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Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways

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Animal Models and Experimental Medicine 2024年第3期7卷 208-221页

作者： Da-zhuang Lu li-jun Zeng Yang li ran-li gu Meng-long Hu Ping Zhang Peng Yu Xiao Zhang Zheng-wei Xie Hao liu Yong-sheng Zhou Department of Prosthodontics Peking University School and Hospital of StomatologyBeijingChina National Center of Stomatology BeijingChina National Clinical Research Center for Oral Diseases BeijingChina Beijing Key Laboratory of Digital Stomatology BeijingChina Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijingChina Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices BeijingChina

Background:Osteoporosis is a chronic bone disease characterized by bone loss and decreased bone ***,current anti-resorptive drugs carry a risk of various *** deep learning-based efficacy prediction system(DLEPS)is a forecasting tool that can effectively compete in drug screening and prediction based on gene expression *** study aimed to explore the protective effect and potential mechanisms of cinobufotalin(CB),a traditional Chinese medicine(TCM),on bone ***:DLEPS was employed for screening anti-osteoporotic agents according to gene profile changes in primary ***-CT,histological and morphological analysis were applied for the bone protective detection of CB,and the osteogenic differentiation/function in human bone marrow mesenchymal stem cells(hBMMSCs)were also *** underlying mechanism was verified using qRT-PCR,Western blot(WB),immunofluorescence(IF),***:A safe concentration(0.25mg/kg in vivo,0.05μM in vitro)of CB could effectively preserve bone mass in estrogen deficiency-induced bone loss and promote osteogenic differentiation/function of *** BMPs/SMAD and Wnt/β-catenin signaling pathways participated in CB-induced osteogenic differentiation,further regulating the expression of osteogenesis-associated factors,and ultimately promoting ***:Our study demonstrated that CB could significantly reverse estrogen deficiency-induced bone loss,further promoting osteogenic differentiation/function of hBMMSCs,with BMPs/SMAD and Wnt/β-catenin signaling pathways involved.

关键词： BMPs/SMAD bone loss cinobufotalin hBMMSCs osteogenesis osteoporosis Wnt/β-catenin signaling pathways

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Cytoplasmic FKBPs are involved in molting and metamorphosis through regulating the nuclear localization of EcR

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Insect Science 2024年第3期31卷 759-772页

作者： Xian Zhang Qiao-ran Wang Qian Wu Jun gu li-Hua Huang guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology School of Life SciencesSouth China Normal UniversityGuangzhouChina guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouChina

Molting and metamorphosis are important physiological processes in insects that are tightly controlled by ecdysone receptor(EcR)through the 20-hydroxyecdysone(20E)signaling *** is a steroid nuclear receptor(SR).Several FK506-binding proteins(FKBPs)have been identified from the mammal SR complex,and are thought to be involved in the subcellular trafficking of ***,their roles in insects are poorly *** explore whether FKBPs are involved in insect molting or metamorphosis,we injected an FKBP inhibitor(FK506)into a lepidopteran insect,Spodoptera litura,and found that molting was inhibited in 61.11%of the larvae,and that the time for larvae to pupate was significantly extended.A total of 10 FKBP genes were identified from the genome of *** and were clustered into 2 distinct groups,according to their subcellular localization,with FKBP13 and FKBP14 belonging to the endoplasmic reticulum(ER)group and with the other members belonging to the cytoplasmic(Cy)*** the CyFKBPs were significantly upregulated in the prepupal or pupal stages,with the opposite being observed for the ER group ***506 completely blocked the transfer of EcR to the nucleus under 20E induction,and significantly downregulated the transcriptional expression of many 20E signaling genes.A similar phenomenon was observed after RNA interference of2 CyFKBPs(FKBP45 and FKBP12b),but not for *** together,our data indicate that the cytoplasmic FKBPs,especially FKBP45 and FKBP12b,mediate the nuclear localization of EcR,thereby regulating the 20E signaling and ultimately affecting molting and metamorphosis in insects.

