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Examining the“revisability”benefit of hip resurfacing arthroplasty

World Journal of Orthopedics 2024年第6期15卷 554-559页

作者： Jose george Adam J Taylor thomas P Schmalzried Department of Orthopedics Harbor UCLA Medical CenterTorranceCA 90509United States

BACKGROUND Hip resurfacing arthroplasty(HRA)is an alternative to total hip arthroplasty(THA)that is typically reserved for young active patients because it preserves ***,the benefits of HRA only hold true if conversion THA after failed HRA provides acceptable *** To compare patient reported outcomes for conversion THA after HRA failure to primary *** A retrospective review of 36 patients(37 hips)that underwent conversion THA for failed HRA between October 2006 and May 2019 by a single surgeon was *** reported outcomes[modified Harris Hip Score(mHHS),University of California Los Angeles(UCLA)activity score]were obtained via an email-based responder-anonymous *** were compared to normative data of a primary THA cohort with similar *** analysis was performed comparing outcomes of conversion THA for adverse local tissue reaction(ALTR)vs all other causes for *** The study group had a lower mHHS than the control group(81.7±13.8 vs 90.2±11.6,P<0.01);however,both groups had similar UCLA activity levels(7.5±2.3 vs 7.2±1.6,P=0.51).Patients that underwent conversion for non-ATLR causes had similar mHHS(85.2±11.5 vs 90.2±11.6,P=0.11)and higher UCLA activity levels(8.5±1.8 vs 7.2±1.6,P<0.01)compared to the control *** that underwent conversion for ATLR had worse mHHS(77.1±14.5 vs 90.2±11.6,P<0.01)and UCLA activity levels(6.1±2.3 vs 7.2±1.6,P=0.05)when compared to the control *** Patient outcomes equivalent to primary THA can be achieved following HRA conversion to ***,inferior outcomes were demonstrated for ALTR-related HRA *** selection and perhaps further studies examining alternative HRA bearing surfaces should be considered.

关键词： Total hip arthroplasty Hip resurfacing arthroplasty Conversion total hip arthroplasty Adverse local tissue reaction Patient reported outcome measures

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World Journal of Gastroenterology 2020年第22期26卷 2931-2947页

作者： Tea L Laursen thomas D Sandahl Konstantin Kazankov Jacob george Henning Gronbæk Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus N DK-8200Denmark Storr Liver Centre Westmead Institute for Medical ResearchWestmead HospitalSydney NSW 2145Australia University of Sydney Sydney NSW 2145Australia

More than five years ago,the treatment of hepatitis C virus infection was revolutionized with the introduction of all-oral direct-acting antiviral(DAA)*** proved highly efficient in curing patients with chronic hepatitis C(CHC),including patients with *** new DAA treatments were alleged to induce significant improvements in clinical outcome and prognosis,but the exact cause of the expected benefit was ***,little was known about how the underlying liver disease would be affected during and after viral *** this review,we describe and discuss the liver-related effects of the new treatments in regards to both pathophysiological aspects,such as macrophage activation,and the time-dependent effects of therapy,with specific emphasis on inflammation,structural liver changes,and liver function,as these factors are all related to morbidity and mortality in CHC *** seems clear that antiviral therapy,especially the achievement of a sustained virologic response has several beneficial effects on liver-related parameters in CHC patients with advanced liver fibrosis or *** seems to be a timedependent effect of DAA therapy with viral clearance and the resolution of liver inflammation followed by more discrete changes in structural liver *** improvements lead to favorable effects on liver function,followed by an improvement in cognitive dysfunction and portal ***,the data provide knowledge on the several beneficial effects of DAA therapy on liverrelated parameters in CHC patients suggesting short-and long-term improvements in the underlying disease with the promise of an improved longterm prognosis.

关键词： Chronic hepatitis C Antiviral treatment Inflammation Liver fibrosis Liver cirrhosis Metabolic liver function Galactose elimination capacity Urea synthesis capacity Portal hypertension Hepatic encephalopathy

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Magnets, children and the bowel: A dangerous attraction?

