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Functional lumen imaging probe use in a high-volume practice:Practical and technical implications

World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 396-405页

作者： Yan Jiang raul vazquez-reyes Afrin Kamal Thomas Zikos George Triadafilopoulos John O Clarke Division of Gastroenterology and Hepatology Stanford University School of MedicineRedwoodCA 94063United States

BACKGROUND The functional lumen imaging probe(FLIP)is a Food and Drug Administration approved tool to aid the diagnosis and management of esophageal ***,widespread adoption of FLIP remains limited and its utility in highvolume practices remains *** To analyze large sample data on clinical use of FLIP and provide insight on several technical aspects when performing *** We conducted a retrospective comparative and descriptive analysis of FLIP procedures performed by a single provider at an academic medical *** was a total of 398 FLIP procedures *** medical records were reviewed and data regarding demographics and procedural details were *** tests,including chi-squared,t-test,and multivariable logistic and linear regression,were *** There was an increase in FLIP cases with each successive time period of 13 months(n=68,146,184,respectively)with notable rises specifically for indications of dysphagia and gastroesophageal reflux *** was a shift toward use of the longer FLIP balloon catheter for diagnostic purposes(overall 70.4%vs 29.6%,P<0.01).Many cases(42.8%)were performed in conjunction with other diagnostics/interventions,such as dilation and wireless pH probe *** were nearly equally performed with anesthesia vs moderate sedation(51.4%anesthesia),with no major *** who had anesthesia were less likely to have recurrent antegrade contractions[odds ratio(OR)=0.4,95%CI:0.3-0.8]and were also more likely to have absent contractility(OR=2.4,95%CI:1.3-CONCLUSION FLIP cases have increased in our practice with expanding indications for its *** limited normative data,providers should be aware of several potential technical issues,including the possible impact of sedation choice when assessing esophageal motility patterns.

关键词： Gastroenterology Endoscopy Functional lumen imaging probe Esophagus Motility

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Etching-free pixel definition in InGaN green micro-LEDs

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Light(Science & Applications) 2024年第8期13卷 1655-1665页

作者： Zhiyuan Liu Yi Lu Haicheng Cao Glen Isaac Maciel Garcia Tingang Liu Xiao Tang Na Xiao raul Aguileta vazquez Mingtao Nong Xiaohang Li Advanced Semiconductor Laboratory Electrical and Computer Engineering ProgramCEMSE DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia

The traditional plasma etching process for defining micro-LED pixels could lead to significant sidewall *** near sidewall regions act as non-radiative recombination centers and paths for current leakage,significantly deteriorating device *** this study,we demonstrated a novel selective thermal oxidation(STO)method that allowed pixel definition without undergoing plasma damage and subsequent dielectric *** annealing in ambient air oxidized and reshaped the LED structure,such as p-layers and InGaN/GaN multiple quantum ***,the pixel areas beneath the pre-deposited SiO_(2)layer were selectively and effectively *** was demonstrated that prolonged thermal annealing time enhanced the insulating properties of the oxide,significantly reducing LED leakage ***,applying a thicker SiO_(2)protective layer minimized device resistance and boosted device efficiency *** the STO method,InGaN green micro-LED arrays with 50-,30-,and 10-μm pixel sizes were manufactured and *** results indicated that after 4 h of air annealing and with a 3.5-μm SiO_(2)protective layer,the 10-μm pixel array exhibited leakage currents density 1.2×10^(-6)A/cm^(2)at-10 V voltage and a peak on-wafer external quantum efficiency of~6.48%.This work suggests that the STO method could become an effective approach for future micro-LED manufacturing to mitigate adverse LED efficiency size effects due to the plasma etching and improve device ***-LEDs fabricated through the STO method can be applied to micro-displays,visible light communication,and optical interconnect-based *** planar pixel geometry will provide more possibilities for the monolithic integration of driving circuits with ***,the STO method is not limited to micro-LED fabrication and can be extended to design other III-nitride devices,such as photodetectors,laser diodes,high-electron-mobility transistors

关键词： annealing protective quantum

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Bivariate Analysis of Pollutants Monthly Maxima in Mexico City Using Extreme Value Distributions and Copula

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Journal of Environmental Protection 2024年第7期15卷 796-826页