关键词： EcR FKBP metamorphosis molting RNAi subcellular localization

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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan li Baoming li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

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Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field

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Journal of Iron and Steel Research International 2024年第6期31卷 1355-1366页

作者： Sheng-hao li Ao Huang Fan-bo Zeng Hui Peng Hao-ran Wei Xue-chun Huang Sheng-qiang Song Hua-zhi gu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

High alumina slag will cause severe corrosion at the interface of alumina refractory,and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory *** static magnetic field is a promising solution for improvement in the slag resistance of *** wetting of alumina refractory ceramics with different basicities of high alumina slags under a weak static magnetic field was analyzed,given that a weak static magnetic field can affect the corrosion behavior of refractory *** slag S_(3) as an example,when there was an external static magnetic field of 1.0 mT at 1600 ℃,the thickness of calcium aluminate reaction layer at the interface decreased by 36.7%,the denting depth of interface decreased by 35.6%,and the apparent wetting angle increased by 20%.The living radicals and their formation path in oxide melts were verified by first-principles calculation combined with electron paramagnetic resonance spectroscopy *** influence of the flux density of a weak static magnetic field on the wetting behavior of slags was also *** contact angle of the slags increased owing to the inhibitory effect of magnetic field on the radicalinvolved reaction at the interface of the slag and the alumina refractory *** relationships between the magnetic flux density,diffusion coefficient,slag microstructure(hyperfine coupling constant),and contact angle were *** provides a theoretical basis for the field control of radical involved reactive wetting between inorganic oxide slags and solid oxide ceramics.

关键词： Alumina refractory ceramic Molten slag Weak magnetic field effect Reactive wetting Free radical

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Wettability-driven synergistic resistance of scale and oil on robust superamphiphobic coating

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Chinese Chemical Letters 2024年第7期35卷 433-438页

作者： Yixuan Wang Jiexin li Zhihao Shang Chengcheng Feng Jianmin gu Maosheng Ye ran Zhao Danna liu Jingxin Meng Shutao Wang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100049China State Key Laboratory of Metastable Materials Science and Technology(MMST) Yanshan UniversityQinhuangdao 066004China

Disgusting deposits(e.g.,scale and crude oil)in daily life and industrial production are always serious problems,posing great threats to the safety and economic ***,most of developed coatings can only conquer one part of these deposits such as superhydrophobic coatings possess antiscaling capacity but would adhere crude *** integrate scale resistance with oil repellence,we herein report a robust superamphiphobic(SAB)coating simultaneously reducing pollution of scale and oil for extended period of time(two weeks with over 98%reduction).Compared with single role of superhydrophobic and amphiphilic surfaces,the SAB coating can not only inhibit interfacial nucleation of scale but also reduce the adhesion of formed scale and polluted *** durability of the SAB coating is evaluated via mechanical tests(sandpaper abrasion,tape stripping and sand falling)and chemical corrosion(corrosive liquid immersing),revealed by sustainable high contact angles and low contact angle hysteresis of water and *** universality of this strategy can be further confirmed by adding different particles like kaolin,Al_(2)O_(3),and SiO_(2),resisting multiple types of scale(i.e.,CaSO_(4),BaSO_(4)and MgCO_(3))and oil(i.e.,glycerol,glycol,and mineral oil).Therefore,this study provides an ideal avenue for resisting scale and oil,which may be used for conquering the complexity of application environments(e.g.,oil production and transportation).

关键词： Superamphiphobic Durability Wettability Anti-scaling Oil repellence

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Ultralow charge-discharge voltage gap of 0.05 V in sunlight-responsive neutral aqueous Zn-air battery

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Carbon Energy 2024年第9期6卷 172-183页

作者： Zhimin Niu Yan Gao Tianhui Wu Fei Zhang ran Zhao Zijia Chen Yiming Yuan Tifeng Jiao Jianmin gu li Lu Desong Wang State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryYanshan UniversityQinhuangdaoChina Department of Mechanical Engineering National University of SingaporeSingaporeSingapore School of Sciences Hebei University of Science and TechnologyShijiazhuangChina

