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Relationship between acute hypercarbia and hyperkalaemia during surgery

World Journal of Clinical Cases 2019年第22期7卷 3711-3717页

作者： laurence Weinberg Amelia Russell lois Mackley Charles Dunnachie Joshua Meyerov Chong Tan Michael li raymond Hu Dharshi Karalapillai Department of Anaesthesia Austin HealthMelbourneVictoria 3084Australia Department of Intensive Care Austin HealthMelbourneVictoria 3084Australia Melbourne Medical School University of MelbourneVictoria 3010Australia

BACKGROUND The relationship between hyperkalaemia and metabolic acidosis is well described in the critical care setting;however,the relationship between acute respiratory acidosis and plasma potassium concentration is less well *** a controlled model of increasing levels of hypercarbia,we tested the hypothesis of whether increasing levels of hypercarbia are associated with changes in plasma potassium *** To determine whether increasing levels of hypercarbia are associated with changes in plasma potassium *** We performed a post-hoc study examining changes in serum potassium in 24 patients who received increased levels of hypercarbia during cardiac *** blood gases and plasma concentrations of potassium were measured at baseline,3 min prior to,and then every 3 min for 15 min during the intervention of *** primary endpoint was the absolute change in serum K+at 15 min compared to the baseline K+*** following secondary endpoints were evaluated:(1)The association between CO2 and serum K+concentration;and(2)The correlation between plasma pH and serum K+*** During the intervention,PaCO2 increased from 43.6 mmHg(95%CI:40.1 to 47.1)at pre-intervention to 83.9 mmHg(95%CI:78.0 to 89.8)at 15 min after intervention;Pl/l at baseline to 4.28(0.33)mmol/l at 15 min(effect size 0.09 mol/l;P=0.22).There was no significant correlation between PaCO2 and potassium(Pearson’s coefficient 0.06;95%CI:-0.09 to 0.21)or between pH and potassium(Pearson’s coefficient-0.07;95%CI:-0.22 to 0.09).CONClUSION Acute hypercarbia and subsequent respiratory acidaemia were not associated with hyperkalaemia in patients undergoing major surgery.

关键词： Anaesthesia Intensive care Biochemistry Surgery

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Aircraft Brake Dust Dispersion (Airwash) Testing

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Occupational Diseases and Environmental Medicine 2022年第4期10卷 255-261页

作者： Charles l. Blake Robert E. Bailey Kevin M. Guth raymond D. Harbison Apex Companies Marietta GA USA ESi Colorado Springs CO USA Center for Environmental and Occupational Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Prior industrial hygiene research involving wheel brake changing on a light general aviation aircraft has shown negligible potential for asbestos fiber exposure to mechanics that perform such work. This is despite the use of organic-style brake friction pads that contained asbestos. It has been otherwise established that chrysotile asbestos is largely degraded to a non-crystalline, amorphous substance by the heat and mechanical shear forces inherent to the braking process. However, trace (le have been found in brake wear dust. Disc-style brakes, the types used on aircraft, are of open design, such that wear dust is typically dispersed into the ambient air during and after brake application. For fixed-gear aircraft, the brake assemblies are also subject to substantial air velocities while the aircraft is in flight. This research was undertaken to measure and characterize the airflows experienced by aircraft wheel assemblies during takeoff, cruise, and landing maneuvers. No wear (brake) dust was observed at any point during the study.

