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Syncope in older adults

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journal of Geriatric Cardiology 2016年第5期13卷 380-386页

作者： Parag Goyal Mathew S maurer Division of Cardiology Weill Cornell Medical College New York NY USA Clinical Cardiovascular Research Lab for the Elderly Columbia University Medical Center New York NY USA

Syncope, defined as a self-limited transient loss of con- sciousness and postural tone due to global cerebral hypoperfusion, is a common reason for emergency room visits, with a third of these visits leading to an inp... 详细信息

关键词： Accidental fall Hypotension Syncope The aged

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骨CT扫描结果的三维重建(评价)

放射学实践 1992年第2期7卷 84-92页

作者： H.P.Carduck R.Vosshenrich j.maurer A.Helwig E.Grabbe 徐霓霓 Abt.Rontgendiagnostik I Kliniken der Georg-August-Universitat GottingenRobert-Koch-StraBe 403400GottingenFRG 北京宜武医院

现今已能对图像进行三维重建,直观显示正常的和病理的骨结构.倘若期待从平面重建得出辅助诊断是不会有什么收获的.但是未来的发展不可估量,所以这期待也是有道理的.

关键词：骨结构 CT

A particle shape-based segmentation method to characterize spray dried materials by X-Ray microtomography

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Particuology 2023年第10期81卷 119-127页

作者： Nora Alina Ruprecht Heike Teichmann reinhard Kohlus University of Hohenheim Institute of Food Science and BiotechnologyDepartment of Process Engineering and Food PowdersGarbenstr.2570599StuttgartGermany

For accurate description of particle structure,single particle properties are required so that the properties of interest can be expressed as distributed parameters.X-Ray microtomography of the powder bed with subsequent particle separation can be used for this *** this paper,a new algorithm for X-Ray microtomography images of spray dried particles was introduced since standard methods tend to fail if the particle size distribution is *** algorithm is based on 2D shape classification and subsequent 3D reconstitution of the particle using only a shape classifier as free *** proposed algorithm was validated *** the algorithm,single particle porosities were obtained,which ranged from 0 to 70%.Prerequisites for the application of the algorithm are that a shape classifier can be set and that the 3D shape is regular.

关键词： Spray drying Particle structure X-Ray microtomography Segmentation algorithm Porosity distribution

Heart failure in older adults：embracing complexity

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journal of Geriatric Cardiology 2016年第1期13卷 8-14页

作者： Altaf Pirmohamed Dalane W Kitzman Mathew S maurer Clinical Cardiovascular Research Lab for the Elderly Columbia University Medical Center Allen Hospital of New York Presbyterian Broadway New York NY USA

Heart failure （HF）, particularly in the setting of preserved systolic function, disproportionately afflicts older individu- als and results in significant morbidity, mortality, and health care costs. In the United States, among the Medicare population （age 〉 65 years）, HF is among the leading cause of hospital admissions. Optimal care for older adults with HF requires knowledge of age-related physiologic changes, complex multi-organ, multi-dimensional syndromes, interdisciplinary teamwork and palliative/end of life care.

关键词： Diastolic dysfunction Ejection fraction Elderly Heart failure

DNA Damage-Induced Transcription of Transposable Elements and Long Non-coding RNAs in Arabidopsis Is Rare and ATM-Dependent

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Molecular Plant 2016年第8期9卷 1142-1155页

作者： Zhenxing Wang Rainer Schwacke reinhard Kunze institute of Biology - Applied Genetics Dahlem Centre of Plant Sciences - DCPS Freie Universit~t Berlin Albrecht-Thaler-Weg 6 14195 Berlin Germany Forschungszentrum jQlich GmbH Institute of Bio- and Geosciences Plant Sciences (IBG-2) 52425 JQlich Germany

Induction and mobilization of transposable elements （TEs） following DNA damage or other stresses has been reported in prokaryotes and eukaryotes. Recently it was discovered that eukaryotic TEs are frequently associated with long non-coding RNAs （IncRNAs）, many of which are also upregulated by stress. Yet, it is unknown whether DNA damage-induced transcriptional activation of TEs and IncRNAs occurs sporadically or is a synchronized, genome-wide response. Here we investigated the transcriptome of Arabidopsis wild- type （WT） and ataxia telangiectasia mutated （atm） mutant plants 3 h after induction of DNA damage. In WT, expression of 5.2% of the protein-coding genes is 〉 2-fold changed, whereas in atm plants, only 2.6% of these genes are regulated, and the response of genes associated with DNA repair, replication, and cell cy- cle is largely lost. In contrast, only less than 0.6% of TEs and IncRNAs respond to DNA damage in WT plants, and the regulation of 〉95% of them is ATM-dependent. The ATM-downstream factors BRCA1, DRM1, jMj30, AGO2, and the ATM-independent AGO4 participate in the regulation of individual TEs and IncRNAs. Remarkably, protein-coding genes located adjacent to DNA damage-responsive TEs and IncRNAs are frequently coexpressed, which is consistent with the hypothesis that TEs and IncRNAs located close to genes commonly function as controlling elements.

