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Mineral concentrations of chickpea and lentil cultivars and breeding lines grown in the *** Northwest

The Crop journal 2018年第3期6卷 253-262页

作者： George j.VANDemark Michael A.Grusak rebecca j.mc gee USDA-ARS Grain Legume Genetics and Physiology Research Unit USDA-ARS Red River Valley Agricultural Research Center

Diseases and health complications caused by mineral deficiencies afflict billions of people globally. Developing pulse crops with elevated seed mineral concentrations can contribute to reducing the incidence of these deficiencies. The objectives of this study were to estimate variance components conditioning seed mineral concentrations of chickpea and lentil grown in Washington and Idaho, determine correlations between different mineral concentrations and between mineral concentrations and yield, 100-seed weight, and days to flowering, and compare seed mineral concentrations between chickpeas and lentils grown in adjacent plots. Genotype effects, although significant in chickpea and lentil for all minerals except selenium, tended to be minimal compared to location, year, and their interaction effects. In both chickpeas and lentils high positive correlations were observed between seed concentrations of phosphorus and potassium, phosphorus and zinc, and potassium and zinc. Correlations between mineral concentration and yield, and mineral concentration and days to 50% flowering were similar for chickpeas and lentils across the majority of minerals. These results may reflect similarities between the two crops in physiological processes for mineral uptake and partitioning. Lentils had higher concentrations of iron and zinc than chickpea when the two crops were grown in adjacent plots,whereas chickpeas had higher concentrations of calcium and manganese. Plant genotypes that are more efficient at obtaining minerals from growing environments will be useful as parental materials to develop improved chickpea and lentil cultivars that have good yield potential coupled with high seed mineral concentrations.

关键词： Chickpea Lentil Mineral Nutrition Pulse

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The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4523-4534页

作者： rebecca R.Florke gee Andrew D.Huber jing Wu Richa Bajpai Allister j.Loughran Shondra M.Pruett-Miller Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Graduate School of Biomedical Sciences St.Jude Children's Research HospitalMemphisTN 38105USA Center for Advanced Genome Engineering and Department of Cell and Molecular Biology St.Jude Children's Research HospitalMemphisTN 38105USA

Pregnane X receptor(PXR)is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes[e.g.,cytochrome P4503A4(CYP3A4)]and *** the regulation of PXR target genes is well-characterized,less is known about the regulation of PXR protein *** screening an RNAi library,we identified the F-box-only protein 44(FBXO44)as a novel E3ligase for *** abundance increases upon knockdown of FBXO44,and,inversely,decreases upon overexpression of *** analysis revealed that FBXO44 interacts with PXR,leading to its ubiquitination and proteasomal degradation,and we determined that the F-box associated domain of FBXO44 and the ligand binding domain of PXR are required for the functional *** summary,FBXO44 regulates PXR protein abundance,which has downstream consequences for CYP3A4 levels and drug-drug *** results of this study provide new insight into the molecular mechanisms that regulate PXR protein level and activity and suggest the importance of considering how modulating E3ubiquitin ligase activities will affect PXR-mediated drug metabolism.

关键词： PXR FBXO44 Ubiquitination Proteasomal degradation CYP3A4 Drug-drug interactions E3 ligase Nuclear receptor

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Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis

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World journal of Gastroenterology 2010年第45期16卷 5669-5681页

作者： Chin-Ann j Ong Pierre Lao-Sirieix rebecca C Fitzgerald MRC Cancer Cell Unit Hutchison-MRC Research CentreCambridgeCB20XZUnited Kingdom

Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application.

