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Pharmacotherapeutics and molecular docking studies of alphasynuclein modulators as promising therapeutics for Parkinson’s disease

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BIOCELL 2022年第12期46卷 2681-2694页

作者： RAHAT ALI AFTAB ALAM SATYENDRA K.RAJPUT razi ahmad Department of Medical Elementology and Toxicology Jamia HamdardNew Delhi110062India Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew Delhi110025India Department of Pharmaceutical Sciences Gurukul Kangri UniversityUttarakhand249404India Department of Pharmacology HIMSR Jamia HamdardNew Delhi110062India

Parkinson’s disease(PD)is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral *** is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the *** date,only a few Food and Drug Administration(FDA)approved drugs are available on the market for the treatment of ***,these drugs show parasympathomimetic related adverse events and remarkably higher toxicity;hence,it is important to find more efficacious molecules to treat *** our study,We chosen 22 natural compounds as inhibitors that potentially block the alpha-synuclein clump-the pathological hallmark of PD-and provide new avenues for its *** of these molecules exhibited good pharmacokinetic behaviors,making them decisively favorable drug candidates to cure *** docking studies were performed to investigate the binding interactions between natural compounds and alpha-synuclein as anti-Parkinson drug *** the examined compounds,curcumin and piperine emerged as promising phytochemicals with the highest binding affinity,key residual stable bindings and showed a good inhibitory ***,the present study indicates that curcumin and piperine hold the potential to be developed as treatment options against *** validations are needed for insights into their mechanism of action and potential clinical application.

关键词： Parkinson’s disease(PD) Alpha-synuclein Molecular docking and dynamics Anti-Parkinson drug Curcumin Piperine

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Colloidal lead-free Cs_(2)AgBiBr_(6)double perovskite nanocrystals:Synthesis,uniform thin-film fabrication,and application in solution-processed solar cells

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Nano Research 2021年第4期14卷 1126-1134页

作者： razi ahmad Gautam Virender Nutan Dinesh Singh Govind Gupta Udit Soni Sameer Sapra Ritu Srivastava Advanced Materials and Devices Metrology Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Indian Reference Materials Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Department of Biotechnology TERI School of Advanced studiesNew Delhi 110070India Department ofChemistryy Indian Institute of Technology Delhi New Delhi 110016India Regional Centre of Advanced Technologies and Materials Faculty of SciencePalacky University OlomoucSlechtitelu 2778371 OlomoucCzech Republic

Recently developed lead-free double perovskite nanocrystals(NCs)have been proposed for the possible application in solutionprocessed optoelectronic ***,the optoelectronic applications of double perovskite NCs have been hampered due to the structural and chemical instability in the presence of polar ***,we report a facile strategy for the synthesis and purification of Cs_(2)AgBiBr_(6)double perovskite NCs that remained stable even after washing with polar *** is realized with our efficient colloidal route to synthesize Cs_(2)AgBiBr_(6)NCs that involve stable and strongly coordinated precursor such as silvertrioctyl phosphine complex together with bismuth neodecanoate,which leads to a significantly improved chemical and colloidal *** layer-by-layer solid-state ligand exchange technique,a compact and crack-free thin film of Cs_(2)AgBiBr_(6)NCs were ***,perovskite solar cells consisting of Cs_(2)AgBiBr_(6)as an absorber layer were fabricated and tested.

关键词： double perovskite nanocrystals colloidal and chemical stability thin film solar cells

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Combined medial patellofemoral ligament and medial patellotibial ligament reconstruction in recurrent patellar instability:A systematic review and meta-analysis

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World Journal of Clinical Cases 2023年第19期11卷 4625-4634页

作者： ahmad Abbaszadeh Mohsen Saeedi Amir Human Hoveidaei Haleh Dadgostar Saeed razi Mohammad razi Department of Orthopedic Emam Khomeini Teaching HospitalAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Sports Medicine Research Center Tehran University of Medical SciencesTehran 14395-578Iran Department of Sports and Exercise Medicine School of MedicineRasool Akram Medical ComplexIran University of Medical SciencesTehran ***Iran Bone and Joint Reconstruction Research Center Department of OrthopedicsSchool of MedicineIran University of Medical SciencesTehran ***Iran Department of Orthopedic Surgery Rasoul Akram HospitalIran University of Medical SciencesTehran ***Iran

