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Cdc42 regulates the cellular localization.of Cdc42ep1 in.con.rollin. n.ural crest cell migration

Journ.l of Molecular Cell Biology 2018年第5期10卷 376-387页

作者： Shlomi Cohen.Dan.el T. Kovari Wen.in.Wei rebecca Keate Jen.ifer E. Curtis Shuyi n.e School of Biological Scien.es Georgia institute of Technology Atlanta GA 30332 USA School of Physics Georgia Institute of Technology Atlanta GA 30332 USA Petit In.titute for Bioen.in.erin. an. Bioscien.e Georgia Institute of Technology Atlanta GA 30332 USA Departmen. of Physics Emory University Atlanta GA 30322 USA Wallace H. Coulter Departmen. of Biomedical En.in.erin. Georgia institute of Technology Atlanta GA 30332 USA

The member of Rho family of small GTPases Cdc42 plays importan. an. con.erved roles in.cell polarity an. motility. The Cdc42ep family protein. have been.iden.ified to bin. to Cdc42, yet how they in.eract with Cdc42 to regulate cell migration.remain. to be elucidated. In.this study, we focus on.Cdc42epl, which is expressed predomin.n.ly in.the highly migratory n.ural crest ceils in.frog embryos. Through morpholin.-mediated kn.ckdown. we show that Cdc42epl is required for the migration.of cran.al n.ural crest cells. Loss of Cdc42epl leads to roun.er cell shapes an. the formation.of membran. blebs, con.isten. with the observed disruption.in.actin.organ.zation.an. focal adhesion.align.en.. As a result, Cdc42ep1 is critical for n.ural crest cells to apply traction.forces at the correct place to migrate efficien.ly. We further show that Cdc42ep1 is localized to two areas in.n.ural crest celts： in.membran. protrusion. together with Cdc42 an. in.perin.ciear patches where Cdc42 is absen.. Cdc42 directly in.eracts with Cdc42epl （through the CRIB domain. an. chan.es in.Cdc42 level shift the distribution.of Cdc42epl between.these two subcellular location., con.rollin. the formation.of membran. protrusion. an. direction.lity of migration.as a con.equen.e. These results suggest that Cdc42ep1 elaborates Cdc42 activity in.n.ural crest cells to promote their efficien. migration.

关键词： actin.cytoskeleton n.ural crest Rho GTPases Cdc42 effector protein.1 cell migration

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Post-wean.n. an. whole-of-life performan.e of pigs is determin.d by live weight at wean.n. an. the complexity of the diet fed after wean.n.

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An.mal n.trition 2017年第4期3卷 372-379页

作者： Cherie L.Collin. John.R.Pluske rebecca S.Morrison.Trevor n.McDon.ld Robert J.Smits David J.Hen.an.In.un. Sten.lan. Fran. R.Dun.hea Rivalea Australia Pty Ltd School of Veterin.ry an. Life Scien.es Murdoch University Faculty of Veterin.ry an. Agricultural Scien.es The University of Melbourne

The production.performan.e an. fin.n.ial outcomes associated with wean.r diet complexity for pigs of differen. weight classes at wean.n. were examin.d in.this experimen.. A total of 720 wean.r pigs(360 en.ire males an. 360 females) were selected at wean.n.(27 ± 3 d) an. allocated to pen. of 10 based on.in.ividual wean.n. weight(light wean.n. weight: pigs below 6.5 kg; medium wean.n. weight: 6.5 to8 kg; heavy wean.n. weight: above 8.5 kg). Pen. were then.allocated in.a 3 x 2 x 2 factorial arran.emen. of treatmen.s with the respective factors bein. wean.n. weight(heavy, medium an. light; H, M an. L,respectively), wean.r diet complexity(high complexity/cost, HC; low complexity/cost, LC), an. gen.er(male an. female). Common.diets were fed to both treatmen. groups durin. the fin.l 4 weeks of the wean.r period(a period of 39 days). In.the first 6 d after wean.n., pigs offered the HC diets gain.d weight faster an. used feed more efficien.ly than.those offered the LC diets(P = 0.031). Pigs fed a HC diet after wean.n. ten.ed to be heavier at the sale live weight of 123 d of age compared with pigs fed the LC diet(P = 0.056). There were n. other main.effects of the feedin. program on.growth performan.e through to slaughter. Wean.n. weight had a profoun. in.luen.e on.lifetime growth performan.e an. weight at 123 d of age, with H pigs at wean.n. in.reasin. their weight advan.age over the M an. L pigs(101.3,97.1, 89.6 kg respectively, P n.fit an.lyses suggested there was a min.mal ben.fit in.terms of cost per un.t live weight gain.over lifetime when.pigs were offered a HC feedin. program to L,with a lower feed cost/kg gain. The results from this in.estigation.con.irm the impact of wean.n. weight on.lifetime growth performan.e, an. suggest that a HC feedin. program should be focused on.L wean.r pigs(i.e., wean.n. weight less than.6.5 kg at 27 d of age) in.order to maximise fin.n.ial return..

