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Nutritiona. epigenetics educa.ion improves diet a.d a.titude of pa.ents of children with a.tism or a.tention deficit/hypera.tivity disorder

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World Journa. of Psychia.ry 2024年第1期14卷 159-178页

作者： Renee J Dufa.lt Ka.herine M a.ler Da.id O Ca.penter Steven G Gilbert raquel a.Crider College of Gra.ua.e Hea.th Studies A.T.Still UniversityKirksvilleMO 63501United States Depa.tment of Resea.ch Food Ingredient and Health Research InstituteNaalehuHI 96772United States Depa.tment of Hea.th Sciences University of New HavenWest HavenCT 06516United States Institute for Hea.th a.d the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Depa.tment of Resea.ch Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Depa.tment of Sta.istics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

Ba.KGROUND Unhea.thy ma.erna. diet lea.s to hea.y meta. exposures from the consumption of ultra.processed foods tha. ma. impa.t gene beha.ior a.ross genera.ions,crea.ing conditions for the neurodevelopmenta. disorders known a. a.tism a.d a.tention deficit/hypera.tivity disorder(a.HD).Children with these disorders ha.e difficulty meta.olizing a.d excreting hea.y meta.s from their bloodstrea.,a.d the severity of their symptoms correla.es with the hea.y meta. levels mea.ured in their *** ma. pla. a.key role in helping pa.ents reduce their ultra.processed food a.d dieta.y hea.y meta. inta.e by providing a.cess to effective nutritiona. epigenetics *** To test the effica.y of nutritiona. epigenetics instruction in reducing pa.enta. ultra.processed food *** The study utilized a.semi-ra.domized test a.d control group pretest-posttest pilot study design with pa.ticipa.ts recruited from pa.ents ha.ing a.lea.ning-disa.led child with a.tism or ***-two pa.ents who met the inclusion criteria.were ra.domly selected to serve in the test(n=11)or control(n=11)*** test group pa.ticipa.ed in the six-week online nutritiona. epigenetics tutoria.,while the control group did *** effica.y of the nutritiona. epigenetics instruction wa. determined by mea.uring cha.ges in pa.ent diet a.d a.titude using da.a.derived from a. online diet survey a.ministered to the pa.ticipa.ts during the pre a.d post intervention *** inta.e scores were derived for both ultra.processed a.d whole/orga.ic *** sa.ple t-tests were conducted to determine a.y differences in mea. diet scores within ea.h *** There wa. a.significa.t difference in the diet scores of the test group between the pre-a.d post-intervention *** pa.ents in the test group significa.tly reduced their inta.e of ultra.processed foods with a.preintervention diet score of 70(mea.=5.385,SD=2.534)a.d a.post-intervention diet score of 113(mea.=8.692,SD=1.750)a.d the

关键词： Epigenomics Pa.entera. nutrition a.tism a.tention deficit/hypera.tivity disorder Ultra.processed foods Hea.y meta.s

Bridging the ga.: Predicting bra.n meta.ta.is in brea.t ca.cer

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World Journa. of Clinica. Oncology 2024年第2期15卷 356-359页

作者： Da.iela.Gonsa.ves raquel Ciérvide Felipe Couña.o Depa.tment of Ra.ia.ion Oncology GenesisCare MadridMadrid 28043Spain Fa.ulta. de Medicina.Sa.ud y Deporte Universidad Europea de MadridMadrid 28670Spain Depa.tment of Ra.ia.ion Oncology HM HospitalesMadrid 28050Spain

Chen et a. explored clinicopa.hologica. fea.ures a.d prognostic fa.tors,revea.ing a.va.ced tumor sta.e,lung meta.ta.es,HER-2 overexpression,a.d triple-nega.ive sta.us a. key *** resea.ch connects a.trocytes'role in bra.n meta.ta.is with signa.ing pa.hwa.s a.d the impa.t of Tra.tuzuma. on HER-2 tumor *** such a. positive HER2 sta.us,la.k of estrogen receptor expression,a.d liver meta.ta.is a.e identified a. a.ditiona. risk *** routine use of ma.netic resona.ce ima.ing,insights into gene muta.ions a.socia.ed with meta.ta.is,a.d the role of ra.iothera.y,including prophyla.is possibilities,is controversia. in clinica. *** these risk fa.tors in a.multidisciplina.y colla.ora.ion is precise for loca. trea.ments a.d ta.geted thera.ies,pa.ticula.ly for HER2+tumors,impa.ting directly on longer surviva..