BACKGROUND The medial patellofemoral ligament(MPFL),along with the medial patellotibial ligament(MPTL)and medial patellomeniscal ligament,aid in the stabilization of the patellofemoral *** the MPFL is the primary stabilizer and the MPTL is a secondary limiter,this ligament is critical in maintaining joint *** have been few studies on the combined MPFL and MPTL reconstruction and its *** To look into the outcomes of combined MPFL and MPTL reconstruction in frequent patellar *** By May 8,2022,four electronic databases were searched:Medline(PubMed),Scopus,Web of Science,and Google *** keywords such as"patellar instability,""patellar dislocation,""MPFL,""medial patellofemoral ligament,""MPTL,"and"medial patellotibial ligament"were co-searched to increase the sensitivity of the *** The pooled effects of combined MPFL and MPTL reconstruction for Kujala score(12-mo followup)and Kujala score(24-mo follow-up)were positive and incremental,according to the findings of this *** mean difference between the Cincinnati scores was also positive,but not statistically *** combination of the two surgeries reduces *** to cumulative meta-analysis,the trend of pain reduction in various studies is declining over *** The combined MPFL and MPTL reconstruction has good clinical results in knee function and,in addition to providing good control to maintain patellofemoral joint balance,the patient's pain level decreases over time,making it a valid surgical method for patella stabilization.

关键词： Medial patellofemoral ligament reconstruction Medial patellotibial ligament patella dislocation Patella instability

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聚合物流体在纳米颗粒和微生物存在下的流动和传热分析

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Journal of Central South University 2023年第4期30卷 1246-1261页

作者： razi KHAN Adeel ahmad Mehwish AFRAZ Yasir KHAN Department of Mathematics and Physics University of Campania“Luigi Vanvitelli”Caserta 81100Italy Department of Mathematics COMSATS University IslamabadIslamabad 45550Pakistan Department of Mathematics University of Hafr Al BatinHafr Al Batin 31991Saudi Arabia

本文采用FENE-P模型,研究纳米颗粒和微生物对聚合物通过水平伸缩薄片的流动和传热的影响以及对阻力系数、Nusselt数,Sherwood数和运动密度数的潜在影响。利用适当的相似性变换,将控制非牛顿聚合物流体流动的非线性偏微分方程组简化为恰... 详细信息

本文采用FENE-P模型,研究纳米颗粒和微生物对聚合物通过水平伸缩薄片的流动和传热的影响以及对阻力系数、Nusselt数,Sherwood数和运动密度数的潜在影响。利用适当的相似性变换,将控制非牛顿聚合物流体流动的非线性偏微分方程组简化为恰当的相似形式。利用基于有限差分格式的MATLAB code bvp4c和修正的边界条件对修正的常微分方程组进行数值求解。以表格形式列出了工业中这些流动参数是如何影响流体物理性能的,并详细分析了相关物理参数对速度、温度、浓度和微生物分布的影响。结果表明,聚合物添加剂降低了阻力系数和Nusselt数。Sherwood数和运动密度数也受到聚合物添加剂的明显影响。

关键词：聚合物边界层流动 FENE-P模型纳米流体微生物阻力降低传质和传热数值解

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Decision Making in Internet of Vehicles Using Pervasive Trusted Computing Scheme

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Computers, Materials & Continua 2021年第8期68卷 2755-2769页

作者： Geetanjali Rathee razi Iqbal Adel Khelifi Department of Computer Science and Engineering Jaypee University of Information TechnologyWaknaghatSolan173234Himachal PradeshIndia Department of Computer Information Systems University of Fraser ValleyCanada Department of Computer Science and IT Abu Dhabi UniversityUnited Arab EmiratesUAE

