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作者：美国O'reilly

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粗粒与剪切结构橄榄岩捕虏体及其单斜辉石微量元素对比

作者：美国O'reilly

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岩石学报 2001年第2期17卷 263-268页

作者：郑建平路凤香 Suzanne Y O'reilly 余淳梅中国地质大学地球科学学院武汉430074 澳大利亚曼魁里大学地球与行星科学系

对山东栖霞具不同结构的“干”尖晶石相橄榄岩进行了全岩化学、微量元素 ,矿物成分和单斜辉石微量元素分析和对比。表明在橄榄岩从粗粒结构向剪切结构的转化中 ,随着变质变形作用的增强存在着复杂的熔 /流体的加入富集和熔体的提取亏损... 详细信息

对山东栖霞具不同结构的“干”尖晶石相橄榄岩进行了全岩化学、微量元素 ,矿物成分和单斜辉石微量元素分析和对比。表明在橄榄岩从粗粒结构向剪切结构的转化中 ,随着变质变形作用的增强存在着复杂的熔 /流体的加入富集和熔体的提取亏损作用 ;交代介质属具强渗透性的 Si O2 不饱和的硅酸盐碳酸岩熔体。同时发现不同结构橄榄岩中单斜辉石的 REE与其全岩的 REE程度有如下的关系 :粗粒结构橄榄岩中矿物与岩石的差别最大 ,但 REE的配分形式可以反映全岩的情况 ;剪切结构橄榄岩中两者的差别较小。其它高度不相容微量元素可能主要赋存在粒间组分或

关键词：微量元素橄榄岩单斜辉石剪切结构捕虏体矿物组成流体包裹体

IN VIVO NEAR-INFRAREdFLUORESCENCEIMAGING OF HUMANCOLONAdENOCARCINOMABY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEdMUCIN

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.dACOSTA YING TANG TUULA KALLIOMAKI RAYMONd M.reilly ROBERT WEERSINK ALISHA R.ELFORd NORMAN E.MARCON BRIAN C.WILSON division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA division of Clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada Campbell Family Institute for Breast Cancer Research University Health Network/Ontario Cancer Institute department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital Center for Therapeutic Endoscopy and Endoscopic Oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

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Immiscible metallic melts in the deep Earth: clues from moissanite(SiC)in volcanic rocks

作者：美国O'reilly

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Science Bulletin 2020年第17期65卷 1479-1488,M0004页

作者： Jin-Xiang Huang Qing Xiong Sarah E.M.Gain William L.Griffin Timothy d.Murphy Andrei A.Shiryaev Liwu Li Vered Toledo Mikhail d.Tomshin Suzanne Y.O’reilly ARC Centre of Excellence for Core to Crust Fluid Systems and GEMOC Department of Earth and Planetary SciencesMacquarie UniversityNorth RydeNSW 2109Australia State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Frumkin Institute of Physical Chemistry and Electrochemistry RAS Moscow 119071Russia Key Laboratory of Gas Geochemistry Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Shefa Gems Ltd. Netanya 42106Israel diamond and Precious Metal Geology Institute SB RASYakutsk 677007Russia Center for Microscopy Characterisation and Analysisthe University of Western AustraliaPerth 6009Australia

The occurrence of moissanite(SiC), as xenocrysts in mantle-derived basaltic and kimberlitic rocks sheds light on the interplay between carbon, hydrogen and oxygen in the lithospheric and sublithospheric mantle. SiC is stable only at fO2d related melts commonly are considered to be much more oxidized. SiC grains from both basaltic volcanoclastic rocks and kimberlites contain metallic inclusions whose shapes suggest they were entrapped as melts. The inclusions consist of Si^0+ Fe3Si7± FeSi2 Ti ± CaSi2Al2± FeSi2Al3± CaSi2, and some of the phases show euhedral shapes toward Si^0. Crystallographically-oriented cavities are common in SiC, suggesting the former presence of volatile phase(s), and the volatiles extracted from crushed SiC grains contain H2+ CH4± CO2± *** observations suggest that SiC crystalized from metallic melts(Si-Fe-Ti-C ± Al ± Ca), with dissolved H2+ CH4± CO2± CO derived from the sublithospheric mantle and concentrated around interfaces such as the lithosphere-asthenosphere and crust-mantle boundaries. When mafic/ultramafic magmas are continuously fluxed with H2+ CH4 they can be progressively reduced, to a point where silicide melts become immiscible, and crystallize phases such as SiC. The occurrence of SiC in explosive volcanic rocks from different tectonic settings indicates that the delivery of H2+ CH4 from depth may commonly accompany explosive volcanism and modify the redox condition of some lithospheric mantle volumes. The heterogeneity of redox states further influences geochemical reactions such as melting and geophysical properties such as seismic velocity and the viscosity of mantle rocks.

关键词： Moissanite Reduced gas Alloy inclusion Mantle

pH-responsive Vesicles with Switchable Corona and Membrane by direct dissolution of a Schizophrenic diblock Copolymer in Water

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pH-responsive Vesicles with Switchable Corona and Membrane b...

药理学方法研究自由基和其它氧代谢物介导的组织损伤

2009年全国高分子学术论文报告会

作者：杜建忠 Rachel O'reilly department of Chemistry University of CambridgeCambridgeCB2 1EWUK department of Chemistry University of WarwickCoventryCV4 7ALUK

＜正＞Block copolymer vesicles with switchable corona and membrane were prepared by changing the solution pH of a new tertiary amine and amino acid based‘schizophrenic’ pH-responsive block *** diblock copolymer was synthesized by a two-step reversible addition-fragmentation chain-transfer（RAFT） polymerization:（i） A tertiary amine monomer,2-（diethylamino）ethyl methacrylate（dEA）,was polymerized using pyrene-ddMAT[ddMAT is

关键词： Self-assembly block copolymer vesicles pH-responsive

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国外医学（创伤与外科基本问题分册） 1991年第3期12卷 166-169页

作者： reilly PM 侯虹鲁

氧的高毒性代谢产物常由细胞有氧代谢产生,且因疾病而大大增加。当氧化物数量超出多种内源性抗氧化物的抗氧化能力时,出现组织损伤。采用药物(如氧反应代谢清除剂、有毒代谢产生物阻滞剂或内源性抗氧能力增强剂)干扰损伤过程的动物实验... 详细信息

氧的高毒性代谢产物常由细胞有氧代谢产生,且因疾病而大大增加。当氧化物数量超出多种内源性抗氧化物的抗氧化能力时,出现组织损伤。采用药物(如氧反应代谢清除剂、有毒代谢产生物阻滞剂或内源性抗氧能力增强剂)干扰损伤过程的动物实验已获成功,并已应用于临床对照试验,亦取得良好效果。

关键词：药理学方法自由基组织损伤

卫生保健管理 : 国际视野 : the global perspective 1

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