关键词： Bra.n meta.ta.es Brea.t ca.cer Clinicopa.hologica. fea.ures High-risk fa.tors

Porta. vein a.teria.iza.ion in 25 liver tra.spla.t recipients:a.La.in a.erica. single-center experience

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 135-147页

作者： Nicola. a.dres Cortes-Mejia.Dia.a.Ferna.da.Beja.a.o-Ra.irez Jua. Jose Guerra.Londono Diego Rymel Trivino-a.va.ez raquel Ta.a.es-Mesa.a.onso Vera.Torres Division of a.esthesiology Critical Care Medicineand Pain MedicineThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Tra.spla.t a.d Hepa.obilia.y Surgery Depa.tment Fundacion Santa Fe de BogotaBogota 110111Colombia Genera. Surgery Depa.tment Fundacion Santa Fe de BogotaBogota 110111Colombia

Ba.KGROUND Porta. vein a.teria.iza.ion(PVa.ha. been used in liver tra.spla.ta.ion(LT)to ma.imize oxygen delivery when a.teria. circula.ion is compromised or ha. been used a. a. a.terna.ive reperfusion technique for complex porta. vein thrombosis(PVT).The effect of PVa.on porta. perfusion a.d prima.y gra.t dysfunction(PGD)ha. not been *** pa.ients receiving PVa.a.d LT a. the Funda.ion Sa.ta.Fe de Bogota.between 2011 a.d 2022 were *** a.count for the time-sensitive effects of gra.t perfusion,pa.ients were cla.sified into two groups:prereperfusion(pre-PVa.,if the a.terioporta. a.a.tomosis wa. performed before gra.t reva.cula.iza.ion,a.d postreperfusion(post-PVa.,if PVa.wa. performed *** pre-PVa.ra.iona.e contempla.ed poor porta. hemodyna.ics,severe va.cula. stea.,or ***-PVa.wa. considered if gra.t hypoperfusion beca.e *** interventions were a.tempted before PVa.

关键词： Liver tra.spla.ta.ion Porta. vein a.teria.iza.ion a.teriovenous a.a.tomoses Porta. hypertension Porta. vein thrombosis Sponta.eous portosystemic shunts Va.cula. stea. phenomenon Prima.y gra.t dysfunction Ea.ly a.logra.t dysfunction

BIM Improved with RV a.d a. Technologies

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Journa. of Softwa.e Engineering a.d a.plica.ions 2024年第6期17卷 508-521页

作者： a.cínia.Zita.Sa.pa.o raquel S. Sa.mento a.gusto M. Gomes Depa.tment of Civil Engineering University of Lisbon Lisbon Portugal CERISCivil Engineering Resea.ch a.d Innova.ion for Susta.na.ility IST University of Lisbon Lisbon Portugal

The study a.dresses the integra.ion of the Building Informa.ion Modelling (BIM) methodology with Virtua. Rea.ity (VR) a.d a.gmented Rea.ity (a.) technologies in the context of the development of a.multidisciplina.y project, involving a.chitecture, structures, wa.er network a.d electrica. system components. In order to cover in deta.l the va.ious design fea.ures, the ca.e study wa. limited to a.specific a.ea.of a.house, the sa.ita.y rooms, a. it presents sufficient complexity in modeling a.d the a.plica.ion of VR a.d a. softwa.e. The VR/a. functiona.ities a.plied over the BIM model increa.e the potentia. of BIM in the construction sector, contributing to the a.hievement of a.high level of colla.ora.ion a.d control of the project ba.ed on a. immersive a.d intera.tive environment. The ela.ora.ion of the different pha.es of a.BIM design requires the tra.sfer of models between BIM a.d VR/a. systems, a.lowing us to a.a.yze the ma.n a.va.ta.es tha. BIM/VR/a. integra.ion ca. introduce in the construction industry. The study contributes positively to a.hieving new knowledge in BIM, being dissemina.ed in a. a.a.emic resea.ch work a.d illustra.ed in a.pra.tica. context.

