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Preparation of aripiprazole-poly(methyl vinyl ether-co-maleic anhydride)nanocomposites via supercritical antisolvent process for improved antidepression therapy

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Regenerative Biomaterials 2022年第1期9卷 917-927页

作者： Lin-Fei Chen Ying Chen You-Yu Duan Man-Man Zhang Pei-Yao Xu ranjith kumar kankala Shi-Bin Wang Ai-Zheng Chen College of Chemical Engineering Huaqiao UniversityXiamen 361021PR China Institute of Biomaterials and Tisszue Engineering Huaqiao UniversityXiamen 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamen 361021PR China

Aripiprazole(ARI),a second-generation atypical antipsychotic drug approved for schizophrenia treatment,shows good efficacy against ***,the poorly aqueous solubility of ARI leads to low bioavailability and increased dose-related side effects,seriously limiting its application in ***,we demonstrated the fabrication of ARI and poly(methyl vinyl etherco-maleic anhydride)(PVMMA)composite nanoparticles(PA NPs)using the supercritical antisolvent(SAS)process for enhancing its water-solubility and curative anti-depressant ***,the optimal experimental conditions(ARI/PVMMA mass ratio of 1:6,pressure of 10MPa,and solution flow rate of 0.75ml min^(-1))were determined by a 23 factorial experimental design,resulting in the PA NPs with an excellent particle *** vitro cell experiments showed that PA NPs significantly inhibited the inflammatory response caused by the microglia activation induced by lipopolysaccharide(LPS).Similarly,mice behavioral tests demonstrated that PA NPs significantly improved LPS-induced depression-like ***,compared with free ARI,the LPS-induced activation of microglia in the mouse brain and the expression of inflammatory factors in serum were significantly reduced after treatment with PA ***,the innovative PA NPs designed by SAS processmight provide a candidate for developing new ARI-based nano-formulations.

关键词： aripiprazole supercritical fluid technology antidepression new nano-formulation

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Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways

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Regenerative Biomaterials 2023年第1期10卷 574-589页

作者： Fengzhu Zhang Aiwen Zhang Youning Xie Haiying Wen ranjith kumar kankala Jing Huang Anjun Zhang Qi Wang Biaoqi Chen Haiyan Dong Zhao Guo Aizheng Chen Dayun Yang Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhou350108PR China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen361021PR China

Cancer metastasis is the primary cause of all cancer-related deaths due to the lack of effective targeted drugs that simultaneously block multiple signaling pathways that drive the dissemination and growth of cancer *** unique proline isomerase Pin1 activates numerous cancer pathways,but its role in cancer metastasis and the inhibitory efficacy of Pin1 inhibitors on cancer metastasis are ***,the applicability of Pin1 inhibitor-all-trans retinoic acid(ATRA)is limited due to its several ***,uniform ATRA-loaded polylactic acid-polyethylene glycol block copolymer nanoparticles(ATRA-NPs)with high encapsulation efficiency,good cellular uptake,excellent controlled release performance and pharmacokinetics are developed using supercritical carbon dioxide processing combined with an optimized ***-NPs exhibited excellent biosafety and significant inhibition on the growth and metastasis of hepatocellular ***1 played a key role in cancer metastasis and was the main target of ***-NPs exerted their potent anti-metastatic effect by inhibiting Pin1 and then simultaneously blocking multiple signaling pathways and cancer epithelial-mesenchymal *** ATRA-NPs could effectively couple the inhibition of cancer cell dissemination with cancer growth,it provided a novel therapeutic strategy for efficiently inhibiting cancer metastasis.

关键词： cancer metastasis targeted therapy Pin1 inhibitor nano delivery signaling pathway

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Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

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Regenerative Biomaterials 2022年第1期9卷 844-857页

作者： Pei-Yao Xu ranjith kumar kankala Yue-Wei Li Shi-Bin Wang Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian 361021PR China

Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic ***,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound ***,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS *** obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination ***,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound ***,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.

