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The Regulation of cGAS

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Virologica Sinica 2018年第2期33卷 117-124页

作者： Meiguang Xiong Suyun Wang Yan-Yi Wang yong ran Wuhan Institute of Virology Chinese Academy of Science

The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. The regulation of cGAS-MITA pathway at MITA-level have been extensively explored and reviewed elsewhere,here we provide a summary and perspective on recent advances in understanding of the cGAS regulation.

关键词： cGAS DNA sensing Regulation Autoimmune

PREPARATION OF POLY(METHYL METHACRYLATE)/LAYERED DOUBLE HYDROXIDES NANOCOMPOSITES via in situ SOLUTION POLYMERIZATION

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Chinese Journal of Polymer Science 2007年第6期25卷 573-579页

作者： Ang-ran Wang yong-zhong Bao Zhi-xue Weng Zhi-ming Huang State Key Laboratory of Chemical Engineering Zhejiang University Hangzhou 310027 China

An exfoliated layered double hydroxides/poly（methyl methacrylate）（LDHs/PMMA） nanocomposite was prepared by in situ solution polymerization of methyl methacrylate （MMA） in the presence of 4-vinylbenzenesulfonate intercalated LDHs（MgAl-VBS LDHs）. MgAl-VBS LDHs was prepared by the ion exchange method, and the structure and composition of the MgAl-VBS LDHs were determined by X-ray diffraction （XRD）, infrared spectroscopy and elemental analysis. XRD and transmission electron microscopy （TEM） were employed to examine the structure of LDHs/PMMA nanocomposite. It was indicated that the LDHs layers were well exfoliated and dispersed in the PMMA matrix. The grafting of PMMA onto LDHs was confirmed by the extraction result and the weight fraction of grafted PMMA increased as the weight fraction of LDHs in the nanocomposites increased.

关键词： Nanocomposite Poly(methyl methacrylate) Layered double hydroxides.

A Gradient-Domain Based Geometry Processing Framework for Point Clouds

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Journal of Computer Science & Technology 2018年第4期33卷 863-872页

作者： Hong-Xing Qin Jin-Long He Meng-Hui Wang Yu Dai Zhi-yong ran College of Computer Science and Technology Chongqing University of Posts and Telecommunications Chongqing 400065 China

The use of point clouds is becoming increasingly popular. We present a general framework for performing geometry filtering on point-based surface through applying the meshless local Petrol-Galelkin （MLPG） to obtain the solution of a screened Poisson equation. The enhancement or smoothing of surfaces is controlled by a gradient scale parameter. Anisotropic filtering is supported by the adapted Riemannian metric. Contrary to the other approaches of partial differential equation for point-based surface, the proposed approach neither needs to construct local or global triangular meshes, nor needs global parameterization. It is only based on the local tangent space and local interpolated surfaces. Experiments demonstrate the efficiency of our approach.

关键词： point clouds processing partial differential equation meshless method gradient-domain

Single DNA Condensation Induced by Hexammine Cobalt with Molecular Combing

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Chinese Journal of Chemical Physics 2012年第3期25卷 359-364,374页

作者： Gao-ming Hu Yu Lin Shi-yong ran Ya n-wei Wang Guang-can Yang College of Physics and Electronic Information Engineering Wenzhou University Wenzhou 325035 China

We investigated the interaction between DNA and hexammine cobalt III [Co（NH3）6]3＋ by a simple molecular combing method and dynamic light scattering. The average extension of A- DNA-YOYO-1 complex is found to be 20.9μm, about 30% longer than the contour length of the DNA in TE buffer （10 mmol/L Tris, 1 mmol/L EDTA, pH=8.0）, due to bis-intercalation of YOYO-1. A multivalent cation, hexammine cobalt, is used for DNA condensation. We find that the length of DNA-[Co（NH3）6]3＋ complexes decrease from 20.9 μm to 5.9μm as the concentration of the [Co（NH3）6]3＋ vary from 0 to 3 μmol/L. This observation provides a direct visualization of single DNA condensation induced by hexammine cobalt. The results from the molecular combing studies are supported by dynamic light scattering investigation, where the average hydrodynamic radius of the DNA complex decreases from 203.8 nm to 39.26 nm under the same conditions. It shows that the molecular combing method is feasible for quantitative conformation characterization of single bio-macromolecules.

