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a.proton-ca.a.yzing prodrug for PDT a.d glycolysis inhibition-synergistic thera.y of tumor in spa.iotempora. dimensions

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Science China.Chemistry 2024年第9期67卷 3162-3178页

作者： Mia. Li Xueying Sun Xiuqin ma Ya.g Ta. Xia.yi Jin Yi Wa.g Fa. Ya.g Qia. Li Honglei Zha. Xia.jun Peng School of Biologica. Engineering Dalian Polytechnic UniversityDalian 116034China Sta.e Key La.ora.ory of Fine Chemica.s Dalian University of TechnologyDalian 116024China

The rea.tive oxygen species(ROS)genera.ion from photosensitizer in photodyna.ic thera.y(PDT)is limited by tumor *** type-i photosensitizers,e.g.,sulfur-substituted Nile blue,still rely on oxygen a. the main center for tra.sferring electrons to genera.e *** off the pa.hwa. of oxygen consumption in tumor ca. help photosensitizers overcome the limita.ion of low oxygen,in order to efficiently genera.e more *** is known tha. glycolysis inhibitor 3-bromopyruvic a.id(3-BP),which could specia.ly ta.get mitochondria.ca. provide more oxygen by inhibiting oxida.ive ***,we successfully designed a.d synthesized a.new 3-BP-coupled sulfur-substituted Nile blue a. prodrug(NBBP)for chemica./photodyna.ic synergistic *** results indica.ed tha. the protons in tumor ca.a.yzed the hydrolysis of NBBP,inhibited photoinduced electron tra.sfer between 3-BP a.d the photosensitizer in NBBP a.d further a.sisted the photosensitizer to be loca.ized in mitochondria.utilizing loca. oxygen a. much a. possible a.d kill tumor cells more ***,the glycolysis inhibition-induced a.topha.y wa. combined with PDT-induced a.topha.y,which could promote the dea.hs of tumor *** other remedies exploiting na.omateria.s,this construction method of NBBP a.hieves the efficient synergy of photodyna.ic thera.y a.d glycolysis inhibition,stronger tha. their theoretica. a.dition,in spa.iotempora. *** study provides not only a.highly efficient pla.form for tumor thera.y but a.so a.design a.proa.h for prodrugs with synergistic effects.

关键词： photodyna.ic thera.y prodrug glycolysis inhibition a.topha.y tumor synergistic thera.y

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Electron deloca.iza.ion-enha.ced sulfur reduction kinetics on a. MXene-derived heterostructured electroca.a.yst

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Na.o Resea.ch 2024年第8期17卷 7153-7162页

作者： Yunmeng Li Yinze Zuo Xia.g Li Yongzheng Zha.g Cheng ma Xia.min Cheng Jia. Wa.g Jitong Wa.g Hongzhen Lin Licheng Ling Sta.e Key La.ora.ory of Chemica. Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China institute of New Energy materia.s a.d Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key La.ora.ory of Specia.ly Functiona. Polymeric materia.s a.d Rela.ed Technology(Ministry of Educa.ion) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-La.&Ca. Key La.ora.ory of Na.ophotonic materia.s a.d Device Suzhou institute of Na.o-Tech a.d Na.o-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz institute Ulm(HiU) D89081 UlmGermany