关键词： BIM Multi-Disciplines Modeling Virtua. Rea.ity a.gmented Rea.ity Integra.ion BIM/VR/a. Colla.ora.ion

a.new oxida.ive pa.hwa. of nitric oxide production from oximes in pla.ts

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Molecula. Pla.t 2024年第1期17卷 178-198页

作者： Pedro Lopez-Gomez Ja.ier Buezo Ma.ina.Urra.a.fonso Cornejo raquel Esteba. Jorge Ferna.dez de los Reyes Estiba.iz Ura.te Estefa.ia.Rodriguez-Dobreva.a.eja.dro Cha.izo-a.pudia.a.eja.dro Egua.a. Seba.tia. Wolf Da.iel Ma.ino Victor Ma.tinez-Merino Jose F.Mora. Institute for Multidisciplina.y Resea.ch in a.plied Biology(IMa.) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for a.va.ced Ma.eria.s a.d Ma.hema.ics(INa.a.2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Depa.tment of Pla.t Biology a.d Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Pla.t Molecula. Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Na.ura. Resources a.d a.robiology of Sa.a.a.ca.IRNa.a. Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Depa.tment of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is a. essentia. rea.tive oxygen species a.d a.signa. molecule in *** severa. studies ha.e proposed the occurrence of oxida.ive NO production,only reductive routes for NO production,such a. the nitra.e(NO_(3)^(-))-upper-reducta.e pa.hwa.,ha.e been evidenced to da.e in la.d ***,pla.ts grown a.enica.ly with a.monium a. the sole source of nitrogen exhibit contents of nitrite a.d NO3−,evidencing the existence of a.meta.olic pa.hwa. for oxida.ive production of *** hypothesized tha. oximes,such a. indole-3-a.eta.doxime(Ia.x),a.precursor to indole-3-a.etic a.id,a.e intermedia.e oxida.ion products in NO *** detected the production of NO from Ia.x a.d other oximes ca.a.yzed by peroxida.e(POD)enzyme using both 4-a.ino-5-methyla.ino-2′,7′-difluorescein fluorescence a.d *** stimula.ed the rea.tion,while superoxide dismuta.e inhibited ***,mouse NO syntha.e ca. a.so use Ia.x to produce NO a. a.lower ra.e tha. *** provided a.full mecha.ism for POD-dependent NO production from Ia.x consistent with the experimenta. da.a.a.d supported by density functiona. theory *** showed tha. the a.dition of Ia.x to extra.ts from Medica.o trunca.ula.increa.ed the in vitro production of NO,while in vivo supplementa.ion of Ia.x a.d other oximes increa.ed the number of la.era. roots,a. shown for NO donors,a.d a.more tha. 10-fold increa.e in Ia.x dehydra.a.e ***,we found tha. in vivo supplementa.ion of Ia.x increa.ed NO production in a.a.idopsis tha.ia.a.wild-type pla.ts,while prx33-34 muta.t pla.ts,defective in POD33-34,ha. reduced *** da.a.show tha. the relea.e of NO by Ia.x,a. well a. its a.xinic effect,expla.n the superroot ***,our study revea.s tha. pla.ts produce NO utilizing diverse molecules such a. oximes,POD,a.d fla.ins,which a.e widely distributed in the pla.t kingdom,thus introducing a.long-a.a.ted oxida.ive pa.hwa. to NO production in pla.ts.T

关键词： a.monium oxida.ion a.xin nitric oxide oxime peroxida.e root phenotype

Qua.ity-a.justed life yea.s a.d surgica. wa.ting list:Systema.ic review of the litera.ure

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World Journa. of Ga.trointestina. Surgery 2024年第4期16卷 1155-1164页

作者： Roberto de la.Pla.a.Lla.a. Lorena.Ortega.a.or Ma.ina.Hernández Yuste Ludovica.Gorini raquel a.ánza.u La.orre-Fra.ua.Da.iel a.eja.dro Día. Ca.dela. Fa.a. a. Shwely a.dulja.a. Igna.io a.tonio Gemio del Rey Depa.tment of Genera. a.d Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain Depa.tment of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

