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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANk.

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj k.mar Babu Sameer Maharana Satyaranjan Chhatria Dibya ranjan Sahoo Ashirbad Nanda Satish k.nhar Prativa k.ehera Sanjib Mohanty Pradeep k.mar Naik.Praveen k.shore sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANk.(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-lik. cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

A review on recent advancements in biodegradable Mg-Ca alloys

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Journal of Magnesium and Alloys 2022年第8期10卷 2094-2117页

作者： Manas ranjan sahu T.S.Sampath k.mar Uday Chak.ingal Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India

The binary Mg-Ca alloys are drawing increasing attention as temporary implant materials because of their excellent biocompatibility,biodegradability, and good mechanical properties. However, their applications are limited due to their high degradation rates in the human physiological environment, the consequent release of hydrogen gas, and rapid loss in mechanical properties. Furthermore, biocompatibility depends upon the degradability of the material. Various researchers have demonstrated that these issues can be addressed by control of Ca content, thermo-mechanical processing to obtain suitable microstructures, deposition of surface coatings, etc. In this manuscript, a detailed review of published literature on Mg-Ca alloys is presented. The challenges and future directions of research in this area are also described.

关键词： Mg-Ca alloy Degradation Temporary implant Biocompatibility

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Application of quasi-oppositional symbiotic organisms search based extreme learning machine for stock.mark.t prediction

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International Journal of Intelligent Computing and Cybernetics 2019年第2期12卷 175-193页

作者： Smita Rath Binod k.mar sahu Manoj ranjan Nayak Institute of Technical Education and Research Siksha O Anusandhan UniversityBhubaneswarIndia

Purpose–Forecasting of stock.indices is a challenging issue because stock.data are dynamic,non-linear and uncertain in *** of an accurate forecasting model is very much essential to predict the next-day closing prices of the stock.*** purpose of this paper is to develop an efficient and accurate forecasting model to predict the next-day closing prices of seven stock.***/methodology/approach–A novel strategy called quasi-oppositional symbiotic organisms search-based extreme learning machine(QSOS-ELM)is proposed to forecast the next-day closing prices *** in the prediction of closing price depends on output weights which are dependent on input weights and *** paper mainly deals with the optimal design of input weights and biases of the ELM prediction model using QSOS and SOS optimization ***–Simulation is carried out on seven stock.indices,and performance analysis of QSOS-ELM and SOS-ELM prediction models is done by tak.ng various statistical measures such as mean square error,mean absolute percentage error,accuracy and paired sample *** performance analysis reveals that the QSOS-ELM model outperforms the SOS-ELM model in predicting the next-day closing prices more accurately for all the seven stock.indices under ***/value–The QSOS-ELM prediction model and SOS-ELM are developed for the first time to predict the next-day closing prices of various stock.*** paired t-test is also carried out for the first time in literature to hypothetically prove that there is a zero mean difference between the predicted and actual closing prices.

关键词： Extreme learning machine Symbiotic organisms search Quasi-oppositional-based learning,Paired sample t-test

Fracture Union in Closed Interlock.ng Nail in Humera Shaft Fractures

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Chinese Medical Journal 2015年第11期 1428-1432页

作者： Ramji Lal sahu Raini ranjan Ajay Lal Department of Orthopaedics SMS and RI Sharda University Greater Noida Uttar Pradesh India

Back.round： Fracture shaft humerus is a major cause of morbidity in patients with upper extremity injuries. The aim of this study was to evaluate the outcome of interlock.ng nail in humeral shaft fractures. Methods： This study was conducted in the Department of Orthopedic Surgery in SMS and R Sharda University from January 2010 to November 2013. Seventy-eight patients were recruited from emergency and out-patient department having a close fracture of humerus shaft. All patients were operated under general anesthesia and closed reamed interlock.ng nailing was done. All patients were followed for 9 months. Results： Out of 78 patients, 69 patients underwent union in 90-150 days with a mean of I 10.68 days. Complications found in four patients who had nonunion, and five patients had delayed union, which was treated with bone grafting. All the patients were assessed clinically and radiologically for fracture healing joint movements and implant thilure. The results were excellent in 88.46% and good in 6.41% patients. Complete subjective, functional, and clinical recovery had occurred in almost 100% of the patients. ConcLusions： The results of the present study indicates that in the presence of proper indications, reamed antegrade intramedullary interlock.d nailing appears to be a method of choice for internal fixation ofosteoporotic and pathologic fractures.