Rechargeable neutral aqueous zinc-air batteries(ZABs)are a promising type of energy storage device with longer operating life and less corrosiveness compared with conventional alkaline ***,the neutral ZABs normally possess poor oxygen evolution reactions(OERs)and oxygen reduction reactions performance,resulting in a large charge–discharge voltage gap and low round-trip ***,we demonstrate a sunlight-assisted strategy for achieving an ultralow voltage gap of 0.05 V in neutral ZABs by using the FeOOH-decorated BiVO4(Fe-BiVO4)as an oxygen *** sunlight,the electrons move from the valence band(VB)of Fe-BiVO_(4) to the conduction band producing holes in VB to promote the OER process and hence reduce the ***,the photopotential generated by the Fe-BiVO_(4) compensates a part of the charging potential of neutral ***,the energy loss of the battery could be compensated via solar energy,leading to a record-low gap of 0.05 V between the charge and discharge voltage with a high round-trip efficiency of 94%.This work offers a simple but efficient pathway for solar-energy utilization in storage devices,further guiding the design of high energy efficiency of neutral aqueous ZABs.

关键词： neutral ZABs oxygen catalytic reactions photocatalysis round-trip efficiency solar energy

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Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate:immune mechanisms of recurrent early pregnancy loss

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National Science Review 2024年第6期11卷 129-145页

作者： Wentong Jia liyang Ma Xin Yu Feiyang Wang Qian Yang Xiaoye Wang Mengjie Fan Yan gu ran Meng Jian Wang Yuxia li Rong li Xuan Shao Yan-ling Wang State Key Laboratory of Stem cell and Reproductive Biology Key Laboratory of Organ Regeneration and ReconstructionInstitute of ZoologyChinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine University of the Chinese Academy of Sciences NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drug and Devices Shanghai Institute for Biomedical and Pharmaceutical Technologies National Clinical Center for Obstetrics and Gynecology Peking University Third Hospital Department of Family Planning The Second Hospital of Tianjin Medical University Department of Prenatal Screening Haidian Maternal and Child Health Hospital

Decidual natural killer（dNK） cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss（RPL） at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG（NOD/Shi-scid/IL-2Rγnull） mice, where human dNK cells predominantly homed into the uteri of recipients. Using this model, we observed a strong correlation between the properties of human dNK cells and pregnancy outcome. The transfer of dNK cells from RPL patients（dNK-RPL）remarkably worsened early pregnancy loss and impaired placental trophoblast cell differentiation in the recipients. These adverse effects were effectively reversed by transferring CD56+CD39+dNK *** studies revealed that CD56+CD39+dNK subset facilitates early differentiation of mouse trophoblast stem cells（m TSCs） towards both invasive and syncytial pathways through secreting macrophage colony-stimulating factor（M-CSF）. Administration of recombinant M-CSF to NOG mice transferred with dNK-RPL efficiently rescued the exacerbated pregnancy outcomes and fetal/placental development. Collectively, this study established a novel humanized mouse model featuring functional human dNK cells homing into the uteri of recipients and uncovered the pivotal role of M-CSF in fetal-supporting function of CD56+CD39+dNK cells during early pregnancy, highlighting that M-CSF may be a previously unappreciated therapeutic target for intervening RPL.

关键词： recurrent pregnancy loss CD56+CD39+ dNK subset NOG mice adoptive transfer placental trophoblast cell fate M-CSF

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Preparation for CSST:Star-galaxy Classification using a Rotationally Invariant Supervised Machine Learning Method

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Research in Astronomy and Astrophysics 2024年第9期24卷 136-146页

作者： Shiliang Zhang guanwen Fang Jie Song ran li Yizhou gu Zesen lin Chichun Zhou Yao Dai Xu Kong Institute of Astronomy and Astrophysics Anqing Normal UniversityAnqing 246133China Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsung-Dao Lee Institute and Key Laboratory for Particle Physics Astrophysics and CosmologyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China Department of Physics The Chinese University of Hong KongShatinN.T.Hong KongS.A.R.China School of Engineering Dali UniversityDali 671003China

