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Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Factor V Leiden in Type 2 Diabetics in Abidjan

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Open Journal of Genetics 2024年第1期14卷 13-25页

作者： N’Guessan-Blao rebecca Yapo Vincent Yayo-Ayé Mireille Adjambri Eusèbe Koné-Koné Fatoumata Sawadogo Duni Hematology and General Biology Unit Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology and Medical Research National Institute of Public Health (INSP) Abidjan Ivory Coast Molecular Biology Unit Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In Africa, the prevalence of diabetes is escalating and remains a concern due to the numerous complications it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in diabetic individuals. Diabetes is a complex and multifactorial disease involving genetic components. With the aim of preventing complications and contributing to an efficient management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in particular the C677T of MTHFR, G20210A of prothrombin, and R506Q of factor V Leiden in type 2 diabetics in Abidjan receiving ambulatory care. A descriptive cross-sectional study was carried out on consenting type 2 diabetic patients. Mutation detection was carried out using the PCR-RFLP method employing restriction enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand factor) were performed using citrate tubes on the Stage? Star Max automated system. Plasminogen activator inhibitor was assayed by ELISA method, and biochemical parameters were determined using the COBAS C311. The study population consisted of 45 diabetic patients, 51.1% of whom presented vascular complications, mainly neuropathy. Disturbances in hemostasis parameters were observed, with 15.5% of patients showing an increase in fibrin monomers. Mutation analysis revealed an absence of factor V mutation (factor V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjects had a heterozygous C677T mutation of MTHFR, with 57% of them being anemic. The exploration of biological and genetic factors associated with thrombotic risk is of significant interest in the optimal management of African type 2 diabetics.

关键词： Type 2 Diabetes C677T of MTHFR G20210A Factor V Leiden Thrombosis

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科学新闻 2024年第2期 63-64页

作者： rebecca Lengnick-Hall 倪伟波华盛顿大学布朗学院

在妈妈被诊断出患有癌症的3个月后，她被送进了重症监护室（ICU）。就在我即将和项目负责人因一项帮助我过渡到教师职位的资助而见面的10分钟前，我得知了这个消息。在最后一刻取消见面是不专业的。但当我疯狂地把东西扔进行李箱时，我...

在妈妈被诊断出患有癌症的3个月后，她被送进了重症监护室（ICU）。就在我即将和项目负责人因一项帮助我过渡到教师职位的资助而见面的10分钟前，我得知了这个消息。在最后一刻取消见面是不专业的。但当我疯狂地把东西扔进行李箱时，我知道自己无法全身心投入。所以，我给项目负责人发了封邮件，解释了情况。她立即回信，让我专注于家庭。后来，当我妈妈离开重症监护室时，我仍然心烦意乱，无法见面。项目负责人重述了一遍她的信息：“未来几周的总体目标就是做一个好女儿，研究可以再等等。”她的话成为了我的人生路标。自从妈妈2020年被诊断出癌症以来，她完成了每

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影像主宰者徕卡SL3相机拍摄体验

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摄影之友 2024年第6期 120-121页

作者： rebecca Lidden(图) 刘一彤(图) 不详

提起徕卡相机,无论是经典的M系列和轻便的Q系列,还是全画幅无反SL系列,都承载了徕卡面向专业领域的重要使命。此次全新升级的SL3是否可以满足职业摄影师的全方位拍摄需求?通过实拍一起验证。

关键词：相机拍摄全画幅徕卡面向专业主宰者重要使命全方位

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Storylines of family medicine Ⅻ:family medicine and the healthcare system

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Family Medicine and Community Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M Campbell Aerial R Petty Hima Ekanadham Kurt C Stange rebecca S Etz William L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon C M Reece Joshua Freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical College NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani College of Medicine TampaFloridaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

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重新思考整个系统,而不仅仅是材料

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青年视觉 2024年第2期 232-239页

作者：王贝贝 Natural Material Studio Peter Vinther rebecca Nordberg Tanaka Kotaro 不详

木炭、贝壳、盐等,这些不起眼的日常用品如何成为构建我们生活空间的建筑材料?如果放弃大规模生产,生物材料是否能够支撑人类现有的生活方式?将目光和行为聚焦到整个系统而不仅仅是材料上,丹麦设计师Bonnie Hvillum以更加宏阔的思维方... 详细信息

