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New therapeutic option for irritable bowel syndrome:Serum-derived bovine immunoglobulin

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World Journal of Gastroenterology 2015年第11期21卷 3361-3366页

作者： Larry Good Roxanne Rosario raymond Panas Department of Gastroenterology South Nassau Communities Hospital Department of Research Good Pharmaceutical Development Company Department of Medical Affairs Entera HealthInc.

Oral prescription medical foods have long been used in hospital settings but are also appropriate therapies for gastrointestinal disorders in outpatient medical *** serum-derived bovine immunoglobulin/protein isolate(SBI) has been shown in clinical studies to reduce loose stools and improve stool consistency as well as other symptoms(i.e.,abdominal pain,bloating,and urgency) in patients with irritable bowel syndrome with diarrhea(IBS-D) and human immunodeficiency virus-associated *** case series reports the outcomes of 14 IBS patients who received SBI as an addition to standard of care at an individual physician's clinical *** patients:2 IBS with constipation(IBS-C),7 IBS-D,2 mixed diarrhea and constipation IBS(IBS-M) and 3 undefined IBS(IBS-U; also described by some physicians as IBS-Bloating),ranged in age from 22-87 ***(5 g or 10 g daily dose) was added to the patient's current standard care and followed for several weeks to determine if symptoms were improved with the addition of ***,12 of the 14 patients indicated some level of improvement through direct questioning of the patients regarding changes from the prior *** IBS-Bloating patient had a resolution of symptoms and two patients(1 IBS-Bloating and 1 IBS-C) discontinued therapy because of insufficient *** 12 patients who continued on therapy reported an overall improvement in symptoms with better stool consistency,decreased frequency as well as reductions in abdominal pain,bloating,distention,and *** most cases,therapeutic effects of SBI were seen within the first four weeks of therapy with continued improvements at subsequent *** has a multifaceted mechanism of action and may help to manage IBS by providing a distinct protein source required to normalize bowel function,gastrointestinal microbiota,and nutritionally enhance tight junction protein expression between intestinal epithelial *** as a medical food provides a safe o

关键词： Irritable bowel syndrome Diarrhea Immu-noglobulin

SIMULATING THE IMPACTS OF INDOOR VERTICAL FLOW CONSTRUCTED WETLANDS ON HVAC PERFORMANCE USING eQUEST AT HAMPSHIRE COLLEGE’S *** CENTER

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Journal of Green Building 2018年第2期13卷 123-144页

作者： Matthew raymond Sarah Hews Christina Cianfrani School of Natural Science Hampshire CollegeAmherst MA Hydrology School of Natural ScienceHampshire CollegeAmherst MA

INTRODUCTION Hampshire College,in Amherst,Massachusetts,is taking part in the green building movement with the construction of the *** Center,which opened in the spring of *** building was certified to meet the Living Building Challenge in spring 2018 and has satisfied building standards such as Net Zero energy and *** meet these standards,the design of the building employs solar photovoltaic panels,a rain water catchment and purification system,a greywater treatment system,storm water infiltration rain gardens,composting toilets,and control monitoring systems to make the building more efficient and decrease its harmful impacts on the environ*** greywater treatment system utilizes both indoor vertical flow constructed wetlands(VFCW)and an outdoor horizontal flow constructed wetland(HFCW)to filter greywater effluent from sinks and a coffee bar,meeting the requirement to treat and handle all wastewater generated on *** the VFCW system performance has been shown to be effective in exterior environments(Sklarz et al.,2009),its use inside a building requires scrutiny to verify that the adoption of this system does not affect the operation of essential building systems.

关键词： wastewater HVAC utilize

Truncated Fractional-Order Total Variation Model for Image Restoration

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Journal of the Operations Research Society of China 2019年第4期7卷 561-578页

作者： raymond Honfu Chan Hai-Xia Liang College of Science City University of Hong KongHong KongChina Department of Mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123JiangsuChina

Fractional-order derivative is attracting more and more interest from researchers working on image processing because it helps to preserve more texture than total variation when noise is *** the existing works,the Grunwald–Letnikov fractional-order derivative is usually used,where the Dirichlet homogeneous boundary condition can only be considered and therefore the full lower triangular Toeplitz matrix is generated as the discrete partial fractional-order derivative *** this paper,a modified truncation is considered in generating the discrete fractional-order partial derivative operator and a truncated fractional-order total variation(tFoTV)model is proposed for image ***,first any boundary condition can be used in the numerical ***,the accuracy of the reconstructed images by the tFoTV model can be *** alternating directional method of multiplier is applied to solve the tFoTV *** convergence is also analyzed *** the numerical experiments,we apply the tFoTV model to recover images that are corrupted by blur and *** numerical results show that the tFoTV model provides better reconstruction in peak signal-to-noise ratio(PSNR)than the full fractional-order variation and total variation *** the numerical results,we can also see that the tFoTV model is comparable with the total generalized variation(TGV)model in *** addition,we can roughly fix a fractional order according to the structure of the image,and therefore,there is only one parameter left to determine in the tFoTV model,while there are always two parameters to be fixed in TGV model.