Most existing star-galaxy classifiers depend on the reduced information from catalogs,necessitating careful data processing and feature *** this study,we employ a supervised machine learning method(GoogLeNet)to automatically classify stars and galaxies in the COSMOS *** traditional machine learning methods,we introduce several preprocessing techniques,including noise reduction and the unwrapping of denoised images in polar coordinates,applied to our carefully selected samples of stars and *** dividing the selected samples into training and validation sets in an 8:2 ratio,we evaluate the performance of the GoogLeNet model in distinguishing between stars and *** results indicate that the GoogLeNet model is highly effective,achieving accuracies of 99.6% and 99.9% for stars and galaxies,***,by comparing the results with and without preprocessing,we find that preprocessing can significantly improve classification accuracy(by approximately 2.0% to 6.0%)when the images are *** preparation for the future launch of the China Space Station Telescope(CSST),we also evaluate the performance of the GoogLeNet model on the CSST simulation *** results demonstrate a high level of accuracy(approximately 99.8%),indicating that this model can be effectively utilized for future observations with the CSST.

关键词： methods:data analysis techniques:image processing stars:imaging

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Research on concrete structure defect repair based on three-dimensional printing

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 731-742页

作者： Yang gu Wei li Xupeng YAO guangjun liU School of Mechanical Engineering Tongji UniversityShanghai 201804China College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Engineering Research Center for Safety Intelligent Control of Building Machinery Shanghai 200032China

Quality assurance and maintenance play a crucial role in engineering construction,as they have a significant impact on project *** common issue in concrete structures is the presence of *** enhance the automation level of concrete defect repairs,this study proposes a computer vision-based robotic system,which is based on three-dimensional(3D)printing technology to repair *** system integrates multiple sensors such as light detection and ranging(liDAR)and *** is utilized to model concrete pipelines and obtain geometric parameters regarding their ***,a convolutional neural network(CNN)is employed with a depth camera to locate defects in concrete ***,a method for coordinate transformation is presented to convert the obtained coordinates into executable ones for a robotic ***,the feasibility of this concrete defect repair method is validated through simulation and experiments.

关键词： concrete defect detection 3D printing deep learning point cloud data

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Built-in electric field induced S-scheme g-C_(3)N_(4)homojunction for efficient photocatalytic hydrogen evolution:Interfacial engineering and morphology control

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Nano Research 2024年第6期17卷 4961-4970页

作者： Yongpan gu Yike li Haoqiang Feng Yanan Han Zhongjun li College of Chemistry Zhengzhou UniversityZhengzhou 450001China

S-scheme possesses superior redox capabilities compared with the II-scheme,providing an effective method to solve the innate defects of g-C_(3)N_(4)(CN).In this study,S-doped g-C_(3)N_(4)/g-C_(3)N_(4)(SCN-tm/CN)S-scheme homojunction was constructed by rationally integrating morphology control with interfacial engineering to enhance the photocatalytic hydrogen evolution ***-situ Kelvin probe force microscopy(KPFM)confirms the transport of photo-generated electrons from CN to *** functional theory(DFT)calculations reveal that the generation of a built-in electric field between SCN and CN enables the carrier separation to be more efficient and *** transient absorption spectrum(fs-TAS)indicates prolonged lifetimes of SCN-tm/CN_(3)(τ1:9.7,τ2:110,andτ3:1343.5 ps)in comparison to those of CN(τ1:4.86,τ2:55.2,andτ3:927 ps),signifying that the construction of homojunction promotes the separation and transport of electron hole pairs,thus favoring the photocatalytic *** visible light irradiation,the optimized SCN-tm/CN_(3)exhibits excellent photocatalytic activity with the hydrogen evolution rate of 5407.3μmol·g^(−1)·h^(−1),which is 20.4 times higher than that of CN(265.7μmol·g^(−1)·h^(−1)).Moreover,the homojunction also displays an apparent quantum efficiency of 26.8%at 435 nm as well as ultra-long and ultra-stable cycle *** work offers a new strategy to construct highly efficient photocatalysts based on the metal-free conjugated polymeric CN for realizing solar energy conversion.

关键词： homojunction built-in electric field morphology control interfacial engineering carrier separation

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