关键词： photothermal therapy supercritical carbon dioxide antibacterial antibiofilm wound healing

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3D bioprinting of conductive hydrogel for enhanced myogenic differentiation

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Regenerative Biomaterials 2021年第5期8卷 14-24页

作者： Ying Wang Qingshuai Wang Shengchang Luo Zhoujiang Chen Xiang Zheng ranjith kumar kankala Aizheng Chen Shibin Wang Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021P.R.China School of Pharmaceutical Engineering and Life Science Changzhou UniversityChangzhou 213164P.R.China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021P.R.China

Recently,hydrogels have gained enormous interest in three-dimensional(3D)bioprinting toward developing functional substitutes for tissue ***,it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted ***,we demonstrate the 3D bioprinting-assisted fabrication of a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene(PEDOT)nanoparticles(NPs)deposited in gelatin methacryloyl(GelMA)for enhanced myogenic differentiation of mouse myoblasts(C2C12 cells).Initially,PEDOT NPs are dispersed in the hydrogel uniformly to enhance the conductive property of the hydrogel ***,the incorporated PEDOT NPs showed minimal influence on the printing ability of ***,C2C12 cells are successfully encapsulated within GelMA/PEDOT conductive hydrogels using 3D extrusion ***,the proliferation,migration and differentiation efficacies of C2C12 cells in the highly conductive GelMA/PEDOT composite scaffolds are demonstrated using various in vitro investigations of live/dead staining,F-actin staining,desmin and myogenin immunofluorescence ***,the effects of electrical signals on the stimulation of the scaffolds are investigated toward the myogenic differentiation of C2C12 cells and the formation of myotubes in ***,our findings demonstrate that the fabrication of the conductive hydrogels provides a feasible approach for the encapsulation of cells and the regeneration of the muscle tissue.

关键词： 3D bioprinting conductive hydrogel electrical stimulation myoblasts myogenic differentiation

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Performances of fissured red sandstone after thermal treatment with constant-amplitude and low-cycle impacts

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 561-587页

作者： Yongjun Chen Tubing Yin P.G.ranjith Xibing Li Qiang Li Dengdeng Zhuang School of Resources and Safety Engineering Central South UniversityChangsha410083China Department of Civil Engineering Monash UniversityMelbourne3800Australia Oulu Mining School University of OuluOuluFI-90014Finland

In the engineering practices,it is increasingly common to encounter fractured rocks perturbed by temperatures and frequent dynamic *** this paper,the dynamic behaviors and fracture characteristics of red sandstone considering temperatures(25℃,200℃,400℃,600℃,and 800℃)and fissure angles(0°,30°,60°,and 90°)were evaluated under constant-amplitude and low-cycle(CALC)impacts actuated by a modified split Hopkinson pressure bar(SHPB)***,fracture morphology and second-order statistics within the grey-level co-occurrence matrix(GLCM)were examined using scanning electron microscopy(SEM).Meanwhile,the deep analysis and discussion of the mechanical response were conducted through the synchronous thermal analyzer(STA)test,numerical simulations,one-dimensional stress wave theory,and material *** multiple regression models between response variables and interactive effects of independent variables were established using the response surface method(RSM).The results demonstrate the fatigue strength and life diminish as temperatures rise and increase with increasing fissure angles,while the strain rate exhibits an inverse ***,the peak stress intensification and strain rate softening observed during CALC impact exhibit greater prominence at increased fissure *** failure is dominated by tensile damage with concise evolution paths and intergranular cracks as well as the compressor-crushed zone which may affect the failure mode after 400℃.The second-order statistics of GLCM in SEM images exhibit a considerable dependence on the ***,thermal damage dominated by thermal properties controls the material structure and wave impedance and eventually affects the incident wave *** tensile wave reflected from the fissure surface is the inherent mechanism responsible for the angle effect exhibited by the fatigue strength and ***,the peak stress intensification and strain rate softening during impact are determ

关键词： Red sandstone Temperature Fissure Constant-amplitude and low-cycle(CALC) impact Fatigue failure Response surface method(RSM)

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Bibliometric analysis of research challenges and trends in urban underground space

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Deep Underground Science and Engineering 2024年第2期3卷 207-215页