关键词： Barrett’s esophagus Esophageal adenocar cinoma Esophageal dysplasia Prognosis

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Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus

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World journal of Diabetes 2021年第6期12卷 868-882页

作者： Leon de Wit Anna B Zijlmans Doortje Rademaker Christiana A Naaktgeboren j Hans DeVries Arie Franx rebecca C Painter Bas B van Rijn Department of Obstetrics and Gynaecology University Medical Center UtrechtUtrecht 3584 EANetherlands Department of Obstetrics and Gynaecology Gelderse Vallei HospitalEde 6716 RPNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers-Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Endocrinology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and Fetal Medicine Erasmus MC Sophia Children HospitalRotterdam 3015 GDNetherlands

BACKGROUND Implementation of new diagnostic criteria for gestational diabetes mellitus(GDM)are still a subject of debate,mostly due to concerns regarding the effects on the number of women diagnosed with GDM and the risk profile of the women newly *** To estimate the impact of the World Health Organization(WHO)2013 criteria compared with the WHO 1999 criteria on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy *** We retrospectively analyzed a single center Dutch cohort of 3338 women undergoing a 75 g oral glucose tolerance test where the WHO 1999 criteria to diagnose GDM were clinically *** were categorized into four groups:non-GDM by both criteria,GDM by WHO 1999 only(excluded from GDM),GDM by WHO 2013 only(newly diagnosed)and GDM by both *** compared maternal characteristics,pregnancy outcomes and likelihood ratios for adverse pregnancy *** Retrospectively applying the WHO 2013 criteria increased the cohort incidence by 13.1%,from 19.3%to 32.4%.Discordant diagnoses occurred in 21.3%;4.1%would no longer be labelled as GDM,and 17.2%were newly *** to the non-GDM group,women newly diagnosed were older,had higher rates of obesity,higher diastolic blood pressure and higher rates of caesarean *** infants were more often delivered preterm,large-for-gestational-age and were at higher risk of a 5 min Apgar score<*** excluded from GDM were older and had similar pregnancy outcomes compared to the non-GDM group,except for higher rates of shoulder dystocia(4.3%vs 1.3%,P=0.015).Positive likelihood ratios for adverse outcomes in all groups were generally low,ranging from 0.54 to *** Applying the WHO 2013 criteria would result in a substantial increase in GDM *** diagnosed women are at increased risk for pregnancy adverse *** risk,however,seems to be lower than those identified by the

关键词： Diagnostic criteria Gestational diabetes Glucose tolerance test Incidence Pregnancy outcome

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Efficient hexane isomers separation in isoreticular bipyrazolate metal-organic frameworks:The role of pore functionalization

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Nano Research 2021年第2期14卷 532-540页

作者： rebecca Vismara Corrado Di Nicola Rodrigo Gil-San Millan Kostiantyn V.Domasevich Claudio Pettinari jorge A.R.Navarro Simona Galli Dipartimento di Scienza e Alta Tecnologiay University delVInsubria 22100 ComoItaly School of Science and Technology University ofCamerino62032 Camerino(MC)Italy Departamento de Quimica Inorganica Universidad de Granada18071 GranadaSpain Taras Shevchenko National University of Kyiv 01601 KyivUkraine School of Pharmacy University of Camerino62032 Camerino(MC)Italy Istituto di Chimica dei Composti Organometallici(ICCOM-CNR) 50019 Sesto FiorentinoItaly Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali 50121 FirenzeItaly Department of Chemistry University of LiverpoolLiverpool L73NYUK

Hydrocarbons separation in petrochemical industries is a key,energy-consuming stage in the manufacture of high-quality added-value products—hence the need for more efficient materials and environmentally friendly methodologies to improve this *** this context,we have studied the effect of metal-organic frameworks(MOFs)pore functionalization in hexane isomers separation,isolating the robust isoreticular zinc(ll)bipyrazolates Zn(BPZ),showing no pore decoration,Zn(Me_(2)BPZ),the pores of which are decorated with apolar methyl groups,and Zn(BPZ(NH_(2))_(2)),the spacers of which possess polar Lewis-basic functions(H_(2)BPZ=1H,1'H-4,4'-bipyrazole;H_(2)Me_(2)BPZ=3,3'-dimethyl-1H,1'H-4,4'-bipyrazole;H_(2)BPZ(NH_(2))_(2)=3,5-diamino-1H,1'H-4,4'-bipyrazole;DMF=dimethylformamide).After characterizing Zn(BPZ(NH_(2))_(2))as per its crystal structure and thermal behaviour,and all the three MOFs as per their textural properties,we investigated,from the experimental and computational points of view,the impact of the square one-dimensional channels decoration on the separation of the hexane isomers,demonstrating the relevance of pore constrictions in the resolution of the title alkanes mixture.