关键词： Image restoration Fractional-order derivative Truncated fractional-order total variation model Total variation Total generalized variation Alternating directional method of multiplier

Using single cell transcriptomics to study the complexity of human retina

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Neural Regeneration Research 2020年第11期15卷 2045-2046页

作者： Daniel Urrutia-Cabrera raymond Ching-Bong Wong Centre for Eye Research Australia Department of Surgery(Ophthalmology)University of MelbourneMelbourneAustralia

The human retina is a specialized multilayered structure composed of numerous cell *** process of vision relies on a robust network integrated by rod photoreceptors,cone photoreceptors,bipolar cells,horizontal cells,amacrine cells and retinal ganglion cells,which detect,process and relay the visual information to the ***,structural and metabolic support is provided by Muller glia,retinal astrocytes and *** 200 genes have been implicated in inherited retinal diseases(RetNet:https://***/retnet/).However,in many cases,the retinal cell types that express these disease-associated genes remain to be *** complexity of the human retina represents a major challenge for the molecular profiling of all retinal cell *** previous studies utilised bulk RNA-seq to profile the whole human adult retina,which only analysed the averaged gene expression levels across all retinal cell *** such,knowledge of the transcriptome profile in specific cell types within the retina would help us to unravel the heterogeneity of retinal cells,advance understanding of the pathogenesis of inherited retinal diseases,and to develop gene therapies that could improve treatment options.

关键词： diseases specialized retina

精神病临床高危人群的症状和功能改变:一项系统综述和三水平元分析

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心理科学进展 2025年第1期33卷 42-61页

作者：赵子卿余锦婷陈嘉彦王芸茹黄佳陈楚侨中国人民大学心理学系北京100872 北京体育大学心理学院北京100091 中国科学院心理研究所心理健康重点实验室神经心理学与应用认知神经科学实验室北京100101 中国科学院大学心理学系北京100101

精神病临床高危(clinical high-risk for psychosis,CHR-P)人群的症状和功能发展存在异质性,澄清这个群体症状和功能的改变及联系,有利于精神病早期预防。元分析纳入54篇文献,探究CHR-P人群各维度临床症状和功能的纵向改变、基线症状对... 详细信息

精神病临床高危(clinical high-risk for psychosis,CHR-P)人群的症状和功能发展存在异质性,澄清这个群体症状和功能的改变及联系,有利于精神病早期预防。元分析纳入54篇文献,探究CHR-P人群各维度临床症状和功能的纵向改变、基线症状对随访功能的预测作用、调节效应。结果发现,CHR-P人群轻微阳性症状、阴性症状、瓦解症状、情感症状、一般精神病理症状、整体功能和角色功能随时间显著改善,社会功能没有显著改善;基线阴性症状显著负向预测随访的整体功能、社会功能、角色功能,基线的瓦解症状、情感症状、一般精神病理症状与随访的整体功能显著负相关;受教育程度显著调节轻微阳性症状和阴性症状的纵向变化,年龄、轻微阳性症状亚组比例和短暂间歇性精神病性症状亚组比例显著调节情感症状的纵向变化。这揭示阴性症状改善少和社会功能损害是CHR-P人群的核心特征,提示未来可针对阴性症状研发干预措施,进而改善社会功能。

关键词：精神病临床高危人群纵向改变三水平元分析阴性症状社会功能

Food preference of the rove beetle, Atheta coriaria Kraatz （Coleoptera： Staphylinidae） under laboratory conditions

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Insect Science 2007年第1期14卷 53-56页

作者： EVA M. BIRKEN raymond A. CLOYD Department of Natural Resources and Environmental Sciences University of Illinois Urbana Illinois USA

A study, involving laboratory choice tests, was conducted to determine the feeding behavior, based on food preference, of the adult and larval stage of the rove beetle, Atheta coriaria Kraatz when presented with both fresh moistened oatmeal and second instar fungus gnat, Bradysia sp. nr. coprophila （Lintner） larvae in Petri dishes. Rove beetles used in this study came from a laboratory-reared colony. A rating scale from 1 to 5, based on percent missing （1 = 0 to 10%, 2 = 11 to 30%, 3 = 31 to 50%, 4 = 51 to 75%, and 5 = 76 to 100%）, was used to objectively assess the amount of oatmeal and number of fungus gnat larvae consumed by each rove beetle adult and larva. In all the choice tests, A. coriaria adults and larvae preferred to feed on fungus gnat larvae （78% and 69%, respectively） significantly more so than oatmeal （9% and 5%, respectively） based on the amount of oatmeal and number of fungus gnat larvae consumed after 4 and 6 hours. There were relatively minimal differences in the amount of food consumed for both adults and larvae after 4 and 6 hours. The results of this study indicate that oatmeal may be an inexpensive supplemental food source, during the rearing process, which will not inhibit the effectiveness of rove beetles to control fungus gnat larvae when released into greenhouses.