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World Journal of Gastroenterology 2012年第38期18卷 5324-5328页

作者： Anil thomas george Sandeep Motiwale Department of Physiology St Mark's Hospital London HA1 3UJ United Kingdom Department of Paediatric Surgery Queen's Medical Center University Hospitals Nottingham NG7 2UH United Kingdom

Reports of magnet ingestion are increasing rapidly globally. However, multiple magnet ingestion, the subsequent potential complications and the importance of the early identification and proper management remain both under-recognized and underestimated. Published literature on such cases could possibly represent only the tip of an iceberg with press reports, web blogs and government documents highlighting further occurrence of many more such incidents. The increasing number of complications worldwide being reported secondary to magnet ingestion point not only to an acute lack of awareness about this condition among the medical profession but also among parents and carers who will be in most cases the first to pick up on magnet ingestion. There still seems to be no consensus on the management of magnet ingestion with several algorithms being proposed for management. Prevention of this condition remains a much better option than cure. Proper education and improved awareness among parents and carers and frontline medical staff is key in addressing this rapidly emerging problem. The goal of managing such cases of suspected magnet ingestion should be aimed at reducing delays between ingestion time, diagnosis time and intervention time.

关键词： Multiple magnet ingestion Children Bowel injury Fistulation Necrosis

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Performance Comparison of Deep CNN Models for Detecting Driver’s Distraction

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Computers, Materials & Continua 2021年第9期68卷 4109-4124页

作者： Kathiravan Srinivasan Lalit Garg Debajit Datta Abdulellah A.Alaboudi N.Z.Jhanjhi Rishav Agarwal Anmol george thomas School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Faculty of Information and Communication Technology University of MaltaMsida2080MSDMalta School of Computer Science and Engineering Vellore Institute of TechnologyVellore632014India College of Computer Science Shaqra UniversityKingdom of Saudi Arabia School of Computer Science and Engineering SCETaylor’s UniversitySubang Jaya47500Malaysia

According to various worldwide statistics,most car accidents occur solely due to human *** person driving a car needs to be alert,especially when travelling through high traffic volumes that permit high-speed transit since a slight distraction can cause a fatal *** though semiautomated checks,such as speed detecting cameras and speed barriers,are deployed,controlling human errors is an arduous *** key causes of driver’s distraction include drunken driving,conversing with co-passengers,fatigue,and operating gadgets while *** these distractions are accurately predicted,the drivers can be alerted through an alarm ***,this research develops a deep convolutional neural network(deep CNN)models for predicting the reason behind the driver’s *** deep CNN models are trained using numerous images of distracted *** performance of deep CNN models,namely the VGG16,ResNet,and Xception network,is assessed based on the evaluation metrics,such as the precision score,the recall/sensitivity score,the F1 score,and the specificity *** ResNet model outperformed all other models as the best detection model for predicting and accurately determining the drivers’activities.

关键词： Deep-CNN ResNet Xception VGG16 data classification

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Bipolarons in Organic Electroluminescence

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Chinese Physics Letters 2010年第10期27卷 183-185页

作者：姜庆云李盛 thomas F. george 孙鑫 Research Center for Quantum Manipulation Department of Physics Fudan University Shanghai 200433 Department of Physics Zhejiang Normal University Jinhua 310004 Office of the Chancellor and Center for Nanoseience Departments of Chemistry 35 Biochemistry and Physics Astronomy University of Missouri-St.Louis St. Louis MO 63121 USA

We investigate the bipolaron channel B＋＋＋ B-- → BX. The dynamical evolutions and transition probabilities of this bipolaron luminescence channel are studied. It is found that this channel avoids the triplet and is able to enhance the efficiency. We suggest that choosing certain polymers and injection structures, in which B is easily formed, can improve the luminescence efficiency. It is believed that these results will motivate further experimental studies about the function of bipolarons in electroluminescence.