Pervasive schemes are the significant techniques that allow intelligent communication among the devices without any human *** Internet of Vehicles(IoVs)has been introduced as one of the applications of pervasive computing that addresses the road safety *** participating within the IoV are embedded with a wide range of sensors which operate in a real time environment to improve the road safety *** mechanisms have been proposed which allow automatic actions based on uncertainty of sensory and managed *** to the lack of existing transportation integration schemes,IoV has not been completely explored by business *** order to tackle this problem,we have proposed a novel trusted mechanism in IoV during communication,sensing,and record *** proposed method uses trust based analysis and subjective logic functions with the aim of creating a trust environment for vehicles to *** addition,the subjective logic function is integrated with multi-attribute SAW scheme to improve the decision metrics of authenticating *** trust analysis depends on a variety of metrics to ensure an accurate identification of legitimate vehicles embedded with IoT devices *** proposed scheme is determined and verified rigorously through various IoT devices and decision making metrics against a baseline *** simulation results show that the proposed scheme leads to 88%improvement in terms of better identification of legitimate nodes,road accidents and message alteration records during data transmission among vehicles as compared to the baseline approach.

关键词： Pervasive computing vehicular networks security trust decision schemes trusted internet of vehicles big data

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An efficient technique to retrieve information from a damaged near-field communication tag

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International Journal of Intelligent Computing and Cybernetics 2017年第1期10卷 41-51页

作者： Dawer Saeed razi Iqbal Al-Khawarizmi Institute of Computer Science University of Engineering and TechnologyLahoreLahorePakistan College of Computer Information Technology American University in the EmiratesDubaiUnited Arab Emirates

Purpose-The purpose of this paper is to discuss a technique of restoring data from a broken/damaged near-field communication(NFC)tag whose coil is damaged and seems ***/methodology/approach-This paper discusses a method to restore data from damaged NFC tags by designing a coil that matches the technical specification of NFC for restoring *** this paper,an NFC tag with a broken antenna coil and its operational NFC chip is used for restoring data by making an external loop antenna for the same ***-If the NFC tag is damaged,the information stored on the tag can be lost and can cause serious *** research provides an excellent mechanism for retrieving all the information accurately from a damaged NFC tag provided the NFC chip is not *** limitations/implications-One of the major limitations of this research is that the NFC chip remains intact without any *** can only be recoverable if just the antenna of the NFC tag is damaged;any damage to the NFC chip would make it impossible for the data to be *** implications-The research is carried out with limited resources in an academic institute and hence cannot be compared to antenna designs of the ***,industry vendors are using aluminum to design the coil;however,in this study a copper coil is used for coil design since it is far less expensive than aluminum ***/value-NFC is a rather new short-range wireless technology and not much work is done in this field as far as antenna study is *** study brings a technique to design a coil antenna for a damaged NFC tag to retrieve all the information without losing even a single bit of sensitive information.

关键词： Near-field communication Radio frequency identification Antenna design Mutual inductance Short-range wireless communication

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Selective Sensing Characteristics of Ca Doped BeO Nano-sized Tube toward H20 and NH3

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Chinese Journal of Chemical Physics 2013年第5期26卷 612-616,I0004页

作者： Maziar Noei Vali Zare-Shahabadi Seyedeh Najmeh razi Department of Chemistry Mahshahr Branch Islamic Azad University Mahshahr Iran Young and Elite Reaserchers Club Mahshahr Branch Islamic Azad University Mahshahr Iran

By means of density functional calculations, the structural and electronic properties of chemical modification of pristine and Ca-doped BeO nanotubes were investigated with NH3 and H20 molecules. It was found that the NH3 and H20 molecules can be adsorbed on the Be atom of the tube sidewall with the adsorption energies of about 36.1 and 39.0 kcal/mol, respectively. Density of states analysis shows that the electronic properties of the BeONT are slightly changed after the adsorption processes. Substitution of a Be atom in the tube surface with a Ca atom increases the adsorption energies by about 7.4 and 14.7 kcal/mol for NH3 and H20, respectively. Unlike the pristine tube, the electronic properties of Ca-doped BeONT are sensitive to NH3 and H20 molecules. Also, the Ca-doped tube is much more sensitive to H20 molecule than NH3 one.

关键词： Doping Density functional theory Sensor B3LYP

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Optimization of process parameters for the bioconversion of activated sludge by Penicillium corylophilum, using response surface methodology

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Journal of Environmental Sciences 2007年第1期19卷 23-28页

作者： Sarkar Mannan ahmadun Fakhru'l-razi Md Zahangir Alam Department of Chemical and Environmental Engineering Faculty of Engineering University Putra Malaysia (UPM)43400 UPM SerdangSelangorD.E.Malaysia. Department of Biotechnology Engineering Faculty of Engineering International Islamic University Malaysia (IIUM)Jalan Gombak53100 Kuala LumpurMalaysia.

