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临床荟萃 2014年第11期29卷 1301-1301页

作者： reinhard M Schwarzer G Briel M 本刊编辑部本刊编辑部

如果将所有患者均纳入考察范围的话，可以发现对无症状性颈内动脉（ICA）狭窄患者进行颈内动脉再通术使患者获益微小。因此，很重要的一点就是能够找出具有较高风险的一类患者，这样才能使颈内动脉再通术治疗成为最优选择。

关键词：颈内动脉狭窄高风险患者工具卒中预测无症状性再通术

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牙齿重度磨耗:欧洲治疗指南共识

中国口腔医学继续教育杂志 2019年第1期22卷 1-8页

作者： Bas Loomans Niek Opdam Thomas Attin David Bartlett Daniel Edelhoff Roland Frankenberger Goran Benic Simon Ramseyer Peter Wctsclaar Bernadette Stcrenborg reinhard Hickel Ulla Pallesen Shamir Mehta Subir Baneiji Adrian Lussi Naim Wilson 杨洋(译) 谭建国(审) 不详北京大学口腔医院修复科

本文介绍了欧洲口腔专家针对牙齿重度磨耗的治疗指南达成的共识。该共识的内容包括牙齿生理性与病理性磨耗的定义和专家推荐的诊断.预防.咨询及监测方法.旨在阐明牙齿磨耗的病因、性质和发病率.提出针对病理性牙齿磨耗所需要采取的治疗... 详细信息

本文介绍了欧洲口腔专家针对牙齿重度磨耗的治疗指南达成的共识。该共识的内容包括牙齿生理性与病理性磨耗的定义和专家推荐的诊断.预防.咨询及监测方法.旨在阐明牙齿磨耗的病因、性质和发病率.提出针对病理性牙齿磨耗所需要采取的治疗手段。如何制定治疗决策由多方面因素共同影响,主要取决于牙齿磨耗的严重程度.对患者产生的影响以及病人的治疗意愿。通过修复的手段进行干预治疗应放在最后再考虑。当患者的情况符合修复治疗的适应证,患者也愿意进行治疗时,应采用保守、微创的手段,同时辅以预防措施。本文将介绍一些微创的、以粘接修复为主的治疗方法。

关键词：治疗指南牙齿磨耗重度磨耗欧洲修复治疗监测方法干预治疗治疗方法

船只排放物对欧洲空气质量及酸性沉降造成的影响

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AMBIO－人类环境杂志 2005年第1期34卷 54-59页

作者： Richard G.Derwent David S.Stevenson Ruth M.Doherty William J.Collins Michael G.Sanderson Colin E.Johnson Janusz Cofala reinhard Mechler Markus Amann Frank J.Dentener 许天虎伦敦皇家学院环境科技部英国爱丁堡大学全国环境研究委员会(NERC)/环境部英国爱丁堡大学 Met办公室哈德利(Hadley)中心埃克塞特的Met办公室哈德利中心奥地利拉克森堡(Laxenburg)的国际应用系统分析研究所奥地利拉克森堡的国际应用系统分析研究所 "跨边界空气污染计划" 意大利Ispra的环境与可持续发展研究所联合研究中心

一个名为"STOCHEM"的三维拉氏化学传输模型被用于描述2000年气候条件下国际海运活动产生的SO_2、NO_x、VOCs和CO排放造成的欧洲大西洋沿岸区域性酸性沉降和臭氧空气质量影响的状况。该模型得出的从西南海域到不列颠群岛和布列塔尼水域... 详细信息

一个名为"STOCHEM"的三维拉氏化学传输模型被用于描述2000年气候条件下国际海运活动产生的SO_2、NO_x、VOCs和CO排放造成的欧洲大西洋沿岸区域性酸性沉降和臭氧空气质量影响的状况。该模型得出的从西南海域到不列颠群岛和布列塔尼水域国际海运活动产生的硫沉降总量高达200mg/m^2·a。夏季国际海运活动对表层臭氧浓度的影响在爱尔兰、布列塔尼和葡萄牙高达约6ppb。在欧洲,海运活动产生的排放物是一种对酸性沉降和臭氧空气质量造成影响的外部因素,并且如果要在将来达到严格的沉降及空气质量目标,就需要采取一系列控制措施。