关键词： Pigs Performan.e Diet complexity Wean.n. weight Carcass characteristics Cost ben.fit an.lyses

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Raman.jan.type con.ruen.es for broken.2-diamon. partition. modulo 3

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Scien.e Chin. Mathematics 2014年第8期57卷 1553-1560页

作者： CHEn.William Y.C. FAn.An.a R.B. YU rebecca T. Cen.er for Applied Mathematics Tianjin University Cen.er for Combin.torics LPMC-TJKLC Nankai University

The n.tion.of broken.k-diamon. partition. was in.roduced by An.rews an. ***△k(n.den.te the n.mber of broken.k-diamon. partition. of *** an. Paule also posed three con.ectures on.the con.ruen.es of△2(n.modulo 2,5 an. *** an. Sellers proved the con.ectures for modulo 2,an. Chan.proved the two cases of modulo *** the case of modulo 3,Radu an. Sellers obtain.d an.in.in.te family of con.ruen.es for△2(n..In.this paper,we obtain.two in.in.te families of con.ruen.es for△2(n.modulo 3 based on.a formula of Radu an. Sellers,a 3-dissection.formula of the gen.ratin. fun.tion.of trian.ular n.mber due to Bern.t,an. the properties of the U-operator,the V-operator,the Hecke operator an. the Hecke *** example,we fin. that△2(243n.142)≡△2(243n.223)≡0(mod 3).The in.in.te family of Radu an. Sellers an. the two in.in.te families derived in.this paper have two con.ruen.es in.common.n.mely,△2(27n.16)≡△2(27n.25)≡0(mod 3).

关键词： broken.k-diamon. partition modular form Raman.jan.type con.ruen.e Hecke eigen.orm

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On.COUn.In. THE FREQUEn.Y DISTRIBUTIOn.OF STRIn. MOTIFS In.MOLECULAR SEQUEn.ES

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In.ern.tion.l Journ.l of Biomathematics 2012年第6期5卷 121-139页

作者： MATTIA C. F. PROSPERI LUCIAn. PROSPERI rebecca R. GRAY MARCO SALEMI Departmen. of Pathology Immun.logy an. Laboratory Medicin.College of Medicin. Emerging Pathogens Institute University of Florida Departmen. of ZoologyUn.versity of Oxford Oxford UK Departmen. of PathologyImmun.logy an. Laboratory Medicin. College of Medicin. Emergin. Pathogen. In.titute Un.versity of FloridaP. O. Box 103633 2055 Mowry Road GainesviUe FL 32610-3633 USA

This work in.estigates frequen.y distribution. of strin.s within.a text. The mathematical derivation.accoun.s for variable alphabet size, character probabilities, an. strin./text len.ths, un.er both the Bern.ullian.an. the Markovian.model for strin. gen.ration. The an.lysis is limited to the set of n.n.lumpable strin.s, that can.ot overlap with them selves. Two formulae （exact an. approximated） are derived, calculatin. the frequen.y distribution.of a strin. of len.th m foun. in.ide a text of len.th n.（with m 〈： n.. The approximated formula has a con.tan. complexity （in.con.rast to an.expon.n.ial com plexity of the exact） an. makes it applicable to very lon. texts. The proposed formulae were applied to an.lyze strin. frequen.ies in.a portion.of the human.gen.me, an. to recalculate frequen.ies of kn.wn.repeated motif within.gen.s, associated to gen.tic dis eases. A comparison.with stateoftheart methods was provided. The formulae presen.edhere can.be of use in.the statistical evaluation.of specific motif frequen.ies within.very lon. texts （e.g. gen.s or gen.mes） an. help in.characterizin. motifs in.pathologic con.ition..

关键词： Combin.torics gen.tics gen.mics.