Lithium-sulfur(Li-S)ba.teries mainly rely on the reversible electrochemica. rea.tion of between lithium ions(Li^(+))a.d sulfur species to a.hieve energy stora.e a.d conversion,therefore,increa.ing the number of free Li^(+)a.d improving the Li^(+)diffusion kinetics will effectively enha.ce the cell ***,Mo-ba.ed MXene heterostructure(MoS_(2)@Mo_(2)C)wa. developed by pa.tia. vulca.iza.ion of Mo_(2)C MXene,in which the introduction of simila. va.ence S into Mo-ba.ed MXene(Mo_(2)C)ca. crea.e a. electron deloca.iza.ion *** theoretica. simula.ions a.d electrochemica. cha.a.terisa.ion,it is demonstra.ed tha. the MoS_(2)@Mo_(2)C heterojunction ca. effectively promote ion desolva.ion,increa.e the a.ount of free Li^(+),a.d a.celera.e Li^(+)tra.sport for more efficient polysulfide *** a.dition,the MoS_(2)@Mo_(2)C materia. is a.so ca.a.le of a.celera.ing the oxida.ion a.d reduction of polysulfides through its sufficient defects a.d va.a.cies to further enha.ce the ca.a.ytic ***,the Li-S ba.tery with the designed MoS_(2)@Mo_(2)C electroca.a.yst performed for 500 cycles a. 1 C a.d still mainta.ned the idea. ca.a.ity(664.7 mah·g^(−1)),a.d excellent ra.e performance(567.6 mah·g^(−1)a. 5 C).Under the extreme conditions of high loa.ing,the cell mainta.ned a. excellent ca.a.ity of 775.6 mah·g^(−1)a.ter 100 *** a.so reta.ned 838.4 mah·g^(−1)for 70 cycles a. a.low tempera.ure of 0℃,a.d demonstra.ed a.low deca. ra.e(0.063%).These results indica.e tha. the deloca.ized electrons effectively a.celera.e the ca.a.ytic conversion of lithium polysulfide,which is more pra.tica. for enha.cing the beha.iour of Li-S ba.teries.

关键词： deloca.ized electron lithium sulfur ba.teries MXene-ba.ed heterostructures ca.a.ytic desolva.ion multi-ca.a.ytic sites

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Simulta.eous determina.ion of typica. toxic a.dehydes formed during food frying a.d digestion using isotope dilution UHPLC-QqQ-MS/MS

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Gra.n & Oil Science a.d Technology 2024年第1期7卷 42-49页

作者： Feng Wa.g Yun Cui Dongjie Liu Cha.les Brenna. Sootta.a. Benja.ul Weiwei Cheng Gengsheng Xia. Luka. ma Key La.ora.ory of Green Processing a.d intelligent manufa.turing of Lingna. Specia.ty Food of Ministry a.d Rura. a.fa.rs College of Light Industry and FoodZhongkai University of Agriculture and EngineeringGuangzhou 510225China School of Science Royal Melbourne Institute of Technology UniversityMelbourneAustralia interna.iona. Center of Excellence in Sea.ood Science a.d innova.ion Faculty of Agro-IndustryPrince of Songkla UniversitySongkhla 90110Thailand College of Food Science a.d Technology Zhejiang University of TechnologyHangzhou 310014China

a. isotope dilution ultra.performance liquid chromatogra.hy-triple qua.rupole mass spectrometry method wa. developed to simulta.eously detect two typica. kinds ofα,β-unsa.ura.ed a.dehydes,na.ely 4-hydroxy-2-hexena.(4-HHE)a.d 4-hydroxy-2-nonena.(4-HNE),in *** proposed method exhibited a.linea. ra.ge of 10-1000 ng/mL with a.limit of detection of 0.1-2.0 ng/g a.d a.limit of qua.tifica.ion of 0.3-5.0 ng/*** recovery ra.es of these typica. toxic a.dehydes(i.e.,4-HHE,4-HNE)a.d their d3-la.eled a.a.ogues were 91.54%-105.12%with a.low matrix ***,this proposed method wa. successfully a.plied to a.rea. frying system a.d a.simula.ed digestion system,wherein the contents of 4-HHE a.d 4-HNE were determined for ***,the obta.ned results provide strong support for further resea.ch into the production of 4-HHE a.d 4-HNE resulting from foods during oil digestion a.d frying.

关键词： UHPLC-QqQ-MS/MS 4-Hydroxy-2-hexena. 4-Hydroxy-2-nonena. Frying Simula.ed digestion

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interfa.ia. a.sembly of 2D polydopa.ine/gra.hene heterostructures with well-defined mesopore a.d tuna.le thickness for high-energy pla.a. micro-superca.a.itors

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Chinese Chemica. Letters 2024年第7期35卷 439-444页

作者： Jieqiong Qin Zhi Ya.g Jia.in ma Lia.gzhu Zha.g Feifei Xing Hongta. Zha.g Shuxia.Tia. Shua.gha. Zheng Zhong-Shua. Wu College of Science Henan Agricultural UniversityZhengzhou 450002China Sta.e Key La.ora.ory of Ca.a.ysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese a.a.emy of Sciences Beijing 100049China Mecha.ica. a.d Electrica. Engineering institute Zhengzhou University of Light IndustryZhengzhou 450002China

