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Hypopharyngeal cancer trends in a high-incidence region:A retrospective tertiary single center study

世界临床病例杂志 2023年第24期11卷 5666-5677页

作者： Alina-Georgiana Vulcu Cordunianu Gabriel Ganea Mihai Alexandru Cordunianu Daniel Cochior Cosmin Alec Moldovan razvan adam Doctoral School of Medicine Titu Maiorescu University of BucharestBucharest 040317Romania Department of Ear Nose Throat Head and Neck Surgery Carol Davila Central University Emergency Military HospitalBucharest 10825Romania Department of Pediatric Orthopedics Victor Gomoiu HospitalBucharest 022102Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu UniversityBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania

BACKGROUND Hypopharyngeal cancer has the bleakest prognosis among head and neck cancers due to its extensive submucosal involvement,advanced tumor stage,and limited surgical reconstruction *** primary causes include alcohol consumption,tobacco use,genetic predisposition,1`diet,and socioeconomic *** squamous cell carcinoma(SCC)accounts for 95%of hypopharyngeal tumors,it remains a rare form,comprising only 3%-5%of all SCC cases in the head and neck ***,Central and Eastern Europe have the highest incidence rates for males(3.9 per 100000)and the third highest for females(2.26 per 100000),underscoring the significance of this seemingly uncommon *** Romania,hypopharyngeal cancer ranked 24th in incidence rate,with 634 new cases in *** To study the incidence,treatment and survival rates of hypopharyngeal tumor cases in a major ear,nose,throat(ENT)surgical *** A retrospective epidemiological clinical study was conducted on patients diagnosed and treated for hypopharyngeal cancer at the ENT department of"Carol Davila Central University Emergency Military Hospital"in Bucharest between January 2018 and August *** study included 53 patients and was authorized by the Ethics Committee of Titu Maiorescu Doctoral School(Bucharest,Romania)and the Ethics Committee of Carol Davila Central University Emergency Military Hospital(Bucharest,Romania).Inclusion criteria required a positive histopathological diagnosis of hypopharyngeal cancer,tumor localization in the hypopharyngeal region,and informed consent for data *** criteria involved major psychiatric pathologies and disagreement for data *** was based on ENT assessment,imaging reports,and laboratory *** methods were determined based on various *** tools,such as Adult Comorbidity Evaluation-27 and Karnofski Performance Status Scale,were used for risk assessment and functional capacity *** of life aspects were

关键词： Hypopharyngeal Cancer Organ conservation therapy Chemotherapy Radiotherapy Surgery

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Ten-year multicentric retrospective analysis regarding postoperative complications and impact of comorbidities in hemorrhoidal surgery with literature review

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World Journal of Clinical Cases 2023年第2期11卷 366-384页

作者： Cosmin Moldovan Elena Rusu Daniel Cochior Madalina Elena Toba Horia Mocanu razvan adam Mirela Rimbu Adrian Ghenea Florin Savulescu Daniela Godoroja Florin Botea Department of Medical Surgical Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Preclinic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of Ear Nose and ThroatIlfov County Clinical Emergency HospitalBucharest 022104Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania Medical Doctoral School Titu Maiorescu University of BucharestBucharest 040317Romania Department of Coloproctology MedLife SA Băneasa HyperclinicBucharest 013693Romania nd Department of Surgery Carol Davila Central Military Emergency University HospitalBucharest 010242Romania Department of Anesthesia Ponderas Academic HospitalBucharest 014142Romania Florin Botea 2nd Department of SurgeryFundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Hemorrhoidal disease(HD)is considered a low-severity pathology by both general population and physicians,but the lengthy conservative therapy and postoperative complications suggest *** To assess the effectiveness of different treatment options,both conservative and surgical,in contrast with some preexisting *** We conducted a retrospective,10-yearlong study between January 2011 and December 2021 in two surgical centers,a private and a state-owned *** compared the efficacy and safety of several treatment options,such as open hemorrhoidectomy,stapled hemorrhoidopexy,rubber band ligation and infrared coagulation in terms of complication rates and types and their correlation with different preexisting comorbidities such as inflammatory bowel disease(IBD),use of anticoagulant medication(AM)and liver *** also conducted a 20-years long PubMed research(1.263 articles)for relevant *** Our study recorded 10940 patients with HD,10241 with conservative and 699 with surgical *** of these,the male-to-female ratio of 1.3,and a peak in age distribution between 59 and 68 years old(32%of patients).For the entire study,we recorded a 90%incidence of immediate pain,immediate bleeding in 1.5%(11 cases),delayed bleeding in 1.0%(7 cases),and 0.6%surgical site *** retention was also present,with 0.2%of patients,anal stricture in 1%and fecal incontinence for 0.5%of patients(4 cases).We recorded no severe complications such as Fournier`s gangrene or rectovaginal *** accounted for 6%of the patients,with ulcerative colitis in 12%and Chron`s disease in 10.5%.6.6%of the patients had AM,determining 4%immediate and 2%delayed bleeding,in surgically treated *** Our study determined that most common complications(pain,urinary retention,bleeding,and stricture)are correlated with each surgical technique and pre-existing comorbidities.

关键词： Retrospective Hemorrhoidal Postoperative Complications Comorbidities

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Wilkie’s syndrome as a cause of anxiety-depressive disorder:A case report and review of literature

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World Journal of Clinical Cases 2022年第5期10卷 1654-1666页

作者： Raluca Cristina Apostu Lucian Chira Doina Colcear Andrei Lebovici Georgiana Nagy Radu razvan Scurtu Radu Drasovean Department of Surgery “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400001Romania Department of Psychiatry Clinical Infectious Disease HospitalCluj-Napoca 400000Romania Department of Radiology “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400006Romania Department of Internal Medicine "Iuliu Hatieganu"University of Medicine and Pharmacy Cluj-Napoca400006Romania

BACKGROUND Superior mesenteric artery syndrome is a disease with a complex diagnosis,and it is associated with complications that make it even harder to ***,a frequent association with psychiatric disorders has been *** numerous case reports and case series,the variability of the disease has not allowed the development of protocols regarding diagnosis and *** SUMMARY A 33-year-old woman presented with abdominal pain,nausea,and bile vomiting over the last 15 mo,associated with a 15-kg weight loss over the last three *** the onset of the symptoms,the patient was diagnosed with anxietydepressive disorder and treated *** examinations excluded an organic cause,and the cause of the symptoms was considered *** persistence of symptoms,even under treatment,prompted a computer tomography angiography examination of the abdomen and *** examination identified emergence at a sharp angle of 13.7°of the superior mesenteric artery,with a reduced distance between the artery and the anterior wall of the aorta up to a maximum of 8 mm.A diagnosis of aortomesenteric clamp was *** treatment by laparoscopic duodenojejunostomy was *** evolution was marked by a patent anastomosis at 1 mo,with a 10-kg weight gain and improvement of the associated *** This case report underlines two major *** aspect refers to the predisposition of patients with superior mesenteric artery syndrome to develop psychiatric disorders,with an excellent outcome when proper treatment is *** second aspect underlines the key role of a multidisciplinary approach and follow-up.

关键词： Wilkie’s syndrome Weight loss Anxiety-depressive disorder Duodenojejunostomy Laparoscopy Case report

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Jet CAT P80 Thermal Analyses and Performance Assessment Using Different Fuels Types

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Journal of Thermal Science 2018年第4期27卷 389-393页

作者： Grigore CICAN Adina TOMA Cristian PUSCASU razvan CATANA Politehnica University of Bucharest Faculty of Aerospace Engineering 1-7 Polizu Street 011061 Bucharest 1 Romania National Research and Development Institute for Gas Turbines - COMOTI 220D Iuliu Maniu Ave Bucharest 6 Romania

The micro gas turbine propulsion systems represent a good choice for the unmanned aerial vehicles(UAVs). The present work monitors the engine parameters, correlating them with other important engine instrumentation data. The aim of this research was to study the operation of the Jet CAT using various types of fuels under various operating conditions: normal acceleration and sudden acceleration. The measured parameters were monitored under different conditions:(A) Engine operation at two different ambient temperatures – outdoor at 0oC and inside at 19oC; and(B) Using 4 fuel types: kerosene, diesel fuel, kerosene with 5% gasoline and kerosene with 10% gasoline. The relevance of this work is given by the fact that a detailed analysis is performed for the idle regime. The paper will present the detailed test plan used and the most relevant charts with the obtained results for: start time, force, temperature before turbine, fuel flow, depending on micro turbo engine speed.

关键词：燃料喷气打字 P80 热分析评价表演操作条件

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GLOBAL DYNAMICS OF A DIFFERENTIAL SUSCEPTIBILITY MODEL

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International Journal of Biomathematics 2012年第5期5卷 219-238页

作者： M. R. razvan S. YASAMAN Sharif University of TechnologyDepartment of Mathematical SciencesP. O. Box 11155-9315 Tehran Iran School of MathematicsInstitute for Research in Fundamental Sciences ( IPM) P. O. Box 19395-5746 Tehran Iran

An SIS epidemiological model in a population of varying size with two dissimilar groups of susceptible individuals has been analyzed. We prove that all the solutions tend to the equilibria of the system. Then we use the Poincaré Index theorem to determine the number of the rest points and their stability properties. It has been shown that bistability occurs for suitable values of the involved parameters. We use the perturbations of the pitchfork bifurcation points to give examples of all possible dynamics of the system. Some numerical examples of bistability and hysteresis behavior of the system has been also provided.

关键词：流行病模型动力学行为易感性稳定性能 SIS 庞加莱双稳态分岔点

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Endoscopic ultrasound-guided fine-needle aspiration pancreatic adenocarcinoma samples yield adequate DNA for next-generation sequencing:A cohort analysis

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World Journal of Gastroenterology 2023年第18期29卷 2864-2874页

作者： Stefania Bunduc Bianca Varzaru razvan Andrei Iacob Andrei Sorop Ioana Manea Andreea Spiridon Raluca Chelaru Adina Emilia Croitoru Gabriel Becheanu Mona Dumbrava Simona Dima Irinel Popescu Cristian Gheorghe Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 020021Romania Digestive Diseases and Liver Transplantation Center Fundeni Clinical InstituteBucharest 022328Romania Center of Excellence in Translational Medicine Fundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Genetic tests are increasingly performed for the management of unresectable pancreatic *** genotyping aimed samples current guidelines recommend using core specimens,although based on moderate quality ***,in clinical practice among the endoscopic ultrasound(EUS) guided tissue acquisition methods,fine needle aspiration(FNA) is the most widely *** To assess the adequacy for next generation sequencing(NGS) of the DNA yielded from EUS-FNA pancreatic adenocarcinoma(PDAC) *** Between November 2018 and December 2021,105 patients with PDAC confirmed by EUS-FNA were included in the study at our tertiary gastroenterology *** 22 gauge(G) or 19G FNA needles were *** pass was dedicated to DNA *** concentration and purity(A260/280,A260/230) were assessed by *** assessed the differences in DNA parameters according to needle size and tumor characteristics(size,location) and the adequacy of the extracted DNA for NGS(defined as A260/280 ≥ 1.7,and DNA yield:≥ 10 ng for amplicon based NGS,≥ 50 ng for whole exome sequencing [WES],≥ 100 ng for whole genome sequencing [WGS]) by analysis of variance and ttest ***,we compared DNA purity parameters across the different DNA yield *** Our cohort included 49% male patients,aged 67.02 ± 8.38 *** 22G needle was used in 71%of the *** DNA parameters across our samples varied as follows:DNA yield:1289 ng(inter quartile range:534.75-3101),A260/280 = 1.85(1.79-1.86),A260/230 = 2.2(1.72-2.36).DNA yield was > 10 ng in all samples and > 100 ng in 93% of them(one sample < 50 ng).There were no significant differences in the concentration and A260/280 between samples by needle *** size was the only independent predictor of A260/230 which was higher in the 22G samples(P =0.038).NGS adequacy rate was 90% for 19G samples regardless of NGS type,and for 22G samples it reached 89% for WGS adequacy and 91% for WES and

关键词： Pancreatic adenocarcinoma Endoscopic ultrasound guided fine needle aspiration Next generation sequencing DNA yield Needle size Genetic testing

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Ultrashort Bessel beam photoinscription of Bragg grating waveguides and their application as temperature sensors

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Photonics Research 2019年第7期7卷 121-129页

作者： Guodong Zhang Guanghua Cheng Manoj K.Bhuyan Ciro D'Amico Yishan Wang razvan Stoian Laboratoire Hubert Curien UMR 5516 CNRSUniversite de LyonUniversite Jean Monnet42000 Saint EtienneFrance State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision MechanicsCASXi'an 710119China School of Electronics and Information Northwestern Polytechnical UniversityXi'an 710072China Academy of Scientific and Innovative Research CSIR-Central Scientific Instruments OrganizationChandigarh 160030India Optical Devices and Systems Division CSIR-Central Scientific Instruments OrganizationChandigarh 160030India

Ultrashort pulsed Bessel beams with intrinsic nondiffractive character and potential strong excitation confinement down to 100nm can show a series of advantages over Gaussian beams in fabricating efficient Bragg grating waveguides(BGWs).In this work, we focus on parameter management for the inscription of efficient BGWs using the point-by-point method employing Bessel *** to their high aspect ratio, the resulting one-dimensional void-like structures can section the waveguides and interact efficiently with the optical modes. Effective first-order BGWs with low birefringence can then be fabricated in bulk fused silica. By controlling the size and the relative location of grating voids via the Bessel pulse energy and scan velocities, the resonant behaviors of BGWs can be well regulated.A high value of 34 dB for 8 mm length is achieved.A simple predictive model for BGWs is proposed for analyzing the influences of processing parameters on the performance of BGWs. The technique permits multiplexing several gratings in the same *** to eight grating traces were straightforwarcliy inscribed into the waveguide in a parallel-serial combined mode, forming the multiplex *** an application, the multiplex BGW sensor with two resonant peaks is proposed and fabricated for improving the reliability of temperature detection.