作者： Juan A. vazquez-Morales Eliane R. Rodrigues Hortensia J. reyes-Cervantes Facultad de Ciencias Fsico-Matemticas Benemrita Universidad Autnoma de Puebla Puebla Mexico Instituto de Matemticas Universidad Nacional Autnoma de Mxico Mexico City Mexico

In the present work, we are interested in studying the joint distributions of pairs of the monthly maxima of the pollutants used by the environmental authorities in Mexico City to classify the air quality in the metropolitan area. In order to obtain the joint distributions a copula will be considered. Since we are analyzing the monthly maxima, the extreme value distributions of Weibull and Fréchet are taken into account. Using these two distributions as marginal distributions in the copula a Bayesian inference was made in order to estimate the parameters of both distributions and also the association parameters appearing in the copula model. The pollutants taken into account are ozone, nitrogen dioxide, sulphur dioxide, carbon monoxide, and particulate matter with diameters smaller than 10 and 2.5 microns obtained from the Mexico City monitoring network. The estimation was performed by taking samples of the parameters generated through a Markov chain Monte Carlo algorithm implemented using the software OpenBugs. Once the algorithm is implemented it is applied to the pairs of pollutants where one of the coordinates of the pair is ozone and the other varies on the set of the remaining pollutants. Depending on the pollutant and the region where they were collected, different results were obtained. Hence, in some cases we have that the best model is that where we have a Fréchet distribution as the marginal distribution for the measurements of both pollutants and in others the most suitable model is the one assuming a Fréchet for ozone and a Weibull for the other pollutant. Results show that, in the present case, the estimated association parameter is a good representation to the correlation parameters between the pair of pollutants analyzed. Additionally, it is a straightforward task to obtain these correlation parameters from the corresponding association parameters.

关键词： Copula Extreme Value Distribution Bayesian Inference Air Pollution Mexico City

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Surfactant-free synthesis of metallic bismuth spheres by microwave-assisted solvothermal approach as a function of the power level

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Frontiers of Materials Science 2016年第4期10卷 394-404页

作者： Miriam ESTRADA FLORES Patricia SANTIAGO JACINTO Carmen M. REZA SAN GERMAN Luis RENDON vazquez raul BORJA URBY Nicolas CAYETANO CASTRO Instituto de Investigaciones en Materiales Circuito Exterior S/N Zona de Institutos Ciudad Universitaria C.P. 04510 Mexico D.F. Mexico Instituto de Fisica Circuito de la Investigaci6n Cientffica Edificio Marcos MoshinskyLaboratorio de Materiales Nanoestructurados Ciudad Universitaria C.P. 04510 Mexico D.F. Mexico Escuela Superior de Ingenierfa Qufmica e Industrias Extractivas Unidad Profesional Adolfo L6pez Mateos Edif. Z-5 2do. Piso Instituto Politecnico Nacional C.P. 07738 Mexico D.F. Mexico Centro de Nanociencias y Micro y Nanotecnologfas. Instituto Politecnico Nacional Av. Luis Enrique Erro S/NUnidad Profesional Adolfo Lopez Mateos Zacatenco Delegaci6n Gustavo A. Madero C.P. 07738 Mexico D.F. Mexico

In the present work, the synthesis of micro- and nano-sized spheres of metallic bismuth by microwave-assisted solvothermal method is reported. The synthesis method was carried out at different power levels and at a unique frequency of microwave irradiation. The sphere sizes were controlled by the microwave power level and the concentration of dissolved precursor. Structural and morphological characterization was performed by SEM, HRTEM, EELS and XRD. The results demonstrated that rhombohedral zero valent Bi spheres were synthesized after microwave radiation at 600 and 1200 W. However, if the power level is decreased to 120 W, a monoclinic phase of Bi203 is obtained with a flake-like morphology. In comparison with a conventional hydrothermal process, the microwave-assisted solvothermal approach provides many advantages such as shorter reaction time, optimum manipulation of morphologies and provides a specific chemical phase and avoids the mixture of structural phases and morphologies which is essential for further applications such as drug delivery or functionalization with organic materials, thanks to its biocompatibility.

