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Development and Evolution of the Size of Polygonal Fracture Systems during Fluid-Solid Separation in Clay-Rich Deposits

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Journal of Earth Science 2018年第6期29卷 1319-1334页

作者： Teodolina Lopez raphael antoine JoséDarrozes Michel Rabinowicz David Baratoux CESBIO Universite de ToulouseCNES/CNRS/IRD/UPSloulousePrance International Space Science Institute(ISSI) BernSwitzerland CEREMA Laboratoire Regional de RouenGroupe Sciences de la TerreCS 90245F-76121 Le Grand QuevillyFrance GET Universite de ToulouseUPS/CNRS/IRD/CNESToulouseFrance Institut Fondamental d'Afrique Noire(IFAN) Cheikh Anta DioDakarSenegal

In continental and oceanic conditions, clay-rich deposits are characterised by the development of polygonal fracture systems（PFS）. PFS can increase the vertical permeability of clay-rich deposits（mean permeability ≤10-16 m2） and are pathways for fluids. On continents, the width of PFS ranges from centimeters to hundreds of meters, while in oceanic contexts they are up to a few kilometers large. These structures are linked to water-solid separation during deposition, consolidation and complete fluid squeeze of the clay horizon. During the last few decades, modeling of melt migration in partially molten plastic rocks led to rigorous quantifications of two-phase flows with a particular emphasis on 2D and 3D induced flow structures. The numerical modeling shows that the melt migrates on distances almost equal to a few times the compaction length L that depends on permeability and viscosity. Consequently, polygonal structures in partially molten plastic rocks are resulted from the melt-rock separation and their sizes are proportional to L. Applying these results to fluid-solid separation in clay-rich horizons, we show that（1） centimetric to kilometric PFS are resulted from the dramatic increase of L during compaction and（2）, this process involves agglomerates with 100 μm to 1 mm size.

关键词： compaction clay deposit agglomerates polygonal fractures desiccation cracks

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Neonatal Risks of Vitamin D and Iodin Supplementations during Pregnancy

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Open Journal of Obstetrics and Gynecology 2019年第11期9卷 1443-1455页

作者： Catherine Lecoq raphael Serreau Midwife School Sorbonne Medicine University Saint-Antoine Hospital Paris France PARADICT-O Clinical Research Unit Orleans Metropole EA INSERM Psycomadd South Saclay Paris University Paris France

Background: The consumption of dietary supplements (DS) has increased by almost 10% last decade. This trend may be true also for pregnant women;however, it was reported that pregnant women do not sufficient and correct knowledge on nutritional needs during pregnancy. Thus, we here attempted to determine the French situation of how French pregnant women take DS and its social-clinical significance using questionnaires, with special reference to vitamin D (VD) overtaking. Materials and Methods: A prospective multi-centric study was performed in three maternities in Paris. One hundred-fifty questionnaires were administered to pregnant women by midwife. Results: Thirty-four patients were interviewed at the maternity ward of the Deaconesses, 61 at the Pitié-Salpêtrière and 55 at Armand Trousseau. During pregnancy, DS started mainly during the first trimester. Frequently, doctors initially prescribe them and women tended to continue to take them thereafter. Possible VD overdosage was observed. Conclusion: We here characterized French pregnant women in terms of DS during pregnancy and also, to our knowledge, for the first time emphasized the risk of vitamin D overdose during pregnancy in France. However, since the cumulative dose throughout the pregnancy was not determined here, definite conclusion of whether women really take overdose of this supplement may not be made. Women of higher socio-professional society tended to consume more DS during pregnancy, and, thus, further monitoring may be needed especially to this fraction of pregnant women.

