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Genetic variability and trait association analysis in linseed(Linum usitatissimum L.)for yield and related traits

Oil Crop Science 2024年第3期9卷 151-159页

作者： Sandeep kumar Yadav Neha Singh Hemant kumar Yadav CSIR-National Botanical Research Institute Rana Pratap MargLucknow226001UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India State Planning Commission LucknowUPIndia

Diversity information mining about a crop for different attributes is an essential step for effective breeding *** present investigation evaluates the quantum of genetic variability and determines the relationship among the important agro-economic traits based on two years of phenotypic data of 210 accessions of *** traits,capsule weight per plant,capsule per plant,husk weight per plant,and seed weight per plant exhibited comparatively higher genetic coefficient of variation(GCV)and phenotypic coefficient of variation(PCV).In contrast,oil content and seed per capsule exhibited a lower *** high magnitude of broad sense heritability was observed for all traits except seeds per capsule and husk weight per *** trait,capsules per plant,plant height,and days to 50%flowering showed high genetic advance coupled with high *** cluster analysis grouped 210 accessions into six distinct *** of 210,144(68.57%)accessions were grouped into three clusters(I,II,and III),in which cluster-III was the largest,containing 64 accessions followed by cluster II and *** highest inter-cluster distance was observed between clusters-I and V(127.85),while the lowest was between clusters-II and IV(27.09).The positive correlation of capsule weight per plant with the seed weight per plant and a negative correlation with the days to 50%flowering indicates that high yielding linseed varieties with early flowering/maturity could be developed through direct and indirect ***,seed yield and oil content could be enhanced together as indicated by ghe positive association among these two important *** this study,high yielding accessions with moderate to high oil content such as GP36,GP31,GP14,GP54,GP26,GP24,GP34,GP21,GP37 and GP27 and early flowering(less than 70 days)accessions such as GP2,GP26,GP27,CG33,CG44,CG42,CG132,and CG31 identified as potential genetic materials that could be exploited for developing early matu

关键词： Linseed Genetic variability Heritability Genetic advance PCA Dendrogram

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Plant endemism in the Nepal Himalayas and phytogeographical implications

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Plant Diversity 2019年第3期41卷 174-182页

作者： Achyut Tiwari Yadav Uprety santosh kumar rana Department of Botany Tri-Chandra Campus Tribhuvan University Kathmandu Nepal Central Department of Botany Tribhuvan University Kirtipur Kathmandu Nepal Research Centre for Applied Science and Technology Tribhuvan University Kathmandu Nepal IUCN (International Union for Conservation of Nature) Kathmandu Nepal Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 Yunnan China University of Chinese Academy of Sciences Beijing 100049 China

Nepal is located in the central part of the greater Himalayan range with a unique series of mountain chains formed by recent mountain building geological events. As one of the youngest mountains in the world it contributes to diversity of plants and also provided barriers to and corridors through which plants migrated during the ice ages. The higher altitudinal variation with the high mountains, deep river valleys and lowland plains combine with the effects of the summer monsoon and dry winter result with an extraordinary diversity of ecosystems including flora and fauna in a relatively small land area. The existing checklists for Nepal record some 6000 species of flowering plants and about 530 ferns. However, the botanical experts estimate that numbers may go up to 7000 when the poorly known remote regions are fully explored. The information on plant endemism in Nepal Himalaya is not adequately known as Nepal is still struggling to complete long awaited Flora of Nepal project. Endemic species are confined to specific areas and are the first to be affected by land use and other global changes. We sought to explore the spatial distribution of endemic plant species in Nepal in relation to the consequences associated with climatic and geologic changes over time in the region with the help of published literature. It was found that the endemism showed marked spatial variation between open moist habitat and dry inner valleys, the former with higher endemism. The updated records showed 312 flowering plant species to be endemic to Nepal with higher endemism around the elevation of 3800e4200 m at sea level. The recent human population explosion, intensified deforestation, habitat fragmentation and modern day environmental changes are posing greater threats to endemic plant in Nepal. The conservation status and threats to these peculiar species are unknown. Nevertheless, environmental degradation and high poverty rates create a potent mix of threats to biodiversity in this l

关键词： Himalaya Topography Endemism

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Impact of dental and orofacial trauma on oral health-related quality of life in adults:A systematic review

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Chinese Journal of Traumatology 2024年第5期27卷 249-253页

作者： santosh kumar Verma Awanindra kumar Jha Om Prakash Subia Ekram Chandmani Tigga Mohammad Kashif Noorani Vini Mehta Aida Meto Agron Meto Luca Fiorillo Marco Cicciù Department of Periodontology&Oral Implantology Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Orthodontic and Dentofacial Orthopedic Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Oral and Maxillofacial Surgery Dental College Rajendra Institute of Medical SciencesRanchi834009JharkhandIndia Prosthodontics and Crown and Bridge and Oral Implantology 800001PatnaIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPimpriPune411018MaharashtraIndia Department of Dentistry Faculty of Dental SciencesUniversity of Aldent1007TiranaAlbania Department of Biomedical and Dental Sciences Morphological and Functional ImagesUniversity of Messina98100MessinaItaly Multidisciplinary Department of Medical-Surgical and Dental Specialties Second University of Naples80100NaplesItaly Department of Surgery and Surgical Specialties University of Catania95100CataniaItaly