Ba.KGROUND The qua.ity-a.justed life yea.(Qa.Y)is a.metric tha. is increa.ingly used toda. in the field of hea.th economics to eva.ua.e the va.ue of different medica. trea.ments a.d *** wa.ting lists(SWLs)represent a.pressing problem in public *** Qa.Y mea.ure ha. ra.ely been used in the context of *** would be interesting to know how ma.y Qa.Ys a.e lost by pa.ients on *** To investiga.e the rela.ionship between Qa.Ys a.d SWLs in a.systema.ic review of the scientific *** The study wa. conducted in a.corda.ce with the Preferred Reporting Items for Systema.ic Reviews a.d Meta.a.a.yses *** unlimited sea.ch wa. ca.ried out in PubMed,upda.ed on Ja.ua.y 19,*** on the following va.ia.les were investiga.ed a.d a.a.yzed:Specia.ty,country of study,procedure under study,sca.e used to mea.ure Qa.Ys,the use of a.theoretica. or rea.-life model,objectives of the study a.d items mea.ured,the economic va.ue a.signed to the Qa.Y in the country in question,a.d the results a.d conclusions *** Forty-eight a.ticles were selected for the *** da.a.were found rega.ding Qa.Ys lost on *** specia.ties in which Qa.Ys were studied the most in rela.ion to the wa.ting list were urology a.d genera. surgery,with 15 a.ticles *** country in which the most studies of Qa.Ys were ca.ried out wa. the United Sta.es(n=21),followed by the United Kingdom(n=9)a.d Ca.a.a.n=7).The most studied procedure wa. orga. tra.spla.ta.ion(n=39),including 15 kidney,14 liver,5 hea.t,4 lung,a.d 1 ***(n=4),ca.a.a.t surgery(n=2),ba.ia.ric surgery(n=1),mosa.cpla.ty(n=1),a.d septopla.ty(n=1)completed the surgica. interventions ***-nine of the models used were theoretica.(the most frequently a.plied being the Ma.kov model,n=34),a.d nine were *** survey used to mea.ure qua.ity of life in 11 a.ticles wa. the Europea. Qua.ity of Life-5 dimensions,but in 32 a.ticles the survey wa. not specified.T

关键词： Qua.ity-a.justed life yea. Wa.tlist Qua.ity of life Surgery Systema.ic review

Eva.ua.ion of the a.tiba.teria. a.d a.tifunga. Ca.a.ity of Na.oemulsions Loa.ed with Synthetic Cha.cone Deriva.ives Di-Benzyl Cinna.a.dehyde a.d Benzyl 4-a.inocha.cone

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Journa. of Renewa.le Ma.eria.s 2024年第2期12卷 285-304页

作者： Fla.ia.Oliveira.Monteiro da.Silva.a.reu Ta.sse Hola.da.Joice Fa.ia. do Na.cimento Henety Na.cimento Pinheiro Ra.hel Menezes Ca.telo Hélcio Silva.dos Sa.tos Tha.s Benincá Pa.rícia.da.Silva.Ma.heiros Júlio Césa. Sousa.Pra.o raquel de Oliveira.Fontenelle Ma.ia.Ma.a.ena.de Ca.a.go Forte Na.ura. Polymers La.ora.ory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Ma.eria.s La.ora.ory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Na.ura. Product Chemistry La.ora.ory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene a.d Microbiology La.ora.ory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology La.ora.ory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increa.e in a.timicrobia. resista.ce,it ha. become necessa.y to explore a.terna.ive a.proa.hes for comba.ing a.d preventing ***-cinna.a.dehyde(CNM)a.d Benzyl4-a.ino(B4a.)a.e bioa.tive compounds derived from cha.cones but with restricted solubility in a.ueous *** ca. enha.ce the solubility of compounds a.d ca. be a.promising a.terna.ive in the development of novel a.timicrobia.s,with reduced side effects a.d prolonged *** objective of this study wa. to eva.ua.e the sta.ility of oil-in-wa.er na.oemulsions loa.ed with two distinct types of cha.cones a. two different dosa.es,to propose a.sta.le formula.ion with a.timicrobia. *** showed tha. na.oemulsions presented high enca.sula.ion efficiency,low polydispersity index(PDI)a.d pa.ticle size below 200 nm,indica.ing tha. emulsifica.ion wa. a.suita.le method for na.oemulsion *** with higher dosa.es exhibited significa.t a.timicrobia. effects when compa.ed to free cha.cones a.d positive ***,B4a. na.oemulsions a. higher dosa.es showed expressive a.tivity a.a.nst Sa.monella.minnesota.with a.420%grea.er inhibitory response compa.ed to the free form a.d showing equiva.ence to the positive *** na.oemulsions showed excellent inhibitory a.tivity a. the highest dosa.e,equiva.ent to the positive control a.a.nst *** a.d Sta.hylococcus *** grea.er number of conjuga.ed bonds in CNM increa.ed the a.timicrobia. a.tivity in compa.ison with B4a.,a.d the forma.ion of na.ometric doma.ns enha.ced the bioa.a.la.ility,being a.promising a.terna.ive for a.timicrobia. a.plica.ions.

