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Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons

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Neuroscience Bulletin 2014年第5期30卷 866-876页

作者： Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong raya Abou Dargham Longzhen Cheng Yun Wang Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Neurology Department Zhongshan HospitalFudan University

Extrasynaptic GABAA receptors （GABAARs）-mediated tonic inhibition is reported to involve in the patho- genesis of epilepsy. In this study, we used cyclo- thiazide （CTZ）-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABAARS by 4,5,6,7-tetra- hydroisoxazolo[5,4-c] pyridine-3-ol （THIP） on the CTZ-induced epileptiform activity in hippocampal neurons. Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes （PSs）in CA1 pyramidal neurons, and treatment with THIP （5 μmol/L） significantly reduced the multiple PS peaks induced by CTZ stimulation. Western blot showed that the 6-subunit of the GABAAR, an extrasynaptic specific GABAAR subunit, was also significantly down-regulated in the cell membrane 2 h after CTZ treatment. Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1 neurons is suppressed by the activation of extrasynaptic GABAARs, and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABAARs plays a prominent role in seizure generation.

关键词： GABAARS tonic inhibition epilepsy population spike cyclothiazide hippocampal CA1 neurons

Role of compositional changes on thermal,magnetic,and mechanical properties of Fe-P-C-based amorphous alloys

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Chinese Physics B 2022年第1期31卷 472-479页

作者： Indah raya Supat Chupradit Mustafa M Kadhim Mustafa Z mahmoud Abduladheem Turki Jalil Aravindhan Surendar Sukaina Tuama Ghafel Yasser Fakri Mustafa Alexander N Bochvar Chemistry Department Faculty of Mathematics and Natural ScienceHasanuddin UniversityMakassarSouth Sulawesi90245Indonesia Department of Occupational Therapy Faculty of Associated Medical SciencesChiang Mai UniversityChiang Mai50200Thailand Department of Dentistry Kut University CollegeKutWasit52001Iraq College of Technical Engineering The Islamic UniversityNajafIraq Department of Pharmacy Osol Aldeen University CollegeBaghdadIraq Department of Radiology and Medical Imaging College of Applied Medical SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj 11942Saudi Arabia Faculty of Health University of CanberraCanberraACTAustralia Faculty of Biology and Ecology Yanka Kupala State University of Grodno230023 GrodnoBelarus Department of Pharmacology Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesChennaiIndia Scientific Research Center Al-Ayen UniversityThi-Qar64001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of MosulMosulIraq Department of materials Physics Eotvos Lorand UniversityPázmány Péter sétány 1/ABudapest1117Hungary

This work aimed to tune the comprehensive properties of Fe-P-C-based amorphous system through investigating the role of microalloying process on the crystallization behavior,glass forming ability(GFA),soft magnetic features,and mechanical *** minor addition of elements into the system,it was found that the simultaneous microalloying of Ni and Co leads to the highest GFA,which was due to the optimization of compositional heterogeneity and creation of near-eutectic ***,the FeCoNiCuPC amorphous alloy exhibited the best anelastic/viscoplastic behavior under the nanoindentation test,which was owing to the intensified structural fluctuations in the ***,the improved plasticity by the extra Cu addition comes at the expense of magnetic properties,so that the saturation magnetization of this alloying system is significantly decreased compared to the FeCoPC amorphous alloy with the highest soft magnetic *** total,the results indicated that a combination of added elemental constitutes,i.e.,Fe69Co5Ni5Cu1P13C7 composition,provides an optimized state for the comprehensive properties in the alloying system.

关键词： Fe-based alloy saturation magnetization glass forming ability viscoplastic

Translocation of pharmaceuticals and personal care products(PPCPs)into plant tissues:A review

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Emerging Contaminants 2017年第4期3卷 132-137页

作者： raya Salim Al-Farsi Mushtaque Ahmed Ahmed Al-Busaidi B.S.Choudri College of Agricultural and marine Sciences Sultan Qaboos UniversityOman Center for Environmental Studies and Research Sultan Qaboos UniversityOman

Occurrence and fate of pharmaceuticals and personal care products(PPCPs)in the environment and the potential consequences for human health is of serious *** the current review,we have tried to provide a summary on recent research and an overview of PPCPs in the soil-plant systems,in the environment and analytical methods used for determination of PPCPs in plant *** review also include highlights on the fate of PPCPs in agricultural soils receiving treated wastewater irrigation or biosolids amendment,and plant uptake of PPCPs under laboratory and field *** have shown to be released to the environment and may cause significant impacts on different environmental *** roots showed their abilities to uptake and transfer of PPCPs into plant *** uptake of PPCPs varies depending on crop type and physiochemical properties of the chemical compound that were *** of contaminated crops with PPCPs residues may cause serious health *** chromatography in combination with mass chromatography was found to be the most popular analytical instrument used for PPCPs determination in different ***,the information gaps and few suggestions for future research have been proposed in this review.

