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Economics of Coalbed Methane in North West Spain

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International Journal of Clean Coal and Energy 2018年第2期7卷 21-38页

作者： Jose A. Gutiérrez raquel garcía Campus de Vegazana Universidad de León León Spain

Coal during its carbonization process produces a gas. This gas, mainly formed by methane, can be used. The use of CBM (Coal bed methane) as an energetic resource is not much known in Spain. This work is the first step to enhance the development of this resource in Castilla y León. A theoretical review and a state of the art description have been carried out, taking into account all the factors that can influence in the development of a CBM project. Then CBM resources have been quantified by Castilla y León accurately for every coal bed. After that, technical feasibility has been used to evaluate total amount of gas that can be recovered. The last step was to evaluate economic feasibility to know how much gas could be economically profitable. This paper covers the economic factor and exploitation options of CBM in Castilla y León, considering technical parameters together with costs and economic requirements for the tow most promising areas in north-west Spain. The main findings include that a CBM system would be feasible in Guardo-Barruelo, however, the economic feasibility will be limited to long operation time of the wells and an increase of the prices of natural gas. In North Leon, the results show a high profitability even under low natural gas prices.

关键词： Coalbed Methane Coal Feasibility Coal Economics Unconventional Natural Gas

Project for Residues Valorisation and Reutilization from an Oxy-Combustion Circulating Fluidized Bed Boiler with CO<sub>2</sub>Capture

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Journal of Power and Energy Engineering 2019年第1期7卷 19-26页

作者： Jose A. Gutierrez Bravo raquel garcía Department of Mining Engineering Universidad de León Campus de Vegazana León Spain

Power generation industry has tackled waste reuse and valorisation for decades. Nevertheless, new technologies, like Circulating fluidized bed (CFB) boilers operating in oxy-combustion, have an important gap of knowledge in residues characterization and valorisation. This project will tackle this. Furthermore, as a result of the high quantity of waste that these installations generate new business models can be opened. The project aims at characterizing the residues from a large scale oxy-CFB facility with carbon, capture, use and storage (CCUS) focusing on the larger and main residues produced: fly ash, bottom ash, and algae production from captured CO2. An analysis of possible uses and treatment needs, such as additives or preparation for use in agriculture or industry, will be carried out. Best re-utilization and valorisation options will be stated for fly ash, bottom ash and algae, aiming for a novel combination of CO2 capture technologies with recovery of valuable materials from different wastes, addressing different and sustainable solutions for their reuse, enhancing the feasibility of CCUS, and combining research with the creation of new business models towards a green economy more attractive to the public perception.

关键词： Coal Residues Valorization Coal Ash CCUS Oxycombustion

Novel Simplified Method for Coalbed Methane Feasibility Evaluation

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International Journal of Clean Coal and Energy 2018年第4期7卷 59-92页

作者： Jose A. Gutiérrez raquel garcía Erasmo Cadena Department of Mining Engineering University of León Leon Spain

Coal during its carbonization process produces a gas. This gas, mainly formed by methane, can be used. This gas, coalbed methane (CBM), is usually mainly formed by methane and can be considered similar to natural gas as energy source. The evaluation of the techno-economic feasibility of the extraction of this gas depends on a large number of complex different factors. The work carried out covers the different aspects to simplify the first approach for CBM feasibility quantification considering a short number of indicators. A theoretical review and a state of the art description have been carried out, taking into account all the factors that can influence in the development of a CBM project. After that, technical feasibility has been used to evaluate total amount of gas that can be recovered. The last step was to evaluate economic feasibility to know how much gas could be economically profitable. Conclusions got have been used to develop a simple method for evaluating CBM economic feasibility considering just four easy known parameters of coal beds. These are: the rank, the thickness, the gas concentration, and the permeability.

关键词： CBM Feasibility Assessments Coal Natural Gas

Conditioned Taste and Place Preferences Induced by Electrical Stimulation of the External Lateral Parabrachial Nucleus: A General Reinforcing Mechanism?