关键词： Aircraft Brakes Asbestos Airwash

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FOlFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts

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World Journal of Gastroenterology 2012年第33期18卷 4533-4541页

作者： Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours léla Bengrine-lefèvre Franck Bonnetain Philippe lévy Eric raymond Philippe Ruszniewski Christophe louvet Pascal Hammel Service de Gastroentérologie-Pancréatologie Hpital Beaujon 100 Boul-evard du Général Leclerc 92110 Clichy La Garenne AP-HP France Service d'Oncologie Médicale Hpital Saint Antoine 184 Rue du Faubourg Saint-Antoine 75012 Paris AP-HP France Unité de Biostatistique et d'Epidémiologie EA 4184 Centre Georges Franois Leclerc 1 Rue du Pr Marion 21079 Dijon France Service d'Oncologie Médicale Hpital Beau-jon 100 Boulevard du Général Leclerc 92110 Clichy La Garenne AP-HP France Département d'Oncologie Médicale Institut Mutualiste Montsouris 42 Boulevard Jourdan 75014 Paris France

AIM: To evaluate the efficacy and safety of the FOlFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOlFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOlFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESUlTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOlFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOlFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOlFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOlFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated w

关键词： Pancreatic cancer Pancreatic adenocarcinoma Metastases Chemotherapy 5-fluorouracil Irinotecan Camptothecin FOlFIRI regimen

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In vitro expression and analysis of the 826 human G protein-coupled receptors

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Protein & Cell 2016年第5期7卷 325-337页

作者： Xuechen lv Junlin liu Qiaoyun Shi Qiwen Tan Dong Wu John J. Skinner Angela l. Walker lixia Zhao Xiangxiang Gu Na Chen lu Xue Pei Si lu Zhang Zeshi Wang Vsevolod Katritch Zhijie liu raymond C. Stevens iHuman Institute ShanghaiTech University Shanghai 201210 China Department of Biological Sciences Bridge Institute University of Southern California Los Angeles CA 90089 USA

G protein-coupled receptors （GPCRs） are involved in all human physiological systems where they are responsible for transducing extracellular signals into cells. GPCRs signal in response to a diverse array of stimuli including light, hormones, and lipids, where these signals affect downstream cascades to impact both health and disease states. Yet, despite their importance as therapeutic tar- gets, detailed molecular structures of only 30 GPCRs have been determined to date. A key challenge to their structure determination is adequate protein expression. Here we report the quantification of protein expression in an insect cell expression system for all 826 human GPCRs using two different fusion constructs. Expression char- acteristics are analyzed in aggregate and among each of the five distinct subfamilies. These data can be used to identify trends related to GPCR expression between dif- ferent fusion constructs and between different GPCR families, and to prioritize lead candidates for future structure determination feasibility.

关键词： G protein-coupled receptors insect,protein expression surface expression analysis fusionconstruct

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Gastrointestinal bleeding in a patient with a continuous-flow biventricular assist device

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World Journal of Radiology 2016年第4期8卷 428-433页

作者： raymond V Mirasol Jason J Tholany Hasini Reddy Billie S Fyfe-Kirschner Christina l Cheng Issam F Moubarak John l Nosher Department of Internal Medicine Jersey Shore University Medical Center Department of Radiology Rutgers Robert Wood Johnson Medical School Department of Pathology Robert Wood Johnson University Hospital Department of Surgery Robert Wood Johnson University Hospital

The association between continuous-flow left ventricular assist devices(CF-lVADs)and gastrointestinal(GI)bleeding from angiodysplasia is well ***,the association between continuous-flow biventricular assist devices(CF-BIVADs)and bleeding angiodysplasia is less *** report a case of GI bleeding from a patient with a *** location of GI bleeding was identified by nuclear red blood cell bleeding *** vascular malformation leading to the bleed was identified and localized on angiography and then by *** intensity of bleeding,reflected by number of units of packed red blood cells needed for normalization of hemoglobin,as well as the time to onset of bleeding after transplantation,are similar to that seen in the literature for CF-lVADs and pulsatile *** angiography only detected a dilated late draining vein,pathology demonstrated the presence of both arterial and venous dilation in the submucosa,vascular abnormalities characteristic of a late arteriovenous malformation.

关键词： Continuous-flow ventricular assist devices Angiodysplasia Gastrointestinal bleeding Angiography Heart failure

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Effects of Fe(Ⅱ) on anammox community activity and physiologic response

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Frontiers of Environmental Science & Engineering 2021年第1期15卷 88-98页

作者： Jing Ding Wanyi Seow Jizhong Zhou raymond Jianxiong Zeng Jun Gu Yan Zhou Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research Institute Nanyang Technological University Institute for Environmental Genomics and Department of Microbiology and Plant University of Oklahoma Earth and Environmental Sciences Lawrence Berkeley National Laboratory School of Environment Tsinghua University Centre of Wastewater Resource Recovery College of Resources and Environment Fujian Agriculture and Forestry University School of Civil and Environmental Engineering Nanyang Technological University

Though there are many literatures studying the effects of iron on anammox process, these studies only focus on the reactor performance and/or the microbial community changes, the detailed effects and mechanisms of Fe(Ⅱ) on anammox bacterial activity and physiology have not been explored. In this study, four Fe(Ⅱ) concentrations(0.03, 0.09, 0.12 and 0.75 mmol/l) were employed into the enriched anammox culture. The enhancement and inhibition effects of Fe(Ⅱ) on anammox process and bacterial physiology were investigated. It was discovered that the anammox process and bacterial growth were enhanced by 0.09 and 0.12 mmol/l Fe(Ⅱ), in which the 0.12 mmol/l Fe(Ⅱ) had advantage in stimulating the total anammox activity and bacterial abundance, while 0.09 mmol/l Fe(Ⅱ) enhanced the relative anammox activity better. The anammox activity could be inhibited by 0.75mmol/l Fe(Ⅱ) immediately, while the inhibition was recoverable. Both 0.09 and 0.12 mmol/l Fe(Ⅱ)induced more genes being expressed, while didn't show a stimulation on the relative expression level of functional genes. And anammox bacteria showed a stress response to detoxify the Fe inhibition once inhibited by 0.75 mmol/l Fe(Ⅱ). This study provides more information about physiologic response of anammox bacteria to external influence(enhancement and inhibition), and may also instruct the future application of anammox process in treating various sources of wastewater(containing external disturbances such as heavy metals) and/or different treatment strategies(*** side-stream to main-stream).

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Effect of the sintering technique on the ferroelectric and d33 piezoelectric coefficients of Bi0.5(Na0.84K0.16)0.5TiO3 ceramic

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Journal of Advanced Ceramics 2019年第2期8卷 278-288页

作者： G.HERNANDEZ-CUEVAS J.R.lEYVA MENDOZA P.E.GARCíA-CASIllAS C.A.RODRíGUEZ GONZálEZ J.F.HERNANDEZ-PAZ G.HERRERA-PéREZ l.FUENTES-COBAS S.DíAZ DE lA TORRE O.raymond-HERRERA H.CAMACHO-MONTES Instituto de Ingeniería y Tecnología Universidad Autónoma de Ciudad JuárezAv.Del Charro 450 Norte Cd.JuárezChihuahua32310México Centro de Investigación en Materiales Avanzados Miguel de Cervantes 120Chihuahua 31109ChihuahuaMéxico Centro de Investigación e Innovación Tecnológica Instituto Politécnico NacionalCerrada de Cecati s/nAzcapotzalcoSanta Catarina02250Ciudad de MéxicoMéxico Centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de MéxicoKm.107 Carretera Tijuana-EnsenadaAP.14Ensenada 22860Baja CaliforniaMéxico

In the search of lead-free piezoelectric materials,ceramic processing techniques offer potential tools to increase the piezoelectric and ferroelectric properties in addition to new chemical *** of pure BNKT16(Bi0.5(Na0.84K0.16)0.5TiO3)phase were synthesized by sol–gel method with a low crystallization temperature(750℃).Ceramic samples were sintered by pressureless sintering(PlS),sinter-forging(SF),and spark plasma sintering(SPS)***,morphological,and chemical characterizations were performed by XRD,Raman,EDS,and *** samples by PlS and SF exhibit rod-like grains associated to bismuth *** highest remanent polarization(11.05μC/cm2),coercive field(26.2 kV/mm),and piezoelectric coefficient(165 pC/N)were obtained for SF *** piezoresponse force microscopy(PFM)analysis shows that the crystallites at the nanoscale exhibit piezoelectric phenomenon and the highest piezoelectric response is reported for PlS *** presence of the rhombohedral phase,the increase in grain and crystallite size,and the oriented rod-like inclusions favoring the crystallographic texture are facts that enhance the piezoelectric coefficient for BNKT16 piezoceramics.

