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Low-cost,simple,and scalable self-assembly of DNA origami nanostructures

Nano Research 2019年第5期12卷 1207-1215页

作者： Patrick D.Halley randy a.patton Amjad Chowdhury John C.Byrd Carlos E.Castro Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA Division of Hematology Department of Internal Medicineand OSU Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH 43210USA Biophysics Graduate Program The Ohio State UniversityColumbusOH 43210USA

Despite demonstrating exciting potential for applications such as drug delivery and biosensing,the development of nanodevices for practical applications and broader use in research and education are still hindered by the time,effort,and cost associated with DNA origami *** and robust methods to perform and scale the DNA origami self-assembly process are critical to facilitate broader use and translation to industrial or clinical *** report a simple approach to fold DNA origami nanostructures that is fast,robust,and *** demonstrate fabrication at scales approximately 100-1,500-fold higher than typical *** further demonstrate an approach we termed low-cost efficient annealing (LEAN) self-assembly involving initial heating at 65 ℃ for 10 min,then annealing at 51 ℃ for 2 h,followed by brief quenching at 4 ℃ that leads to effective assembly of a range of DNA origami structures *** contrast to other methods for scaling DNA origami assembly,this approach can be carried out using cheap and widely available equipment (e.g.,hot plates,water baths,and laboratory burners) and uses standard recipes and materials so is readily applied to any existing or new DNA origami *** envision these methods can facilitate device development for commercial applications and facilitate broader use of DNA origami in research and education.

关键词： DNA origami DNA nanotechnology self assembly scalable nanofabrication low cost fabrication nanotechnology education

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