关键词： Dietary Supplement (DS) Pregnancy Hypercalcemia Vitamin D (VD) Iodine

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Zebl represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1^(+) T cell development

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Cellular & Molecular Immunology 2021年第9期18卷 2140-2152页

作者： Jiang Zhang Melanie Wencker Quentin Marliac Aurore Berton Uzma Hasan raphael Schneider Daphne Laubreton Dylan E.Cherrier Anne-Laure Mathieu Amaury Rey Wenzheng Jiang Julie Caramel Laurent Genestier antoine Margais Jacqueline Marvel Yad Ghavi-Helm Thierry Walzer CIRI Centre International de Recherche en InfectiologieUniv LyonInsermU1111Universite Claude Bernard Lyon 1CNRSUMR5308ENS de LyonF-69007 LyonFrance Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina lnstitut de Genomique Fonctionnelle de Lyon CNRS UMR 5242Ecole Normale Superieure de LyonUniversity Claude Bernard Lyon 146 allée d'ltalieF-69364 LyonFrance CRCL Centre de Recherche sur le Cancer de LyonINSERM U1052—CNRS UMR5286Centre Léon BerardUniversity Claude Bernard Lyon 1LyonFrance

T cell development proceeds un der the in fluence of a n etwork of transcription factors(TFs).The precise role of Zeb1,a member of this network,remains ***,we report that Zeb1 expression is induced early during T cell development in CD4^(-)CD8^(-)double-negative(DN)stage 2(DN2).Zeb1 expression was further increased in the CD4^(+)CD8^(+)double-positive(DP)stage before decreasing in more mature T cell *** performed an exhaustive characterization of T cells in Cellophane mice that bear Zeb 7 hypomorphic *** Zebl mutation profoundly affected all thymic subsets,especially DN2 and DP ***1 promoted the survival and proliferation of both cell populations in a cell-intrinsic *** the periphery of Cellophane mice,the number of conventional T cells was near normal,but invariant NKT cells,NK1.1^(+)γδ T cells and Ly49^(+)CD8 T cells were virtually *** suggested that Zebl regulates the development of unconventional T cell types from DP progenitors.A transcriptomic analysis of WT and Cellophane DP cells revealed that Zebl regulated the expression of multiple genes involved in the cell cycle and TCR sign aling,which possibly occurred in cooperation with Tcf1 and *** deed,Cellophane DP cells displayed stron ger signaling than WT DP cells upon TCR engagement in terms of the calcium respons巳phosphorylation events,and expression of early ***,Zebl is a key regulator of the cell cycle and TCR signaling during thymic T cell *** propose that thymocyte selection is perturbed in Zeb7-mutated mice in a way that does not allow the survival of unconventional T cell subsets.

关键词： T cell selection TCR signaling Zebl transcription development

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阿基坦创意经济与文化中心

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城市环境设计 2019年第2期118卷 74-83页

作者： Alexander Codda Alicia Marie Sarah Borhardt Annette Birthe Jensen ?smund Skeie Aya Fibert Bartosz Kobylakiewicz Bernhard Touzet Brigitta Gulyás David Tao Edouard Champelle Espen Vik Greta Krenciute Greta Tafel Hyojin Lee Ivan Genov Jan Magasanik Jeffrey Mark Mikolajewski Karol Bogdan Borkowski Katarzyna Swiderska Kekoa Charlot Lorenzo Boddi Maria Teresa Fernandez Rojo Melissa Andres Michael Sch?nemann Jensen Nicolas Millot Ola Hariri Ole Dau Mortensen Pascale Julien Paul-antoine Lucas raphael Ciriani Santiago Palacio Villa Se Hyeon Kim Sebastian Liszka Seunghan Yeum Snorre Emanuel Nash J?rgensen Teresa Fernández Thiago De Almeida Thomas Jakobsen Randb?ll Yang Du Zoltan David Kalaszi Ivan Mata Laurent de Carniere 朱翰林

这栋建筑将三个文化机构融入其中:FRAC(阿基坦区当代艺术基金会)、ECLA(写作、音乐、电影和广播文化机构)和OARA(阿基坦区行为艺术家工作室)。现在它们被共同整合为阿基坦创意经济与文化中心,即MéCA文化中心。我们希望设计一栋可以将... 详细信息

这栋建筑将三个文化机构融入其中:FRAC(阿基坦区当代艺术基金会)、ECLA(写作、音乐、电影和广播文化机构)和OARA(阿基坦区行为艺术家工作室)。现在它们被共同整合为阿基坦创意经济与文化中心,即MéCA文化中心。我们希望设计一栋可以将波尔多滨水步道整合其中的建筑,允许公众生活路线从中穿过。

关键词：阿基坦波尔多城市客厅经济与文化

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