关键词： Bone Grafting Close Reamed Interlock.ng Nail Humeral Shaft Fractures Union

Fracture Union in Closed Interlock.ng Nail in Humeral Shaft Fractures

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中华医学杂志(英文版) 2015年第11期128卷 1428-1432页

作者： sahu Ramji Lal ranjan Rajni Lal Ajay Department of Orthopaedics SMS and RI Sharda University Greater Noida Uttar Pradesh India

Back.round: Fracture shaft humerus is a major cause of morbidity in patients with upper extremity injuries. The aim of this study was to evaluate the outcome of interlock.ng nail in humeral shaft ***: This study was conducted in the Department of Orthopedic Surgery in SMS and R Sharda University from January 2010 to November 2013. Seventy-eight patients were recruited from emergency and out-patient department having a close fracture of humerus shaft. All patients were operated under general anesthesia and closed reamed interlock.ng nailing was done. All patients were followed for 9 ***: Out of 78 patients, 69 patients underwent union in 90–150 days with a mean of 110.68 days. Complications found in four patients who had nonunion, and five patients had delayed union, which was treated with bone grafting. All the patients were assessed clinically and radiologically for fracture healing, joint movements and implant failure. The results were excellent in 88.46% and good in 6.41% patients. Complete subjective, functional, and clinical recovery had occurred in almost 100% of the ***: The results of the present study indicates that in the presence of proper indications, reamed antegrade intramedullary interlock.d nailing appears to be a method of choice for internal fixation of osteoporotic and pathologic fractures.

关键词： Bone Grafting Close Reamed Interlock.ng Nail Humeral Shaft Fractures Union

Fracture union in percutaneous k.rschner wire fixation in paediatric tibial shaft fractures

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Chinese Journal of Traumatology 2016年第6期19卷 353-357页

作者： Ramji Lal sahu Rajni ranjan Department of Orthopaedics SMS&R Sharda University Creater Noida UP India

Purpose： To evaluate the efficacy of intramedullary k.rschner wires for the treatment of unstable tibial shaft fractures in children. Methods： This prospective study was conducted at the Department of Orthopaedic Surgery in Maharishi Mark.ndeshwar Medical College from June 2005 to June 2010. Sixty-six children having closed fracture of the tibial shaft with a mean age of 7.7 years （range, 2-14 years） were recruited from emergency and outpatient department. They were treated with percutaneous intramedullary k.rschner wires. The clinical results of our study were rated on the basis of the criteria of union, nonunion, delayed union or malunion. All children were followed for one year. Results： Children achieved union in a mean time of 8 week. （range, 6-10 week.）. Postoperatively, three children （4.55%） had delayed union, one （1.52%） valgus deformity of lower leg, three （4.55%） post- operative k.ee pain and twelve （18.18%） sk.n irritation at pin site. Wires were removed after 8-22 week. without any complications. No patient was lost to follow-up. The results were excellent in 95.45% and good in 4.55% children. Conclusion： This technique is cost-effective, simple, quick.to perform, safe and reliable and avoids pro- longed hospitalization with good results.

关键词： k.rschner wires Tibial shaft fractures Children

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Effect of Exercise on NAFLD and Its Risk.Factors:Comparison of Moderate versus Low Intensity Exercise

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 120-126页

作者： Preetam Nath Manas k.mar Panigrahi Manoj k.mar sahu Jimmy Narayan ranjan k.mar Sahoo Ananya Apurba Patra Satyaswarup Jena Arun k.mar Patnaik.Anjan Jena Shivaram Prasad Singh Department of Gastroenterology&Hepatology Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology All India Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology IMS and SUM HospitalBhubaneswarOdishaIndia Department of Radiodiagnosis&Imaging Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Radiology IMS and SUM HospitalBhubaneswarOdishaIndia Dispensary Biju Patnaik State Police AcademyBhubaneswarOdishaIndia Department of Gastroenterology S.C.B.Medical College753007 CuttackOdishaIndia