关键词： lead-free piezoelectrics sol–gel pressureless sintering (PlS) sinter-forging (SF) spark plasma sintering(SPS) piezoresponse

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封封情意结

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疯狂英语（阅读版） 2010年第5期 46-48页

作者： raymond l. Aaron Tulip

我女儿朱莉安出生后不久，我就开始养成了一个爱意浓浓的习惯，后来跟别人聊起自己这一特别做法，我知道有人也开始这么做了。每年，在女儿生日那天，我会给她写封“年信”。

关键词：英语课外阅读译文翻译方法

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每年一封信

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英语自学 2004年第6期 13-14页

作者： raymond l.Aaron 李威

在我的女儿朱莉安出生之后不久,我就和周围许多人一样,继续我们的爱心传统。(我周围的很多人继我之后,也都像我开始了这个计划。)现在,我就把这个主意告诉你,希望我的故事能够温暖你的心灵,并鼓励你在你自己的家庭中也开始这个传统。

关键词：我的女儿一封信我的故事 tradition daughter write letter note

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CD30阳性窦状大B细胞淋巴瘤：形态学上酷似退行发育的大细胞淋巴瘤

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世界医学杂志 2001年第12期5卷 23-27页

作者： raymond lai l Jeffrey Medeiros 等

最近，人们认为退行发良的大细胞淋巴瘤（anaplastic large cell lymphoma,AlCl)是一种独特的临床病理学实体，是T／裸细胞谱系中CD30阳性的弥漫性大细胞淋巴瘤的一种亚型，AlCl的某些特点，例如CD30抗原的表达以及淋巴窦中多形态大淋... 详细信息

最近，人们认为退行发良的大细胞淋巴瘤（anaplastic large cell lymphoma,AlCl)是一种独特的临床病理学实体，是T／裸细胞谱系中CD30阳性的弥漫性大细胞淋巴瘤的一种亚型，AlCl的某些特点，例如CD30抗原的表达以及淋巴窦中多形态大淋巴细胞的浸润，也可偶见于弥漫性大B细胞淋巴瘤，我们收集了11个这种病例，并对它们的临床，形态和免疫表型的特点进行了检查，病人的年龄范围为36－82岁（平均63．2岁），男性与女性之比为1比1．2，所有肿瘤均为窦状浸润型淋巴结肿瘤，但其中4例同时还有融合生长的病灶，8例肿瘤主要由多形态的大细胞构成，偶尔带有Reed0Sternberg样细胞；在其余3例肿瘤中，单形态大淋巴细胞所占的比例比较高，另一常见的特点为坏死和混杂有粒性白细胞，在免疫表型上，所有病例均为CD30和CD20或CD79a阳性，8例作了退行发育淋巴瘤激酶1免疫反应性检测，结果均为阴性，8例进行了Epstein-Barr病毒RNA原位杂交，其中2例呈阳性，除了1例由于是会诊病例而没有临床跟踪资料外，6名病人在3年之内死于该病，1名病人在1年内复发，我们的结论是，在弥漫性大B细胞淋巴瘤中有一个不常见的变种，它可能酷似AlCl，不过，这些肿瘤由于属B细胞谱系，并且不表达退行发育淋巴瘤激酶1而与AlCl不同，在这一小亚型中可见Epstein-Barr病毒感染。

关键词：大细胞淋巴瘤 AlCl 窦状大B细胞淋巴瘤免疫组织化学 CD30阳性形态细胞病例

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