Purpose:Dental and orofacial trauma among the adult population constitutes a major public health *** impact is not just physical but also *** analyse the impacts of dental and orofacial trauma on oral health-related quality of life(OHRQoL)in adults and determine whether the 2 variables are closely ***:This is a systematic *** terms“dental trauma”,“orofacial trauma”,“oral health”,“oral health related impact life”,“OHRQoL”,“positive and negative affect scale”,“quality of life”,“facial injuries”,“adults”,and“young adults”were researched in the databases of PubMed,ScienceDirect,Scopus and Google Scholar for associated studies up to December 30,2022.A comprehensive search was designed and the articles were independently screened for eligibility by 2 *** included studies’author,year of publication,the country where the study was conducted,population demographics(number and age),an instrument used for assessing OHRQoL and the relevant result were recorded and *** quality of the evidence was assessed using Joanna Briggs Institute checklist for observational ***:Out of 482 unique records,3 articles were included for data *** studies were *** studies did not mention confounding *** scales were used for dental and orofacial trauma and *** has a directly proportional relationship with orofacial *** with orofacial trauma have a significant impact on this value with a prevalence of 88.4%.Conclusion:The highest impact on OHRQoL was seen immediately after the diagnosis of an orofacial *** impact increases with the severity of the ***,to promote overall dental and general health,health education initiatives should include information on the causes,prevention,and requirement for prompt responses by the populace in seeking dental intervention.

关键词： Dental trauma Oral health Oral health-related quality of life Orofacial trauma

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Determining bioclimatic space of Himalayan alder for agroforestry systems in Nepal

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Plant Diversity 2018年第1期40卷 1-18页

作者： santosh kumar rana Hum Kala rana Krishna kumar Shrestha Suresh Sujakhu Sailesh Ranjitkar Key Laboratory{or Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Systematics and Biodiversity Unit Central Department of BotanyTribhuvan UniversityKirtipurKathmanduNepal jade Consult Private Limited KabilmargThapathaliKathmanduPOB 746Nepal World Agroforestry Centre East and Central Asia 132 Lanhei RdHeilongtanKunmingChina

Himalayan alder species are proven to be very useful in traditional as well as contemporary agroforestry practice. These nitrogen-fixing trees are also useful in the land restoration. Therefore, understanding the distribution of Himalayan alder and the potential zone for plantation is meaningful in the agroforestry sector. Suitable climatic zones of Alnus spp. were modelled in Max Ent software using a subset of least correlated bioclimatic variables for current conditions(1950 -2000), topographic variables(DEM derived) and Landuse Landcover(LULC) data. We generated several models and selected the best model against random models using ANOVA and t-test. The environmental variables that best explained the current distribution of the species were identified and used to project into the future. For future projections, ensemble scenarios of climate change projection derived from the results of 19 Earth System Models(ESM) were used. Our model revealed that the most favorable conditions for Alnus nepalensis are in central Nepal in the moist north-west facing slope, whereas for Alnus nitida they are in western *** major climatic factor that contributes to Alnus species distribution in Nepal appears to be precipitation during the warmest quarter for A. nepalensis and precipitation during the driest quarter for A. nitida. Future projections revealed changes in the probability distribution of these species, as well as where they need conservation and where they can be planted. Also, our model predicts that the distribution of Alnus spp. in hilly regions will remain unchanged, and therefore may represent sites that can be used to revitalize traditional agroforestry systems and extract source material for land restoration.

关键词： Alder Agroforestry Species distribution modeling Climate change MaxEnt

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Molecular phylogeny,biogeography and character evolution of the montane genus Incarvillea Juss.(Bignoniaceae)

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Plant Diversity 2021年第1期43卷 1-14页

作者： santosh kumar rana Dong Luo Hum Kala rana Shaotian Chen Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of Sciences Beijing 100049China College of Pharmaceutical Science Yunnan University of Chinese MedicineKunming 650500China

The complex orogeny of the Himalaya and the Qinghai-Tibet Plateau(QTP)fosters habitat fragmentation that drives morphological differentiation of mountain plant ***,determining phylogenetic relationships between plant subgenera using morphological characters is ***,we used both molecular phylogeny and historical biogeographic analysis to infer the ancestral states of several vegetative and reproductive characters of the montane genus *** determined the taxonomic position of the genus Incarvillea within its family and inferred the biogeographical origin of taxa through Bayesian inference(BI),maximum likelihood(ML)and maximum parsimony(MP)analyses using three molecular data sets(trnL-trnF sequences,nr ITS sequences,and a data set of combined sequences)derived from 81%of the total species of the genus *** the genus-level phylogenetic framework,we examined the character evolution of 10 key morphological characters,and inferred the ancestral area and biogeographical history of the *** analyses revealed that the genus Incarvillea is monophyletic and originated in Central Asia during mid-Oligocene ca.29.42 *** earliest diverging lineages were subsequently split into theWestern Himalaya and Sino-Himalaya during the early Miocene ca.21.12 *** lineages resulted in five re-circumscribed subgenera(Amphicome,Olgaea,Niedzwedzkia,Incarvillea,and Pteroscleris).Moreover,character mapping revealed the ancestral character states of the genus Incarvillea(e.g.,suffruticose habit,cylindrical capsule shape,subligneous capsule texture,absence of capsule wing,and loculicidal capsule dehiscence)that are retained at the earliest diverging ancestral nodes across the *** phylogenetic tree of the genus Incarvillea differs from previously proposed phylogenies,thereby recommending the placement of the subgenus Niedzwedzkia close to the subgenus Incarvillea and maintaining two main divergent lineages.

