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Comparison of outcomes for patients with primary sclerosing cholangitis associated with ulcerative colitis and Crohn’s disease

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Gastroenterology Report 2016年第1期4卷 43-49,I0002页

作者： Udayakumar Navaneethan Preethi GK Venkatesh ramprasad jegadeesan Vennisvasanth Lourdusamy Jeffrey P Hammel Ravi P Kiran Bo Shen Department of Gastroenterology Digestive Disease InstituteThe Cleveland ClinicClevelandOHUSA Department of Colorectal Surgery Columbia University Medical CenterNew York Presbyterian HospitalNew YorkNYUSA.

Background:The comparative outcomes of ulcerative colitis(UC)and Crohn’s disease(CD)in patients with primary sclerosing cholangitis(PSC)are unclear;the aim of our study was to make an objective ***:A total of 273 patients with PSC and inflammatory bowel disease(223 with UC and 50 with CD)were *** and demographic variables were ***:The PSC risk score was similar for both *** median follow-up period in patients with PSC-UC was 12 years(range 0–38)and that for PSC-CD was 14 years(range 1–36).The median number of disease flares per year was higher in PSC-UC patients than in the PSC-CD group[1vs.0(ranges 0–20 and 0–9,respectively);P<0.001].More patients with UC developed colon neoplasia than CD(35.9%vs.18%;P=0.009).On proportional hazards analysis for the risk of colectomy,UC patients had a 12%higher risk for colectomy[hazard ratio(HR)=0.88;95%confidence interval(CI)0.51–1.51;P=0.64].Liver transplantation for PSC was associated with decreased risk(HR=0.57;95%CI 0.37–0.89;P=0.013),while colon neoplasia increased the risk(HR=3.83;95%CI 2.63–5.58;P<0.001)for *** proportional hazards analysis for the risk of colon neoplasia,UC patients had 56%higher risk of developing colon neoplasia than CD(HR=0.44;95%CI 0.16–1.25;P=0.12).Conclusions:PSC patients with CD appear to be associated with a lower risk of colon neoplasia and colectomy than PSC patients with UC.

关键词： primary sclerosing cholangitis ulcerative colitis Crohn’s disease colon neoplasia colectomy liver transplantation

Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function

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World Journal of Gastroenterology 2016年第20期22卷 4918-4925页

作者： Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota ramprasad jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja Department of Gastroenterology Q3 Cleveland Clinic Department of Radiology Cleveland Clinic Department of Cardiothoracic Surgery Cleveland Clinic

AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in ***: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for ***: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg res

关键词： Achalasia Dysphagia Heller myotomy Peroral endoscopic myotomy Manometry Pneumatic dilation

Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience

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World Journal of Gastrointestinal Endoscopy 2014年第3期6卷 74-81页

作者： Udayakumar Navaneethan Norma G Gutierrez ramprasad jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi Department of Gastroenterology and Hepatology Digestive Disease Institute Cleveland Clinic Foundation

AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergo

关键词： Endoscopic retrograde cholangiopancreatography Cholangitis Outcomes

Noise degradation system using Wiener filter and CORDIC based FFT/IFFT processor

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Journal of Central South University 2015年第10期22卷 3849-3859页

作者： Yasodai A ramprasad A V Department of Electronics and Communication Engineering Vickram College of Engineering Department of Electronics and Communication Engineering K L N College of Engineering

On augmentation of past work, an effective Wiener filter and its application for noise suppression combined with a formed CORDIC based FFT/IFFT processor with improved speed were executed. The pipelined methodology was embraced for expanding the execution of the system. The proposed Wiener filter was planned in such an approach to evacuate the iteration issues in ordinary Wiener filter. The division process was supplanted by a productive inverse and multiplication process in the proposed design. An enhanced design for matrix inverse with reduced computation complexity was executed. The wide-ranging framework processing was focused around IEEE-754 standard single precision floating point numbers. The Wiener filter and the entire system design was integrated and actualized on VIRTEX 5 FPGA stage and re-enacted to approve the results in Xilinx ISE 13.4. The results show that a productive decrease in power and area is developed by adjusting the proposed technique for speech signal noise degradation with latency of n/2 clock cycles and substantial throughput result per every 12 clock cycles for n-bit precision. The execution of proposed design is exposed to be 31.35% more effective than that of prevailing strategies.

