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Design of a Centrifugal Compressor for Micro Gas Turbine: Investigation of Scaling and Tip Clearance Effects

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Open Journal of Fluid Dynamics 2019年第1期9卷 49-62页

作者： Dario Barsi Alberto Bottino Andrea Perrone luca ratto Pietro Zunino Department of Mechanical Energy Management and Transportation Engineering University of Genova Genova Italy

The aim of this paper is to investigate the design in similarity of a centrifugal compressor for micro gas turbine and the related scaling effects on performance using CFD investigations. This work is part of a research project carried out by the Department DIME of the University of Genova, with the purpose of investigating the performance of a micro gas turbine in the change from 100 kW electrical output to 250 kW, while maintaining the compressor pressure ratio and geometry in similarity. The first part of the work focuses on the comparison between the original and the scaled machine, while the second part of the study deeply investigates the tip gap effect in the new configuration. The aim is to provide information about the performance of the compressor designed in geometrical similarity and to evaluate the tip gap height impact. From the efficiency point of view, the scaled-up machine has higher efficiency (up to 1.4% increment in design conditions) keeping the same technological limit for impeller manufacturing. However, the variation of tip gap height in the range 0 ÷ 1 mm strongly affects this parameter, leading to 10% alteration in design conditions between the ideal and worst case. The results, both in terms of overall performance and flow fields, are widely discussed in order to obtain simple yet reliable correlation for preliminary design.

关键词： Centrifugal Compressor Scaling Tip Gap CFD

From mice to humans:a need for comparable results in mammalian neuroplasticity

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Neural Regeneration Research 2025年第2期20卷 464-466页

作者： Marco Ghibaudi Enrica Boda luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi OrbassanoItaly Department of Veterinary Sciences University of TurinTurinItaly Department of Neuroscience Rita Levi-Montalcini University of TurinTurinItaly

Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall,different types of plasticity,including stem cell-driven genesis of new neurons(adult neurogenesis),cells in arrested maturation(dormant neurons),neuro-glial and synaptic plasticity,can coexist and contribute to grant plastic changes in the brain,from a cellular to system level(Benedetti and Couillard-Despres,2022;Bonfanti et al.,2023).

关键词： plasticity al. arrest

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Genetic signatures of ERCC1 and ERCC2 expression, along with SNPs variants, unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology research 2025年第1期33卷 45-55页

作者： Enrico Caliman Sara Fancelli Federico Scolari Adriano Pasqui Clara Manneschi Daniele Lavacchi Francesca Mazzoni Francesca Gensini Valeria Pasini Camilla Eva Comin luca Voltolini Serena Pillozzi Lorenzo Antonuzzo Clinical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Medicine University of Florence Florence 50134 Italy. Department of Health Sciences University of Florence Florence 50134 Italy. Medical Oncology Unit Careggi University Hospital Florence 50134 Italy. Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Florence 50134 Italy. Section of Anatomic Pathology Department of Health Sciences University of Florence Florence 50139 Italy. Section of Surgery Histopathology and Molecular Pathology University of Florence Florence 50139 Italy. Thoracic Surgery Unit Careggi University Hospital Florence 50134 Italy.

Background:Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients' survival.Materials and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes-namely , , and -were performed on patient tumor samples.Results:Overall, elevated expression of genes was observed in SCLC patients compared to healthy controls. Patients with low and expression levels exhibited a better median progression-free survival (mPFS = 7.1 . 4.9 months, = 0.39 for and mPFS = 6.9 . 4.8 months, = 0.093 for ) and overall survival (mOS = 8.7 . 6.0 months, = 0.4 for and mOS = 7.2 . 6.2 months, = 0.13 for ). Genotyping analysis of five SNPs of genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the rs11615 SNP ( = 0.24 for PFS and = 0.14 for OS) and of the rs13181 and rs1799793 SNPs ( = 0.43 and = 0.26 for PFS and = 0.21 and = 0.16 for OS, respectively) compared to patients with homozygous mutant genotypes.Conclusions:The comprehensive analysis of gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： ERCC genes Nucleotide excision repair (NER) pathway Platinum-chemotherapy (CT) Single nucleotide polymorphisms (SNPs) Small cell lung cancer (SCLC)

Autism spectrum disorders in adolescence and adulthood: Long-term outcomes and relevant issues for treatment and research

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Science China(Life Sciences) 2015年第10期58卷 1010-1015页

作者： Allison B.ratto Gary B.MESIBOV Department of Psychology University of North Carolina at Chapel Hill Department of Psychiatry University of North Carolina at Chapel Hill

The advances in research and treatment of autism spectrum disorders(ASD) over the past three decades have focused largely on early childhood and school-age years. Although ASD is a lifelong condition, there has been relatively little attention paid to ASD during the adolescent and adulthood periods. As the population of those with ASD continues to rise and age, the need to provide research and treatment for this group has become increasingly evident. This paper reviews the current literature available on symptoms, functioning, and treatment of adolescents and adults with ASD, as well as the unique issues that arise for individuals with ASD after childhood. Adulthood outcomes for ASD are generally poor, even for those with average to above average cognitive ability. Further research and additional clinical resources are needed for this rapidly increasing group.