关键词： Biodiversity hotspots Biogeography Incarvillea Molecular phylogeny Phytools Stochastic character mapping

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In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

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Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul Islam Abu Hena Mostofa Kamal Md. Ziaur Rahman Protul kumar Roy A.Y.K. Md. Masud rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. Free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants Free Radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

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Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

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World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande rana Rathor Roy Debopriyo Mondal Ashesh Halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

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Computation of pressure drop for dilute gas-solid suspension across thin and thick orifices

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Particuology 2021年第2期19卷 209-221页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

The present work deals with the computation of the gas-solid two-phase flow pressure drop across thin and thick orifices for a vertically downward flow configuration at the higher limits of a dilute phase flow situation(0.01≤αs,in≤0.10).The Eulerian-Eulerian(two-fluid)model has been used in conjunction with the kinetic theory of granular flow with a four-way coupling *** validation of the solution process has been performed by comparing the computational result with the existing experimental *** is observed that the two-phase flow pressure drop across the orifice increases with an increase in the thickness of the orifice,and the effect is more prominent at higher solid *** pressure drop is found to increase with an increase in the solid volume *** increase in the Reynolds number or the area ratio increases the pressure *** increase in the size of the particles reduces the pressure drop across the orifice at both small and relatively large solid volume ***,a two-phase multiplier has been proposed in terms of the relevant parameters,which can be useful to evaluate the gas-solid two-phase flow pressure drop across the orifice and can subsequently help to improve the system performance.

关键词： Dilute phase flow Gas-solid flow Thin and thick orifice Vertically downward flow Pressure drop

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Pressure recovery characteristics for a dilute gas-particle suspension flowing vertically downward in a pipe with a sudden expansion: A two-fluid modeling approach

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Particuology 2020年第3期18卷 100-111页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

This work applies the Eulerian-Eulerian model in conjunction with the kinetic theory of granular flow and inter-particle collisions to study the characteristics of pressure recovery for a dilute gas-particle suspension flowing through a pipe with a sudden expansion at a relatively higher solid *** do so,the numerical procedure was validated against experimental results for relatively small dilute phase flows in a pipe with a sudden expansion;a satisfactory agreement was ***,the effect of the two significant numerical parameters namely,the speculairty coefficient and the coefficient of restitution for particle-particle collisions were investigated and then,for fixed combinations of these parameters the effect of particle-phase volume fraction,particle density,particle size,and inlet slip ratio were *** was concluded that pressure recovery diminishes as the speculairty coefficient increases and the particle-particle coefficient of restitution *** recovery was found to increase with increasing solid volume fraction for coarse particles whereas,for fine particles,a critical volume fraction is obtained above which pressure recovery *** increase in slip ratio is found to diminish pressure ***,at relatively higher solid volume fractions,a critical diameter was found,above and below which pressure recovery decreases.

关键词： Gas-solid flow Sudden expansion pipe Eulerian-Eulerian model Pressure recovery Vertically downward flow

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Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

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Neural Regeneration Research 2021年第12期16卷 2349-2352页

作者： Asit kumar santosh kumar Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA

Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of death and disability *** acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive *** date,there is no effective pharmaceutical products for the treatment to reduce secondary damage after brain *** discovery of extracellular vesicles has attracted considerable scientific attention due to their role in cell-to-cell *** vesicles have shown their potential to carry not only biological molecules but also as a drug delivery *** a carrier of molecular information,extracellular vesicles have been involved in physiological functions as well as in the modulation of immune ***,we aim to provide new insights into the contrasting role of extracellular vesicles in the propagation of inflammatory responses after brain *** a carrier of pro-inflammatory molecules,their role as functional mediators in the pathophysiology of brain injury is discussed,addressing the inhibition of the extracellular vesicle pathway as an anti-inflammatory or neuroprotective approach to improve the outcome of both acute and chronic inflammation following brain ***,we summarize therapeutic strategies to diminish the risk the neurodegeneration post brain injury and propose that neutral sphingomyelinase inhibitors could be used as potentially useful therapeutic agents for the treatment of brain injury associated neuroinflammation.

关键词： brain injury ceramide extracellular vesicles microglia neuroinflammation neuroprotection neutral sphingomyelinase

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