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Involvement of adenosine and standardization of aqueous extract of garlic(Allium sativum Linn.)on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury

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The Journal of Biomedical Research 2012年第1期26卷 24-36页

作者： Ashish kumar Sharma Arshee Munajjam Bhawna Vaishnav Richa Sharma Ashok Sharma Kunal Kishore Akash Sharma Divya Sharma Rita kumari Ashish Tiwari santosh kumar Singh Samir Gaur Vijay Singh Jatav Barthu Parthi Srinivasan Shyam Sunder Agarwal Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar University Department of Pharmacology Delhi Institute of Pharmaceutical Sciences & Research

The present study investigated the effect of garlic （Allium sativum Linn.） aqueous extracts on ischemic pre- conditioning and ischemia-reperfusion induced cardiac injury, as well as adenosine involvement in ischemic pre- conditioning and garlic extract induced cardioprotection. A model of ischemia-reperfusion injury was established using Langendorff apparatus. Aqueous extract of garlic dose was standardized （0.5%, 0.4%, 0.3%, 0.2%, 0.1%, 0.07%, 0.05%, 0.03%, 0,01%）, and the 0.05% dose was found to be the most effective. Higher doses （more than 0.05%） were highly toxic, causing arrhythmia and cardiodepression, whereas the lower doses were ineffective. Garlic exaggerated the cardioprotective effect of ischemic preconditioning. The cardioprotective effect of ischemic preconditioning and garlic cardioprotection was significantly attenuated by theophylline （1,000 ~tmol/L） and 8-SPT （10 mg/kg, i.p.） and expressed by increased myocardial infarct size, increased LDH level, and reduced nitrite and adenosine levels. These findings suggest that adenosine is involved in the pharmacological and molecular mechanism of garlic induced cardioprotection and mediated by the modulation of nitric oxide.

关键词： Allium sativum Linn. ischemic preconditioning cardioprotection adenosine nitrite

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Extensional collapse of the Gondwana orogen: Evidence from Cambrian mafic magmatism in the Trivandrum Block, southern India

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Geoscience Frontiers 2019年第1期10卷 263-284页

作者： Qiong-Yan Yang Sohini Ganguly E.Shaji Yunpeng Dong V.Nanda-kumar School of Earth Science and Resources China University of Geosciences Department of Earth Science Goa University Department of Geology University of Kerala State Key Laboratory of Continental Dynamics Department of Geology Northwest University National Center for Earth Science Studies Akkulam Trivandrum India

The assembly of Late Neoproterozoice Cambrian supercontinent Gondwana involved prolonged subduction and accretion generating arc magmatic and accretionary complexes, culminating in collision and formation of high grade metamorphic orogens. Here we report evidence for mafic magmatism associated with post-collisional extension from a suite of gabbroic rocks in the Trivandrum Block of southern Indian Gondwana fragment. Our petrological and geochemical data on these gabbroic suite show that they are analogous to high Fe tholeiitic basalts with evolution of the parental melts dominantly controlled by fractional crystallization. They display enrichment of LILE and LREE and depletion of HFSE with negative anomalies at Zre Hf and Ti corresponding to subduction zone magmatic regime. The tectonic affinity of the gabbros coupled with their geochemical features endorse a heterogeneous mantle source with collective melt contributions from sub-slab asthenospheric mantle upwelling through slab break-off and arc-related metasomatized mantle wedge, with magma emplacement in subduction to post-collisional intraplate settings. The high Nb contents and positive Nbe Ta anomalies of the rocks are attributed to inflow of asthenospheric melts containing ancient recycled subducted slab components and/or fusion of subducted slab materials owing to upwelling of hot asthenosphere. Zircon grains from the gabbros show magmatic crystallization texture with low U and Pb content. The LA-ICPMS analyses show ^(206) Pb/^(238) U mean ages in the range of 507-494 Ma suggesting Cambrian mafic magmatism. The post-collisional mafic magmatism identified in our study provides new insights into mantle dynamics during the waning stage of the birth of a supercontinent.