关键词： Molecular combing Hexammine cobalt Condensation Dynamic light scatter-ing Fluorescent microscopy

Quantitative data about active tectonics and possible locations of strong earthquakes in the future in the northwestern Beijing

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Acta Seismologica Sinica(English Edition) 2001年第5期14卷 534-546页

作者： ran yong-kang 1. Institute of Geology China Seismological Bureau 100029 Beijing China

Deterministic, probabilistic and composite-grading methods are used to get the possible locations of strong earthquakes in the future in Northwest Beijing and its vicinity based on the quantitative data and their accuracy about active tectonics in the research area and by ordering, some questions in the results are also discussed. It shows that the most dangerous fault segments for strong earthquakes in the future include: segments B and A of the southern boundary fault of the Yangyuan basin, the southern boundary fault of the Xuanhua basin, the east segment of the southern Huai'an fault and the east segment of the northern Yanggao-Tianzhen fault. The most dangerous area is Yangyuan-Shenjing basin, the second one is Tianzhen-Huai'an-Xuanhua basin and the third dangerous area are Wanquan-Zhangjiakou and northeast of Yuxian to southwest of Fanshan.

关键词： Northwestern Beijing quantitative data of active tectonics comprehensive method locations of strong earthquakes

Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE Shuang-yi GAO Jian LI yong-ran JIANG Shu-xin ZHANG Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

Sorption and desorption of 1,4-dichlorobenzene on peat

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Chinese Science Bulletin 2000年第S1期45卷 47-52页

作者： ran yong LIN Zheng WANG Xili MIN Yushun SHENG Guoying FU Jiamo State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

Sorption and desorption of 1,4-dichlorobenzene (DCB) on peat (>92% organic matter) display large-scale hysteresis and nonlinearity. The magnitude of desorption hysteresis decreases in the order: untreated Pahokee peat (P)> acid treated peat (FP)> humin (TP). The desorption percentages are lower than 28% of the sorbed 1, 4-DCB after desorbing for 6 days. The sorption and desorption isotherms are well fitted to Freundlich equation, whose parameter 1/n ranges from 0.055 to 0.527. Moreover, the parameter 1/n of the desorption isotherm is significantly lower than that of the sorption isotherm, but the parameter logK increases on contrary to 1/n. The desorption isotherms are very well fitted to Langmuir equation, whose Qm decreases in the order: TP>FP> P. The apparent partition coefficients (Kp) increase with increasing sorption time or decreasing aqueous equilibrium concentration of DCB. And Kp of P is significantly higher than that of FP or TP.

关键词： 1 4-dichlorobenze sorption desorption natural organic matter isothermal equation.

Suspended particulate and colloidal matter in natural waters

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Journal of Environmental Sciences 2000年第2期12卷 4-12页

作者： ran, yong Fu, Jia-Mo Sheng, Guo-Ying Beckett, R. Hart, B.T. State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Water Studies Center Monash University Caulfield East Vic. 3145 Australia

The association of pollutants (nutrients, heavy metals and organic compounds) with colloidal and suspended particle matter(SPM) plays a dominant role in determining their transport, fate, biogeochemistry, bioavailability and toxicity in natural waters. A scheme for the fractionation and composition of colloidal and suspended particulate matter from river waters has been tested. Sieving, continuous flow centrifugation and tangential flow filtration were used to collect gram amounts of colloidal and particulate matters. The separation scheme was able to process large samples(100L), within reasonable times(1 day) and the apparatus was portable. The aquatic colloid was also separated with high resolution, and sized using sedimentation field\|flow fractionation technique. The mass\|based particle size distribution for the river water sample showed a broad size distribution between 0\^05 and 0\^4 μm with the maximum around 0\^14 μm. There was a systematic increase in the content of organic carbon, Mg, Ca, Na, Cu and Zn with decreasing particle size, highlighting the importance of the colloidal(<1 μm) fraction.

关键词： suspended particulate colloidal matter natural waters pollutants CLC number: X132 Document code: A

Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode

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Chinese Chemical Letters 2011年第8期22卷 964-968页

作者： Ling Ren Wang Fen ran yong Tao Tan Lei Zhao Ling Bin Kong Long Kang State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials Lanzhou University of Technology Lanzhou 730050 China

Coral reef-like PANI nanotubes composed of nanopaticles were successfully synthesized by a reactive template of manganese *** structure was characterized by using SEM,TEM,and FT-IR,and the supercapacitive behaviors of these nanotubes were investigated with cyclic voltammetry（CV）,and charge-discharge tests,respectively.A maximum specific capacitance of 533 F/g could be achieved in 1mol/L aqueous H_2SO_4 with the potential range of -0.2 to 0.8 V（*** saturated calomel electrode） in a half-cell setup configuration for PANI electrode,suggesting its potential application in the electrode material for electrochemical capacitors.

关键词： Electrochemical capacitors PANI Reactive template Specific capacitance