作者： You Zhang Liang Zheng Lingling He Yuyong Jiao Hanfa Peng ranjith PGamage Faculty of Engineering China University of GeosciencesWuhanChina Department of Civil Engineering Monash UniversityClaytonVictoriaAustralia Sinohydro Engineering Bureau Co. LtdPower ChinaXiningChina 4Wuhan Geomatic InstituteWuhanChina

The utilization and development of urban underground space play a crucial role in optimizing the layout of civic architecture and enhancing the urban ecological environment,which contributes toward increasing the overall carrying capacity and promoting sustainable development in *** delve into the research progress of urban underground space,knowledge maps were created using the information visualization software *** literature was systematically extracted from three prominent databases,namely,Web of Science,Scopus,and China National Knowledge *** to the bibliometric analysis of the co-citation and core words co-occurrence,the trends and challenges of research on urban underground space were *** highlighted by the results obtained,it still remains highly challenging to achieve interdisciplinary collaboration in urban underground space research;the research trends of urban underground space consist of collaborative planning and whole life cycle sustainable development,multisource geological data informatization and resource evaluation,infrastructure design optimization,and intelligent *** knowledge map,drawn using bibliometric methods,offers a quantitative analysis of literature retrieval across various *** is recognized as an essential tool for exploring and identifying challenges and trends in urban underground space.

关键词： bibliometric analysis knowledge groups urban underground space VOSviewer

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Reinforcement Learning in Process Industries:Review and Perspective

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 283-300页

作者： Oguzhan Dogru Junyao Xie Om Prakash ranjith Chiplunkar Jansen Soesanto Hongtian Chen Kirubakaran Velswamy Fadi Ibrahim Biao Huang Department of Chemical and Materials Engineering University of AlbertaEdmontonT6G 1H9Canada IEEE

This survey paper provides a review and perspective on intermediate and advanced reinforcement learning(RL)techniques in process industries. It offers a holistic approach by covering all levels of the process control hierarchy. The survey paper presents a comprehensive overview of RL algorithms,including fundamental concepts like Markov decision processes and different approaches to RL, such as value-based, policy-based, and actor-critic methods, while also discussing the relationship between classical control and RL. It further reviews the wide-ranging applications of RL in process industries, such as soft sensors, low-level control, high-level control, distributed process control, fault detection and fault tolerant control, optimization,planning, scheduling, and supply chain. The survey paper discusses the limitations and advantages, trends and new applications, and opportunities and future prospects for RL in process industries. Moreover, it highlights the need for a holistic approach in complex systems due to the growing importance of digitalization in the process industries.

关键词： Process control process systems engineering reinforcement learning

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纳米材料用于铁死亡联合治疗的研究进展

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化工进展 2023年第7期42卷 3684-3694页

作者：徐沛瑶陈标奇 kankala ranjith kumar 王士斌陈爱政华侨大学生物材料与组织工程研究所福建厦门361021 福建省生物化工技术重点实验室福建厦门361021

铁死亡作为一种新发现的调节性细胞死亡形式已成为新型的肿瘤治疗策略,然而复杂的肿瘤微环境及肿瘤部位特殊的病理微环境严重限制了铁死亡的治疗效果。将铁死亡与传统的抗肿瘤治疗方式结合,能提高治疗效率并减少毒副作用。为实现药物在... 详细信息

铁死亡作为一种新发现的调节性细胞死亡形式已成为新型的肿瘤治疗策略,然而复杂的肿瘤微环境及肿瘤部位特殊的病理微环境严重限制了铁死亡的治疗效果。将铁死亡与传统的抗肿瘤治疗方式结合,能提高治疗效率并减少毒副作用。为实现药物在肿瘤部位富集效果并发挥协同治疗效果,基于纳米材料的药物递送体系在抗肿瘤领域显示出广阔的临床应用前景和发展价值。本文首先介绍了不同种类纳米材料(铁基纳米材料及非铁基纳米材料)用于铁死亡协同肿瘤治疗的相关进展,归纳了铁死亡与多种治疗方法(包括化学治疗、光热治疗、光/声动力治疗、其他治疗方式等)协同治疗的相关研究;最后阐明了铁死亡协同肿瘤治疗的挑战,并指出确认铁死亡的具体抗癌机制、开发多功能纳米材料并探索高效协同治疗手段将是未来的研究方向。

