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Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 73-76页

作者： Rozainanee Mohd Zain Nabila Ibrahim Suriani Ismail Jeyanthi Suppiah Nor Aziyah Mat Rahim ravindran thayan Virology Unit Institute for Medical ResearchInfectious Disease Research CentreJalan Pahang50588Kuala LumpurMalaysia

Objective: To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia,Methods: A total of 45 samples from four hospitals that provide HIV viral load services were subjected to the amplification of the protease and two third of reverse transcriptase regions of the pol gene by RT-PCR and Sanger sequencing,Drug resistance mutation(DRM) interpretation reports the presence of mutations related to protease inhibitors(PIs),Nucleoside reverse-transcriptase inhibitors(NRTI) and Non-nucleoside reverse-transcriptase inhibitors(NNRTI) based on analysis using Stanford HIV database program,Results: DRMs were identified in 35% of patients,among which 46.7% of them showed minor resistance to protease inhibitor with A71 V and L10 l were the commonest DRMs detected,About 21.4% and 50.0% of patients had mutations to NRTIs and NNRTIs,respectively,CRF01_AE was found to be the predominant HIV-1 subtype,Conclusions: These findings have served as an initial crucial data in determining the prevalence of transmitted HIV-1 drug resistance for the country,However,more samples from various parts of the country need to be accumulated and analyzed to provide overall HIV-1 drug resistance in the country.

关键词： HIV Resistance Malaysia Antiretroviral treatment naive

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Sharing experiences from a reference laboratory in the public health response for Ebola viral disease, MERS-CoV and H7N9 influenza virus investigations

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 199-200页

作者： T.S.Saraswathy Subramaniam ravindran thayan Mohd Apandi Yusof Jeyanthi Suppiah Tengku Rogayah Tg Abd Rashid Zarina Mohd Zawawi Nor Aziyah Mat Rahim Fauziah Kassim Rozainanee Mohd Zain Zainah Saat Virology Unit Institute for Medical Research

The International Health Regulations was enforced in June 2007,emphasizing the obligation of State Parties to detect,report,and respond to public health emergencies[1].An effective public health response requires a coordinated laboratory response in the Ministry of Health(MOH)network with credible laboratories capable of providing accurate and reliable results in a timely manner to enable effective public health measures

关键词： obligation providing coordinated enable timely capable laboratories manner sequencing detecting

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Reducing the incidence of hepatocellular carcinoma due to hepatitis C virus infection by detecting resistance-associated substitutions in hepatitis C virus NS5A nonstructural protein

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Cancer Biology & Medicine 2018年第S1期15卷 7-7页

作者： RozainaneeMohd Zain Nurul Asshikin Ruslan Sairulahkma Awang Muhammad Adib Abd Wahab ravindran thayan Virology Unit Infectious Disease Research CenterInstitute for Medical ResearchJalan PahangKuala LumpurMalaysia

Objective:Hepatocellular carcinoma(HCC)is one of the leading causes of liver cancer *** Malaysia,liver cancer is one of the main cancers detected in the population with an annual mortality rate of 6.1%in *** C virus(HCV)infection is one of the causes attributed to the incidence of *** infection remains a major concern in Malaysia as many people are unaware of their infection *** the accessibility and effectiveness of Direct Acting Agents(DAAs).

关键词： Reducing incidence hepatocellular

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