关键词： autism spectrum disorder (ASD) adolescence adulthood developmental trajectory

Factors that Influence Product Development and their Integration Level in Project Management Approaches

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Journal of Systems Science and Systems Engineering 2023年第4期32卷 462-482页

作者： luca Leib Faculty of Business and Economics Mendel University in BrnoBrnoCzech Republic

Project management literature provides various approaches to organize project ***,several factors influence product development about its efficiency and *** paper analyses the factors that affect product development and evaluates their integration level in project management concerning modern requirements imposed in a volatile,uncertain,complex,and ambiguous(VUCA)*** concludes by identifying undervalued influencing factors worth investigating in future research.

关键词： Communication decision making product development project management team organization VUCA

DLC coatings for hydraulic applications

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中国有色金属学会会刊：英文版 2009年第4期19卷 810-813页

作者： luca NOBILI luca MAGAGNIN Dip. Chimica Materiali e Ingegneria Chimica ＂G. Natta＂ Politecnico di Milano Via Mancinelli 7-20131 Milano Italy

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被... 详细信息

与水或低粘性的液体润滑油的代替在许多工业领域里是高度合乎需要的，由于环境、节俭的优点。水的低润滑可能为水力的部件的合适的操作是不够的，并且像钻石的碳(DLC ) 涂层作为稳固的润滑剂电影很吸引人。一个遥远血浆的 PACVD 过程被利用扔 hydrogenated DLC 涂层(交流: H ) 在不同底层上。Microindentation 大小证明涂层坚硬在 35 GPa 附近。Tribological 行为被测试与氧化铝在水和水里执行了的 block-on-ring 评估。wear 率在由激光 profilemeter 测量 wear 体积以后被计算。wear 轨道的词法、组合的分析表明那涂层失败可以由磨料发生穿或分层，取决于底层性质。难、光滑的底层给最好的结果，驱散的氧化铝粒子增加 wear 率。

关键词：类金刚石涂层液压元件氧化铝颗粒应用等离子体辅助类金刚石碳固体润滑膜 CVD工艺

Prospective evaluation of a new device for the treatment of anal fistulas

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World Journal of Gastroenterology 2016年第30期22卷 6936-6943页

作者： Carlo ratto Francesco Litta Lorenza Donisi Angelo Parello proctology unit Department of Surgical Sciences Catholic University 00168 Rome Italy

AIM: To evaluate the safety of the implantation of a new device for the treatment of anal fistulas. The short-term clinical efficacy was also assessed. METHODS: This study took place at a tertiary care university hospital. Patients with a complex anal fistula of cryptoglandular origin were enrolled in the study and were treated with insertion of the new device. All patients were evaluated by clinical and physical examination, including an endoanal ultrasound at the baseline, and then at the 2 wk and 1, 2, 3 and 6-mo follow-up visits. RESULTS: Morbidity, continence status, and success rate were the main outcome measures. Ten patients underwent the placement of the new device. The fistulas were transphincteric in eight patients and extrasphincteric in the remaining two. The median duration of the surgical procedure was 34.5(range, 27-42) min. Neither intra- nor postoperative complications occurred, and all patients were discharged the day after the procedure. At the 6-mo follow-up evaluation, the final success rate was 70%. Three failures were registered: a device expulsion(on the 10 th postoperative day), the persistence of inflammatory tissue around the fistula tract(at the 2-mo follow up), and the persistence of serum discharge(at the 6-mo follow up). No patient experienced any change incontinence, as assessed by the Cleveland Clinic Fecal Incontinence score. CONCLUSION: The technical procedure is simple and has low risk of perioperative morbidity. The pre- and post-operative continence status did not change in any of the patients. The initial results at the 6-mo follow up seem to be promising. However, a longer follow-up period and a larger sample size are needed to confirm these preliminary results.

关键词： Anal fistula Device Fistula plug Faecal incontinence Recurrence Endoanal ultrasound

Utilization of irradiance ratios for calculating the effect of reflections from obstructions in building energy simulation

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Building Simulation 2021年第4期14卷 945-967页

作者： Gian luca Brunetti Politecnico di Milano Department of Architecture and Urban Studies(DAStU)via Bonardi 320133MilanoItaly

The ability to take into account reflections from obstructions is of fundamental importance in building energy simulation (BES), because reflections can have a substantial influence on solar gains. In BES tools, this ability is often implemented duplicating functionalities that have already been solved efficiently in lighting simulation tools. This happens because importing those functionalities from a lighting simulation tool (source) into a BES tool (target) is usually a complex operation producing non-portable results. This article demonstrates that this ability can be imported modularly and portably without intervening in the internals of the two tools. This can be obtained by: (1) creating, in the source tool, pairs of models which are analogue-on the one hand-to the original model in the target tool, and-on the other hand-to the model in the target tool hypothetically enriched with some predictive ability only available in the source tool;(2) measuring, at each time step, the ratio between the performances predicted by the source tool as regards the two analogue models;(3) re-scaling, at each time-step, the performance predicted by the target tool on the basis of that ratio. When appropriate analogue models are utilized, this strategy enables distinct simulation tools to work like an integrated computing unit.

关键词： irradiance ratios shading factors analogue models solar reflections insolation factors