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Epidemiological, prevention and control updates of yellow fever outbreak in Brazil

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 49-59页

作者： Marli do Carmo Cupertino rebeca garcia Andréia Patrícia Gomes Sérgio Oliveira de Paula Nicholas Mayers Rodrigo Siqueira-Batista Medical School Dinamica College of the Piranga Valley Laboratory of Epidemiological and Computational Methods in Health Department of Medicine and Nursing Federal University of Vicosa Laboratory of Immunovirology Department of General Biology Federal University of Vicosa Department of Veterinary Medicine Universidade Federal de Vicosa

Yellow fever is an acute viral disease endemic to tropical countries, like Brazil, where, since the 1940 s, has no significant documented outbreaks similar to that observed between 2016/2018(2 045 confirmed cases and 677 deaths; caused by the sylvatic form).The principal manipulating factors inciting this change were absence of appropriate vaccination campaigns and increased urbanization & population growth in forest areas, with prevalence of the virus in the species inhabiting of these *** 2016/2018 outbreaks exhibited incidence in areas with historically low or no yellow fever virus activity, triggering a surge in recorded deaths-mainly in the Southeastern states of *** Brazilian government aggressively responded, reforming the countries' prophylactic measures, including vaccine implementation-as of March, 2018, switching from the former double dose regimen of the vaccine, to a single dose protocol, deemed as ***, some states appropriated the fractionated dosage(1/5 of the standard dose), in foresight of potential vaccine *** prevent the uprising of new sylvatic yellow fever cases in Brazil, it's obligatory the development of effective combative plans, including adaptation of prophylactic measures individually(use of repellents, protective clothing etc.), applicable vaccination campaigns in every endemic region, to raise awareness to locals and visitors *** these preventative strategies, the persistence of cases and the recent outbreaks in Brazil, highlight the possible ineffectiveness of combative *** on these considerations, the objective of this review was to raise more awareness of the epidemiological impact of the disease in Brazil.

关键词： Infectious disease Epidemiology Arboviruses Yellow fever Aedes aegypti

Ethnobotany, Pharmacology and Chemistry of Medicinal Orchids from Veracruz

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Journal of Agricultural Science and Technology(A) 2015年第9期5卷 745-754页

作者： Leticia Margarita Cano Asseleih rebeca Alicia Menchaca garcia Jose Yader Sageth Ruiz Cruz Centro de lnvestigaciones Tropicales (ClTRO) Universidad Veracruzana Xalapa 91000 Mexico

Orchidaceae is a large family of 1,260 species in Mexico, of which 433 grow in the state of Veracruz, Mexico. Although economically important in horticulture because of the beauty of their flowers, researches have done little work regarding their medicinal properties. This paper aimed to present the results of ethnobotanical, pharmacological and active compounds research on Veracruz medicinal orchids. The ethnobotanical information was obtained by consulting the Atlas of the Mexican Traditional Medicine Plants, Veracruz Medicinal Flora Database （CITRO-UV project） and through field work in the Nahuatl community of Cuautlajapa, Veracruz. To obtain pharmacological and active compounds information of registered species, a search was carded out through MEDLINE （USA National Library of Medicine Journal Citation database）. Twelve medicinal orchids were recorded for Veracruz, i.e., Epidendrum chlorocorymbos Schltr., Habenaria floribunda Lindl., Isochillus latibracteatus A. Rich. ＆ Galeotti, lsochillus major Schltdl. ＆ Cham., Mormodes maculata var. unicolor （Hook.） L. O. Williams, Oestlundia luteorosea （A. Rich. ＆ Galeotti） W. E. Higgins, Oncidium ascendens Lindl., Scaphyglottis fasciculata Hook., Sobralia macrantha Lindl., Spiranthes eriophora （Rob. ＆ Greenm.）, Stanhopea oculata （G. Lodd.） Lindl. and Vanilla planifolia Andrews. Only two species have been investigated in terms of their pharmacology and active compounds. Also, information for another five species closely related to already identified ones was obtained. Given the relative poverty of current information on the topic, this paper demonstrates the need to further study the ethnobotanical, pharmacological and chemical aspects of the region＇s medicinal orchids.

关键词： Orchids medicinal orchids traditional medicine Veracruz medicinal orchids.

Oviductal epithelial cells selected boar sperm according to their functional characteristics

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Asian Journal of Andrology 2017年第4期19卷 396-403页

作者： rebeca Lepez-Ubeda Francisco A garcia-Vazquez Joaquin Gadea Carmen Matas Department of Physiology Veterinary Faculty University of Murcia International Excellence Campus for Higher Education and Research (Campus Mare Nostrum) Murcia 30100 Spain IMIB-Arrixaca (Institute for Biomedical Research of Murcia) Murcia Spain