关键词：酸性沉降空气质量排放物欧洲国际海运船只臭氧浓度传输模型气候条件

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大连国际会议中心

城市环境设计 2020年第4期 220-233页

作者：沃尔夫·狄·普瑞克斯 Nico Boyer Jan Brosch Jessie Chen Yue Chen Debora Creel Simon Diesendruck Pola Dietrich Wendy Fok Keigo Fukugaki Francois Gandon Alice Gong reinhard Hacker Thomas Hindelang Veronika Janovska Moritz Keitel Matt Kirkham Ariane Marx Gaspar Gonzalez Melero Matthias Niemeyer reinhard Platzl Ian Robertson Peter Rose Liisi Salumaa Anja Sorger Giacomo Tinari Vanessa Castro Vélez Markus Wings Hui-Cheng Manfred Yuen Cristiano Bianchi Duccio Malagamba ShuHe COOP HIMMELB(L)AU Markus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:03/2008规划设计/Start of Planning:07/2008动工/Start of Construction:11/2008竣工/Completion:09/2012项目参数/PROJECT DATA用地面积/Site Area:40 000m2会议中心总建筑面积/Gross Floor Area Conference Center:91 250m2,总建筑面积/Total:146 180m2占地面积/Footprint:33 000m2表皮面积/Fa?ade Area:30 600m2屋顶面积/Roof area:28 000m2建筑高度-长度-宽度/Building Height-Length-Width:60m-220m-200m层数/Number of Floors:8

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仿虹膜人工晶体在外伤性无虹膜中的应用

Oncology and Translational Medicine 1995年第3期12卷 48-48页

作者： T.reinhard,R.Sundmacher,C.Althaus,王浩 Augenklinik der Heinrich-Heine-Universitat Moorenstr.5 D-40225 Düsseldorf Germany Augenklinik der Heinrich-Heine-Universitat Moorenstr.5 D-40225 Düsseldorf Germany Augenklinik der Heinrich-Heine-Universitat Moorenstr.5 D-40225 Düsseldorf Germany 同济医科大学附属同济医院

眼球破裂伤时常出现外伤性无虹膜、角膜白斑、大泡性角膜病、晶体脱出、外伤性白内障以及继发性青光眼。常用的治疗方法是穿透性角膜移植联合白内障手术加传统人工晶体植入。

关键词：人工晶体手术穿透性外伤性无虹膜虹膜撕脱角膜移植

Molecular phenotypes of human parvovirus B19 in patients with myocarditis

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World Journal of Cardiology 2014年第4期6卷 183-195页

作者： C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix reinhard Kandolf Department of Molecular Pathology University Hospital of Tuebingen Robert Koch Institute Department of Physiology University of Tuebingen Department of Cardiology and Cardiovascular Medicine University Hospital of Tuebingen Clinics for Internal Medicine B Ernst-MoritzArndt-University Department of Molecular Pathology University Hospital of Tuebinge

AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional *** were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology *** tissues were obtained at autopsy from 34 victims of accidents,crime or *** of mononuclear cell infiltrates in EMBs was performed using immunohistological ***-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture *** experiments were conducted using human endothelial cells *** reporter assays were performed to determine B19Vreplication *** analysis and graphical representation were calculated using SPSS and Prism5 ***:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was ***-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B1

关键词： Myocarditis Dilated cardiomyopathy Parvovirus B19 B19V-genotypes B19V co-infection

颗粒和格子状角膜营养不良行穿透性角膜缘-角膜移植:供体角膜缘干细胞的存活和过渡期临床结果

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世界核心医学期刊文摘(眼科学分册) 2005年第2期 62-62页

作者： Spelsberg H.,reinhard T. ,Henke L ,王建洲 Eye Hospital H einrich-Heine Univ. Dusseldorf Dusseldorf Germany Dr.

Purpose To assess clinical follow-up data, and to identify donor epithelial c ells after homologous penetrating central limbo-keratoplasty in patients with g ranular and lattice corneal dystrophies compared with patients who underwent con ventional penetrating keratoplasty (PK). Design Mixed retrospective and prospect ive nonrandomized comparative case series. Participants and controls Twenty-six patients who underwent 33 limbo-keratoplasty procedures for granular or lattic e corneal dystrophy since May 1995 and a historical control group of 24 patients who underwent 36 PK procedures between November 1986 and May 1995. Methods Post operatively, all but 2 limbo-keratoplasty patients were treated with systemic i mmunosuppressants for 6 months. All patients received long-term topical immunep rophylaxis with prednisolone-21-acetate 1%(2 drops per day). After obtaining informed consent, epithelial cells were harvested from 10 limbo-keratoplasty ey es of 8 patients with granular dystrophy and 7 limbo-keratoplasty eyes of 7 pat ients with lattice dystrophy. Conjunctival epithelium or buccal mucosal epitheli um for recipient identification and corneal epithelial cells from 3 graft sites were harvested. Deepfrozen donor corneoscleral rims were analyzed to characteriz e donor features. Genetic analysis was performed by polymerase chain reaction of short tandem repeat (STR) loci. Main outcome measures The ratio of dystrophy re currences in the graft was clinically assessed. Donor features in epithelial cel ls were genetically established if at least 1 STR profile differed from that of the recipient. Resuits There were 5 recurrences in limbokeratoplasty eyes with g ranular dystrophy and 2 recurrences in limbo-keratoplasty eyes with lattice dys trophy, compared with 15 and 6 recurrences in PK eyes, respectively. The differe nces between limbo-kera- toplasty and PK were not staistically significant over time (log-rank test; P =0.14 for granular dystrophy and P=0.56 for lattice dy