关键词： PPCPs Root uptake Translocation Human exposure Analytical methods

Revealing pion and kaon structure via generalised parton distributions

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Chinese Physics C 2022年第1期46卷 80-101页

作者： K.raya Z-F.Cui L.Chang J.M.Morgado C.D.Roberts J.Rodríguez-Quintero School of Physics Nankai UniversityTianjin 300071China Departamento de Física Teórica y del Cosmos Universidad de GranadaE-18071GranadaSpain Instituto de Ciencias Nucleares Universidad Nacional Autónoma de MéxicoApartado Postal 70-543CDMX 04510México School of Physics Nanjing UniversityNanjingJiangsu 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjingJiangsu 210093China Department of Integrated Sciences and Center for Advanced Studies in Physics Mathematics and ComputationUniversity of HuelvaE-21071 HuelvaSpain

Clear windows onto emergent hadron mass(EHM)and modulations thereof by Higgs boson interactions are provided by observable measures of pion and kaon structure,many of which are accessible via generalised parton distributions(GPDs).Beginning with algebraic GPD Ansätze,constrained entirely by hadron-scaleπand K valence-parton distribution functions(DFs),in whose forms both EHM and Higgs boson influences are manifest,numerous illustrations are *** include the properties of electromagnetic form factors,impact parameter space GPDs,gravitational form factors and associated pressure profiles,and the character and consequences of allorders *** analyses predict that mass-squared gravitational form factors are stiffer than electromagnetic form factors;reveal that K pressure profiles are tighter than profiles,with both mesons sustaining near-core pressures at magnitudes similar to that expected at the core of neutron stars;deliver parameter-free predictions for and K valence,glue,and sea GPDs at the resolving scale l=2GeV;and predict that at this scale the fraction of meson mass-squared carried by glue and sea combined matches that lodged with the valence degrees-of-freedom,with a similar statement holding for mass-squared radii.

关键词： continuum Schwinger function methods emergence of hadron mass Nambu-Goldstone modes-pions and kaons nonperturbative quantum field theory parton distributions strong interactions

Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

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Neural Regeneration Research 2017年第4期12卷 588-595页

作者： Teresa Neri-Gomez Judith Espinosa-raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan manuel Gallardo Christian Guerra-Araiza Unidad de Investigación Médica en Farmacología Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Laboratorio de Farmacología Conductual Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Sto. Tomás Ciudad de México México Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Querétaro México Enfermedades Neurológicas (Neurological Diseases) Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Enfermedades Nefrológicas (Kidney Diseases) Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de Mexico Mexico

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles （NFTs）; these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone （TIB） have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB （0.01 mg/kg and 1mg/kg, intragastrically for 12 weeks） on the content of total and hyperphosphorylated Tau （PHF-1） proteins and the regulation of GSK3β/Akt/PI3K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB： it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes.

关键词： nerve regeneration Tibolone hippocampus aged mice sex steroids Akt GSK3β PI3K neuralplasticity Tau neurofibrillary tangles neural regeneration

时尚摄影之花——访巴黎新锐青年女摄影师raya

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数码 2006年第3期 209-211页

作者：蒋永华 raya（图）

关于raya和摄影raya是个美丽的、比较随性的女孩，年轻时的她不知道什么才是自己真正想去做的事，只是想做和艺术相关的工作。20多岁时她来到时尚之都巴黎，随便找了个工作，只为了挣钱交房租和买衣服。

关键词：摄影师巴黎青年艺术

Analysis of Growth and Productivity of Green Chickpea Using Nitrogen and Phosphorus Fertilization

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1193-1203页

作者： maricela Apáez-Barrios JoséAlberto Salvador Escalante-Estrada Patricio Apáez-Barrios Yurixhi Atenea raya-Montaño Juan CarlosÁlvarez-Hernández Facultad de Ciencias Agropecuarias-Universidad Michoacana de San Nicolás de Hidalgo Apatzingán60670México Colegio de Postgraduados-Campus Montecillo Texcoco56230México Facultad de Agrobiología“Presidente Juárez” Universidad Michoacana de San Nicolás de HidalgoUruapan60190México

