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A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminiumgarnet laser capsulotomy

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 590-596页

作者： Rahul Bhargava Prachi kumar Shiv kumar Sharma Avinash Kaur Department of Ophthalmology Laser Eye Clinic Department of Pathology Santosh Medical College and Hospital Department of Ophthalmology Rotary Eye Hospital Department of Ophthalmology Santosh Medical College and Hospital

AIM: To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification(PCO).METHODS: A prospective, randomized, double blind,study was done at Rotary Eye Hospital, Maranda,Palampur, India, santosh Medical College Hospital,Ghaziabad, India and Laser Eye Clinic, Noida *** patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction(ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity(CDVA), intra-operative and postoperative complications were ***: A total of 634 patients participated in the study, and 314(49.5%) patients were randomized to surgical peeling and aspiration group and 320(50.5%) to the Nd:YAG laser group. The mean pre-procedural log MAR CDVA in peeling and neodymium: yttrium-aluminium-garnet(Nd:YAG) laser group was 0.80 ±0.25 and 0.86 ±0.22, respectively. The mean final CDVA in peeling group(0.22 ±0.23) was comparable to Nd:YAG group(0.24 ±0.28; t-test, P =0.240). There was a significant improvement in vision after both the procedures(P <0.001). A slightly higher percentage of patients in Nd:YAG laser group(283/88.3%) than in peeling group(262/83.4%) had a CDVA of 0.5(20/63) or better at 9mo(P <0.001). On the contrary, patients havingCDVA worse than 1.00(20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group(25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001% risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group,thick PCO had a stronger impact on complication

关键词： posterior capsule neodymium Elschnig pearls yttrium-aluminium-garnet capsulotomy

Phytochemicals as therapeutics against COVID-19: An in-silico study

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Microenvironment & Microecology Research 2021年第3期3卷 14-19页

作者： Debraj Koiri Ditam Chakraborty Pranotosh Das Rajkumar rana Soumyanil Chatterjee Tanmoy Das Paltu kumar Dhal Department of Life Science and Biotechnology Jadavpur UniversityKolkata-700032West BengalIndia. Department of Life Science and Biotechnology Jadavpur University188 Raja S.C.Mullick RoadKolkata-700032West BengalIndia.

Since December 2019,the worldwide spread of COVID-19 has brought the majority of the world to a standstill,affecting daily lives as well as *** these conditions,it is imperative to develop a cure as soon as *** account of some of the adverse side effects of the existing conventional drugs,researchers all around the world are screening natural antiviral phytochemicals as potential therapeutic agents against *** paper aims to review interactions of some specific phytochemicals with the receptor binding domain(RBD)of the Spike glycoprotein of SARS-CoV-2 and suggest their possible therapeutic *** search was done based on the wide array of in-silico studies conducted using broad spectrum phytochemicals against SARS-CoV-2 and other viruses.26 such phytochemicals specifically targeting the S protein and its interactions with host receptors were shortlisted *** validate the previously published results,molecular docking was performed using the AutoDock Vina application and 6 high potential phytochemicals were identified for therapeutic use based on their binding *** this,availability of these compounds,their mode of action,toxicity data and cost-effectiveness were also taken into *** review specifically identifies 6 phytochemicals that can be used as potential treatments for COVID-19 based on their availability,toxicology results and low costs of ***,all these compounds need to be further validated by wet lab experiments and should be approved for clinical use only after appropriate trials.

关键词： Phytochemicals SARS-CoV-2 S-Protein Molecular docking ACE 2

A randomized controlled trial of omega-3 fatty acids in dry eye syndrome

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 811-816页

作者： Rahul Bhargava Prachi kumar Manjushrii kumar Namrata Mehra Anurag Mishra Department of Ophthalmology Santosh Medical College and Hospital Department of Pathology Santosh medical College andHospital Department of Microbiology Narayan Medical College andHospital

AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye ***:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye *** hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry *** to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression ***:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer’s test value and TBUT values in the omega-3group(P<0.001),both ***,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer’s test *** mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,*** mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic ***:Omega-3 fatty acids have a definite role for dry eye *** benefit seems to be more marked in conditions such as blepharitis and meibomian gland *** role of omega fatty acids in tear production and secretion needs further evaluation.