关键词： Arabidopsis thaliana ataxia telangiectasia mutated DNA damage response transposable element,long non-coding RNA

Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells

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World journal of Gastroenterology 2014年第29期20卷 10038-10049页

作者： Matilde Spampatti George Vlotides Gerald Spttl julian maurer Burkhard Gke Christoph j Auernhammer Department of Internal Medicine Ⅱ University-Hospital Campus GrosshadernInterdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM)Ludwig-Maximilians-University of Munich U.O.C.Gastroenterologia 2 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Università degli Studi di Milano

AIM: To investigate the effect of aspirin on neuroendocrine tumor (NET) cell growth and signaling in vitro.

关键词： Neuroendocrine tumors Aspirin Cell Viability Mammalian target of rapamycin protein

Deep reinforcement learning for the optimized operation of large amounts of distributed renewable energy assets

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Energy and AI 2023年第1期11卷 106-117页

作者： jan Martin Specht reinhard Madlener Institute for Future Energy Consumer Needs and Behavior(FCN) School of Business and Economics/E.ON Energy Research CenterRWTH Aachen UniversityMathieustraße 1052074AachenGermany Department of Industrial Economics and Technology Management Norwegian University of Science and Technology(NTNU)Sentralbygg 17491GløshaugenTrondheimNorway

This study utilizes machine learning and,more specifically,reinforcement learning(RL)to allow for an optimized,real-time operation of large numbers of decentral flexible assets on private household scale in the electricity *** potential and current obstacles of RL are demonstrated and a guide for interested practitioners is provided on how to tackle similar tasks without advanced skills in neural network *** the application in the energy domain it is demonstrated that state-of-the-art RL algorithms can be trained to control potentially millions of small-scale assets in private *** detail,the applied RL algorithm outperforms common heuristic algorithms and only falls slightly short of the results provided by linear optimization,but at less than a thousandth of the simulation ***,RL paves the way for aggregators of flexible energy assets to optimize profit over multiple use cases in a smart energy grid and thus also provide valuable grid services and a more sustainable operation of private energy assets.

关键词： Reinforcement learning Virtual power plant Aggregation of energy Value stacking Flexibility of decentral energy assets

A comprehensive review of miniatured wind energy harvesters

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Nano Materials Science 2021年第2期3卷 170-185页

作者： Quan Wen Xianming He Zhuang Lu reinhard Streiter Thomas Otto Key Laboratory of Fundamental Science of Micro/Nano-Device and System Technology Chongqing UniversityChongqing400044People's Republic of China Microsystem Research Center Chongqing UniversityChongqing400044People's Republic of China Fraunhofer Institute for Electronic Nano Systems(ENAS) Chemnitz09131Germany

Following the current rapid development of the Internet of Things(IoT)and wireless condition monitoring systems,energy harvesters which use ambient energy have become a key part of achieving an energy-autonomous *** wind energy harvesters have attracted widespread attention because of their great potential of power density as well as the rich availability of wind energy in many possible areas of *** article provides readers with a glimpse into the state-of-the-art of miniature wind energy *** crucial factors for them to achieve high working efficiency under lower operational wind speed excitation are *** potential energy coupling mechanisms are discussed in *** approaches for broadening operational wind-speed-range given a variety of energy coupling mechanisms are also presented,as observed in the *** enhancement mechanisms including hydrodynamic configuration optimization,and non-linear vibration pick-up structure are *** are drawn and the outlook for each coupling mechanisms is presented.

关键词： Energy harvester Wind energy Miniature wind-induced vibration energy harvester Energy coupling mechanism Performance enhancement mechanisms

New measurement of melting and thermal conductivity of iron close to outer core conditions

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Geoscience Frontiers 2020年第2期11卷 565-568页

作者： Abhisek Basu Matthew RField Dougal GMcCulloch reinhard Boehler Geophysical Laboratory Carnegie Institution of WashingtonWashingtonDC20015USA RMIT Microscopy&Microanalysis Facility RMIT UniversityMelbourneVIC3001Australia Physics School of ScienceRMIT UniversityMelbourneVIC3001Australia Earth Ocean and Atmospheric ScienceFlorida State UniversityTallahasseeFlorida32306USA Oak Ridge National Laboratory Oak RidgeTennessee37831USA

The amount of literature on both melting and thermal conductivity of iron at Earth’s core conditions is overwhelming and the discrepancies are very *** is a broad range of experimental techniques each of which is flawed to a certain degree,which may explain the *** this report,we present new data using a different method for determining the phase behavior and resistivity of iron in the laser-heated diamond cell by measuring the electrical resistance of both solid and liquid iron *** experiment avoids some of the major flaws of previous experiments,the most important of which is the detection of the onset of *** measurements confirm a shallow melting curve found earlier and the resistivity data imply a trend towards low thermal conductivity in the liquid outer core.

关键词： Outer core Thermal conductivity Iron phase diagram Diamond anvil cell High pressure