木炭、贝壳、盐等,这些不起眼的日常用品如何成为构建我们生活空间的建筑材料?如果放弃大规模生产,生物材料是否能够支撑人类现有的生活方式?将目光和行为聚焦到整个系统而不仅仅是材料上,丹麦设计师Bonnie Hvillum以更加宏阔的思维方式探索材料提取、转化、使用、回收的全生命周期。她将自己定位为一名交互工作者,而不仅仅是设计师。

关键词：建筑材料全生命周期生活空间日常用品思维方式重新思考设计师

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新天鹅护理休闲区,本特利,澳大利亚

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世界建筑 2024年第6期 66-71页

作者：无 Adrian Iredale Finn Pedersen Martyn Hook Tom See Hoo rebecca Angus Mary McAree rebecca Hawkett Catherine Dupuy Gian Tonossi Jordan Blagaich Jake Gethin Daniel Martin Peter Bennetts(摄影) 伊代尔-佩德森-霍克建筑事务所不详

新天鹅护理休闲区旨在通过减少隔离、鼓励安全的活动和社交互动来改善居民的健康和福祉,并欢迎朋友、家人和周边居民的到来。Iph建筑事务所挑战了之前的总体规划,将车辆和道路从中心空间移除,取而代之的是一条宽阔、笔直且清静的人行林... 详细信息

新天鹅护理休闲区旨在通过减少隔离、鼓励安全的活动和社交互动来改善居民的健康和福祉,并欢迎朋友、家人和周边居民的到来。Iph建筑事务所挑战了之前的总体规划,将车辆和道路从中心空间移除,取而代之的是一条宽阔、笔直且清静的人行林荫道。林荫大道从天鹅护理中心的主要入口街道(阿迪苑)延伸至新的休闲区,并继续通向到远处的老年人关怀设施。一条蜿蜒曲折的小路与林荫大道相接,方便人们慢步闲逛。随着总体规划逐渐深化,这些小路将继续延伸,为老年痴呆症患者提供安全的活动空间。

关键词：护理中心建筑事务所主要入口林荫大道本特利休闲区蜿蜒曲折林荫道

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Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第3期14卷 331-337页

作者： rebecca Saich Roger Chapman The Department of Gastroenterology The John Radcliffe Hospital Headley Way Headington Oxford Oxfordshire OX3 9DU United Kingdom

Primary sclerosing cholangitis （PSC） is a chronic progressive disorder of unknown aetiology characterised by chronic inflammation and stricture formation of the biliary tree. Symptoms include itch and lethargy and in advanced cases cholangitis and end-stage liver disease, however increasing numbers of asymptomatic individuals are being identified. The disease is rare in the general population but is strongly associated with inflammatory bowel disease （IBD） affecting up to 5% of patients with Ulcerative Colitis, with a slightly lower prevalence （up to 3.6%） in Crohns disease. The strength of this association means that the vast majority （〉 90%） of patients with PSC also have IBD, although many may have only mild gastro-intestinal symptoms. Usually IBD presents before PSC, although vice-versa can occur and the onset of both conditions can be separated in some cases by many years. Mean age of diagnosis of PSC is in the fitch decade of life with a strong male predominance. Risk is increased in those with a family history of PSC, suggesting a genetic predisposition and the disease is almost exclusive to non-smokers. The ulcerative colitis associated with PSC is characteristically mild, runs a quiescent course, is associated with rectal sparing, more severe right sided disease, backwash ilieitis and has a high risk of pouchitis post-colectomy. Most worrisome is the high risk of colorectal malignancy which necessitates routine colonoscopic surveillance. Cholangiocarcinoma is also a frequent complication of PSC with a 10%-15% lifetime risk of developing this condition. Treatment with high dose ursodeoxycholic acid offers some chemoprotective effects against colorectal malignancy and may decrease symptoms, biochemical and histological progression of liver disease. Small duct PSC patients characteristically have normal cholangiography, and liver biopsy is required for diagnosis, it appears to have a more favourable prognosis. Autoimmune Hepatitis （AIH） is also more prevalent