Chickpea contains high levels of protein,vitamins and *** chickpea yield is the result of meeting nitrogen and phosphorus *** effect of appropriately meeting such requirements reflects on growth and can easily be evaluated using growth *** research determined:(a)The effect of nitrogen and phosphorus fertilization on phenology,net assimilation rate,number of green leaves,leaf area,leaf area index and leaf area duration;(b)Green chickpea yield and number of pods due to fertilization;and(c)The combination of nitrogen and phosphorus fertilization that yields the most net *** and phosphorus fertilization was evaluated;each at the doses of 0,75 and 150 kg ha–1(N0,N75,N150;P0,P75 and P150,respectively).The combination of the levels of both nutrients generated nine combinations of treatments which were distributed in the field in a randomized complete block design in an arrangement of divided plots with four *** of phenological phases were similar among *** and phosphorus fertilization increased number of leaves,leaf area index,and leaf area duration that translated into increased green chickpea yield(GCY).Combinations N150-P75 and N150-P150 produced the highest *** highest net revenue and revenue per peso invested was obtained with N150-P75.

关键词： Cicer arietinum economic analysis leaf area number of leaves yield

Mechanical and histological properties of an electrospun scaffold with a modified surface by plasma polymerization implanted in an in vivo model

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BIOCELL 2022年第3期46卷 829-836页

作者： maRÍA G.FLORES-SÁNCHEZ ROBERTO OLAYO J.MORALES-CORONA ATLÁNTIDA M.raya-RIVERA DIEGO R.ESQUILIANO-RENDÓN Research Vice-Rectory Faculty of EngineeringUniversity La Salle México06140México Department of Physics Metropolitan Autonomous University09340México Department of Tissue Engineering Child Hospital of México Federico Gómez06720México

This article presents the construction of scaffolds composed of polylactic acid(PLA)with different concentrations of hydroxyapatite(HA)by electrospinning,which were superficially modified with polypyrrole(PPy/I)by plasma polymerization.A preliminary study was conducted of the biological and mechanical behavior of the scaffolds when they were implanted in the back of rabbits for 30 days;bone cells differentiated from mesenchymal stem cells(MSCs)were *** bone cell and scaffold structures were characterized by histological,immunohistochemical,and mechanical stress ***–eosin staining showed good tissue *** immunohistochemical tests highlighted the presence of the main bone tissue proteins,such as collagen,osteocalcin,and *** PLA/HA scaffolds were observed to exhibit cell adhesion and proliferation properties;however,the response was much better in the scaffolds that had a higher concentration of HA and that were coated with PPy/*** results of the mechanical tests of the scaffolds indicated that the plasma treatment improved the adhesion and cell proliferation properties and contributed to the mechanical support,allowing the formation of neotissues with good viability of cell growth.

关键词： Hydroxyapatite Polylactic acid pyrrole Electrospinning Surface activation

CRISPR/Cas9 editing of the polygalacturonase FaPG1 gene improves strawberry fruit firmness

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Horticulture Research 2023年第3期10卷 201-210页

作者： Gloria López-Casado Cristina Sánchez-raya Pablo D.Ric-Varas Candelas Paniagua Rosario Blanco-Portales Juan Muñoz-Blanco Sara Pose Antonio J.matas Jose A.Mercado Departamento de Botánica y Fisiología Vegetal Instituto de Hortofruticultura Subtropical y Mediterránea‘La Mayora’(IHSM-UMA-CSIC)Universidad de Málaga29071 MálagaSpain Departamento de Bioquímica y Biología Molecular Universidad de Córdoba14071CórdobaSpain

Firmness is one of the most important fruit quality traits in *** postharvest shelf life of this soft fruit is highly limited by the loss of firmness,where cell wall disassembly plays an important *** studies demonstrated that the polygalacturonase FaPG1 has a key role in remodelling pectins during strawberry *** this study,FaPG1 knockout strawberry plants have been generated using the CRISPR/Cas9 system delivered via Agrobacterium *** independent lines,cv.“Chandler”,were obtained,and all of them were successfully edited as determined by PCR amplification and T7 endonuclease *** targeted mutagenesis insertion and deletion rates were analyzed using targeted deep *** percentage of edited sequences varied from 47%up to almost 100%,being higher than 95%for seven of the selected *** analyses showed that 7 out of the eight lines analyzed produced fruits significantly firmer than the control,ranging from 33 to 70%increase in *** was a positive relationship between the degree of FaPG1 editing and the rise in fruit *** changes were observed in other fruit quality traits,such as colour,soluble solids,titratable acidity or anthocyanin *** fruits showed a reduced softening rate during postharvest,displayed a reduced transpirational water loss,and were less damaged by Botrytis cinerea *** analysis of four potential off-target sites revealed no mutation *** conclusion,editing the FaPG1 gene using the CRISPR/Cas9 system is an efficient method for improving strawberry fruit firmness and shelf life.

关键词： fir straw PG1