关键词： dry eye syndrome omega-3 fatty acids conjunctival impression cytology meibomian gland disease

Post-myocardial infarction giant left ventricular pseudoaneurysm presenting with severe heart failure

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World Journal of Cardiology 2012年第11期4卷 309-311页

作者： Rajesh Vijayvergiya Alok kumar Sandeep S rana Harkant Singh Goverdhan D Puri Manphool Singhal Department of Cardiology Advanced Cardiac CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160 012India Department of Cardiac Surgery Advanced Cardiac CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160 012India Department of Anesthesia Advanced Cardiac CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160 012India Department of Radio-diagnosis Advanced Cardiac CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160 012India

Left ventricle(LV) pseudoaneurysm is a late mechanical complication of myocardial infarction.A giant LV pseudoaneurysm is a rare *** report a case of giant LV pseudoaneurysm in a post-MI patient who presented with gross congestive heart *** patient had a successful surgical repair of the aneurysm and had a favorable 3-mo *** imaging modality and surgical treatment of the pseudoaneurysm are discussed.

关键词： Congestive heart failure Left ventricle pseudoaneurysm Myocardial infarction Surgical repair

A study on the transmission of <i>helicobacter pylori</i>from food prepared and consumed under hygienic and unhygienic conditions: A first study using biopsy samples

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Health 2014年第4期6卷 274-283页

作者： Khawaja Shakeel Ahmed Basheer Madompoyil Janak Dulari Ahi Aleem Ahmed Khan santosh kumar Tiwari Mohammed Aejaz Habeeb Asmara College of Health Sciences Department of Clinical Laboratory Sciences Microbiology Unit Asmara Eritrea Centre for Liver Research and Diagnostics Deccan College of Medical Sciences Hyderabad India Dr. Hari Singh Gour University Sagar Madhya Pradesh India Orotta School of Medicine and Dentistry Asmara Eritrea

Objective: A comparative analysis on transmission of Helicobacter pylori in people who consumed food prepared in both hygienic and unhygienic conditions. Method: The study was carried out in 1000 people across India. The Ratio of Male: female was 700: 300 with age group ranging from 20 - 39. Three gastric biopsies were collected for identification of Helicobacter pylori. PCR (Polymerase Chain Reaction) amplification was done by using 16srRNA primers. Result: The analysis showed the prevalence of H. pylori as 70.8% in individuals frequently consuming food prepared under less hygienic condition (street vendor’s food) whereas 60% (less prevalence) in individuals consuming food prepared under hygienic conditions. Conclusion: The results showed that most of the food that we consume daily is not involved much in the transmission of Helicobacter pylori. The study also showed that the street vendor’s food is not directly involved in the transmission of this bacterium. The unhygienic preparation of food and poor personal hygiene play a vital role in the transmission of these bacteria.

关键词： Helicobacter pylori Hygiene PCR 16SrRNA Food Biopsy

Poncet's disease: An unusual presentation of tuberculosis in a diabetic lady

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World Journal of Clinical Cases 2015年第4期3卷 385-388页

作者： Partha Pratim Chakraborty Sayantan Ray Chitra Selvan rana Bhattacharjee Sanjay kumar Mandal Department of Endocrinology IPGMER and SSKM Hospital Department of General Medicine Medical College and Hospital