关键词： microwave oven power level metallic bismuth spherical structures mechanism of formation electron energy loss spectroscopy (EELS)

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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

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Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： Priscila vazquez-Leon Abraham Miranda-Paez Jesus Chavez-reyes Gonzalo Allende Paulino Barragan-Iglesias Bruno A.Marichal-Cancino Departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats,such as immobility or flight from a *** activity is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the ventral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv)pontine nucleus;(v)bed nucleus of the stria terminalis;and(vi)*** models have suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is evidence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical review,we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray Reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

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Ventral Tegmental Area Neuronal Activity Correlates to Animals’ Behavioral Response to Chronic Methylphenidate Recorded from Adolescent SD Male Rats

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Journal of Behavioral and Brain Science 2014年第4期4卷 168-189页

作者： Zachary Jones Cruz reyes vazquez Nachum Dafny Department of Neurobiology and Anatomy University of Texas Medical School at Houston Houston USA Departmento de Fisiologia Divivion de Investigacion Facultad de Medicina Universidad Nacional Autonoma de Mexico Mexico City Mexico

Methylphenidate (MPD) is considered as the first-line pharmacotherapy to treat ADHD. More recently, MPD has also been used as a cognitive enhancement recreationally. Its therapeutic effects are not fully understood, nor are the long term effects of the drug on brain development. The ventral tegmental area (VTA) neuronal activity was recorded from freely behaving adolescent rats using a wireless recording system. Five groups were used: saline, 0.6, 2.5, 5.0 and 10.0 mg/kg MPD. The experiment lasted for 10 days. This study demonstrated that VTA neurons respond to MPD in a dose response characteristic and the same dose of MPD can cause both behavioral sensitization and behavioral tolerance. The neuronal unit activity was evaluated based on the animals’ behavioral activity following chronic MPD administration. The study showed that the animals’ behavioral response to different acute MPD of 0.6, 2.5 and 10.0 mg/kg doses responded in a dose response characteristics. Moreover, the same chronic dose of 0.6, 2.5, and 10.0 mg/kg MPD elicits in some animals’ behavioral sensitization and in some others behavioral tolerance. Therefore, the neuronal activity recorded from animals expressing behavioral sensitization was analyzed separately from the neuronal activity recorded from of behaviorally tolerant animals and it was found that the VTA units of the behaviorally sensitization animals responded significantly different to the drug than those VTA units recorded from animals expressing behavioral tolerance.

关键词： Ritalin Electrophysiology Neuronal Activity Behavior Ventral Tegmental Area

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SENP7 overexpression protects cancer cells from oxygen and glucose deprivation and associates with poor prognosis in colon cancer

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Genes & Diseases 2022年第6期9卷 1419-1422页

作者： Francisco Gallardo-Chamizo Nieves Lara-Urena Juan F.Correa-vazquez Jose C.reyes Benoit R.Gauthier Mario Garcia-Dominguez Cell Dynamics and Signaling Department CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Cell Therapy and Regeneration Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabo´licas Asociadas(CIBERDEM) Madrid 28029Spain

To the Editor,Constricted oxygen and glucose supplies are common conditions that healthy cells following a stress such an ischemic insult as well as cancer cells within a solid tumor need to overcome in order to *** conditions are a serious challenge for cells,which accurately measure the impact to make a life or death *** cancer cells,aberrant gene expression and/or protein regulation,frequently linked to appearing mutations,may confer selective advantages to survive under these adverse *** the past years,cumulative evidence indicates that protein modification by covalent attachment of the Small Ubiquitin-like MOdifier(SUMO)plays a role in cell survival after oxygen and glucose deprivation(OGD).

关键词： cancer deprivation colon

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Sharp Bounds for Fractional One-sided Operators

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Acta Mathematica Sinica,English Series 2016年第11期32卷 1255-1278页

作者： Maria Silvina RIVEROS raul Emilio VIDAL FaMAF-CIEM UNC-CONICET Ciudad Universitaria 5000 Cdrdoba Argentina

In this paper, we characterize the sharp boundedness of the one-sided fractional maximal function for one-weight and two-weight inequalities. Also a new two-weight testing condition for the one-sided fractional maximal function is introduced extending the work of Martin-reyes and de la Torre. Improving some extrapolation result for the one-sided case, we get weak sharp bounded estimates for one-sided fractional maximal function and weak and strong sharp bounded estimates for one-sided fractional integral.