关键词： adsorption molecular sieving nitrogen-donor ligands gas separation pow der diffraction variable-tem perature pulse gas chromatography

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Error reporting in the emergency department:do we do what we say we do?

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World journal of Emergency Medicine 2012年第4期3卷 261-264页

作者： rebecca jeanmonod Benjamin Katz St.Luke's Hospital and Health Network BethlehemPA 18015USA Amc Emergency Medicine Group 47 New Scotland AvenueMC 139AlbanyNY 12208USA

BACKGROUND:The joint Commission accreditation manual contains standards in improving organization performance related to report and review of patient care issues causing unexpected *** spite of regulations mandating reporting,it remains inconsistent,varying by provider type and *** purpose was to determine current attitudes,knowledge,and practice of error reporting among emergency department(ED) ***:We administered a survey assessing ED staff practice regarding error *** involved reporting of errors in which the practitioner was directly involved,errors the practitioner observed,and general awareness of reporting *** also questioned individuals regarding fear of repercussions for ***:Fifty-two surveys were *** most errors,providers were more likely to tell their supervisor about the issue than to tell the *** percent of respondents did not think that referring errors for review was their *** 31%of respondents were aware of standardized institution-wide pathways to report *** respondent who was aware of the institution-wide pathway also felt responsibility for error ***-three percent of the respondents were concerned about negative repercussions from reporting *** querying the hospital reporting system,263 cases were referred for quality issues over the previous year,51%of them were referred by nurses,27%by medical technicians(MTs),2%by mid-level providers(MLPs),1%by physicians,and 19%by other ***:Although most of the ED staff are responsible for patient safety,most are not aware of systems available to assist in reporting,and even many do not utilize those systems.

关键词： Error reporting Quality assurance Medical error

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High-pressure/low-temperature Metamorphism in Northern Hubei Province,Central China

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资源环境与工程 2016年第B4期30卷 89-104页

作者： G.Zhou Y.j.Liu E.A.Eide j.G.Liou W.G.Ernst Hubei Bureau of Geology and Mineral Resources Wuhan Hubei 430022 Department of Geology Stanford UniversityStanford California 94305

The Qinling-Dabie accretionary fold belt in east-central China represents the E-W trending suture zone between the Sino-Korean and Yangtze cratons. A portion of the accretionary complex exposed in northern Hubei Province contains a high-pressure / low-temperature metamorphic sequence progressively metamorphosed from the blueschist through greenschist to epidote-amphibolite / eclogite facies. The Hongan metamorphic belt can be divided into three metamorphic zones,based on progressive changes in mineral assemblages: Zone Ⅰ,in the south,is characterized by transitional blueschist-greenschist facies; ZoneⅡis characterized by greenschist facies; ZoneⅢ,in the northern most portion of the belt,is characterized by eclogite and epidote-amphibolite facies sequences. Changes in amphibole compositions from south to north as well as the appearance of increasingly higher pressure mineral assemblages toward the north document differences in metamorphic P-T conditions during formation of this belt. Preliminary P-T estimates for Zone I metamorphism are 5 ~ 7 kbar,350 ~ 450℃; estimates for Zone III eclogites are 10 ~ 22 kbar,500 ±50℃. The petrographic,chemical and structural characteristics of this metamorphic belt indicate its evolutionin a northward-dipping subduction zone and subsequent uplift prior to and during the final collisionbetween the Sino-Korean and Yangtze cratons.

关键词： central China eclogite high-P/T belt transitional blueschist-greenschist

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

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