关键词： photoinscription waveguides temperature detection

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Difficulties in diagnosing anorectal melanoma: A case report and review of the literature

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World Journal of Clinical Cases 2021年第36期9卷 11369-11381页

作者： Raluca Cristina Apostu Elena Stefanescu Radu razvan Scurtu Gabriel Kacso Radu Drasovean Department of Surgery "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400006Romania Department of Anesthesia and Intensive Care Emergency County Clinical HospitalCluj-Napoca 400006Romania Department of Surgery University of Medicine and Pharmacy"Iuliu Hatieganu"Cluj-NapocaCluj Napoca 400006Romania Department of Medical Oncology and Radiotherapy “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400006Romania

BACKGROUND Anorectal melanoma is a tumour that is difficult to identify due to its rarity and variability of *** data published in the literature do not allow for diagnostic and treatment guidelines to be *** melanoma has the worst prognosis among mucosal melanomas and is frequently misdiagnosed by standard identification *** SUMMARY A 66-year-old woman presented with intermittent anal bleeding,pain,and tenesmus in the past month,with no associated weight *** revealed a cauliflower-like tumour with a diameter of 1.5 cm,with exulcerated areas and an adherent clot but without *** results identified an inflammatory rectal polyp with nonspecific chronic *** markers CA 19-9 and CEA were within the normal *** 6 mo,due to the persistence of symptoms,a pelvic magnetic resonance imaging scan was performed.A lesion measuring 2.8 cm×2.7 cm×2.1 cm was identified at the anorectal junction,along with two adjacent *** distant metastases were *** was performed on the second set of biopsies,and a diagnosis of anorectal melanoma was *** treatment by abdominoperineal resection was *** was marked by the appearance of lung metastases at 1 mo postoperatively,detected on a positron emission tomography-computer tomography scan,and perineal recurrence after 5 *** molecular testing,the patient was included in an immunotherapy *** This case highlights the difficulty of establishing a definitive early diagnosis of anorectal melanoma,the importance of performing histological analysis on a wellrepresented biopsy specimen,and the poor prognosis,even with radical surgery.

关键词： Mucosal melanoma Anorectal Immunohistochemistry Melanocytes Molecular targeted therapy Case report

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飞秒激光诱导金属钨表面周期性自组织结构的研究

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光学学报 2016年第5期36卷 312-318页

作者：李晨程光华 Stoian razvan 中国科学院西安光学精密机械研究所瞬态光学与光子技术国家重点实验室陕西西安710119 中国科学院大学北京100049 Laboratoire Hubert Curien UMR 5516 CNRSUniversite de LyonUniversite Jean MonnetSaint Etienne France 42000

飞秒激光诱导金属表面周期性自组织微纳米条纹结构,在调控热辐射源、摩擦、超亲水性、超疏水性和打标等方面具有广泛的应用前景.研究了800nm飞秒激光诱导金属钨表面周期性自组织结构的形成规律和形成机理.采用Sipe干涉模型和有限时域差... 详细信息

飞秒激光诱导金属表面周期性自组织微纳米条纹结构,在调控热辐射源、摩擦、超亲水性、超疏水性和打标等方面具有广泛的应用前景.研究了800nm飞秒激光诱导金属钨表面周期性自组织结构的形成规律和形成机理.采用Sipe干涉模型和有限时域差分法,仿真了第1个飞秒激光脉冲刻蚀后随机粗糙表面引起的激光电磁场能量表面分布和第20个脉冲后低空间频率条纹结构引起的激光电磁场能量表面分布.揭示了低空间频率条纹与高空间频率条纹的形成机理,考察了表面微观形貌的演化和条纹周期随着脉冲增多而递减的现象.

关键词：超快光学飞秒激光微加工钨有限时域差分法

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Deliberate external pancreatic fistula after pancreaticoduodenectomy performed in the setting of acute pancreatitis, and its internalization through fistula-jejunostomy

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 94-96页

作者： Sorin T Alexandrescu Andrei C Zlate razvan T Grigorie Mihnea Ionescu Irinel Popescu Fundeni Clinical Institute Dan Setlacec Centre of General Surgery and Liver TransplantationSos.Fundeni nr.258sector 2BucharestRomania Carol Davila University of Medicine and Pharmacy BucharestRomania Titu Maiorescu University Faculty of MedicineBucharestRomania

To the Editor:Many patients with tumors of the pancreatic head or of the ampulla of Vater require endoscopic manipulation of the duodenal papilla in order to achieve tumor biopsy or for common bile duct *** interventional endoscopy approaches may lead to acute *** iatrogenic acute pancreatitis will influence the surgical strategy in patients scheduled for pancreaticoduodenectomy(PD).Due to the small number of cases,the surgical strategy in patients who require PD in the context of acute pancreatitis has not been standardized.

关键词： pancreatitis acute Vater

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