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Retinal ganglion cell complex changes using spectral domain optical coherence tomography in diabetic patients without retinopathy

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 427-433页

作者： Ahmed I.hegazy rash. h.zedan Tamer A.Macky Soheir M.Esmat Department of Ophthalmology Cairo UniversityKasr Alainy Faculty of Medicine Ringgold Standard Institution

AIM：To assess the ganglion cell complex（GCC）thickness in diabetic eyes without retinopathy. METhODS：Two groups included 45 diabetic eyes without retinopathy and 21 non diabetic eyes. All subjects underwent full medical and ophthalmological history,full ophthalmological examination,measuring GCC thickness and central foveal thickness（CFT）using the RTVue~？ spectral domainoptical coherence tomography（SD-OCT）,and hbA1C ***：GCC focal loss volume（FLV%）was significantly more in diabetic eyes（22.2% below normal）than normal eyes（P=0.024）. No statistically significant difference was found between the diabetic group and the control group regarding GCC global loss volume（GLV%）（P=0.160）. CFT was positively correlated to the average,superior and inferior GCC（P=0.001,0.000 and 0.001 respectively）and negatively correlated to GLV% and FLV%（P=0.002 and0.031 respectively）in diabetic eyes. C/D ratio in diabetic eyes was negatively correlated to average,superior and inferior GCC（P=0.015,0.007 and 0.017 respectively）. The FLV% was negatively correlated to the refraction and level of hb A1c（P=0.019 and 0.013 respectively）and positively correlated to the best corrected visual acuity（BCVA）in log MAR in diabetic group（P=0.004）.CONCLUSION：Significant GCC thinning in diabetes predates retinal vasculopathy,which is mainly focal rather than diffuse. It has no preference to either the superior or inferior halves of the macula. Increase of myopic error is significantly accompanied with increased focal GCC loss. GCC loss is accompanied with increased C/D ratio in diabetic eyes.

关键词： retina ganglion cell complex diabetes optical coherence tomography

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酸性调控对大豆分离蛋白纤维功能性质的影响

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中国粮油学报 2024年第2期39卷 113-119页

作者：高喧翔梅馨澜朱泽丹陈鸿杰樊继开杨素华刘玲玲班兆军浙江科技学院生物与化学工程学院浙江省农产品化学与生物加工技术重点实验室浙江省农业生物资源生化制造协同创新中心杭州310023

近年来,蛋白淀粉样纤维因其独特的材料学特性,在结构化和功能化食品领域引起广泛的关注。然而人们对蛋白纤维基材料的功能特性及相关调控机理还不甚了解。本文研究了不同酸诱导剂对大豆分离蛋白(SPI)自组装纤维的结构、乳化特性、凝胶... 详细信息

近年来,蛋白淀粉样纤维因其独特的材料学特性,在结构化和功能化食品领域引起广泛的关注。然而人们对蛋白纤维基材料的功能特性及相关调控机理还不甚了解。本文研究了不同酸诱导剂对大豆分离蛋白(SPI)自组装纤维的结构、乳化特性、凝胶特性及成膜性质的影响。结果表明,经盐酸或醋酸诱导均能形成纤维化蛋白,蛋白质的二级结构则由α-螺旋转变为β-折叠结构。相较于盐酸诱导的短而硬的蛋白纤维(h-SPI),醋酸诱导的蛋白纤维(C-SPI)形状更加柔顺且规则。除此之外,C-SPI拥有更大的粒径、更高的凝胶硬度、更优的乳化稳定性和成膜性。因此,通过选择适宜的酸诱导剂种类能够改善蛋白纤维的理化和功能性质。

关键词：大豆分离蛋白淀粉样纤维盐酸醋酸理化性质

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Toxicity of hypofractionated Radiotherapy Following Breast Conservative Surgery in Breast Cancer

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Journal of Cancer Therapy 2019年第5期10卷 371-381页

作者： Aiat Morsy Sara h. hammouda Samir Shehata Ali zedan Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Assiut University Assiut Egypt Radiotherapy Department South Egypt Cancer Institute Assiut University Assiut Egypt Department of Surgical Oncology South Egypt Cancer Institute Assiut University Assiut Egypt