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Journal of Behavioral and Brain Science 2013年第5期3卷 422-431页

作者： Maria J. Simon raquel garcía Amadeo Puerto Department of Psychobiology University of Granada Granada Spain

This study examined the stimulus specificity of external lateral parabrachial (LPBe) rewarding stimulation by using two identical learning procedures that may dissociate conditioned reinforcement to either the place or the flavor stimulus. Animals were presented with two distinct flavors in two different positions (left and right) that were varied throughout the experimental sessions. In the first experiment, LPBe stimulation was associated with one or other flavor, while in the second it was conditioned to one or other place in which these flavors were offered. The results show that, despite stimulus interferences, the animals develop specific conditioned preferences for the flavor stimuli (experiment 2A), and also for the place of their presentation (experiment 2B). These data are discussed in the context of brain reward systems and the biological constraints that characterize some learning modalities.

关键词： Electrical Stimulation External Lateral Parabrachial Nucleus (LPBe) Reward Conditioning Flavor Placement

VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura Gómez-Jaramillo raquel Romero-garcía Gema Jiménez-Gómez Lisa Riegle Ana Belén Ramos-Amaya JoséAntonio Brieva Marie Kelly-Worden Antonio Campos-Caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins

Diagnostic and prognostic value of cardiac imaging in amyloidosis

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World Journal of Cardiology 2020年第12期12卷 599-614页

作者： Rafael Vidal-Perez raquel Vázquez-garcía Gonzalo Barge-Caballero Alberto Bouzas-Mosquera Rafaela Soler-Fernandez Jose Maria Larrañaga-Moreira Maria Generosa Crespo-Leiro Jose Manuel Vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña(CHUAC)Santiago de Compostela 15706A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A Coruña(CHUAC)A Coruña 15006A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaUnidad de Insuficiencia Cardiaca Avanzada y Trasplante CardiacoInstituto de Investigación Biomédica de A Coruña(INIBIC)Centro de Investigación Biomédica en Red(CIBERCV)-Instituto de Salud Carlos IIIA Coruña 15006A CoruñaSpain

Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent *** types of amyloidosis can affect the *** amyloidosis and light chain amyloidosis are the two most common types of cardiac *** entities have a poor prognosis,so accurate diagnostic techniques are imperative for determining an early therapeutic *** advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to histological confirmation,such as endomyocardial *** performed a review on the diagnostic and prognostic implications of different cardiac imaging techniques in cardiac *** mainly focus on reviewing echocardiography,cardiac magnetic resonance,computed tomography and nuclear imaging techniques and the different safety measurements that can be done with each of them.

关键词： Cardiac imaging techniques Transthyretin cardiac amyloidosis Immunoglobulin light-chain amyloidosis Echocardiography Magnetic resonance imaging Nuclear imaging

On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.J.garcíA-garcíA P.FARINAS-ALVARINO Department of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the purely turbulent component(PTC),and the contributions are analyzed separately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for plane-parallel laminar flows is reported,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow

Quality assessment of the Topo-Iberia CGPS stations and data quality's effects on postfit ionosphere-free phase residuals

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Geodesy and Geodynamics 2024年第2期15卷 189-199页

作者： Juan A.garcía-Armenteros Center for Advanced Studies in Earth Sciences Energy and Environment(CEACTEMA)University of Jaén23071 JaenSpain

This paper analyzed GPS data from the Topo-Iberia network spanning almost 12 years(2008-2020).The data quality information for all 26 Topo-Iberia stations is provided for the first time,complementing the Spanish Geological Survey’s storage *** analyses based on quality indicators obtained using TEQC have been carried *** guidelines and data quality information from the IGS stations have been considered as the quality references,with the stations ALJI,EPCU,and TIOU standing out as the worst stations,while on the contrary,FUEN,PALM,PILA,and TRIA meet the quality requirements to become an IGS *** relationship between the GPS data quality and their GAMIT-and Gipsy X-derived postfit ionosphere-free phase residuals has also been investigated,and the results reveal an inversely proportional *** has been found that the stations showing an increase in elevation of the horizon line,also show an increase in cycle slips and multipath,are among the poorest quality stations,and among those with the highest postfit RMS of phase ***,the evolution of the vegetation around the antenna should be considered as it could cause a progressive loss of quality,which is not complying with the IGS *** quality assessment shows that the Topo-Iberia stations are appropriate for geodetic purposes,but permanent monitoring would be necessary to avoid the least possible loss of data and *** addition,a method to characterize the GNSS data quality is proposed.

关键词： GPS dataquality's effects IGS quality standard Postfit LC phase residual Qualityassessment Topo-Iberia CGPS network

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal raquel garcía Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera Department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCNatal-Barcelona Center for Maternal–Fetal and Neonatal Medicine(Hospital Clínic and Hospital Sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac