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Retinoprotective compounds,current efficacy,and future prospective

Neural Regeneration Research 2023年第12期18卷 2619-2622页

作者： Rachele Marino rebecca sappington Marco Feligioni Laboratory of Neuronal Cell Signaling EBRI Rita Levi-Montalcini FoundationRomeItaly Department of Neurobiology and Anatomy Wake Forest School of MedicineAtrium Health Wake Forest Baptist Medical CenterWinston-SalemNCUSA Department of Ophthalmology Wake Forest School of MedicineWinston-SalemNCUSA Department of Neurorehabilitation Sciences Casa di Cura IgeaMilanItaly

Retinal dysfunction is the most common cause of vision loss in several retinal *** has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy *** different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis *** changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these *** treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal ***,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective ***,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for *** review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical ***,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each *** approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关键词： age-related macular degeneration anti-inflammatory drugs antioxidants diabetic retinopathy glaucoma neuroprotective compounds retinitis pigmentosa retinopathies vision loss

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