关键词： One-sided fractional integrals one-sided maximal fractional function extrapolation Saw-yer weights

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XRD Characterization of Crystallinity of Human Tooth Enamel under Influence of Mechanical Grinding

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Materials Sciences and Applications 2015年第6期6卷 464-472页

作者： Jose reyes-Gasga Olga Koudriavtseva raul Herrera-Becerra Arturo Escobosa Instituto de Física UNAM Circuito de la Investigación s/n Ciudad Universitaria México D.F. México Dep. Ingeniería Eléctrica—SEES CINVESTAV—IPN México D.F. México

Crystallinity refers to the degree of structural order in a solid and has a big influence on hardness, density, transparency and diffusion. Even within materials that are crystalline completely, the degree of structural perfection can vary, reflecting size and elastic strain of many independent crystalline regions (grains or crystallites) of which these materials are composed. In this work it was attempted to reduce the crystallinity of human enamel using a technique of mechanical grinding (MG) with an ultra-compact FRITSCH Mini-Mill PULVERISETTE 23 machine. Variation in the crystallinity through the MG was monitored by X-ray diffraction (XRD) by broadening of the diffraction peak and examined using the Williamson-Hall plot method. Crystallites in human enamel are regularly arranged and oriented (in the [001] direction) perpendicularly to the interface of enameldentin junction. The results showed an anisotropic feature in crystallinity. Reduction of the crystallinity along the a-axis is due to the crystal strain rather than to the refinement of crystal, and vice versa along the c-axis. After 230 h of the MG, the length of crystallites decreased from 100 nm to 30 nm and width from 40 nm to 37 nm approximately.

关键词： Human Tooth Enamel Crystal Structure Mechanical Grinding X-Ray Diffraction Crystallites

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Effect of Anti-TNF Therapy on Resistance to Insulin in Patients with Rheumatoid Arthritis

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第3期3卷 167-171页

作者： Mario Pérez raul Ariza Ruben Asencio Adolfo Camargo Heladia Garcia Miguel Angel vazquez Leonor Barile-Fabris Hospital Angeles del Pedregal Mexico City Mexico. UMAE Specialty Hospital “Bernardo Sepulveda” CMNSXXI IMSS Mexico City Mexico

Objective: To evaluate the effect of anti-TNF therapy on resistance to insulin in patients with rheumatoid arthritis (RA) compared with patients with RA being treated with non-biological DMARDs. Methods: Inactive patients diagnosed with RA (ACR 1987 criteria) (DAS 28 2.6) were included, being treated with anti-tumor necrosis factor inhibitors (anti-TNF) (cases) and non-biological disease-modifying anti-rheumatic drugs (DMARD) (controls), without risk factors for insulin resistance (administration of steroids, body mass index > 25 kg/m2, diabetes mellitus or use of glucose lowering agents, systemic arterial hypertension or use of anti-hypertensive drugs, triglycerides > 150 mg/dl, hypercholesterolemia > 200 mg/dl, high-density lipoproteins 40 mg/dl in men and 50 mg/in women, or with lipids lowering agents, waist measurement > 88 cm in women and > 102 cm in men). We used HOMA (Homeostasis Model Assessment) to determine insulin resistance in both groups, HOMA being defined as >1 and sensitivity to insulin using QUICKI (Insulin Sensitivity Check Index), ≥0.38 being considered as normal. The Mann Whitney U was used for the statistical analysis. Results: A total of 28 patients, 15 being treated with non-biological DMARDs and 13 with anti-TNF therapy, were evaluated;89.7%, of which were women. Average age: 43.5 (range 21 - 62);the average HOMA index of the non-biological DMARD group was 1.58 (range 0.7 - 5.4), compared with patients treated with anti-TNF therapy, 1.18 (range 0.2 - 4.3) (P = 0.5). The average QUICKI index was 0.36 (range 0.30 - 0.42) in patients treated with non-biological DMARD, compared with0.37 inpatients treated with anti-TNF therapy (range 0.30 - 0.51) (P = 0.8). Conclusion: Resistance to insulin manifested itself in both groups, although there was a greater trend of less insulin resistance and greater sensitivity in the anti-TNF group;this was probably not statistically significant due to the sample size.

关键词： Anti-TNF Resistance to Insulin Rheumatoid Arthritis

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