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Association of macular pigment optical density with early stage of non-proliferative diabetic retinopathy in Chinese patients with type 2 diabetes mellitus

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1433-1438页

作者： Chong-Yang She Hong Gu Jun Xu Xiu-Fen Yang Xue-tao ren Ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key Laboratory Department of Ophthalmology Ningbo Medical Treatment Center Lihuili Hospital Department of Ophthalmology Beijing Friendship HospitalCapital Medical University Department of Ophthalmology Huaxin HospitalTsing Hua University

AIM：To detect the association between macular pigment optical density（MPOD）,which reflects the antioxidant ability of retina,and diabetic retinopathy（DR）and to investigate the correlated factors of ***： Totally 435 subjects of urban Chinese were recruited to the study and divided into 3 groups： non-diabetes mellitus controls（NDM）,diabetic patients without retinopathy（DWR）,and patients with early stage of non-proliferative diabetic retinopathy（DR）.Demographic and lifestyle characteristics were ascertained by questionnaire.A food-frequency questionnaire,general physical and ophthalmic examinations were completed for all *** was measured by heterochromatic flicker *** thickness was measured by optical coherence *** difference of MPOD among 3 groups was analyzed by analysis of *** correlation analyses of MPOD with the candidate influence factors were assessed using the generalized estimating equations（GEE） ***： Of the 435 participants,34 could not perform the MPOD *** analysis included 401 subjects,including 48 were in DR group,134 in DWR group,and 219 in NDM *** was not significantly different among DR（0.49 ±0.21）,DWR（0.45 ±0.21）,and NDM（0.49±0.17） groups（P=0.24） after adjustment for fasting plasma glycemia,central foveal thickness,green vegetables,Chinese wolfberry,carotene and vitamin *** all the 401 participants included,MPOD was positively associated with central foveal thickness（E=0.0007,P=0.001）,Chinese wolfberry（E=0.0345,P=0.01）,and green vegetables（E=0.0596,P〈0.001） ***： The data suggest that MPOD level is not statistically significantly influenced by the onset of diabetes or early stage of DR in the studied *** level is positively associated with thicker central foveal thickness and higher intake of foods containing carotenoids.

关键词： diabetic retinopathy diet foveal thickness macular pigment optical density

Skarn mineralogy and its geological significance for the Tayuan (Cu-Mo)-Pb-Zn deposit, northern Daxinganling metallogenic belt

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Acta Geochimica 2017年第1期36卷 89-101页

作者： Chao Li tao ren Jian-Guo Huang Run-Sheng Han He-Jun Yin Hong-Yang Zhou Zhi-Hong Feng Kunming University of Science and Technology Kunming 650093 China Yunnan Chihong Zinc & Germanium Limited Liability Company Kunming 650000 China Daxinganling Yunye Mining Development Limited Liability Company Jiagedaqi 165021 China

The Tayuan(Cu-Mo)-Pb-Zn deposit is located in the northern part of Daxinganling,NE *** ore body occurs in the skarn *** skarn minerals mainly include garnet,pyroxene,epidote and *** microprobe analysis shows that the end member of garnet is mainly andradite(Ad_(62-97)Gr_(11-45),the pyroxene is mainly diopside,and epidote is mainly *** characteristics indicate that the Tayuan polymetallic skarn deposit is mainly calcareous *** the content zonation can be observed in *** one garnet crystal,content is shifty from the core to the *** general,the iron content in the core is higher than in the *** content in the garnet shows that the garnet in the Tayuan deposit formed from weak oxidation in alkaline environment with the oxygen fugacity increasing,suggesting that the hydrothermal fluid evolved from an acidic to a slight alkaline *** the Tayuan polymetallic deposit,the ratio of Mn/Fe in pyroxene is about 1.3,and of Mg/Fe,it is about *** components of garnet in the Tayuan deposit plot in the field of the typical skarn Zn,Cu,Mo deposits in the world.

关键词： Skarn minerals (Cu Mo) Pb Zn deposit Physical chemical condition Tayuan

Comparison between Ophthalmologists and Community Health Workers in Screening of Shallow Anterior Chamber with Oblique Flashlight Test

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Chinese Medical Sciences Journal 2010年第1期25卷 50-52页

作者： Yusoh Nuriyah Xue-tao ren Li Jiang Xi-pu Liu Yan-hong Zou Department of Ophthalmology Sekwa Eye Hospital Beijing 100088 China Department of Ophthalmology First Hospital of Tsinghua University Beijing 100016 China

Objective To study the agreement between ophthalmologists and community health workers in detecting shallow anterior chamber with oblique flashlight test. Methods Totally 425 subjects were given an eye examination in a community health center. The anterior chamber depth of each subject was examined by one ophthalmologist and two trained community health workers (one nurse and one non-professional health worker) using oblique flashlight test. Inter-observer agreement was determined using the weighted kappa statistic. Results Among the enrolled subjects,148 (35%) were male and 277 (65%) were female. Good agreement was noted in all the three observers. The comparison between the ophthalmologist and the nurse showed a kappa statistic of 0.42 for both eyes (P<0.001). The kappa statistic was 0.54 and 0.52 for right and left eyes respectively between the ophthalmologist and the non-professional health worker (P<0.001). As for agreement between the nurse and the non-professional health worker,the kappa statistic was 0.49 and 0.38 for right and left eyes,respectively (P<0.001). Conclusion The oblique flashlight test may be used as an applicable tool by trained community health workers for screening of shallow anterior chamber and play a role in blindness prevention in community.