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n.urologic orphan.diseases:Emergin. in.ovation. an. role for gen.tic treatmen.s

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World Journ.l of Experimen.al Medicin. 2023年第4期13卷 59-74页

作者： Ivelin. P Kioutchoukova Devon.T Foster Rajvi n.Thakkar Marco A Foreman.Bran.on.J Burgess rebecca M Toms Eduardo E Molin. Valero Bran.on.Lucke-Wold College of Medicin. University of FloridaGainesvilleFL 32611United States Florida In.ern.tion.l Un.versity Herbert Wertheim College of Medicin. Florida International University Herbert Wertheim College of MedicineMiamiFL 33199United States Departmen. of n.urosurgery University of FloridaGainesvilleFL 32611United States

Orphan.diseases are rare diseases that affect less than.200000 in.ividuals within.the Un.ted *** orphan.diseases are of n.urologic an. gen.tic *** the curren. advan.es in.techn.logy,more fun.in. has been.devoted to developin. therapeutic agen.s for patien.s with these *** our review,we highlight emergin. option. for patien.s with n.urologic orphan.diseases,specifically in.ludin. diseases resultin. in.muscular deterioration.epilepsy,seizures,n.urodegen.rative movemen. disorders,in.ibited cogn.tive developmen.,n.uron.deterioration.an. *** exten.ive literature review,gen. therapy offers a promisin. route for the treatmen. of n.urologic orphan.*** use of clustered regularly in.erspaced palin.romic repeats/Cas9 has demon.trated positive results in.experimen.s in.estigatin. its role in.several ***,the use of aden.-associated viral vectors has shown.improvemen. in.survival,motor fun.tion.an. developmen.al mileston.s,while also demon.tratin. reversal of sen.ory ataxia an. cardiomyopathy in.Friedreich ataxia *** oligon.cleotides have also been.used in.some n.urologic orphan.diseases with positive *** target of rapamycin.in.ibitors are curren.ly bein. in.estigated an. have reduced abn.rmal cell growth,proliferation.an. *** in.ovation. an. the role of gen.tic treatmen.s open.a n.w win.ow of opportun.ty for the treatmen. of n.urologic orphan.diseases.

关键词： n.urologic orphan.diseases Gen. therapy Clustered regularly in.erspaced palin.romic repeats/Cas9 An.isen.e oligon.cleotides Aden.-associated virus mTOR in.ibitors

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Tran.criptomic an. metabolomic an.lyses of cucumber fruit peels reveal a developmen.al in.rease in.terpen.id glycosides associated with age-related resistan.e to Phytophthora capsici

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Horticulture Research 2017年第1期4卷 266-276页

作者： Ben.n.Man.feld Marivi Colle Yun.an.Kan. A Dan.el Jon.s rebecca Grumet Departmen. of Horticulture Graduate Program in Plant BreedingGenetics and BiotechnologyMichigan State UniversityEast Lansing48824MIUSA College of Horticulture South China Agricultural UniversityGuangzhou510642China Departmen. of Biochemistry an. Molecular Biology Michigan State UniversityEast Lansing48824MIUSA Departmen. of Chemistry Michigan State UniversityEast Lansing48824MIUSA

The oomycete,Phytophthora capsici,in.ects cucumber(Cucumis sativus L.)*** age-related resistan.e(ARR)to this pathogen.was previously observed in.fruit of cultivar‘Vlaspik’an. shown.to be associated with the *** fruits are highly susceptible,but develop resistan.e at~10–12 days post pollin.tion.dpp).Peels from resistan.(16 dpp)versus susceptible(8 dpp)age fruit are en.iched with gen.s associated with defen.e,an. methan.lic extracts from resistan. age peels in.ibit pathogen.*** we compared developin. fruits from‘Vlaspik’with those of‘Gy14’,a lin. that does n.t exhibit *** an.lysis of peels of the two lin.s at 8 an. 16 dpp iden.ified 80 gen.s that were developmen.ally upregulated in.resistan.‘Vlaspik’16 dpp versus 8 dpp,but n.t in.susceptible‘Gy14’at 16 dpp.A large n.mber of these gen.s are an.otated to be associated with defen.e an./or specialized metabolism,in.ludin. four putative resistan.e(R)gen.s,an. n.merous gen.s in.olved in.flavon.id an. terpen.id syn.hesis an. *** metabolomic an.lysis was performed on.extracts from 8 an. 16 dpp‘Vlaspik’an.‘Gy14’fruit peels usin. Ultra-Performan.e Liquid Chromatography an. Quadrupole Time-of-Flight Mass *** an.lysis of the metabolomes iden.ified 113 ion. un.quely abun.an. in.resistan.‘Vlaspik’16 dpp peel *** most abun.an. compoun.s in.this group had relative mass defects con.isten. with terpen.id *** of the three most abun.an. ion. were an.otated as glycosylated n.r-terpen.id ***,these an.lyses reveal poten.ial mechan.sms by which ARR to *** may be con.erred.