关键词：双极化子电致发光动力学演化工作效率喷射结构发光效率光通道聚合物

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Identification and Characterization of Genes Responsible for Drought Tolerance in Rice Mediated by Pseudomonas fluorescens

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Rice science 2017年第5期24卷 291-298页

作者： Manjesh SAAKRE Thirthikar Meera BABURAO Abida Puthenpeedikal SALIM Rose Mary FFANCIES Valasala Poothecty ACHUTHAN george thomas Sajeevan Radha SIVARAJAN Centre for Plant Biotechnology and Molecular Biology/Department of Genetics and Plant Breeding/Department of Agronomy College of Horticulture Kerala Agricultural University Vellanikkara Thrissur 680656 Kerala India

Drought is one of the major abiotic stresses which adversely affect crop plants limiting growth and yield *** and functional characterization of drought stress-induced genes has contributed to a better understanding of how plants respond and adapt to the drought *** the present study,differential display technique was employed to study the gene expression of rice plants at the reproductive stage that were subjected to drought stress by withholding water,Pseudomonas fluorescens strain(Pf1) treated plants subjected for drought stress by withholding water and control(well-watered).Differentially expressed c DNAs of six genes(COX1,PKDP,b ZIP1,AP2-EREBP,Hsp20 and COC1) were identified,cloned and ***-time q PCR analysis showed that all the six genes were upregulated in drought-stressed plants treated with *** revealed that the remarkable influence of Pf1 colonization leads to drought tolerance at the reproductive *** results showed that high levels of gene expression in plants lacking adequate water can be remarkably influenced by Pf1 colonization,which might be a key element for induced systemic tolerance by microbes.

关键词： rice drought tolerance Pseudomonas fluorescens differential display reverse transcription polymerase chain reaction quantitative real-time PCR transcript derived fragment

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Gastric per-oral endoscopic myotomy: Current status and future directions

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World Journal of Gastroenterology 2019年第21期25卷 2581-2590页

作者： Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia thomas A Zikos Afrin Kamal george Triadafilopoulos John O Clarke Division of Gastroenterology and Hepatology Stanford University School of Medicine

Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field.

关键词： Gastroparesis Gastric per-oral endoscopic myotomy Per-oral endoscopic pyloromyotomy Myotomy Endoscopic myotomy Peroral endoscopic myotomy Gastric emptying

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Demographic variation and habitat specialization of tree species in a diverse tropical forest of Cameroon

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Forest Ecosystems 2014年第4期1卷 201-213页

作者： David Kenfack george B Chuyong Richard Condit Sabrina E Russo Duncan W thomas Center for Tropical Forest Science - Forest GEO Botany Department Smithsonian Tropical Research Institute Department of Botany and Plant Physiology University of Buea Center for Tropical Forest Science Smithsonian Tropical Research Institute School of Biological Sciences University of Nebraska Department of Biological Sciences Washington State University

Background： Many tree species in tropical forests have distributions tracking local ridge-slope-valley topography. Previous work in a 50-ha plot in Korup National Park, Cameroon, demonstrated that 272 species, or 63% of those tested, were significantly associated with topography. Methods： We used two censuses of 329,000 trees ≥1 cm dbh to examine demographic variation at this site that would account for those observed habitat preferences. We tested two predictions. First, within a given topographic habitat, species specializing on that habitat （＇residents＇） should outperform species that are specialists of other habitats （＇foreigners＇）. Second, across different topographic habitats, species should perform best in the habitat on which they specialize （＇home＇） compared to other habitats （＇away＇）. Species＇ performance was estimated using growth and mortality rates. Results： In hierarchical models with species identity as a random effect, we found no evidence of a demographic advantage to resident species. Indeed, growth rates were most often higher for foreign species. Similarly, comparisons of species on their home vs. away habitats revealed no sign of a performance advantage on the home habitat. Conclusions＂ We reject the hypothesis that species distributions along a ridge-valley catena at Korup are caused by species differences in trees _〉1 cm dbh. Since there must be a demographic cause for habitat specialization, we offer three alternatives. First, the demographic advantage specialists have at home occurs at the reproductive or seedling stage, in sizes smaller than we census in the forest plot. Second, species may have higher performance on their preferred habitat when density is low, but when population builds up, there are negative density-dependent feedbacks that reduce performance. Third, demographic filtering may be produced by extreme environmental conditions that we did not observe during the census interval.