关键词： glaucoma shallow anterior chamber oblique flashlight test

Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3

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World Journal of Gastroenterology 2008年第48期14卷 7321-7328页

作者： Zhi-Jun Dai Xi-Jing Wang Zong-Fang Li Zong-Zheng Ji Hong-tao ren Wei Tang Xiao-Xu Liu Hua-Feng Kang Hai-tao Guan Ling-Qin Song Department of Oncology the Second Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of General Surgery the Second Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of life Science Shaanxi Normal University Xi'an 710061 Shaanxi Province China

AIM： To study the growth inhibitory and apoptotic effects of Scutellaria barbata *** （S. barbata） and to determine the underlying mechanism of its antiturnor activity in mouse liver cancer cell line ***： Proliferation of H22 cells was examined by MTT assay. Cellular morphology of PC-2 cells was observed under fluorescence microscope and transmission electron microscope （EM）. Mitochondrial transmembrane potential was determined under laser scanning confocal microscope （LSCM） with rhodamine 123 staining. Flow cytometry was performed to analyze the cell cycle of H22 cells with propidium iodide staining. Protein level of cytochrome C and caspase-3 was measured by semi-quantitive RT-PCR and Western blot analysis. Activity of caspase-3 enzyme was measured by ***： M-I-I- assay showed that extracts from S. barbata （ESB） could inhibit the proliferation of H22 cells in a time-dependent manner. Among the various phasesof cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G1 phase was increased. Flow cytometry assay also showed that ESB had a positive effect on apoptosis. Typical apoptotic morphologies such as condensation and fragmentation of nuclei and blebbing membrane of apoptotic cells could be observed under transmission electron microscope and fluorescence microscope. To further investige the molecular mechanism behind ESB-induced apoptosis, ESB-treated cells rapidly lost their mitochondrial transmembrane potential, released mitochondrial cytochrome C into cytosol, and induced caspase-3 activity in a dose-dependent manner. CONCLUSION： ESB can effectively inhibit the proliferation and induce apoptosis of H22 cells involving loss of mitochondrial transmembrane potential, release of cytochrome C, and activation of caspase-3.

关键词： Scute/laria barbate Hepatoma Apoptosis Mitochondrial transmembrane potential Serum pha-rmacology

The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 561-566页

作者： Mcng Zhao Xiu-Fcn Yang Xuan Jiao Apiradee Lim Xue-tao ren Torkel Snellingen Ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Department of Ophthalmology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Mathematics and Computer Science Facultyof Science and TechnologyPrince of Songkla UniversityPattani CampusMuang Pattani 90112Thailand Sekwa Institute of Medical Science Beijing 100088China

AIM： To investigate the pattern of diurnal variations of choroidal thickness of macular region of healthy individuals. ~ METHODS： A prospective study of 32 healthy female subjects was conducted. Each subject underwent 1） a questionnaire on daily schedule, 2） the Pittsburgh Sleep Quality Index questionnaire （PSQI）, and 3） ocular examinations including an eye dominance test, fundus photography, and sequential optical coherence tomography （OCT） imaging, on two separate days at five fixed 3h time intervals. Choroidal thickness was measured by two masked graders. RESULTS： A significant diurnal variation of choriodal thickness at fovea （P〈0.001）, at 500 μm nasal （P〈0.001）, temporal to fovea （P=0.01） or 1500 μm nasal to fovea （P= 0.001） was observed. The median choroidal thickness peaked at 11：00 at fovea （P=0.01）, at 500μm nasal （P = 0.009） and temporal （P=0.03） to fovea. The median amplitude of foveal choroidal thickness was 20.5 pm （13, 31） and 20.0 μm （12.5, 28.2） for the first and second series of measurements, respectively. The greater amplitude of foveal choroidal thickness was associated with thickner initial foveal choroidal thickness [ 0.05 （0.03, 0.08）, P= 0.01], dominant eye 10.51 （4.02, 14.60）, P=0.04] in the multivariate linear regression. CONCLUSION： Our data show a significant diurnal variation of the choroidal thickness at fovea, at 500 μm nasal and temporal to fovea and 1500 μm nasal to fovea. Thicker initial foveal choroidal thickness and being dominant eye may influence the amplitude of foveal choroidal thickness.