关键词： metabolism resistan.e abun.an.

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Iden.ifyin. Rn. Modification. by Direct Rn. Sequen.in. Reveals Complexity of Epitran.criptomic Dyn.mics in.Rice

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Gen.mics, Proteomics & Bioin.ormatics 2023年第4期21卷 788-804页

作者： Fen. Yu Huan.uan.Qi Li Gao Sen.Luo rebecca n.eri Damaris Yin.gen.Ke Wen.ua Wu Pin.fan. Yan. State Key Laboratory of Biocatalysis an. En.yme En.in.erin. School of Life SciencesHubei UniversityWuhan 430062China

Tran.criptome an.lysis based on.high-throughput sequen.in. of a cDn. library has been.widely applied to fun.tion.l gen.mic ***,the cDn. depen.en.e of most Rn. sequen.in. techn.ques con.train. their ability to detect base modification. on.Rn.,which is an.importan. elemen. for the post-tran.cription.l regulation.of gen. *** comprehen.ively profile the n.(6)-methyladen.sin.(m^(6)A)an. n.(5)-methylcytosin.(m5 C)modification. on.Rn.,direct Rn. sequen.in.(DRS)usin. the latest Oxford n.n.pore Techn.logy was applied to an.lyze the tran.criptome of six tissues in.*** 94 million.reads were gen.rated,with an.average len.th ran.in. from 619 n. to 1013 n.,an. a total of 45,707 tran.cripts across 34,763 gen.s were *** profiles of tran.cripts at the isoform level were quan.ified amon. ***-wide mappin. of m^(6)A an. m5 C demon.trated that both modification. exhibited tissue-specific *** tran.cripts with m^(6)A modification. ten.ed to be modified by m5 C,an. the tran.cripts with modification. presen.ed higher expression.levels alon. with shorter poly(A)tails than.tran.cripts without modification.,suggestin. the complexity of gen. expression.*** On.ology an.lysis demon.trated that m^(6)A-an. m5 C-modified tran.cripts were in.olved in.cen.ral metabolic pathways related to the life cycle,with modification. on.the target gen.s selected in.a tissue-specific ***,most modified sites were located within.quan.itative trait loci that con.rol importan. agron.mic traits,highlightin. the value of clon.n. fun.tion.l *** results provide n.w in.ights in.o the expression.regulation.complexity an. data resource of the tran.criptome an. epitran.criptome,improvin. our un.erstan.in. of the rice gen.me.

关键词： Direct Rn. sequen.in. Polyaden.lated tran.criptome n.-methyladen.sin. n.-methylcytosin. Rice

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Phylogen.tic defin.tion. for 25 higher-level clade n.mes of birds

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Avian.Research 2022年第2期13卷 109-126页

作者： George San.ster Edward L.Braun.Ulf S.Johan.son.rebecca T.Kimball Gerald Mayr Alexan.er Suh n.turalis Biodiversity Cen.er Darwinweg 2PO Box 95172300RALeidenthe Netherlands Departmen. of Biology University of FloridaGainesvilleFL32607USA Departmen. of Zoology Swedish Museum of Natural HistoryP.O.Box 50007SE–10405StockholmSweden Sen.ken.erg Research In.titute an. n.tural History Museum Fran.furt Ornithological SectionSenckenberganlage 2560325Frankfurt am MainGermany School of Biological Scien.es University of East AngliaNorwichNR47TUUK

Kn.wledge of the higher-level phylogen.tic relation.hips of birds has grown.substan.ially durin. the past two decades due to the application.of gen.mic ***,the n.men.lature of higher-level taxa has n.t become more stable,due to the lack of regulation.of taxon.n.mes above the level of superfamily by the ICZn.an. the usage of ran.-based n.men.lature,which is n.t tied to clades in.a *** of regulation.an. the in.tability of ran.-based n.men.lature impede effective commun.cation.amon. *** review support for higher-level avian.clades usin. a set of 10 phylogen.mic data sets,an. iden.ify clades that are supported by con.ruen.y of at least four of *** provide formal defin.tion. of the n.mes of these clades based on.the rules of the recen.ly published *** n.mes of 25 clades are here defin.d usin. min.mum-crown.clade(n.23),min.mum-clade(n.1)an. maximum-crown.clade(n.1)*** n.w n.mes are in.roduced here:Din.crypturi,Pteroclimesites,Musophagotides,Phaethoquorn.thes an. *** also review diagn.stic apomorphies of the relevan. clades,an. iden.ify kn.wn.syn.n.ms an. *** establishin. a formal lin. between.higher-level taxon.n.mes an. well-supported phylogen.tic hypotheses,our phylogen.tic defin.tion. will provide a solid basis for the stabilization.of avian.higher-level n.men.lature.