Two-dimensiona.(2D)mesoporous pseudoca.a.itive polymer/gra.hene heterostructures combine the a.va.ced merits of 2D materia.s a.d mesoporous materia.s,possessing unique na.osheet structure,la.ge specific surfa.e a.ea.SSa.,a.unda.t oxygen/nitrogen-conta.ning groups,desira.le electrica. conductivity a.d a.mira.le electrochemica. redox a.tivity,a.d hold grea. potentia. for constructing high-performance pla.a. micro-superca.a.itors(MSCs).Herein,we demonstra.e the interfa.ia. a.sembly of 2D mesoporous polydopa.ine/gra.hene(mPDG)heterostructures with well-defined mesopore structure(12 nm)a.d a.justa.le thickness(7.5–14.1 nm)for pla.a. high-energy pseudoca.a.itive *** to medium thickness,exposed mesopore of 12 nm a.d la.ge SSa.of 108 m^(2)/g,the m PDG with 10.8 nm thickness revea.s prominent mass ca.a.ita.ce of 419 F/g a.d impressive cycling sta.ility with~96%ca.a.ita.ce retention a.ter 5000 ***,the symmetric mPDG-ba.ed MSCs with“wa.er-in-sa.t”gel electrolyte present wide volta.e window of 1.6 V,superior volumetric energy density of 11.5 mWh/cm^(3),outsta.ding flexibility a.d self-integra.ion ***,this work offers a.new pla.form of controlla.ly synthesizing 2D mesoporous heterostructures for high-performance MSCs.

关键词： 2D materia.s Mesopores Heterostructures Polydopa.ine High energy density Micro-superca.a.itors

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a.single degenera.ed primer significa.tly improves COX1 ba.coding performance in soil nematode community profiling

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Soil Ecology Letters 2024年第2期6卷 31-44页

作者： Yinca. Ren Dorota.L. Pora.inska.Qua.hui ma Shuha. Liu Hongmei Li Xue Qing Depa.tment of Pla.t Pa.hology Nanjing Agricultural UniversityNanjing210095China Depa.tment of Entomology a.d Nematology University of FloridaGainesvilleFL32611USA institute of Gra.sla.d Science Key Laboratory of Vegetation Ecology of the Ministry of EducationJilin Songnen Grassland Ecosystem National Observation and Research StationNortheast Normal UniversityChangchun130024China

a.new COX1 primer for soil nematode meta.a.coding wa. designed,a.d this primer outperforms other commonly used COX1 primer pa.rs in species recovery a.d qua.tity of PCR products.•The la.k of reference da.a.a.e is the main rea.on tha. led to the low species recovery in COX1 meta.a.coding.•We expa.ded current NCBi da.a.a.e by a.ding 51 newly genera.ed COX1 reference *** nematodes pla. importa.t roles in soil ecosystems a.d often serve a. bioindica.ors of soil *** identifica.ion of soil nematodes is often difficult due to their limited dia.nostic cha.a.ters a.d high phenotypic *** ba.coding a.d meta.a.coding techniques a.e promising but la.k universa. primers,especia.ly for mitochondria. COX1 *** this study a.degenera.ed COX1 forwa.d primer COiFGED wa. *** primer pa.r(COiFGED/JB5GED)outperforms other four commonly used COX1 primer pa.rs in species recovery a.d qua.tity of polymera.e cha.n rea.tion(PCR)*** meta.a.coding a.a.ysis,the rea.s obta.ned from the new primer pa.r ha. the highest sequencing sa.ura.ion threshold a.d a.plicon sequence va.ia.t(a.V)diversity in compa.ison to other COX1 a. well a. 18S rRNa.*** a.nota.ion of a.Vs suggested the new primer pa.r initia.ly recovered 9 a.d 6 out of 25 genera.from mock communities,respectively,outperformed other COX1 primers,but underperformed the widely used 18S NF1/18Sr2b primers(16 out of 25 genera..By supplementing the COX1 da.a.a.e with our reference sequences,we recovered a. a.ditiona. 6 mock community species bringing the ta.ly closer to tha. obta.ned with 18S *** summary,our newly designed COX1 primers significa.tly improved species recovery a.d thus ca. be supplementa.y or a.terna.ive to the conventiona. 18S meta.a.coding.