The interaction of oviductal epithelial cells （OECs） with the spermatozoa has beneficial effects on the sperm functions. The aim of this study is to evaluate the in vitro fertilizing capacity of incubating spermatozoa previously selected by density gradient in OEC and determinate some sperm characteristics that could explain the results obtained. In this study, we assessed in vitro fertilization （IVF）, tyrosine phosphorylation, phosphatidylserine translocation, nuclear DNA fragmentation, and chromatin decondensation. Three experimental sperm groups, previously selected by Percoll gradient, were established according to the origin of the sperm used for IVF：（i） W30 group： spermatozoa were incubated with oocytes in the absence of OEC; （ii） NB group： after sperm incubation in OEC, the unbound spermatozoa were incubated with oocytes, in the absence of OEC; and （iii） B group： after sperm incubation with OEC, the bound spermatozoa were incubated with oocytes in the OEC plates. The results showed that sperm from the NB group led to a lower IVF yield, accompanied by low penetration rates （NB： 19.6%, B： 94.9%, and W30： 62.9%; P 〈 0.001） and problems of nuclear decondensation. Moreover, higher levels of tyrosine phosphorylation were observed in the NB group compared with the W30 and B groups （NB： 58.7%, B： 2.5%, and W30： 4.5%; P 〈 0.01）. A similar trend was observed in phosphatidylserine translocation （NB： 93.7%, B. 5.7%, and W30： 44.2%; P 〈 0.01）. These results demonstrate that the OEC exerts a rigorous degree of sperm selection, even within an already highly selected population of spermatozoa, and can capture the best functional spermatozoa for fertilization.

关键词： DNA status in vitro fertilization oviductal epithelial cells phosphatidylserine translocation sperm selection tyrosinephosphorylation

Microangiopathic Hemolytic Anemia and Diffuse Bone Metastasis by Signet Ring Cell Adenocarcinoma

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Journal of Cancer Therapy 2010年第2期1卷 94-96页

作者： Andres JMunoz Martin Pilar garcia Alfonso Maria Carmen Riesco Martinez Virginia Martinez Marin Yolanda Jerez Gilarranz rebeca Mondejar Solis Miguel Martin Jimenez Medical Oncology Service Hospital General Universitario“Gregorio Maranon”MadridSpain.

Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome and is typically associated with gastric adenocarcinoma. We report a 47-year-old woman who presented with asthenia, lower back pain and bleeding. Twelve years ago the patient underwent total gastrectomy due to gastric adenocarcinoma and achieved complete remission. The patient was diagnosed with MAHA and diffuses bone metastasis of signet ring cell adenocarcinoma of unknown origin and was treated successfully with polichemotherapy based on cisplatin and 5-fluorouracil.

关键词： Microangiopathic Haemolytic Anemia Gastric Cancer Paraneoplastic Syndrome Chemotherapy Signet Ring Cell Adenocarcinoma

Resistive Cerebral Blood Flow as a Potential Marker of Subclinical Brain Damage in Essential Hypertension

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World Journal of Cardiovascular Diseases 2014年第4期4卷 169-178页

作者： Sergio Gonzalez-garcia Zenaida Hernandez-Diaz Luis Quevedo-Sotolongo Marisol Pena-Sanchez Yaima Pino-Pena rebeca Fernandez-Carriera Caridad Menendez-Sainz Alina Gonzalez-Quevedo Janis Eells Institute of Neurology and Neurosurgery La HabanaCuba Cira garcia Central Clinic La HabanaCuba College of Health Sciences University of Wisconsin-MilwaukeeMilwaukeeUSA

Introduction: Subclinical brain damage in essential hypertension is more prevalent than cardiovascular or renal impairment;nevertheless, screening for nervous system involvement is difficult due to the low accessibility and high costs of these techniques. Objective: To assess the frequency of silent target organ damage in a cohort of asymptomatic hypertensive patients and to evaluate the potential usefulness of carotid ultrasonographic (US) variables as predictors of subclinical brain damage. Patients and Methods: Thirty four neurologically asymptomatic subjects (mean age 59 years) with essential hypertension were included. Target organ damage was evaluated: degree of hypertensive retinopathy, heart, kidney and brain. Structural and hemodynamical carotid Doppler US parameters were also investigated. Results: The brain was the most frequently affected target organ (70.6%), followed by the heart (67.9%) and kidney (58.6%). Carotid US parameters showed no association of intima media thickness with brain MRI results;nevertheless, decreased diastolic flow velocity and increased resistive index pointed to a resistive carotid flow pattern in patients with classical brain MRI lesions and predicted subclinical lesions with a sensitivity of 70% and 74% and a specificity of 72% and 80% respectively. Conclusions: This study supports previous findings that place the brain as the most frequently affected target organ in essential hypertensive patients and sheds more light on the potential usefulness of carotid structure and hemodynamics as imaging biomarkers of subclinical brain lesions.

关键词： Subclinical Brain Damage Essential Hypertension Carotid Doppler

氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究

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辣椒杂志 2021年第3期19卷 36-48页

作者： Lucas de ávila Silva rebeca P.Omena-garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa Natália Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰吉雪花(译) 不详石河子大学农学院乌鲁木齐832003

比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinens... 详细信息

比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。

关键词：辣椒叶片形态和解剖结构组织密度遮阴