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In-silico and in-vitro evaluation of docetaxel and berberine as potential p53 modulating apoptotic inducers in oral squamous cell carcinoma

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 530-540页

作者： Smrutipragnya Samal Rajesh kumar Meher Debasmita Dubey Showkat Ahmad Mir Binata Nayak Mahesh Chandra Sahu Pradeep kumar Naik Goutam Rath santosh kumar Swain Department of Otorhinolaryngology and Head and Neck Surgery IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyotiviharBurlaSambalpurOdishaIndia Medical Research Laboratory IMS and SUM HospitalSiksha‘O’Anusandhan Deemed to be UniversityK8Kalinga NagarBhubaneswar-751003OdishaIndia School of Life Sciences Sambalpur UnivesityJyotiviharBurlaSambalpurOdishaIndia ICMR-Regional Medical Research Centre ChandrasekharpurBhubaneswar-751023India School of Pharmaceutical Sciences Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar-751030India

Objective:To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell ***:The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were *** studies were performed to determine any toxic impact of the drugs on the vital organs of tested ***:In silico results revealed the molecular interaction of docetaxel and berberine with p53 and the molecules were found to be potential p53 *** and berberine inhibited the proliferation of cancer cells in a concentration-dependent *** cytometry analysis revealed that docetaxel and berberine at IC50 concentrations upregulated the expression of p53 in oral squamous cell carcinoma cells,thus triggering apoptotic cell *** addition,no toxicity was observed in the liver and kidney tissues of mice after docetaxel and berberine ***:Docetaxel and berberine significantly suppressed the proliferation of oral cancer cells by activating p53 expression and causing apoptotic cell *** compounds can be potential agents for the treatment of oral cancer,with little to no toxicity at the tissue level.

关键词： Docetaxel Berberine PC-3 OVCAR-3 OSCC SCC-29B p53 Anticancer Apoptosis

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Exploring the dynamics of a Holling-Tanner model with cannibalism in both predator and prey population

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International Journal of Biomathematics 2018年第1期11卷 225-253页

作者： Aladeen Al Basheer rana D. Parshad Emmanuel Quansah Shengbin Yu Ranjit kumar Upadhyay Mathematics Department The University of Georgia 240A Riverbend Rd Athens GA 30602 USA Department of Mathematics Clarkson University Potsdam New York 13699 USA Pacific Source Health PlansSpringfield Oregon 97477 USA Department of Basic Teaching and ResearchYango University Fuzhou Fujian 350015 P. R. China Department of Applied MathematicsIndian Institute of Technology (ISM) Dhanbad 826004 Jharkhand India

Cannibalism is an intriguing life history trait, that has been considered primarily in the predator, in predator-prey population models. Recent experimental evidence shows that prey cannibalism can have a significant impact on predator-prey population dyna- mics in natural communities. Motivated by these experimental results, we investigate a ratio-dependent Holling-Tanner model, where cannibalism occurs simultaneously in both the predator and prey species. We show that depending on parameters, whilst prey or predator cannibalism acting alone leads to instability, their joint effect can actually stabilize the unstable interior equilibrium. Furthermore, in the spatially explicit model, we find that depending on parameters, prey and predator cannibalism acting jointly can cause spatial patterns to form, while not so acting individually. We discuss ecologicalconsequences of these findings in light of food chain dynamics, invasive species control and climate change.

关键词： Holling-Tanner model prey cannibalism predator cannibalism stability global attraction Turing instability.

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Gold Nanorod, an Optical Probe to Track HIV Infection

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Journal of Sensor Technology 2012年第1期2卷 38-47页

作者： santosh kumar Department of Applied Sciences Radha Govind Engineering College Meerut India

Infectious diseases caused by the human immunodeficiency virus (HIV) remain the leading killers of human beings worldwide, and function to destabilize societies in Africa, Asia and the Middle East. Driven by the need to detect the presence of HIV viral sequence, here we demonstrate that the second order nonlinear optical (NLO) properties of gold nanorods can be used for screening HIV-1 viral DNA sequence without any modification, with good sensitivity (100 pico-molar) and selectivity (single base pair mismatch). The hyper Rayleigh Scattering (HRS) intensity increases 58 times when label-free 145-mer, ss-gag gene DNA, was hybridized with 100 pM target DNA. The mechanism of HRS intensity change has been discussed with experimental evidence for higher multipolar contribution to the NLO response of gold nanorods.