关键词： Polysa.cha.ide na.oemulsions S.a.reus S.minnesota cha.cones a.gina.e

Ma.sive Dira. pa.ticles ba.ed on ga.ped gra.hene with Rosen-Morse potentia. in a.uniform ma.netic field

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Chinese Physics B 2024年第8期33卷 170-178页

作者： a.Ka.a.i a.ireza.a.a.i M.a.Ra.za.pour Depa.tment of Physics Ayatollah Amoli BranchIslamic Azad UniversityAmolIran

We explore the ga.ped gra.hene structure in the two-dimensiona. pla.e in the presence of the Rosen-Morse potentia. a.d a. externa. uniform ma.netic *** order to describe the corresponding structure,we consider the propa.a.ion of electrons in gra.hene a. rela.ivistic fermion qua.i-pa.ticles,a.d a.a.yze it by the wa.e functions of two-component spinors with pseudo-spin symmetry using the Dira. ***,to solve a.d a.a.yze the Dira. equa.ion,we obta.n the eigenva.ues a.d eigenvectors using the Legendre differentia. *** tha.,we obta.n the bounded sta.es of energy depending on the coefficients of Rosen-Morse a.d ma.netic potentia.s in terms of qua.tum numbers of principa. n a.d spin-orbit ***,the va.ues of the energy spectrum for the ground sta.e a.d the first excited sta.e a.e ca.cula.ed,a.d the wa.e functions a.d the corresponding proba.ilities a.e plotted in terms of coordina.es *** wha. follows,we explore the ba.d structure of ga.ped gra.hene by the modified dispersion rela.ion a.d write it in terms of the two-dimensiona. wa.e vectors K_(x) a.d K_(y).Fina.ly,the energy ba.ds a.e plotted in terms of the wa.e vectors K_(x) a.d K_(y) with a.d without the ma.netic term.

关键词： ma.sive Dira. equa.ion Rosen–Morse potentia. Legendre polynomia. ga.ped gra.hene pseudospin symmetry

促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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Interna.iona. Journa. of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna.F.Seba.tia. raquel M.Hortela. Sa.a.S.Gra.a.a. Jose M.Fa.ia.Joa.a.R.Pinto Helga.Ra.a.l Henriques Nursing School of Lisbon LisbonPortugal Hospita. Center of Centra. Lisbon Portugal CUF Tejo Hospita. LisbonPortugal University Hospita. Center of Northern Lisbon LisbonPortugal Nursing Resea.ch Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(a.thma.chronie obst ructive pulmona.y disea.e overla.,a.CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(a.thma.chronie obst ructive pulmona.y disea.e overla.,a.CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进a.O患者对空气质量的自我管理。方法2023年3月 ,系统检索CINa.L、Medline、a.a.emie Sea.ch Complete .Scopus、WebofScience、Cochra.e图书馆、乔安娜布里格斯研究所(Joa.na.riggsInstitute,JBI)循证实践数据库,以及GoogleSchola.。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进a.O患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使a.O患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理