Background:Adjuvant radiotherapy has increased disease-free and overall survival rates in breast cancer. Conventionally fractionated radiotherapy delivers 50 Gy over 5 weeks which is the standard approach. A shorter duration of hypofractionated radiotherapy (hFRT) will be more convenient for patients and treatment providers if found safe and equally effective. Material and Methods: Fifty-four breast cancer patients who underwent breast conservative surgery (BCS) were enrolled in this study. The patients received 4005 cGy/15 fractions. A boost to the tumor bed was administered in all patients. In this study, radiotherapy induced toxicity was evaluated. Results: In this study, the median age of our patients was 48 years with age ranged from 28 to 69 years. Acute skin toxicity was assessed, and it was noted that grade 2 skin toxicity was shown in only 6 patients (11.1%) at the end of radiotherapy and disappeared after 6 weeks of treatment. Late skin toxicity (telangectasia, hyperpigmentation, and subcutaneous fibrosis) was assessed and showed that most patients had grade 0 toxicity with no grade 3 toxicity at all. Regarding pulmonary toxicity, 5 patients (9.3%) developed acute pneumonitis and as regards chronic lung toxicity, it was evident in only 3 patients, 2 patients (3.7%) were grade 1 and 1 patient (1.9%) was grade 2. Cardiac toxicity was evident in 2 patients (7.1%) of the left breast cancer patients. Regarding lymphoedema, most patients that showed lymphoedema were grade 1. Conclusion: The results confirm the safety and feasibility of adjuvant hypofractionated whole breast radiotherapy in breast cancer patients in terms of acute and late toxicity.

关键词： Breast Cancer hypofractionated Radiotherapy Breast Conservative Surgery Toxicity

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Intersphincteric Resection Is the Optimal Procedure for Very Low Rectal Cancer: Techniques, Morbidity, Oncologic and Functional Outcomes

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Journal of Cancer Therapy 2019年第5期10卷 400-410页

作者： Ali zedan Anwar Tawfik Ebrahim Aboeleupn Asmaa Salah Aiat Morsy Surgical Oncology Department South Egypt Cancer Institute Assiut University Egypt Radiation Oncology & Nuclear Medicine Department South Egypt Cancer Institute Assiut University Egypt Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Assiut University Egypt

Background: The intersphincteric resection the most extreme form of a sphincter-preserving alternative for the abdominoperineal resection. Aim of the Work: We investigated oncological, functional outcomes and morbidity after ISR. Methods: This retrospective study included 164 patients who underwent ISR with between 2010 and 2015, Male 56.1%, Female 43.9%, with a median age was 54.5 years, Median follow-up time was of 48 months, Average surgical time was 230 min, Median blood loss was 700 mL and median hospital stay was nine days. Mean tumour size was34 mm. The surgical procedure through a laparotomy (72.6%), laparoscopically (27.4%). Neoadjuvant radiotherapy 89.6% {long-course radiotherapy 74.4%, short-course radiotherapy 15.2%}, neoadjuvant chemotherapy 28.7% and adjuvant chemotherapy 70.1%. Colonic J-pouch 16.5%, Transverse coloplasty 15.9%, a side-to-end anastomosis 26.8% and straight coloanal anastomosis 40.9%. Partial-ISR 36.6%, subtotal-ISR 37.2%, total-ISR 26.2%, diverting ileostomy 6.7%. Results: Operative mortality 1.2%, morbidity 14.6% (anastomotic leakage 3.7%, anastomotic stenosis 1.8%, a recto-vaginal fistula 2.4% bowel obstruction 3%, surgical site infection 3%. Respiratory tract infection 1.2%, local 7.9%, distant recurrence 15.2%, 5-year overall 79.8%, disease-free survival 75.8%, R0 resection 95.1%. Pathologic complete response 11%. Circumferential margin involvement 2.4%. Median number of lymph nodes 17. Mean distal margin20 mm, after 12 months Median Wexner score 6. Incontinence for (flatus 11%, liquid 4.9%, solid 4.3%). Median bowel motions in a 24-h were 3. Faecal urgency 17.7%. Stool fragmentation 18.9%. Difficult evacuation 17.7%, lifestyle alteration 14.6%. Difficulty Feces/flatus discrimination 43.3%. Nocturnal soiling in 17.1%. Daytime soiling 11%. Pad wearing 23.8%. Anti-diarrhoea medication loperamide 14%. Conclusion: ISR is a feasible surgical procedure for low rectal cancer. Oncologic and functional, outcomes after are acceptable.