关键词： Primary sclerosing cholangitis Autoimmunehepatitis Liver disease Inflammatory bowel disease Crohns disease Ulcerative colitis

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Do males choose their mates in the lekking moth Achroia grisella？ Influence of female body mass and male reproductive status on male mate choice

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Insect Science 2018年第5期25卷 861-868页

作者： Marlene Goubault rebecca Burlaud Institut de Recherche sur la Biologie de I'Insecte UMR 7261 CNRS-Universite Francois-Rabelais Tours France

Lekking males aggregate to attract females and contribute solely to egg fer- tilization, without any further parental care. Evolutionary theory therefore predicts them to be nonchoosy toward their mates, because any lost mating opportunities would out- weigh the benefits associated with such preferences. Nevertheless, due to time costs, the production of energetically costly sexual displays, and potential sperm limitation, the mat- ing effort of lekking males is often considerable. These factors, combined with the fact that many females of varying quality are likely to visit leks, could favor the evolution of male mate preferences. Here, we show that males of the lekking lesser wax moth, Achroia grisella, were indeed more likely to mate with heavier females in choice experiments, even at their virgin mating （i.e., when their reproductive resources have not yet been depleted by previous matings）. This differential female mating success could not be attributed to female behavior as heavy and light females showed similar motivation to mate （i.e., la- tency to approach the males） and time to copulate. Males seem to benefit from mating with heavier females, as fecundity positively correlated with female mass. This new em- pirical evidence shows that male mate choice may have been tmderestimated in lekking species

关键词： fecundity lek lesser wax moth mate choice mating status sexual behavior

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Last electroweak WIMP standing: pseudo-dirac higgsino status and compact stars as future probes

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Chinese Physics C 2018年第4期42卷 117-134页

作者： rebecca Krall Matthew Reece Department of Physics Harvard University

Electroweak WIMPs are under intense scrutiny from direct detection, indirect detection, and collider experiments. Nonetheless the pure（pseudo-Dirac） higgsino, one of the simplest such WIMPs, remains elusive. We present an up-to-date assessment of current experimental constraints on neutralino dark matter. The strongest bound on pure higgsino dark matter currently may arise from AMS-02 measurements of antiprotons, though the interpretation of these results has sizable uncertainty. We discuss whether future astrophysical observations could offer novel ways to test higgsino dark matter, especially in the challenging regime with order Me V mass splitting between the two neutral higgsinos. We find that heating of white dwarfs by annihilation of higgsinos captured via inelastic scattering could be one useful probe, although it will require challenging observations of distant dwarf galaxies or a convincing case to be made for substantial dark matter content in ω Cen, a globular cluster that may be a remnant of a disrupted dwarf galaxy. White dwarfs and neutron stars give a target for astronomical observations that could eventually help to close the last, most difficult corner of parameter space for dark matter with weak interactions.

关键词： dark matter higgsino supersymmetry

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Update on nutritional status,body composition and growth in paediatric inflammatory bowel disease

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World Journal of Gastroenterology 2014年第12期20卷 3191-3197页

作者： rebecca J Hill Children’s Nutrition Research Centre Queensland Children’s Medical Research Institute The University of QueenslandHerston School of Medicine The University of QueenslandHerston

Growth and nutritional status are important issues in paediatric inflammatory bowel disease(IBD).While linear growth is easy to assess,nutritional status is more complicated,with reports often compromised by the use of simple measures,such as weight and the body mass index,to assess nutritional status rather than more appropriate and sophisticated techniques to measure body *** review is an update on what is currently known about nutritional status as determined by body composition in paediatric ***,this review will focus on the impact of biologics on growth in paediatric *** lean mass deficits have been reported in children with IBD compared with controls,and there is evidence these deficits persist over ***,data imply that gender differences exist in body composition,both at diagnosis and in response to *** respect to growth improvements following treatment with biologics,there are conflicting *** some studies report enhancement of growth,others do *** relationship between disease severity,impaired growth and the requirement for biologics needs to be considered when interpreting these ***,key features associated with improvements in growth appear to be successful clinical response to treatment,patients in early stages of puberty,and the presence of growth failure at the onset of treatment.

关键词： Crohn’ s disease, Ulcerative colitis, Lean mass, Pubertal status, Infliximab, Inflammatory bowel disease

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