OH_2O values of ore-forming fluid vary from -2.3‰ to 0.4‰ using the quartz-water fractionation equations and the mineralization temperature. Oxygen and hydrogen isotopic compositions show that the ore-forming fluid was derived from basin fluid. Rock-mineral identifications show that both of the mineral grain maturity and the structural maturity are high in the Jurassic Huakaizuo Formation, reflecting a far-source accumulation and lake facies sedimentatary environment. Based on tectonic determination diagram of the Al_2O_3/SiO_2-TFe+MgO, the sandstone samples collected from the Huakaizuo Formation were plotted in the passive continental margin. The collision of the Indian and Eurasian blocks during the Cenozoic formed large-scale strikeslips and thrust nappe structures in margin of the basin. With the tectonic movement, Cu-rich basin fluid from the basement of basin migrated upward along the contemporaneous fault and into the high porosity strata. At the same time, in organic matter-riched condition, bacterial sulfate reduction(BSR) has been triggered, forming a large number of S^(2-) ions, and th

关键词： Laos sandstone-type copper deposit geology geochemistry genesis

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基于双分支编码的闭环分割网络

计算机系统应用 2024年第1期33卷 110-118页

作者：任玉涛程远志青岛科技大学信息科学技术学院青岛266061

Transformer模型中,卷积视觉转换器(CvT)具备同时提取图像的局部和全局特征的能力而受到关注.对于腹部器官分割问题,为了解决CNN模型分割目标边界轮廓模糊不清的问题,提出了一种新颖的基于CvT和CNN的双分支闭环分割模型DBLNet.模型利用... 详细信息

Transformer模型中,卷积视觉转换器(CvT)具备同时提取图像的局部和全局特征的能力而受到关注.对于腹部器官分割问题,为了解决CNN模型分割目标边界轮廓模糊不清的问题,提出了一种新颖的基于CvT和CNN的双分支闭环分割模型DBLNet.模型利用形状先验和预测结果的分割轮廓显式监督并指导网络学习过程.模型包括:轮廓提取编码模块(CEE)、边界形状分割网络(BSSN)和闭环结构.CEE模块首次利用改造的3D CvT和3D门控卷积层(GCL)捕获多层级轮廓特征,并辅助BSSN训练.BSSN模块设计形状特征融合模块(SFF)同时捕获目标区域和轮廓特征,推动CEE训练拟合.闭环结构使得双分支的分割结果互相反馈并辅助对方的训练.DBLNet在BTCV排行榜上测试,平均Dice得分为0.878,排名第13位;在临床医院数据进行应用测试,表现出强大的性能.

关键词：腹部器官边缘轮廓双分支编码器闭环结构卷积视觉转换器医学影像处理特征融合图像分割

Design and Analysis of an Active Helical Drive Downhole Tractor

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Chinese Journal of Mechanical Engineering 2017年第2期30卷 428-437页

作者： Yujia LI Qingyou LIU Yonghua CHEN tao ren School of Mechatronic Engineering Southwest Petroleum University Key Laboratory of Fluid and Power Machinery of Ministry of Education Xihua University Department of Mechanical Engineering The University of Hong Kong

During oil-gas well drilling and completion, downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works. Downhole tractors have been used to convey tools in complex wellbores, however a very large tractive force is needed to carry more downhole tools to accomplish works with high efficiency. A novel serial active helical drive downhole tractor which has significantly improved performance compared with previous work is proposed. All previously reported helical drive downhole tractors need stators to balance the torque generated by the rotator. By contrast, the proposed serial downhole tractor does not need a stator; several rotator-driven units should only be connected to one another to achieve a tractive force multifold higher than that was previously reported. As a result, the length of a single unit is shortened, and the motion flexibility of the downhole tractor is increased. The major performance indicators, namely, gear ratio, velocity, and tractive force, are analyzed. Experimental results show that the maximum tractive force of a single-unit prototype with a length of 900 mm is 165.3 kg or 1620 N. The analysis and experimental results show that the proposed design has considerable potential for downhole works.

关键词： Serial · Active · Helical · Downhole · Tractor Wellbore

Facile synthesis of molybdenum carbide nanoparticles in situ decorated on nitrogen-doped porous carbons for hydrogen evolution reaction

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Journal of Energy Chemistry 2019年第5期28卷 78-84页

作者： Jin-tao ren Yue-Jun Song Zhong-Yong Yuan National Institute for Advanced Materials School of Materials Science and EngineeringNankai UniversityTianjin 300350China Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)Nankai UniversityTianjin 300071China

Molybdenum-based electrocatalysts are promising candidates of platinum (Pt)-based materials in electrocatalyzing hydrogen evolution reaction (HER), due to their cost-efficient and resembled electronic properties. Reported herein is the preparation of molybdenum carbide nanoparticles uniformly decorated on nitrogen-modified carbons (Mo2C/NC) through the carbonization of Mo-based polymers under hydrogen atmosphere by using poly(p-phenylenediamine) and ammonium heptamolybdate polymer analogue as precursors. And the molybdenum nitride nanoparticles loaded on porous N-doped carbons (Mo2N/NC) are also fabricated by calcination the polymer precursors in nitrogen gas. The Mo2C/NC shows more excellent electrocatalytic activity than Mo2N/NC in 0.5 M H2SO4, together with robust long-term durability. The well-crystalline nanoparticles and the increased electron conductivity are the main characters responded for the high catalytic efficiency of the fabricated electrocatalysts. This easily fabrication procedure may provide a facile route to prepare non-noble metal carbide/nitride catalysts featuring wellengineered structural and textural peculiarities for realistic energy conversion system.

关键词： Molybdenum carbide Molybdenum nitride Nitrogen-doped carbon Hydrogen evolution reaction Electrocatalysis