关键词： Atheta coriaria biological control choice tests feeding behavior fungus gnats

Production of electrical energy from living plants in microbial fuel cells

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Clean Energy 2023年第2期7卷 408-416页

作者： raymond Daniel Rodriguez Martinez Maria Eugenia Alvarez Bermudez Department of Industrial Production Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela Department of Energy and Automation Faculty of EngineeringUniversidad Metropolitana1073 CaracasVenezuela

Growing energy demand is a current problem with greater incidence in the *** research objective is to establish seed bases to give a leading role to plants used in anthropogenic production activities and consumption,and even plants belonging to wildlife in terms of energy *** use of living plants to obtain electrical energy through a microbial-vegetable fuel cell is proposed as a mech-anism to supply the energy demand with easy access worldwide,especially in areas far from urban *** this work,the voltage produced by microbial-vegetable fuel cells was measured using graphite electrodes and plants belonging to the species of aloe(Aloe vera),corn(Zea mays),black beans(Phaseolus vulgaris),tomato(Solanum lycopersicum)and moss(Dicranidae).They were selected for their presence in everyday life and their great commercial and agricultural value,reaching a maximum voltage of 884 mV from *** is evidence that all plants can be a source of energy to a greater or lesser extent and that their performance is given by the plant root interactions at the ***,an extensive root system can favour the accumulation of substrate after the hydrolysis of dead roots,provided that their presence does not interfere with microbial activity on the anodic *** this,using plants with low resistance to thermal stress can lead to a substrate richer in substances that can be ***,it is recommended to use plants according to their life cycle and the morphology of their roots,and plants that can grow in waterlogged conditions or without direct contact with the Sun.

关键词： ecosystems microorganisms renewable energy photosynthesis sustainability

BSKCN and BSAML: blind signatures from the module lattice and the asymmetric module lattice

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Frontiers of Computer Science 2023年第6期17卷 175-177页

作者： Xiaofan LIU Wei REN Kim-Kwang raymond CHOO School of Computer Science China University of GeosciencesWuhan 430074China Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX 78249-0631USA

1 Introduction Blind signature allows a user to obtain the signature of a message from a signer without revealing the information of the message,as well as defending against *** recent years,there have been increased efforts to design post-quantum blind signature schemes,since it is known that classical cryptography assumptions(e.g.,integer factoring problem and discrete logarithm problem)are not secure against attacks carried out using quantum computers[1].One popular approach is to design blind signature schemes using *** first lattice-based blind signature scheme is proposed by Rückert[2],who also presented a general process of constructing lattice-based blind signature influenced by Lyubashevskys’s secure framework[3].Rückert’s approach achieves both blindness and one-more unforgeability in the random oracle *** then,many other blind signature schemes have extended Rückert signature *** example,based on Crystals-Dilithium[4](one of the NIST post-quantum signature standardization),Le et al.[5]created a blind signature from module lattices.

关键词： signature blind constructing

Production of secondary metabolite E2.2 from Phaleria macrocarpa endophytic fungus

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 881-885页

作者： Beatrix Trikurnia Gasong raymond Rubianto Tjandrawinata Dexa Laboratories of Biomolecular Sciences Dexa Medica Industri Selatan V Block PP no.7 Kawasan Industri Jababeka Ⅱ

Objective: To isolate new endophytic fungus from Phaleria macrocarpa(P. macrocarpa)that is able to produce E2.2 ***: Endophytic fungi were isolated from P. macrocarpa. Morphological and molecular identification was done to determine the species of the endophytic *** performance liquid chromatography was used to determine the ability of this fungus to produce E2.2 compound and to quantify the total yield of E2.2 from fungal fermentation. Fermentation process was optimized by observing suitable medium, p H and length of fermentation process. Phloroglucinol and gallic acid addition were examined to determine the effect of each compound on E2.2 ***: One endophytic fungus was successfully isolated from P. macrocarpa *** and molecular identification showed that it was a Colletotrichum gloeosporioides which belonged to Glomerellaceae family. This fungus showed highest production of E2.2 when incubated in potato dextrose broth with initial p H value of the medium at 5, and was incubated for 15 days. Phloroglucinol was found to better enhance E2.2 ***: Colletotrichum gloeosporioides found in P. macrocarpa plant is promising as a potential alternative source of E2.2.

关键词： Endophytic fungi Phaleria macrocarpa Secondary metabolite Colletotrichum gloeosporioides E2.2