关键词： HRS Nanomaterial HIV

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New Convenient Synthesis of 8-C-Methylated Homoisoflavones and Analysis of Their Structure by NMR and Tandem Mass Spectrometry

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International Journal of Organic Chemistry 2021年第1期11卷 46-54页

作者： santosh kumar Yadav Department of Organic Chemistry & FDW Andhra University Visakhapatnam India DMPK Sai Life Sciences Ltd. Pune Maharashtra India

Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and biological evaluation. Author’s current objective is to synthesize 8-C-Methylated homoisoflavones by the reaction of 3-C-methylated dihydrochalcones with N,N’-dimethyl (chloromethylene) ammonium chloride generated in situ from DMF and PCl5 for one carbon extension at about room temperature. The 3-C-methylated dihydrochalcones were synthesized by the reduction of 3-C-methylated chalcones, which were prepared from 3-C-methylated acetophenones and aromatic aldehydes in the presence of base. All the synthesized novel homoisoflavones’s structures were characterized by NMR and Tandem Mass Spectrometry.

关键词： 8-C-Methylated Homoisoflavones 3-C-Methylated Dihydrochalcones 3-C-Methylated Chalcones 3-C-Methylated Acetophenones Dimethylformamide BF3·Et2O PCl5

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Equilibrium Positions of a Cable-Connected Satellites System under Several Influences

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International Journal of Astronomy and Astrophysics 2016年第3期6卷 288-292页

作者： santosh kumar Sangam kumar P. G. Department of Physics L. S. College B. R. A. Bihar University Muzaffarpur Bihar India

The present paper deals with the study of equilibrium positions of the motion of a system of two artificial satellites connected by a light, flexible, inextensible and non-conducting cable under the influence of solar radiation pressure, earth’s oblateness, shadow of the earth and air resistance. Here, we study the case of circular orbit of the centre of mass of the system. We derive differential equations of motion of the system. General solutions of the differential equations are beyond the reach. On the other hand, the general solutions do not serve our purpose. Jacobian integral of the system has also been obtained. Thereafter equilibrium positions of the motion of the system have been obtained.

关键词： Equilibrium Positions Two Cable-Connected Satellites Circular Orbit

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Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 20-32页

作者： Prem Prakash Kushwaha santosh kumar Maurya Amit Singh kumari Sunita Prajapati Atul kumar Singh Mohd Shuaib Shashank kumar Molecular Signaling&Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India Department of Computational Sciences Central University of PunjabBathinda 151401India.

Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(***)***:Several previous studies and databases were used to retrieve the ligands and target protein *** molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics ***:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter *** score analysis revealed that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead ***:The in-silico study demonstrated that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings.

关键词： Cancer drug resistance ABC-transporter natural inhibitors Bulbine frutescens MM-GBSA

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Inguinoscrotal region as an unusual site of extra-pancreatic collections in infected pancreatic necrosis

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Gastroenterology Report 2016年第3期4卷 246-250,I0003页

作者： Saurabh Kalia Rahul Gupta Sunil DShenvi Hemanth kumar Rajesh Gupta Mandeep Kang Surinder Singh rana Deepak kumar Bhasin Rajinder Singh Surgical Gastroenterology Division Department of General SurgeryPostgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Radiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Severe acute pancreatitis often leads to pancreatic and peripancreatic collections but,rarely,it can lead to collections at sites remote from the *** male patients presented with abdominal pain and inguinoscrotal *** were initially misdiagnosed with obstructed inguinal hernia,epididymo-orchitis and hydrocele,***,their diagnosis of acute pancreatitis was revealed on laparotomy in one patient and on computed tomography(CT)in the remaining two *** these cases had extensive peripancreatic necrosis and paracolic collections tracking along the psoas muscle,downwards towards the *** collections were initially managed by percutaneous drainage and saline irrigation as a part of the‘step-up’*** of these patients required open necrosectomy,while all required incision and drainage of inguinoscrotal *** the patients were discharged in satisfactory *** swelling is unusual as a first presentation of acute pancreatitis.A high index of suspicion,with careful study of patient’s history and examination along with CT,may provide an accurate *** drainage may be required to control sepsis and also provide an egress route for intra-abdominal collections.