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肿瘤原代培养物免疫荧光染色法评价化疗药物选择性的研究

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泸州医学院学报 2015年第4期38卷 392-396页

作者：姜伟黄文芳 Lan kiuwe Victor-F.Mautner Reinnard E.Driedrich 四川省医学科学院四川省人民医院检验科四川成都610072 汉堡大学医学中心神经内科汉堡大学医学中心口腔颌面外科

目的:探索建立基于肿瘤原代培养物免疫荧光染色评价化疗物选择性和特异性的新方法。方法:利用手术切除的丛状神经纤维瘤(PNF)组织,混合培养原代肿瘤细胞和非肿瘤细胞并使用尼罗替尼(Nilotinib)和伊马替尼(Imatinib)进行处理,测定细胞增... 详细信息

目的:探索建立基于肿瘤原代培养物免疫荧光染色评价化疗物选择性和特异性的新方法。方法:利用手术切除的丛状神经纤维瘤(PNF)组织,混合培养原代肿瘤细胞和非肿瘤细胞并使用尼罗替尼(Nilotinib)和伊马替尼(Imatinib)进行处理,测定细胞增殖和毒性。利用特异性免疫荧光抗体染色处理后的细胞,通过Image J软件计数肿瘤细胞和非肿瘤细胞并计算两者比例变化,评价药物效能。结果:药物处理后,细胞增殖的降低和毒性的增加与药物浓度成正比。荧光细胞计数显示肿瘤细胞和非肿瘤细胞数量在药物处理后均减少,但药物效能具有个体差异性。结论:利用特异性免疫荧光染色计数同一组织混合培养的肿瘤细胞和非肿瘤细胞在药物处理后比例变化,可以评价化疗药物的选择性和特异性。

关键词：原代培养免疫荧光染色化疗药物个体化治疗

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牙科美容学中的伦理

中国口腔医学继续教育杂志 2006年第2期9卷 57-64页

作者： Michael Lieble Alessandro Devigus Ros C. Randall F.J.Trevor Burke Ulla Pallesen Antonio Cerutti Angelo Putignano Didier Cauchie reinhard Kanzler Kari P. Koskinen Henrik Skjerven Gunhild V. Strand Rob W.A. Vermaas 冯朝华（译）王嘉德（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

患者对于美观的要求普遍提高了，究其主要的原因是患者的自尊心所趋。然而，一些重要的伦理问题包含在纯粹因为美观的原因而进行的治疗中。患者和医生对美学的感知也是不一样的。因此本文围绕伦理、患者的美容治疗以及通过3个病例来解... 详细信息

患者对于美观的要求普遍提高了，究其主要的原因是患者的自尊心所趋。然而，一些重要的伦理问题包含在纯粹因为美观的原因而进行的治疗中。患者和医生对美学的感知也是不一样的。因此本文围绕伦理、患者的美容治疗以及通过3个病例来解释美学健康对于不同的人有着不同的意义。

关键词：伦理问题牙科美容学美容治疗患者自尊心美观美学

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自体转位角膜成形术后内皮细胞的丢失

世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 46-46页

作者： Birnbaum F. reinhard T. Bhringer D. Sundmacher R. 刘玮 Eye Hospital Albert Ludwigs University 79106 Freiburg Germany

Purpose: To investigate whether it may be possible to ascertain the influence of immunological factors on chronic endothelial cell loss by comparing chronic endothelial cell loss after autologous rotational penetrating keratoplasty and after homologous penetrating keratoplasty. Methods: For six patients who had undergone autologous rotational penetrating keratoplasty the relative annual loss of endothelial cells was calculated by means of an exponential regression analysis. The findings were compared with those in a homogeneous historical control group (53 patients undergoing homologous penetrating keratoplasty for keratoconus). Results: After autologous rotational keratoplasty relative annual loss of endothelial cells was 1.1% ± 2.6% (mean ± standard deviation). Relative annual loss of endothelial cells in the control-group was 16.7% ± 20.8% . Conclusions: The results of the study lead to the assumption that immunological influences might be the main cause for chronic endothelial cell loss after homologous penetrating keratoplasty.

关键词：角膜成形术内皮细胞同源性圆锥角膜丢失率性因子自身免疫免疫学