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Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

American Journal of Analytical Chemistry 2016年第11期7卷 754-771页

作者： Andrea Mantuano regina cely barroso Liebert Parreiras Nogueira Marcos Vinicius Colaço Carla Lemos Mota Arissa Pickler Delson Braz Camila Salata Samara Ferreira-Machado Carlos Eduardo de Almeida Alessandra Gianoncelli Physics Institute Rio de Janeiro State University Rio de Janeiro Brazil Nuclear Engineering Program Federal University of Rio de Janeiro Rio de Janeiro Brazil Radiological Science Laboratory State University of Rio de Janeiro Rio de Janeiro Brazil Elettra-Sincrotrone Trieste S.C.p.a. Trieste Italy

Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction;Magnesium, because it is important in the cardiac metabolism;and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTR

关键词： Micro-X-Ray Fluorescence Low-Z Elements Distribution Myocardial Cardiac Tissue

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Evaluation of antibiotic activity produced by Pseudomonas aeruginosa LV strain against Xanthomonas arboricola ***

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Agricultural Sciences 2014年第1期5卷 71-76页

作者： Fernanda Corrêa da Silva Vasconcellos Admilton Gonçalves de Oliveira Lucilene Lopes-Santos Jamile Priscila de Oliveira Beranger Martha Viviana Torres cely Ane Stefano Simionato Juliana Fonteque Pistori Flavia regina Spago João Carlos Palazzo de Mello Juca Abramo Barrera San Martin Celia Guadalupe Tardeli de Jesus Andrade Galdino Andrade Departamento de Microbiologia Laboratório de Ecologia MicrobianaUniversidade Estadual de LondrinaLondrinaBrazil Departamento de Farmácia e Farmacologia Laboratório de Produtos FitoterápicosUniversidade Estadual de MaringáMaringáBrazil Departamento de Biologia Geral Laboratório de Microscopia e MicroanáliseUniversidade Estadual de LondrinaLondrinaBrazil

Bacterial spot caused by Xanthomonas arboricola pv. pruni (Xap) is considered as a major problem in peach orchards. Copper and antibiotics are used to control, and biocontrol should be a new alternative with low environment impact. The objective was evaluated by the antibiotic activity of the metabolite produced by Pseudomonas aeruginosa LV strain. The free cells supernatant was fractionated with a serial organic solvent with crescent polarity and a dichloromethane phase was concentrated and lyophilised, and after was fractionated using vacuum liquid chromatography. The antibiotic activity of the F3 fraction containing an organometallic compound was tested on Xap in vitro and in a greenhouse conditions. Plants were sprayed with F3 before or after Xap infection and the results showed changes in exopolysaccharides and cell morphology. The F3 concentration of 450 μg·mL-1 was more effective. The results showed that F3 fraction could be a new alternative to control bacterial spot.

关键词： Peach Tree Bacterial Spot Biological Control Leaf Lesions Xanthomonas arboricola Pv.pruni

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Application of Medicinal Plants on Menopause Symptoms

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Journal of Pharmacy and Pharmacology 2021年第7期9卷 245-255页

作者： Yosvany Urquiola Martínez Ana Elena Rodríguez Cadalso regina de Caridad Rodríguez Muñoz Viviana Silvia Rodríguez Jiménez Marelys Medina barroso Ramón Florencio Duarte Chaviano Filial of Medical Sciences Elena Fernández de Castro Unit Trinidad 62600Sanctis Spíritus.Cuba

Objectives:To relate the symptoms of menopause and the use of medicinal ***:it was carried out a study that applied the qualitative method,by means of a bibliographical and documental revision in sources of digital data of wide reach(Google,SciELO,DOAJ,Latindex and SCOPUS).It was kept in mind the quality and the present ***:It was based on the search of articles in Virtual the Library in Health(Spanish:BVS)and using the key words:menopause,medicinal plants,phytotherapy,menopause symptoms.

关键词： Menopause medicinal plants phytotherapy menopause symptoms.

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