关键词： degenera.ed primers DNa.meta.a.coding mitochondria. cytochrome oxida.e c subunit i gene phylogeny ribosomal RNa.gene soil nematodes

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Diversifica.ion of interfa.es triggered hydrogen stora.e properties enha.cement

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Ra.e Meta.s 2024年第5期43卷 2324-2330页

作者： Jia.Xin Zha.g Xin Ding Rui-Run Chen Xia.g-Feng ma Wen-Cha. Ca. Yong Zha.g Jing-Jie Guo Na.iona. Key La.ora.ory for Precision Hot Processing of Meta.s Harbin Institute of TechnologyHarbin 150001China

Dua. effects of gra.n refinement a.d a.loying a.e a.hieved a.d the mecha.ism of"diverse interfa.es reinforcement"for hydrogen stora.e Mg a.loys is first *** interfa.e reinforced Mg-Y-Zn-a. a.loy for hydrogen stora.e is *** work figures out tha. the a.venturous a.-rich pha.e exhibits a. ordered fa.e-centered cubic(FCC)structure with composition of(31±2)a.%Y-(28±1)a.%Zn-(41±3)a.%a.,i.e.,Y_(3)Zn_(3)a._(4),a.d a. incoherent interfa.e between Y3Zn3a.4pha.e a.d Mg substra.e is observed.

关键词： hydrogen a.loying a.loy

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a.bizzia.chinensis(Osbeck)Merr extra.t YS a.eliora.es etha.ol-induced a.ute ga.tric ulcer injury in ra.s by regula.ing NRF2 signa.ing pa.hwa.

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a.imal Models a.d Experimenta. Medicine 2024年第3期7卷 275-282页

作者： Bo Ta.g Lia.gning Li Yua.zhi Yu Guibin Wa.g Shua.gga.g ma Shisha. Yu Jia.jun Zha.g institute of materia.Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Sta.e Key La.ora.ory of Digestive Hea.th BeijingChina Sta.e Key La.ora.ory of Bioa.tive Substa.ce a.d Function of Na.ura. Medicines BeijingChina

Ba.kground:a.ound the world,there is a.high incidence of ga.tric ***,a. extra.t from the Chinese herb a.bizzia.chinensis(Osbeck)Merr,ha. potentia. thera.eutic a.plica.ions for ga.trointestina. *** we elucida.ed the protective effect a.d underlying mecha.ism of a.tion of YS on ga.tric ulcer in ra.s injured by ***:The etha.ol-i nduced ga.tric ulcer ra. model wa. used to a.sess the protective effect of YS.a.pa.hologica. exa.ina.ion of ga.tric tissue wa. performed by H&E ***-1 cells da.0}ged by hydrogen peroxide were used to simula.e oxida.ive da.0}ge in ga.tric mucosa. epithelia. *** NRF2 wa. knocked down using small interfering *** wa. used to detect ubiquitina.ion of ***-i mmunoprecipita.ion wa. used to detect the NRF2-Kea.1 ***:YS(10 a.d 30 mg/kg,i.g.)significa.tly reduced the ulcer index,decrea.ed MDa.level,a.d increa.ed SOD a.d GSH levels in ga.tric tissues da.0}ged by *** promoted NRF2 tra.sloca.ion from cytopla.m to nucleus a.d enha.ced the NQO1 a.d HO-1 expression levels in injured ra. ga.tric *** a.dition,YS regula.ed NQO1 a.d HO-1 via.NRF2 in H_(2)O_(2)-i nduced oxida.ive injured GES-1 *** studies on the underlying mecha.ism indica.ed tha. YS reduced the intera.tion between NRF2 a.d Kea.1 a.d decrea.ed ubiquityla.ion of NRF2,thereby increa.ing its sta.ility a.d expression of downstrea. ***2 knockdown a.olished the effect of YS on MDa.a.d SOD in GES-1 cells trea.ed with H_(2)O_(2).Conclusion:YS reduced the NRF2-Kea.1 intera.tion,promoting NRF2 tra.sloca.ion into the nucleus,which increa.ing the tra.scription a.d tra.sla.ion of NQO1 a.d HO-1 a.d improved the a.tioxida.t ca.a.ity of ra. stomach.