关键词：纳米材料药物铁死亡自由基抗肿瘤

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Effect of samarium doping on structural, optical and magnetic properties of vertically aligned ZnO nanorod arrays

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Journal of Rare Earths 2017年第10期35卷 1002-1007页

作者： D.ranjith kumar K.S.ranjith L.R.Nivedita R.T.Rajendra kumar Department of Nanoscience and Technology Bharathiar University Coimbatore India Advanced Materials and Devices Laboratory (AMDL) Department of Physics Bharathiar University Coimbatore India

Samarium doped vertically aligned one dimensional ZnO nanorod（NR） arrays were grown by vapor phase transport（VPT） method through vapor solid（VS） growth process. Influence of different concentrations（0% to 8%） of Sm（all Sm contents in the paper are in mass fraction） on the ZnO NR arrays were investigated by X-ray diffraction（XRD）, field emission scanning electron microscopy（FESEM）, photoluminescence（PL）, Raman spectroscopy and vibrating sample magnetometry（VSM） techniques, respectively. X-ray diffraction studies revealed that the ZnO NR arrays were perfectly oriented along（002） crystallographic orientation with wurtzite crystal structure. Photoluminescence results showed an increase in oxygen vacancies due to increase in Sm doping. M-H curves revealed enhanced ferromagnetic behavior, and the magnetic moment values were 0.45, 0.363, 1.694, 3.613 and 2.197 emu/cm^3 for（0–8%） Sm doped ZnO NR arrays respectively. The curve revealed that paramagnetic behavior was observed for undoped ZnO NR arrays and on increasing the Sm dopant to 4%, paramagnetic switched to ferromagnetic behavior.

关键词： Sm doped ZnO room temperature ferromagnetism(RTFM) defects rare earths

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The growth of biopolymers and natural earthen sources as membrane/separator materials for microbial fuel cells:A comprehensive review

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Journal of Energy Chemistry 2023年第5期80卷 402-431,I0010页

作者： Gowthami Palanisamy Sadhasivam Thangarasu ranjith kumar Dharman Chandrashekar S.Patil Thakur Prithvi Pal Singh Negi Mahaveer D.Kurkuri ranjith Krishna Pai Tae Hwan Oh School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Centre for Research in Functional Materials(CRFM) JAIN(Deemed-to-be University)Jain Global CampusBengaluru 562112KarnatakaIndia Technology Mission Division-(Energy&Water) Department of Science and Technology(DST)Ministry of Science and Technology-Govt.of IndiaNew Delhi 110016India

Microbial fuel cell(MFC)technology has emerged as an effective solution for energy insecurity and ***,identifying suitable components(particularly separators or membranes)with the required properties,such as low cost and high performance,remains challenging and restricts practical *** membranes,such as Nafion,exhibit excellent performance in ***,these membranes have high production costs,which considerably increase the overall MFC unit cell *** the numerous types,the separators or membranes developed from biopolymers and naturally occurring earthen sources have proven to be a novel and efficient concept due to their natural abundance,cost-effectiveness(approximately$20 m^(-2),$5 m^(-2),and$1 kg-1for biopolymers,ceramics,and earthensources,respectively),structural properties,proton transportation,manufacturing and modification ease,and environmental *** this review,we emphasize cost-effective renewable green materials(biopolymers,bio-derived materials,and naturally occurring soil,clay,ceramics or minerals)for MFC applications for the first *** with good thermal,mechanical,and water retention properties,sustainability,and environmental friendliness,such as cellulose and chitosan,are typically ***,the modification or introduction of various functional groups in biopolymers to enhance their functional properties and scale MFC power density is ***,separator/membrane development using various bio-sources(such as coconut shells,banana peels,chicken feathers,and tea waste ash)is ***,naturally occurring sources such as clay,montmorillonite,and soils(including red,black,rice-husk,and Kalporgan soil)for MFC were *** conclusion,the existing gap in MFC technology was filled by providing recommendations for future aspects based on the barriers in cost,environment,and characteristics.

关键词： Biomembrane Bioseparator Microbial fuel cell Energy harvesting Bioenergy Wastewater treatment

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