关键词： choroidal thickness diurnal variation optical coherence tomography

Rescue of a patient with a 50 cm broken PICC tube retracted and wrapped in pulmonary artery:a case report

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Frontiers of Nursing 2021年第4期8卷 445-450页

作者： Sha Yang ren-tao Yu Hui-Lan Zhang Xue Jiang Jian-Ping You Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Pulmonary Department The General Hospital of Western Theater CommandChengduSichun 610083China

Objective:With the increasing use of a peripherally inserted central catheter(PICC)in clinical application,the breaking of the PICC is increasing as well,which would turn into the emboli and drift to the heart and pulmonary artery,causing severe ***,few cases have been reported on the rescue of patients with a broken *** concerns:A 33-year-old man,diagnosed with chronic hepatitis B-related decompensated cirrhosis and cryptococcal meningitis,was treated with amphotericin B combined with flucytosine and fluconazole by means of PICC *** patient was discharged with a catheter;when he returned for re-examination,a 50cm length of PICC broke and slipped into the vein after his sudden *** aid was immediately administered,and then the intervention therapy to extricate the tube,including pulmonary artery angiography and intravascular removal of foreign matter,was performed based on the consensus of the in-hospital vein treatment *** last,the broken PICC fragment was successfully taken out of the ***-examination after surgery showed that he recovered ***:Once the catheter is broken,the X-ray examination should be performed at the first instance and re-examined ***,the involvement of a multidisciplinary team should be formed to decide the appropriate method of treatment to ensure a successful rescue.

关键词： case report fracture gooseneck catcher PICC pigtail catheter

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硅灰对硫氧镁水泥力学性能和耐水性能的影响

江西建材 2024年第4期 8-10页

作者：姜威梁芬芬赵峰郭陶明任涛张清华山西工程技术学院材料科学与工程系山西阳泉045000

文中以硫氧镁水泥为基料,柠檬酸钠为外加剂,硅灰为掺料,制备硫氧镁水泥试块,通过抗压强度和耐水性试验进行分析,表明基准配合比为水硫比0.9、氧硫比1.8、柠檬酸掺量1.2%、硅灰掺量为20%时,硫氧镁水泥力学性能最好。3 d抗压强度可达到43.... 详细信息

文中以硫氧镁水泥为基料,柠檬酸钠为外加剂,硅灰为掺料,制备硫氧镁水泥试块,通过抗压强度和耐水性试验进行分析,表明基准配合比为水硫比0.9、氧硫比1.8、柠檬酸掺量1.2%、硅灰掺量为20%时,硫氧镁水泥力学性能最好。3 d抗压强度可达到43.2 MPa,7 d可达到48.5 MPa,28 d可达到65.4 MPa。这是由于硅灰的掺入使得放热反应形成的内应力减小,同时生成粗大晶粒受到阻碍。耐水软化系数可达到0.83,填充料颗粒分散填充在水化体系的空隙中,提高了材料的密实度、稳定性和抗水性。

关键词：硫氧镁水泥力学性能耐水性能硅灰

Numerically investigation of particle distribution in industrial-scale DTB crystallizer based on CFD

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Particuology 2024年第10期93卷 186-202页

作者： Jinju Ma Weiyu Wang Wei Huang Wei Liu Xinding Yao tao Li Baozeng ren School of Environment Engineering Yellow River Conservancy Technical InstituteKaifeng475004China School of Chemical Engineering Zhengzhou UniversityZhengzhou450001China School of Chemistry and Chemical Engineering Wuhan University of Science and TechnologyWuhan430081China Kaifeng Engineering Research Center for Municipal Wastewater Treatment Kaifeng475004China Henan Engineering Technology Research Center of Green Coating Materials 475004KaifengChina

The suspension state of crystals in the crystallizer is one of the important indicators for evaluating the adaptability of the *** study adopted the Euler-Eulerian two-fluid model to simulate and analyze the fluid motion of solid-liquid two-phase flow in the industrial-grade DTB crystallization kettle,as well as the phase suspension distribution of crystal *** main influencing factors investigated are:the heat transfer effect,the height of the bottom of the crystallizer,the number and position of the stirring paddle,crystal size and crystal volume *** on the research of Euler-Eulerian method to simulate fluids,the Euler-Lagrangian method was further used to simulate the motion state of particle phases with different particle sizes in the *** was found that the designed DTB crystallizer has good recycle mixing *** particles can be mixed evenly during the operation,which can fully realize the solid-liquid mixing and suspension effect of the drug under study.

关键词： Draff tube baffle(DTB)crystallizer Two-fluid model Numerical simulation Turbulence modelling

Method for replica creation in data grids based on complex networks

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 110-115页

作者： CHEN Dan-wei ,ZHOU Shu-tao,ren Xun-yi,KONG Qiang College of Computer,Nanjing University of Posts and Telecommunications,Nanjing 210003,China College of Computer Nanjing University of Posts and Telecommunications Nanjing 210003 China

In order to reduce makespan and storage consumption in data grids, a node selection model for replica creation is proposed. The model is based on the degree distribution of complex networks. We define two candidate replica nodes： a degree-based candidate pool and a frequency-based candidate pool, through which a degree-based candidate pool is defined in consideration of onsidering the access frequency; a candidate pool-based frequency is also defined. The data replica is copied to the node with the minimum Local cost in the two pools. Further, this paper presents and proves a replica creation theorem. A dynamic multi-replicas creation algorithm （DMRC） is also provided. Simulation results show that the proposed method may simultaneously reduce makespan and data used in space storage consumption.

关键词： data grid replica creation complex networks