关键词： tree Demographic variation and habitat specialization of tree species in a diverse tropical forest of Cameroon Figure

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Biochars produced from coconut palm biomass residues can aid regenerative agriculture by improving soil properties and plant yield in humid tropics

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Biochar 2020年第2期2卷 211-226页

作者： Murali Gopal Alka Gupta K.Shahul Hameed Neenu Sathyaseelan T.H.Khadeejath Rajeela george V.thomas ICAR-Central Plantation Crops Research Institute KasaragodKerala 671124India Present Address:Winsome F&D Consultant DubaiUAE Council for Food Research and Development KonniKeralaIndia

Lignin-rich recalcitrant biomass residues of coconut palms viz.(i)mature coconut husk,(ii)tender(immature or green)coconut husk(iii)coconut leaf petiole and(iv)coir-pith were successfully pyrolysed using a simple charring kiln into carbon-rich,black,light weight and porous *** alkalinity and good ash content made them fit for remediating acid *** potassium content in these biochars could help reduce the use of inorganic *** analysis showed the mass loss phases of husk and coconut leaf petiole biochars to be ***,all four biochars gave smooth curves indicating thermal stability of the *** seed germination and earthworm avoidance tests proved their potential as soil *** incubation studies with coconut biochars in graded doses,alone or in combination with coconut leaf vermicompost,increased the pH,organic carbon and potassium contents,and promoted plant-beneficial microbiota and enzyme *** studies with tender coconut husk biochar and coconut leaf vermicompost enhanced the dry weight of cowpea plants accompanied with increased arbuscular mycorrhizal sporulation and root colonization,and root nodule dry weight.A field trial resulted in higher chilli yields with tender coconut husk biochar+coconut leaf vermicompost *** results from our studies highlight the potential of pyrolysis as an innovative technology for quick recycling of highly recalcitrant coconut palm biomass residues to biochars as a local source of soil amendment to aid regenerative agriculture in humid tropics.

关键词： Coconut husks Biochar Plant-beneficial microbiota Earthworm avoidance Mycorrhizae

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Preparedness,knowledge,and perception of nursing students about climate change and its impact on human health in India

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Regional Sustainability 2024年第1期5卷 107-118页

作者： Ramya Kundayi RAVI Priya BABY Nidhin ELIAS Jisa george thomas Kathyayani Bidadi VEERABHADRAIAH Bharat PAREEK College of Nursing Medical and Health Sciences UniversityRas Al Khaimah11172United Arab Emirates College of Nursing National Institute of Mental Health and Neuro sciencesBangalore560011India College of Nursing Amrita Institute of Medical SciencesKochi682041India College of Nursing All India Institute of Medical SciencesBhopal462020India Saraswati Professional and Higher Education College of Nursing Mohali140413India

Higher education plays an important role in all aspects of *** climate change and sustainability into the curriculum is important to prepare future health-care professionals for climate change and sustainability actions to build resilient health *** this study,we evaluated the preparedness,knowledge,and perception regarding climate change and its impact on human health among Indian nursing students.A quantitative descriptive survey was conducted among 644 undergraduate nursing students studying in three institutes in the southern,northern,and western parts of *** used a structured online questionnaire with established validity and reliability to collect *** data were analyzed using Statistical Package for the Social Sciences version 26 *** results showed that more than half of the students reported experiencing excessive increase(362;56.2%)and decrease(374;58.1%)in temperature in recent *** more than three quarters of the students(494;76.7%)accepted the general truth that climate change is mainly caused by human activities,only less than half of the students(309;48.0%)perceived the impact of climate change to be *** quarters of the students(483;75.0%)had a high level of knowledge regarding climate *** students who had a high level of knowledge about climate change exerted a high perceived impact of climate change(χ^(2)=75.47;P<0.01).More than half of the students(50.9%)felt that they needed information about climate change to be included in the nursing curriculum,and only one sixth of the students(16.1%)were highly confident about engaging in climate change-related conversation with *** of the students who participated in the study had basic knowledge about climate change and its impact on human ***,there is an observed gap between knowledge and their preparedness and confidence to engage in climate change ***,we propose to strengthen the nursing curriculum by integra

关键词： Climate change Curriculum Nursing students Human health India

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