关键词： Mafic dykes Geochemistry Zircon Ue Pb geochronology Post-collisional extension Gondwana supercontinent

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源自车辆的微粒磁性与Ficus infectoria(一个关键种)对它的改善

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AMBIO－人类环境杂志 2005年第B12期34卷 639-640页

作者： Sudhir kumar Pandey B.D.Tripathi santosh kumar Prajapati Virendra kumar Mishra Alka Rani Upadhyaya Prabhat kumar Rai Atul Prakash Sharma 王胜 Pollution Ecology Research Laboratory Centre of Advanced Study in Botany Banaras Hindu University

引言源自车辆燃烧的磁性矿物质主要是磁铁矿和金属铁颗粒,大小为0.1～0.7 μm[1].这种大小的颗粒对人类特别有害,因为它能被吸入肺里.而且,在悬浮尘粒中,磁铁与其它重金属(如锌、镉、铬)[2]和对人体健康有害的诱变有机化合物[3]结合在一起.

关键词：车辆排放磁性关键种微粒车辆制动系统燃烧过程有机化合物不规则形状铁颗粒人体健康

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Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats

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The Journal of Biomedical Research 2012年第3期26卷 200-210页

作者： Ashish kumar Sharma Akash Sharma Rita kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma santosh kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin kumar Raikwar Muneem kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar UniversityJagatpuraJaipur(Rajasthan)302025India Department of Pharmacology Delhi Institute of Pharmaceutical Sciences&ResearchPushpviharNew Delhi 110017India Department of Pharmacology Kota Collage of PharmacyRIICO Industrial AreaRanpurKota(Rajasthan)Pincode 302025India

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

关键词： diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline

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Characterization of winged bean (<i>Psophocarpus tetragonolobus</i>(L.) DC.) based on molecular, chemical and physiological parameters

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American Journal of Molecular Biology 2013年第4期3卷 187-197页

作者： Chandra Sekhar Mohanty Sushma Verma Vinayak Singh Shahina Khan Priyanka Gaur Priya Gupta M. Abdul Nizar Nilamani Dikshit Rojalin Pattanayak Alpika Shukla Abhishekh Niranjan Nayan Sahu Soumit kumar Behera Tikam Singh rana CSIR-National Botanical Research Institute Rana Pratap Marg Lucknow Uttar Pradesh India National Bureau of Plant Genetic Resources Regional Station Akola Maharashtra India Sanjay Gandhi Institute of Post-Graduate Medical Sciences Lucknow Uttar Pradesh India University of Lucknow Lucknow Uttar Pradesh India

Winged bean (Psophocarpus tetragonolobus (L.) DC.) is a potential legume crop of the tropics with high protein and oil content in the seeds. Analysis of the mutual genotypic relationships among twenty four genotypes of P. tetragonolobus through Mantel test found a significant correlation (r = 0.839) between similarity matrices of the results obtained from the use of the RAPD and ISSR molecular markers. The UPGMA tree based on Jaccard’s similarity coefficient generated from their cumulative data showed two distinct clusters and seven sub-clusters among these accessions. Quantification of total polyphenols, flavonoids and tannin revealed the highest percentage of occurrence of kaempferol (1.07-790.5 μg/g) and the lowest percentage of gallic acid (0.09-3.49 μg/g) in the seeds. Phytochemical analysis of the winged bean genotypes revealed that, some of the exotic lines are distinct. Analysis of photosynthesis rate, photosynthetic yield and stomatal conductance data also showed two clusters and was in congruence with the phytochemical affinities of the genotypes. The overall high level of polymorphism and varied range of genetic distances across the genotypes revealed a wide range of genetic base of P. tetragonolobus. The present investigation therefore, has provided significant insights for further improvement of winged bean germplasm for its qualitative and quantitative traits.

