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Comparison of the inhibitory effect of different doses of subconjunctival bevacizumab application in an experimental model of corneal neovascularization

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1090-1095页

作者： Burak Ulas rana altan-yaycioglu Nebil Bal Department of Ophthalmology Baskent University School of Medicine Department of Pathology Baskent University School of Medicine

AIM： To evaluate the inhibitory effect of subconjunctival bevacizumab as single-and multiple-dose application, and compare their effects on corneal neovascularization in a rat model. METHODS： Thirty adult Sprague-Dawley rats were used in this experimental study. The central cornea of the rats was cauterized chemically. The rats were randomly enrolled into three groups. All groups received subconjunctival injections. In Group 1（control group, n=10）, 0.05 m L 0.9% Na Cl solution was injected on the first day. In Group 2（single-dose group, n=10）, 0.05 m L bevacizumab（1.25 mg） was injected on the first day. In Group 3（multiple-dose group, n=10）, four doses of 0.05 m L bevacizumab（1.25 mg） were injected on the first, third, fifth and seventh day. Slit-lamp examination of all rats was performed at the third and ninth day. Digital images of the corneas were taken and analyzed using image analysis software to calculate corneal neovascularization area. All rats were sacrificed on the tenth day. In corneal sections, the number of blood vessels, state of inflammation and collagen formation was evaluated histopathologically. RESULTS： In Group 3, corneal edema grades were significantly lower than Group 1 and Group 2（P=0.02, and P=0.035, respectively）. The mean percentage of neovascularized corneal area in Group 3 was significantly lower than Group 2（P=0.005）. On histopathological examination, Group 2 and Group 3 showed significantly less number of blood vessels than Group 1（P=0.005, and P=0.001, respectively）. Additionally, Group 3 showed significantly less number of blood vessels compared to Group 2（P=0.019）. Inflammation and edema grades were significantly lower in Group 3 compared to Group 1（P=0.001）. CONCLUSION： Subconjunctival bevacizumab injection is effective in inhibition of newly formed corneal neovascularization. The multiple-dose bevacizumab treatment seems to be more effective compared to single-dose treatment.

关键词： cornea corneal neovascularization bevacizumab inflammation rat

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Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1420-1425页

作者： rana altan-yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas Department of Ophthalmology Baskent University School of Medicine

AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication.

关键词： conjunctivitis corneal opacity infectious keratoconjunctivitis keratoconjunctivitis povidone-iodine viral conjunctivitis

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Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 725-729页

作者： Muge Coban-Karatas rana altan-yaycioglu Burak Ulas Selcuk Sizmaz Handan Canan Cagla Sariturk Department of Ophthalmology Baskent University School of Medicine Department of Ophthalmology Cukurova University School of Medicine Division of Biostatistics Baskent University Adana Clinic and Research Center

AIM： To evaluate central macular thickness（CMT） and mean choroidal thickness（MCT） in eyes with branch retinal vein occlusion（BRVO）, before and after ranibizumab treatment using spectral domain-optical coherence tomography（SD-OCT）.·METHODS： Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 μm intervals up to 1500μm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab（0.5 mg/0.05 m L）. Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Preinjection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis.· RESULTS： At baseline, there was a significant difference between the BRVO and fellow eyes in MCT[BRVO eyes 245（165-330） μm, fellow eyes 229（157-327） μm]and CMT [BRVO eyes 463（266-899） μm, fellow eyes 235（148-378） μm（P =0.041, 0.0001, respectively）]. Following treatment, CMT [295（141-558） μm] and MCT [229（157-329） μm] decreased significantly compared to the baseline measurements（P =0.001, 0.006, respectively）.Also BCVA（log MAR） improved significantly（P=0.0001） in the BRVO eyes following treatment. After treatment CMT[BRVO eyes 295（141-558） μm, fellow eyes 234（157-351） μm]and MCT [BRVO eyes 229（157-329） μm, fellow eyes 233（162-286） μm] values did not reveal any significant difference in BRVO eyes and fellow eyes（P=0.051, 0.824,respectively）.· CONCLUSION： In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection.

关键词： branch retinal vein occlusion choroidal thickness macular edema optical coherence tomography ranibizumab

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3mL和5mL利多卡因眼球筋膜囊下麻醉在超声乳化手术中的比较研究(英文)

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国际眼科杂志 2015年第11期15卷 1847-1850页

作者： Muge Coban-Karatas Oya Yalcin Cok rana altan-yaycioglu Baskent大学医学院眼科土耳其亚达那01250 Baskent大学医学院麻醉科土耳其亚达那01250

目的:分析比较3mL和5mL利多卡因眼球筋膜囊下麻醉对白内障超声乳化手术中眼压,镇痛效果和眼外肌失运动能力的作用效果。眼球筋膜囊下麻醉是白内障超声乳化术中常用的局麻方式。作为一种剂量依赖型的阻滞方式,良好的眼压、镇痛效果以及... 详细信息

目的:分析比较3mL和5mL利多卡因眼球筋膜囊下麻醉对白内障超声乳化手术中眼压,镇痛效果和眼外肌失运动能力的作用效果。眼球筋膜囊下麻醉是白内障超声乳化术中常用的局麻方式。作为一种剂量依赖型的阻滞方式,良好的眼压、镇痛效果以及眼外肌失运动是手术成功需要考虑的重要因素。方法:在获得伦理批准和患者的知情同意后,随机纳入70例患者作为研究对象,分别给予3m L利多卡因(组一)和5m L利多卡因(组二)作眼球筋膜囊下麻醉。麻醉前测量眼压,麻醉后10min评估眼压,镇痛效果和眼外肌失运动能力,并记录球结膜水肿和结膜下出血等并发症。结果:在麻醉管理期间,由于两名患者要求镇静,故从本研究中排除。比较组内及组间患者在麻醉前、后的基本特征,如年龄、体质量、身高、眼轴长度以及ASA生理状态,均无明显差异。与组一相比,组二患者眼外肌失运动能力及镇痛效果均明显较好。组二中有13例患者(38.2%)可达到眼球完全不运动,而组一没有患者可达到该程度。组一中有18例患者(56.3%)术中完全无痛觉,14例患者(43.7%)存在轻微痛觉,组二中有28例患者(82.4%)无痛觉,6例患者(17.6%)术中有轻微痛觉。此外,两组患者在麻醉前与麻醉后10min,其眼压的变化均无统计学差异(P<0.05)。两组患者并发症发生情况无明显差异。结论:3m L利多卡因和5m L利多卡因作眼球筋膜囊下麻醉对眼压均无影响,但在白内障超声乳化手术中给予5m L利多卡因作麻醉,在镇痛及眼外肌失运动能方面效果更好。

关键词：眼球筋膜囊下麻醉眼压超声乳化失运动能痛觉

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