The optimization of process parameters for the bioconversion of activated sludge by Penicillium corylophilum was investigated using response surface methodology （RSM）. The three parameters namely temperature of 33℃, agitation of 150 r/min, and pH of 5 were chosen as center point from the previous study of fungal treatment. The experimental data on chemical oxygen demand （COD） removal （%） were fitted into a quadratic polynomial model using multiple regression analysis. The optimum process conditions were determined by analyzing response surface three-dimensional surface plot and contour plot and by solving the regression model equation with Design Expert software. Box-Behnken design technique under RSM was used to optimize their interactions, which showed that an incubation temperature of 32.5℃, agitation of 105 r/min, and pH of 5.5 were the best conditions. Under these conditions, the maximum predicted yield of COD removal was 98.43%. These optimum conditions were used to evaluate the trail experiment, and the maximum yield of COD removal was recorded as 98.5%.

关键词： optimization response surface methodology Penicillium activated sludge domestic wastewater sludge

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Detailed electro-dynamic model of an ultra-fast disconnector including the failure mode

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High Voltage 2020年第5期5卷 549-555页

作者： Mario Zaja Ali Asghar razi-Kazemi Dragan Jovcic School of Engineering University of AberdeenAB243UEAberdeenUK

Ultra-fast disconnector(UFD)is a key component of hybrid DC circuit breakers and it is also studied as the main switch in some DC grid topologies.A UFD model suitable for DC grid studies and considering both normal operation and failure mode is *** dynamic motion of contacts is analysed in detail and it is concluded that Thomson coil inductances including parasitic parameters play an important role and it is recommended to use finite element *** arcing mode of UFD is repressed using a variable resistance in series with an ideal *** variable resistance is calculated analytically based on the instantaneous position of contacts and the circuit *** different arc models are recommended:for the air-insulated UFD and SF6 UFD,and in each case,two operating regimes should be considered:high and low *** UFD model is verified for both normal operation and failure mode using measurements on a 5 kV laboratory UFD and the results show very good *** 320 kV SF6 UFD model is evaluated using limited reported results from manufacturers.

关键词： mode dynamic Thomson

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Evaluation of fungal potentiality for bioconversion of domestic wastewater sludge

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Journal of Environmental Sciences 2004年第1期16卷 132-137页

作者： Zahangir Alam A. Fakhru'l-razi Abul H. Molla Department of Chemical and Environmental Engineering Faculty of EngineeringUniversiti Putra Malaysia 43400 UPM SerdangSelangor DE Malaysia Department of Biotechnology Engineering Faculty of Engineering International Islamic University Malaysia Jalan Gombak 53100 Kuala Lumpur Malaysia

This study was undertaken to screen the filamentous fungi isolated from its relevant habitats(wastewater, sewage sludge and sludge cake) for the bioconversion of domestic wastewater sludge. A total of 35 fungal strains were tested against wastewater sludge (total suspended solids, TSS 1%—5% w/w) to evaluate its potentiality for enhancing the biodegradability and dewaterability using liquid state bioconversion(LSB) process. The strains were divided into five groups i.e. Penicillium, Aspergillus, Trichoderma, Basidiomycete and Miscellaneous, respectively. The strains WWZP1003, SCahmA103, SCahmT105 and PC-9 among their respective groups of Penicillium, Aspergillus, Trichoderma and Basidiomycete played potential roles in terms of separation(formation of pellets/flocs/filaments), biodegradation(removal of COD) and filtration(filterability) of treated domestic wastewater sludge. The Miscellaneous group was not considered due to its unsatisfactory results as compared to the other groups. The pH value was also influenced by the microbial treatment during fermentation process. The filterability of treated sludge was improved by fungal treatment, and lowest filtration time was recorded for the strain WWZP1003 and SCahmA103 of Penicillium and Aspergillus groups respectively compared with other strains.

关键词： filamentous fungi screening wastewater sludge pellets filtration liquid state bioconversion

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