Back.round and Aims: Lifestyle (exercise and dietary) modification is the mainstay of treatment for non-alcoholic fatty liver disease (NAFLD). However, there is paucity of data on effect of intensity of exercise in management of NAFLD, and we aimed to study the effect of variable intensities of exercise on NAFLD. Methods: The study was performed in the Department of Gastroenterology of the SCB Medical Col-lege, Cuttack.and the Biju Patnaik.State Police Academy, Bhu-baneswar. The subjects were police trainees [18 in a moderate intensity exercise group (MIG) and 19 in a low in-tensity exercise group (LIG)] recruited for a 6-month physical training course (261.8 k.alorie, 3.6 metabolic equivalent in MIG and 153.6 k.alorie, 2.1 metabolic equivalent in LIG). NAFLD was diagnosed by ultrasonography, with exclusion of all secondary causes of steatosis. All participants were eval-uated by anthropometry (weight, height, body mass index (BMI), waist circumference), assessed for blood pressure and biochemical parameters (blood glucose, liver function test, lipid profile, serum insulin), and subjected to transabdo-minal ultrasonography before and after 6 months of physical training, and the results were compared. Results: Both the groups had similar BMI, fasting plasma glucose, AST, gamma-glutamyl transpeptidase, insulin, and homeostatic model as-sessment-insulin resistance (k.own as HOMA-IR) (p>0.05). However, subjects in the LIG were older and had lower alanine transaminase, higher triglycerides and lower high-density lip-oproteins than MIG subjects. There was a significant reduc-tion in BMI (27.0±2.1 to 26.8±2.0;p=0.001), fasting blood glucose (106.7±21.6 to 85.8±19.0;p<0.001), serum trigly-cerides (167.5±56.7 to 124.6±63.5;p=0.017), total choles-terol (216.8±29.2 to 196.7±26.6;p=0.037), low-density lipoprotein cholesterol (134.6±21.4 to 130.5±21.9;p=0.010), serum aspartate transaminase (39.3±32.2 to 30.9±11.4;p<0.001), serum alanine transaminase (56.6 ±28.7 to 33.0±11.3;p<0.

关键词： Exercise NAFLD Intensity Physical activity

Compact Metamaterial Microstrip Low-Pass Filter

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Journal of Electromagnetic Analysis and Applications 2011年第10期3卷 399-405页

作者： Sudhak.r sahu Rabindra k.shore Mishra Dipak.ranjan Poddar 不详

Complimentary hexagonal-omega structures are used to design compact, low insertion loss (IL), low pass filter with sharp cut-off. It has been designed for improvement of roll-off performance based on both μ and ε negative property of the complimentary hex-omega structure while maintaining the filter pass-band performance. By properly designing and loading the hexagonal-omega structure in the ground of microstrip line not only improve the roll-off of the low pass filter, but also reduced the filter size. The simulated results indicate that the proposed filter achieves a flat pass band with no ripples as well as selectivity of 19.68 dB/GHz, corresponding to 5-unit cells hex-omega structures. This significantly exceeds the 5.6 dB/GHz selectivity of the conventional low pass filter design, due to sub-lambda dimensions of the hex-omega structure. A prototype filter implementing area is: 0.712λg x 0.263λg, λg being the guided wavelength at 3-dB cut-off frequency (fc). The proposed filter has a size smaller by 36.2%.

关键词： Hex-Omega Structure Microstrip Low-Pass Filter Metamaterial Sharp Cut-Off

Glomus tympanicum removal using transcanal endoscopic assisted surgery:An experience with six cases

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World Journal of Otorhinolaryngology-Head and Neck.Surgery 2023年第4期9卷 302-307页

作者： Pradipt ranjan Sahoo Monalisa sahu Imran Wasfi k.an k.bik.nta Samantaray Department of ENT and Head and Neck.Surgery Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Infectious Diseases Yashoda HospitalsHyderabadIndia

Objective:To evaluate an endoscopic approach in the management of glomus tumor,and also to investigate and evaluate its appropriateness and ***:Glomus tumors,also k.own as paragangliomas,are benign primary tumors of the middle *** advent of endoscopic ear surgery has provided new dimensions to the management of this highly vascular *** analysis of six patients of glomus tympanicum,operated between July 2014 and June 2019,with modified Fisch classification Type A and B1,who were managed by a retroauricular transcanal endoscopic *** and postoperative analysis was done for these ***:The chief complaint was pulsatile tinnitus,which disappeared in five cases and reduced in severity in one of *** was improved with reduction in air‐bone gap in all the *** major complications or recurrence were observed in any of the patients after 12 months of follow‐***:This endoscopic approach serves as a safe and reliable technique for tumor *** thus provides postoperative comfort for most of the patients.

关键词： glomus tumor glomus tympanicum pulsatile tinnitus transcanal endoscopic tympanic paraganglioma

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