关键词： acute pancreatitis inguinoscrotal collections step-up approach necrosectomy

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Protein Precipitation to Remove Carbohydrates that Interfere in Protein-Bound Tryptophan Quantification in Soybean Seeds

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Journal of Analysis and Testing 2020年第3期4卷 238-247页

作者： Zhentian Lei santosh kumar Saurav J.Sarma Ritesh kumar Barbara W.Sumner Minviluz G.Stacey Lloyd W.Sumner University of Missouri Metabolomics Center ColumbiaMO 65211USA Division of Biochemistry University of MissouriColumbiaMO 65211USA Division of Plant Sciences University of MissouriColumbiaMO 65211USA

Tryptophan is one of the nine essential amino acids in humans that can only be obtained through diets and *** is a precursor to many biological processes,such as serotonin,melatonin,kynurenin,and niacin(nicotinamide)vitamin *** content of tryptophan in foods,such as soybean is an important indicator of nutritional ***,accurate quantification of tryptophan in soybean is crucial to soybean nutritional *** of soybean protein-bound amino acids first involves acid hydrolysis of total protein to liberate amino ***,tryptophan quantification following acid hydrolysis is difficult or impossible due to its reactions with soybean ***,removal of carbohydrates from soy proteins prior to acid hydrolysis is *** this study,we compared four common protein precipitation methods(i.e.,methanol,acetonitrile,acetone,and trichloroacetic acid(TCA)protein precipitation methods)to determine the best method to separate soy proteins from carbohydrates,and concluded that acetone provided the highest recovery of soy *** content in the precipitated proteins was determined after acid hydrolysis of the proteins using liquid chromatography-tandem mass spectrometry multiple reaction monitoring(LC-MS/MS-MRM).No significant difference in the tryptophan content was found among proteins precipitated with methanol,acetonitrile,and TCA,suggesting that these precipitated proteins have similar compositions.A slightly lower,but statistically significant tryptophan content was found in the acetonitrile-precipitated proteins,suggesting that these proteins contain slightly higher glycosylated proteins.

关键词： Tryptophan Acid hydrolysis LC-MS/MS MRM Soybean seeds Protein precipitation

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An unusual cause of simultaneous common bile and pancreatic duct dilation

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Gastroenterology Report 2015年第3期3卷 258-261页

作者： Puneet Chhabra Surinder Singh rana Vishal Sharma Ravi Sharma Rajesh Gupta Deepak kumar Bhasin Department of Gastroenterology Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia Department of Surgery Postgraduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Simultaneous dilation of both the common bile duct and the pancreatic duct(double-duct sign)is usually because of ampullary or pancreatic *** we report an unusual cause of double-duct dilation;we describe the case of a 49-year-old female who developed afferent loop syndrome after pylorus-preserving pancreaticoduodenectomy:crosssectional imaging of the abdomen revealed a double-duct sign.

关键词： afferent loop syndrome pylorus preserving pancreaticoduodenectomy

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Conquering new battlegrounds:Successful management of isolated giant retrovesical hydatid cyst with robotic assistance

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Asian Journal of Urology 2021年第3期8卷 327-331页

作者： santosh kumar Abhishek Chandna Vignesh Manoharan Kalpesh M.Parmar Subhajit Mandal Department of Urology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Hydatid disease(HD)is an accidental human parasitic infestation by cestodes and is most commonly caused by Echinococcus *** happens to be the most common site of involvement,although involvement of other organ symptoms is not *** of the retrovesical pouch by hydatidosis is generally secondary in nature with an incidence of 0.1%-0.5%*** retrovesical hydatid cyst(RVHC)is extremely rare with only few cases in existing *** can present with a wide gamut of symptoms ranging from asymptomatic to obstructive uropathy.A 38-year-old male presented to us with complaints of lower urinary tract symptoms(LUTS)and was found to have an isolated primary retrovesical hydatid cyst on *** RVHC had compressed the right ureter leading to a grossly hydronephrotic non-functional right *** patient was started on albendazole therapy and underwent robot assisted right nephroureterectomy and partial pericystectomy for the *** postoperative period was uneventful with resolution of *** report highlights the various clinical presentations of RVHC as well as the minimal invasive management of this rare entity.

关键词： Retrovesical hydatid cyst Robotic pericystectomy Hydatid disease

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