关键词： Psophocarpus tetragonolobus Polyphenols Flavonoid RAPD ISSR Physiological Parameter

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Single polarization photonic crystal fiber filter based on surface plasmon resonance

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Frontiers of Optoelectronics 2019年第2期12卷 157-164页

作者： Md. Nazmul HOSSEN Md. FERDOUS Kawsar AHMED Md. Abdul KHALEK Sujan CHAKMA Bikash kumar PAUL Department of Information and Communication Technology(ICT) Mawlana Bhashani Science and Technology University(MBSTU)SantoshTangail 1902Bangladesh Group of Biophotomatix SantoshTangail 1902Bagladesh Department of Software Enineering(SWE) Daffodil International UniversityShukrabadDhaka 1207Bangladesh

In this paper,we propose a photonic crystal fiber(PCF)polarization filter based on surface plasmon resonance(SPR)*** nanowire is used as the active plasmonic *** into silica core becomes coupled to gold nanowire stimulating SPR. It soplits light into two orthogonal(x-polarization and y-polarization)polarization in the second order of surface plasmon *** investigations of the proposed PCF filter is finite element method(FEM).By position,the performance of the propsed PCF filter is inspected *** of any polarization can be obtained by properly placing the metal *** maximum cnfinement loss of x-polarization is 692.25dB/cm and y-polarization is 1.13dB/cm offers at resonance position 1.42μ*** a confinement loss difference between two orthogonal polarizations makes PCF a talented candidate to filter ***,the recommended PCF structure is useful for polarization device.

关键词： photonic crystal fiber (PCF) surface plasmon resonance (SPR) perfectly match layer polarization filter

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Psychiatric morbidities in respiratory disorders:a cross sectional report providing insight into consultation-liaison psychiatry services in India

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Psychosomatic Medicine Research 2023年第1期5卷 6-10页

作者： Roshan Sutar santosh kumar Chaturvedi Akshata Jayachamarajapura Shivananjaiah Department of Psychiatry All India Institute of Medical Sciences(AIIMS)BhopalMadhya Pradesh 462026India Leicestershire Partnership NHS Trust Leicester LE48BLUK SDS TRC and Rajiv Gandhi Institute of chest diseases Bangalore Karnataka 560011India.

Background:Respiratory disorders are among the leading disorders contributing to extensive morbidity and mortality *** variants,like Chronic Obstructive Pulmonary Diseases(COPD)in developed and developing countries,as well as infectious causes,like Tuberculosis(TB)in developing countries,contribute to significant disease *** literature points towards the coexistence of psychiatric disorders with respiratory disorders responsible for poorer *** the extensive burden of respiratory disorders and the presence of concurrent psychiatric disorders,studies focusing on their prevalence are limited in ***:A cross-sectional psychiatric screening was carried out on sequential patients attending the tertiary respiratory unit over eight *** screened positive were interviewed in detail for psychiatric diagnosis and challenges in the management were *** diagnosis,pulmonary TB and medical comorbidity were assessed for correlation with demographic and clinical variables and analyzed by using the Chi-square test and logistic regression method using SPSS version ***:Psychiatric morbidity was present in 100 out of 350 patients(28.57%).Tuberculosis was the most common diagnosis(46%)in subjects attending the respiratory clinic services while common mental disorders like depression,anxiety,and insomnia were the most common psychiatric concern(88%)in this ***:Psychiatric disorders and medical morbidities are common in patients with respiratory *** factors determine the treatment adherence in both respiratory and psychiatric *** for psychiatric disorders with the help of a consultation-liaison psychiatrist in respiratory units is *** studies should focus on developing dedicated psychiatry services to enhance overall outcomes in patients with respiratory disorders.

关键词： psychiatric morbidity depression tuberculosis consultation-liaison psychiatry respiratory disorders psychosomatic

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Emerging leishmaniasis in southern Himalayas:A mini-review

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World Journal of Clinical Infectious Diseases 2023年第2期13卷 11-23页

作者： Ashwani Sharma santosh kumar Prasan kumar Panda Sweety Yadav Deepjyoti Kalita Department of Community and Family Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Internal Medicine All India Institute of Medical SciencesRishikesh 249203India Department of Microbiology All India Institute of Medical SciencesRishikesh 249203India

Leishmaniasis is a vector-borne parasitic disease affecting millions of people ***,in the last decade,the number of cases has been reduced from well-documented endemic parts,but sporadic cases have been reported widely from various non-endemic areas,especially from the southern Himalayan *** raises concerns about the emergence of new ecological *** warrants a critical evaluation of key factors causing this rapid spread and possibly indigenous *** mini-review article is aimed to briefly address the parasite,the vector,and the environmental aspects in the transmission of leishmaniasis in these new foci against a background of worldwide endemic leishmaniasis with a special focus on the southern Himalayan *** the lack of knowledge about the causative parasites,vectors,reservoir hosts,atypical presentations,and their management make the problem serious and may lead to the emergence of public health *** present works also reviewed the existing information regarding clinical variations,diagnostic methods,treatment,its outcome,and ignite for further research in these aspects of the disease.