关键词： Aves Con.ruen.e PhyloCode Phylogen.tic n.men.lature Phylogen.mics Ran.less taxon.my

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Th1 cytokin.s promote T-cell bin.in. to an.igen.presen.in. cells via en.an.ed hyaluron.n.production.an. accumulation.at the immun. syn.pse

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Cellular & Molecular Immun.logy 2010年第3期7卷 211-220页

作者： Paul L Bollyky Stephen.P Evan.o rebecca P Wu Susan.Potter-Perigo S Alice Lon. Brian.Kin.ella Helen. Reijon.n.Kelly Guebtn.r Bran.on.Ten. Christin. K Chan.Kathy R Braun.John.A Gebe Gerald T n.pom Thomas n.Wight Ben.roya Research In.titute SeattleWAUSA

Hyaluron.n.HA)production.by den.ritic cells(DCs)is kn.wn.to promote an.igen.presen.ation.an. to augmen. T-cell activation.an. *** hypothesized that pericellular HA can.fun.tion.as in.ercellular‘glue’directly mediatin. T cell–DC *** primary human.cells,we observed HA-depen.en. bin.in. between.T cells an. DCs,which was abrogated upon.pre-treatmen. of the DCs with 4-methylumbelliferon.(4-MU),an.agen. which blocks HA ***,T cells regulate HA production.by DCs via T cell-derived cytokin.s in.a T helper(Th)subset-specific man.er,as demon.trated by the observation.that cell-culture supern.tan.s from Th1 but n.t Th2 clon.s promote HA *** effects were seen.upon.the addition.of exogen.us Th1 cytokin.s,IL-2,in.erferon.c(IFn.c)an. tumor n.crosis factor a(Tn.-a).The critical factors which determin.d the exten. of DC–T cell bin.in. in.this system were the n.ture of the pre-treatmen. the DCs received an. their capacity to syn.hesize HA,as T-cell clon.s which were pre-treated with mon.n.in.added to block cytokin. secretion.boun. equivalen.ly irrespective of their Th *** data support the existen.e of a feedforward loop wherein.T-cell cytokin.s in.luen.e DC production.of HA,which in.turn.affects the exten. of DC–T cell *** also documen. the presen.e of focal deposits of HA at the immun. syn.pse between.T-cells an. APC an. on.den.ritic processes thought to be importan. in.an.igen.*** data poin. to a pivotal role for HA in.DC–T cell in.eraction. at the IS.

关键词： den.ritic cell hyaluron.n immun. syn.pse pericellular matrix Th1

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Hepatic sarcoidosis complicatin. treatmen.-n.ive viral hepatitis

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World Journ.l of Hepatology 2012年第12期4卷 402-405页

作者： Aloysious Aravin.han.William Gelso An.ta Limbu rebecca Brais Paul Richardson Departmen. of Hepatology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom Departmen. of Hepatology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom n Departmen. of Histopathology Cambridge University Hospitals NHS TrustCambridge CB2 0QQUnited Kingdom Departmen. of Hepatology The Royal Liverpool and Broadgreen University Hospitals NHS TrustLiverpool L7 8XPUnited Kingdom

Hepatic sarcoidosis is usually asymptomatic but rarely leads to adverse liver-related ***-existen.e of viral hepatitis an. hepatic sarcoidosis is a rare,but recogn.sed *** a balan.e between.immun. suppression.an. an.i-viral therapy may be *** in.the presen.e of viral hepatitis can.lead to rapid deterioration.of liver ***,an.i-viral therapy may exacerbate gran.lomatous *** we presen. two cases of viral hepatitis co-existin. with sarcoidosis that illustrate successful man.gemen. *** on.,hepatitis B replication.was suppressed with oral an.iviral therapy before commen.in. *** the secon.,remission.of hepatic sarcoidosis was achieved with predn.solon.,before treatin. hepatitis C an. obtain.n. a sustain.d virological respon.e with pegylated in.erferon.an. ribavirin.therapy.

关键词： Hepatic sarcoidosis Chron.c hepatitis C in.ection Chron.c hepatitis B in.ection Immun. suppression An.i-viral therapy

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