关键词： Intersphincteric Resection ISR Cancer Rectum Functional Outcomes Oncologic Outcomes

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Effects of pre-sowing treatments on seed germination of Melia azedarach

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Journal of Forestry Research 2010年第2期21卷 193-196,I0006页

作者： Md.Salim Azad Md.zedan-Al-musa Md.Abdul Matin Forestry and Wood Technology Discipline Khulna University Centre for Tropical and Subtropical Agriculture and Forestry(CeTSAF) Georg-August-University

A germination experiment of pre-treated seeds of Melia azedarach was conducted in the nursery of Forestry and Wood Technology Discipline,Khulna University,*** seeds of Melia azedarach were collected from healthy trees of National Botanical Garden,Bangladesh and were treated with five pre-sowing treatments（control,immersion in cold water,immersion in hot water,scarification with sand paper,and immersion in concentrated h2SO4） on seed *** revealed that the germination rates of pre-sowing treated seeds were significantly increased compared to those in control,except for cold water *** highest germination success（80%） was found in scarification with sand paper,followed by 74% and 69% in immersion in h2SO4 and hot water treatment,*** started on 8-11 days and completed on 20-21 days of the germination period in all *** of variance showed the significance difference in germination success among the treatments but no significance difference in germination period among the *** water treatment may be recommended on seed germination of the species in rural Bangladesh.

关键词： germination Melia azedarach pre-sowing treatment seed

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Therapeutic Mammoplasty in Management of Breast Cancer: A Prospective Clinical Study

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Advances in Breast Cancer Research 2017年第4期6卷 107-116页

作者： Ahmed Mohamed Farahat Amr Abdel Meguid Attia Mohamed Aly M. El Shafei El Zawahry Mohamed h. zedan hussein Osama Soliman National Cancer Institute Cairo University Giza Egypt

Background: The introduction of oncoplasticbreast surgery, with a concomitant contralateral symmetrization procedure, allows the surgical oncologist the freedom to perform wider excisions, with more favorable cosmetic outcomes. Objective: To assess the feasibility of bilateral breast reduction for the management of breast cancer, and to determine the most suitable surgical technique of therapeutic mammoplasty for each patient. And to evaluate the cosmetic outcome during the postoperative period. Methods: This study was from June 2014 until June 2016, and included 86 female patients with breast cancer;divided in 3 groups;group A;had bilateral superior pedicle reduction mammoplasty, group B;had bilateral inferior pedicle reduction mammoplasty, group C;had bilateral batwing mastopexy. 1 month postoperative, patients were asked to answer a 5-scale questionnaire evaluating their own cosmetic outcome. Criteria they were asked to evaluate were: symmetry, shape and volume, projection, correction of ptosis, visibility of the scars and overall satisfaction. A similar questionnaire was answered by a panel made up of a surgeon and breast-care nurse after seeing the pre- and post-operative photos of the patients in question. Results: Group A had a mean tumor size of 2.7 ± 0.69 cm, least resected margins 1.2 - 4.3 cm, Group B had a mean tumor size of 3.2 ± 1.19 cm, least resected margins 0.7 - 3.8 cm, Group C had a mean tumor size of 3.4 ± 1.12 cm, least resected margins 1.7 - 5.2 cm. Cosmetic results fared high above average. Group C fared better in overall satisfaction but Group B fared better in ptosis correction, projection and symmetry. The panel answers showed difference regarding shape and volume;the only two criteria to be almost of the same result among the three groups. Conclusion: Bilateral TM has some advantages when compared to standard conventional BCS techniques without having any unfavorable effects on surgical margin confidence, local recurrence, and survival rat

关键词： Breast Oncoplasty Therapeutic Mammoplasty Surgery Oncology Plastic Symmetry

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麻子仁丸对便秘型小鼠模型通便功能、胃蛋白酶活性和对淋巴细胞增殖的实验研究

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世界中医药 2017年第9期12卷 2143-2146页

作者：张泽丹谭平中国人民解放军福州总医院干部保健科福州350025 福建医科大学福总临床医学院福州350025

目的:观察麻子仁丸对便秘型小鼠模型通便功能、胃蛋白酶活性和对淋巴细胞增值的实验研究。方法:72只小鼠随机分为空白组、模型组、观察组,每组24只,其中模型组和观察组建立便秘模型。空白对照组和模型组不采取任何干预,观察组10丸/d麻... 详细信息

目的:观察麻子仁丸对便秘型小鼠模型通便功能、胃蛋白酶活性和对淋巴细胞增值的实验研究。方法:72只小鼠随机分为空白组、模型组、观察组,每组24只,其中模型组和观察组建立便秘模型。空白对照组和模型组不采取任何干预,观察组10丸/d麻子仁丸溶水灌胃。1次/d,疗程7 d。通过墨汁推进法计算肠道推进率观察小鼠通便功能;采用苏木素-伊红染色(hE染色)在显微镜下观察肠道病理学情况;检测胃蛋白酶活性,并通过MTT和流式细胞仪检测淋巴细胞增殖表达情况。结果:1)观察组和模型组的粪便粒数、粪便重量、粒粪便重量和肠道推进率均较空表组减少(Ph胃液量和胃蛋白酶活性明显下降(Ph胃液量和胃蛋白酶活性明显提高(P<0.05)。4)与空白组比较,模型组和观察组淋巴细胞增殖能力(P<0.05),包括T淋巴细胞亚群CD4^+、CD8^+百分数和CD4^+/CD8^+比例均下降(P<0.05);与模型组比较,观察组中淋巴细胞增殖能力(P<0.05),包括T淋巴细胞亚群CD4^+、CD8^+百分数和CD4^+/CD8^+比例均身高(P<0.05)。结论:麻子仁丸能有效改善便秘型小鼠通便功能,提高小鼠胃液蛋白酶活性,其疗效机制可能与提高了淋巴细胞增殖能力,尤其是T淋巴细胞亚群CD4^+、CD8^+百分数和CD4^+/CD8^+比例有关。

关键词：麻子仁丸便秘型小鼠通便功能胃蛋白酶活性淋巴细胞增殖

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右美托咪定对大鼠脊髓缺血再灌注损伤的影响及其机制

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第三军医大学学报 2015年第5期37卷 433-438页

作者：王中权王府冉龙宽田泽丹陈玉培重庆医科大学附属第二医院麻醉科重庆400010

目的观察右美托咪定对大鼠脊髓缺血再灌注损伤的影响,并探讨其可能的机制。方法96只成年SD大鼠按随机数字表法分为4组（n=24）：假手术组（S组）、缺血再灌注组（IR组）、缺血再灌注右美托咪定组（DEX组）和缺血再灌注右美托咪定＋育亨... 详细信息

目的观察右美托咪定对大鼠脊髓缺血再灌注损伤的影响,并探讨其可能的机制。方法96只成年SD大鼠按随机数字表法分为4组（n=24）：假手术组（S组）、缺血再灌注组（IR组）、缺血再灌注右美托咪定组（DEX组）和缺血再灌注右美托咪定＋育亨宾组（DY组）,每组再分为灌注后12、24、48、72 h 4个亚组（n=6）。采用临床常用的首次负荷量加持续微量泵给药方式予以右美托咪定和育亨宾处理,并通过改良Zivin法阻断双肾间腹主动脉建立脊髓缺血再灌注损伤模型,采用BBB法对大鼠运动功能评分,hE染色观察大鼠脊髓病理学改变（L4~L6）,免疫组化观察脊髓Bax、Bcl-2表达,采用TUNEL法计数脊髓细胞凋亡率,Western blot检测Caspase3表达。结果与IR组比较,DEX组和DY组BBB运动评分升高,hE染色病理损伤明显减轻,TUNEL染色细胞凋亡率下降,免疫组化Bcl-2升高,Bax降低（P〈0.05）,Western blot显示Caspase3表达减少;与DEX组比较,DY组BBB运动评分降低,hE染色病理损伤加重,TUNEL染色细胞凋亡率升高,免疫组化Bcl-2降低,Bax升高（P〈0.05）,Western blot检测结果显示Caspase3表达增加。结论右美托咪定对大鼠脊髓缺血再灌注损伤具有明显的保护效应,其机制与激动α2肾上腺素受体,增加FAK磷酸化,并上调Bcl-2表达,下调Bax和Caspase3表达的抗细胞凋亡作用有关。

关键词：缺血再灌注损伤右美托咪定育亨宾脊髓

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超声引导与体表定位头皮神经阻滞用于术中唤醒开颅手术的效果比较

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陆军军医大学学报 2023年第6期45卷 547-553页

作者：万孟宁陈玉培邓友良田泽丹景胜陈远航重庆医科大学附属第一医院麻醉科重庆400016 重庆医科大学附属第二医院麻醉科重庆400010 陆军军医大学(第三军医大学)第二附属医院麻醉科重庆400037

目的对比术中唤醒开颅手术(awake craniotomy,AC)中应用超声引导下头皮神经阻滞(ultrasound-guided scalp nerve block,US-guided SNB)与体表定位头皮神经阻滞(scalp nerve block,SNB)的效果差异。方法采用回顾性队列研究,分析2016年1月至2022年1月就诊于重庆医科大学附属第一医院及陆军军医大学第二附属医院神经外科的82例脑功能区病变患者的病历资料。其中接受US-guided SNB的纳入观察组(n=39),患者年龄(50.51±16.49)岁,男19例,体质指数(22.10±3.66)kg/m^(2)。接受体表定位SNB的纳入对照组(n=43),患者年龄(48.02±16.44)岁,男24例,体质指数(22.98±3.55)kg/m^(2)。比较两组患者的一般资料、手术相关指标及术后并发症情况。记录入室时(T0)、切皮完成时(T1)、唤醒时(T2)、唤醒后10 min(T3)、唤醒后20 min(T4)的平均动脉压(mean arterial pressure,MAP)和心率(heart rate,hR)。结果观察组的术中唤醒时间(6.53±1.84)min、唤醒期体动次数(4.92±2.61)次/h、盐酸尼卡地平(0.97±0.27)mg、瑞芬太尼(1.08±0.35)mg、盐酸右美拖咪定(1.30±0.33)mg以及枸橼酸舒芬太尼(22.42±2.63)ug的用量显著低于对照组,差异均有统计学意义(均PhR在T1-T4均呈逐渐上升趋势,其中对照组hR上升更明显,组间比较差异有统计学意义(F=35.978,P<0.001)。观察组MAP在T1-T2逐渐上升,在T3-T4呈下降趋势,对照组T1-T3呈上升趋势,T4期有所回降,且明显高于观察组,组间比较差异有统计学意义(F=43.286,P<0.001)。结论US-guided SNB技术具有提升AC手术唤醒期手术质量、减少术中全身麻醉药用量、稳定血流动力学的作用。

关键词：超声引导头皮神经阻滞唤醒开颅手术脑功能区病变

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氧化亚氮对hIFU治疗患者Fhb及ICAM-1含量的影响

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重庆医学 2014年第35期43卷 4757-4759页

作者：陈佳但伶田泽丹黄燕周瑜张昭莉重庆医科大学附属第二医院麻醉科 400000 重庆市肿瘤研究所护理部 400030

目的观察氧化亚氮（N2O）对高强度聚焦超声（hIFU）治疗患者血清游离血红蛋白（Fhb）及细胞间黏附分子1（ICAM-1）含量的影响,探讨其组织损伤的作用机制。方法将50例原发性肝癌行hIFU治疗的患者（ASAⅠ-Ⅱ级）,分为对照组（C组）与试验... 详细信息

目的观察氧化亚氮（N2O）对高强度聚焦超声（hIFU）治疗患者血清游离血红蛋白（Fhb）及细胞间黏附分子1（ICAM-1）含量的影响,探讨其组织损伤的作用机制。方法将50例原发性肝癌行hIFU治疗的患者（ASAⅠ-Ⅱ级）,分为对照组（C组）与试验组（N组）,每组25例。两组均使用全身麻醉方式,C组采用全凭静脉麻醉,N组采用静吸复合麻醉,两组麻醉诱导方式相同,N组麻醉维持在C组基础上吸入N2O。分别在麻醉前（T1）、手术前（T2）、术中第1小时（T3）、第2小时（T4）、第3小时（T5）,及术后24h（T6）抽取桡动脉血,采用类过氧化物酶反应法和双抗体夹心ELISA法检测血清中Fhb及ICAM-1含量;用hIFU治疗仪超声显像系统测量两组患者术前、术后腹壁厚度值。结果随着手术过程中麻醉时间的延长,血清中Fhb及ICAM-1含量之较前均明显增多（P〈0.05）;同一时间点,与C组相比,N组Fhb和ICAM-1增多明显（P〈0.05）;与C组相比,N组术前、术后腹壁厚度值变化明显增加（P〈0.05）。结论 N组在hIFU治疗过程中,机体产生更多的Fhb及ICAM-1,继发引起腹壁皮肤明显肿胀,这可能与N2O增强超声空化效应有关。

关键词：氧化亚氮高强度聚焦超声腹壁厚度游离血红蛋白

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