关键词： Anthroponosis Kala azar sandfly Sporadic transmission Southern Himalaya

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Design and Optimization of Photonic Crystal Fiber Based Sensor for Gas Condensate and Air Pollution Monitoring

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Photonic Sensors 2017年第3期7卷 234-245页

作者： Md. Ibadul ISLAM Kawsar AHMED Shuvo SEN Sawrab CHOWDHURY Bikash kumar PAUL Md. Shadidul ISLAM Mohammad Badrul Alam MIAH Sayed ASADUZZAMAN Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and Technology University Santosh Tangail 1902 Bangladesh Group of Bio-photomatix Tangail 1902 Bangladesh Department of Software Engineering (SWE) Daffodil International University Sukrabad Dhaka 1207 Bangladesh

In this paper, a hexagonal shape photonic crystal fiber （H-PCF） has been proposed as a gas sensor of which both micro-structured core and cladding are organized by circular air cavities. The reported H-PCF has a single layer circular core which is surrounded by a five-layer hexagonal cladding. The overall pretending process of the H-PCF is completed by using a full vectorial finite element method （FEM） with perfectly matched layer （PML） boundary condition. All geometrical parameters like diameters and pitches of both core and cladding regions have fluctuated with an optimized structure. After completing the numerical analysis, it is clearly visualized that the proposed H-PCF exhibits high sensitivity with low confinement loss. The investigated results reveal the relative sensitivity of 56.65% and confinement loss of 2.31×10^-5 dB/m at the 1.33%tm wavelength. Moreover, effective area, nonlinearity, and V-parameter of the suggested PCF are also briefly described.

关键词： Relative sensitivity confinement loss gas sensor effective area nonlinearity and photonic crystal fiber

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非生物因素对印度芥菜菌核病发生的影响(英文)

非生物因素对印度芥菜菌核病发生的影响(英文)

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第十二届国际油菜大会

作者： C.Chattopadhyay R.L.Meena Sumana Roy U.S.rana Arvind kumar National Research Centre on Rapeseed-Mustard SewarBharatpur 321303India

目前,在印度由核盘菌引起的芥菜腐烂变的很严重,其他地方也有很高的疾病突发率,产量下降直接导致种植者的积极性下降。据报道,病原菌感染大约400多种植物,且至今没有发现并证实在任何宿主中有抵抗这类疾病数据报告。本试验在农场的中心... 详细信息

目前,在印度由核盘菌引起的芥菜腐烂变的很严重,其他地方也有很高的疾病突发率,产量下降直接导致种植者的积极性下降。据报道,病原菌感染大约400多种植物,且至今没有发现并证实在任何宿主中有抵抗这类疾病数据报告。本试验在农场的中心[77°27′E,27°12′N,海拔160m,具有很厚很肥沃的淤积层土壤,pH8.0]进行,一块5m×4.8m的土地被随机划分成30cm×10cm大小的小区,并设计4个重复,3个日期播种(07,28Oct,18Nov2006)用测试Rohini多样性来了解疾病发生时不同非生物因素的影响。每周通过重量分析方法对每块地进行湿度分析并记录数据。在花期每天08:00-10:00收集花瓣,并且把他们放在含有氯霉素的马铃薯葡萄糖琼脂培养基上培养,以记录印度芥菜花瓣上菌核病的孢子数量.气候因素有:最高和最低温度,上午和下午的相对湿度,以及在离试验地点200m远的气象台观察到的日照长度。数据分析显示:花瓣病原菌孢子的感染数量与光照时间成正相关(R2=0.97)。菌核病导致的腐烂范围与土壤的相对湿度成正相关(R2=0.84),特别是在开花季节和播种后的500天。在苗期500天的临界期,凉爽而干净的天气与高湿度的土壤似乎使试验地的印度芥菜上菌核病发生率更高。

关键词： Brassica juncea Sclerotinia sclerotiorum epidemiology

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