关键词： a.tioxida.ive etha.ol ga.tric ulcer NRF2 YS

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Un a.unto ca.dente en Dubâi

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今日中国（西文版） 2024年第1期 46-49页

作者： ma Mla.Mla.

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a. unexpected stereochemica. effect of thio-substituted a.p in na.ive chemica. liga.ion

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Chinese Chemica. Letters 2024年第8期35卷 278-281页

作者： Min Fu Pa. He Sen Zhou Wenqia.g Liu Bo ma Shiying Sha.g Ya.ha. Li Ruiha. Wa.g Zhongping Ta. Sta.e Key La.ora.ory of Bioa.tive Substa.ce a.d Function of Na.ura. Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pha.maceutica. Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemica. Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents a. unexpected finding tha. the cis isomer of β-thio-a.p exhibits higher liga.ion a.-tivity tha. the tra.s *** discovery sheds light on the intrica.e na.ure of na.ive chemica. liga.ion a.d highligh... 详细信息

关键词： Na.ive chemica. liga.ion Stereochemistry Liga.ion a.tivity β-Thio-a.p intra.olecula. hydrogen bond

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2.4 V ultra.igh-volta.e a.ueous MXene-ba.ed a.ymmetric micro-superca.a.itors with high volumetric energy density towa.d a.self-sufficient integra.ed microsystem

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Funda.enta. Resea.ch 2024年第2期4卷 307-314页

作者： Yua.yua. Zhu Shua.gha. Zheng Jieqiong Qin Jia.in ma Pra.teek Da. Feng Zhou Zhong-Shua. Wu Sta.e Key La.ora.ory of Ca.a.ysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese a.a.emy of Sciences Shijingshan DistrictBeijing 100049China College of Science Henan Agricultural UniversityZhengzhou 450002China Da.ia. Na.iona. La.ora.ory for Clea. Energy Chinese Academy of SciencesDalian 116023China Key La.ora.ory of Spin Electron a.d Na.omateria.s of a.hui Higher Educa.ion institutes Suzhou UniversitySuzhou 234000China

Two-dimensiona. MXenes a.e key high-ca.a.ita.ce electrode materia.s for micro-superca.a.itors(MSCs)ca.ering to integra.ed ***,the na.row electrochemica. volta.e windows of conventiona. a.ueous electrolytes(≤1.23 V)a.d symmetric MXene MSCs(typica.ly≤0.6 V)substa.tia.ly limit their output volta.e a.d energy *** concentra.ed a.ueous electrolytes exhibit lower wa.er molecule a.tivity,which inhibits wa.er splitting a.d consequently widens the opera.ing volta.e ***,we report ultra.igh-volta.e a.ueous pla.a. a.ymmetric MSCs(a.SCs)ba.ed on a.highly concentra.ed LiCl-gel qua.i-solid-sta.e electrolyte with MXene(Ti3C2Tx)a. the nega.ive electrode a.d MnO_(2) na.osheets a. the positive electrode(MXene//MnO_(2)-a.SCs).The MXene//MnO_(2)-a.SCs exhibit a.high volta.e of up to 2.4 V,a.ta.ning a. ultra.igh volumetric energy density of 53 mWh cm−***,the in-pla.e geometry a.d the qua.i-solid-sta.e electrolyte ena.led excellent mecha.ica. flexibility a.d performance uniformity in the seria.ly/pa.a.lel connected pa.ks of our ***,the MXene//MnO_(2)-a.SC-ba.ed integra.ed microsystem,in conjunction with sola. cells a.d consumer electronics,could efficiently rea.ize simulta.eous energy ha.vesting,stora.e,a.d *** findings of this study provide insights for constructing high-volta.e a.ueous MXene-ba.ed a.SCs a. sa.e a.d self-sufficient micropower sources in smart integra.ed microsystems.

关键词： a.ymmetric micro-superca.a.itors MXene MnO_(2) a.ueous electrolyte High volta.e integra.ed microsystem

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