Authors describe a 53-year-old woman who presentedto their diabetes clinic with a three week history of multiple painful and swollen joints. She had been diagnosed with type 2 diabetes 5 years back. On examination, both knee joints and left ankle were swollen. A soft tissue swelling appeared over the medial end of the left clavicle few days later. Rheumatoid arthritis, collagen vascular diseases and other common causes of polyarthritis were ruled out by appropriate investigations. Non steroidal anti-inflammatory drugs failed to give satisfactory pain relief and the arthritis persisted. Conventional cultures of synovial fluid samples including cultures for tuberculosis were negative. Computed tomography showed a space occupying lesion involving the left sternoclavicular joint. Fine needle aspiration from the lesion was performed and acidfast bacilli were demonstrated in the smear using ZiehlNeelsen stain. The explanation of her arthritis was therefore tuberculous arthritis in left sternoclavicular joint and reactive arthritis in the rest of the joints. A diagnosis of Poncet's disease was considered in her case. We treated her with standard anti-tuberculosis drugs and the arthritis resolved within a few days. She remained symptom-free at her 2 years' follow-up.

关键词： Poncet’s disease Diabetes Tuberculous arthritis Reactive arthritis Acid-fast bacilli

The epidemiology and prevalence of Ulcerative colitis in the South of India

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Open Journal of Immunology 2012年第4期2卷 144-148页

作者： Sivaram Gunisetty santosh kumar Tiwari Avinash Bardia Meka Phanibhushan Vishnupriya Satti Mohammed Aejaz Habeeb Aleem Ahmed Khan Centre for Liver Research and Diagnostics Deccan College of Medical Sciences Hyderabad India Department of Genetics Osmania University Hyderabad India Society for Translational and Regenerative Medicine Secunderabad India

Ulcerative colitis is considered frequent in majority of European and North American population and exceptional in most of the developing Asian countries. There is a dearth of reported data from South India on the incidence of the disease and its prevalence. Hence the present study was designed to estimate the prevalence of ulcerative colitis in a tertiary care hospital of Hyderabad, South India. The study population consisted of 157 Ulcerative colitis and 204 healthy subjects. All subjects were interviewed by means of a questionnaire for general demographical details and socioeconomic conditions, health related quality of life and history of UC. Patients were categorized based on disease severity;moderate: 95, and severe: 62 and disease manifestation: 73 (46.5%) pancolitis, 60 (38.2%) left-sided colitis and 24 (15.3%) had proctosigmoiditits. Disease prevalence was high in patients

关键词： Ulcerative Colitis Epidemiology Prevalence South India

Hypertension and its physio-psychosocial risks factors in elderly people:a cross-sectional study in north-eastern region of Bangladesh

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Journal of Geriatric Cardiology 2021年第1期18卷 75-82页

作者： Gowranga kumar Paul Mohammad Meshbahur Rahman Mohammad Hamiduzzaman Zaki Farhana Somaresh kumar Mondal Saleha Akter Shayla Naznin Department of Statistics Mawlana Bhashani Science and Technology UniversitySantoshTangail-1902Bangladesh Biomedical Research Foundation Dhaka-1230Bangladesh Flinders University Rural Health SA College of Medicine&Public HealthFlinders UniversitySouth AustraliaAustralia Bangladesh Bank-The Central Bank of Bangladesh Bangladesh Asian University of Bangladesh DhakaBangladesh Department of Statistics Shahjalal University of Science and TechnologySylhetBangladesh

Hypertension has been increasingly cited mortality cause in developing countries including Bangladesh,[1–4]and generally associated with coronary artery disease,stroke,heart failure,atrial fibrillation,peripheral vas... 详细信息

关键词： mortality coronary sectional

Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia

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Eye and Vision 2019年第1期6卷 51-62页

作者： Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah santosh G.K.Gadde Ashwin Mohan Rohit Shetty Naresh kumar Yadav Department of Retina and Vitreous Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India. Department of Cornea and Refractive surgery Narayana Nethralaya#121/C1st R BlockChord RoadRajaji NagarBengaluru 560010India

Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in ***:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment *** eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;*** macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,*** correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual ***:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 *** were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual *** negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual ***:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these *** research is required to investigate this.

关键词： Myopia Axial elongation Spherical equivalent OCT Optical coherence tomography angiography Structure Visual acuity