关键词： Wiener filter iterations power spectrum FFT/IFFT floating point noise suppression speech enhancement VLSI speed power area

A deep learning framework to emulate density functional theory

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npj Computational Materials 2023年第1期9卷 687-695页

作者： Beatriz G.del Rio Brandon Phan Rampi ramprasad Departamento de Física Teórica Atómica yÓpticaUniversidad de ValladolidPaseo de Belén 747011 ValladolidSpain School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive NWAtlantaGA 30332USA

Density functional theory(DFT)has been a critical component of computational materials research and discovery for ***,the computational cost of solving the central Kohn–Sham equation remains a major obstacle for dynamical studies of complex phenomena ***,we propose an end-to-end machine learning(ML)model that emulates the essence of DFT by mapping the atomic structure of the system to its electronic charge density,followed by the prediction of other properties such as density of states,potential energy,atomic forces,and stress tensor,by using the atomic structure and charge density as *** deep learning model successfully bypasses the explicit solution of the Kohn-Sham equation with orders of magnitude speedup(linear scaling with system size with a small prefactor),while maintaining chemical *** demonstrate the capability of this ML-DFT concept for an extensive database of organic molecules,polymer chains,and polymer crystals.

关键词： functional theory system

Machine learning in materials informatics:recent applications and prospects

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npj Computational Materials 2017年第1期3卷 1-13页

作者： Rampi ramprasad Rohit Batra Ghanshyam Pilania Arun Mannodi-Kanakkithodi Chiho Kim Department of Materials Science&Engineering and Institute of Materials Science University of Connecticut97 North Eagleville Rd.Unit 3136StorrsCT 06269-3136USA Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-614195 BerlinGermany Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Center for Nanoscale Materials Lamont National Laboratory9700 S.Cass Ave.LemontIL 60439USA

Propelled partly by the Materials Genome Initiative,and partly by the algorithmic developments and the resounding successes of data-driven efforts in other domains,informatics strategies are beginning to take shape within materials *** approaches lead to surrogate machine learning models that enable rapid predictions based purely on past data rather than by direct experimentation or by computations/simulations in which fundamental equations are explicitly ***-centric informatics methods are becoming useful to determine material properties that are hard to measure or compute using traditional methods—due to the cost,time or effort involved—but for which reliable data either already exists or can be generated for at least a subset of the critical *** are typically interpolative,involving fingerprinting a material numerically first,and then following a mapping(established via a learning algorithm)between the fingerprint and the property of ***,also referred to as“descriptors”,may be of many types and scales,as dictated by the application domain and *** may also be extrapolative—extending into new materials spaces—provided prediction uncertainties are properly taken into *** article attempts to provide an overview of some of the recent successful data-driven“materials informatics”strategies undertaken in the last decade,with particular emphasis on the fingerprint or descriptor *** review also identifies some challenges the community is facing and those that should be overcome in the near future.

关键词： overcome subset properly

Parental attitudes towards influenza vaccination for children in South India

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World Journal of Pediatrics 2017年第1期13卷 84-90页

作者： Chethan ramprasad Rajeev Zachariah Mark Steinhoff Anna Simon University of Miami Miller School of Medicine MiamiFloridaUSA Christian Medical College VelloreTamil NaduIndia Cincinnati Children's Hospital Medical Center CincinnatiOhioUSA Christian Medical College VelloreTamil NaduIndia

Background:The rate of influenza vaccination is low for children in *** purpose of this study is to assess parental attitudes towards influenza vaccination in South ***:Participants were parents who brought their children to the Well Baby Clinic of Christian Medical College Hospital,Vellore,India for routine *** answered questions by written survey while waiting for their children’s vaccination.

关键词： doctor recommendation influenza immunization parental attitudes vaccination

Synthesis and antimycobacterial screening of new N-(4-(5-aryl-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrazol-1-yl)phenyl)-4-amide derivatives

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Chinese Chemical Letters 2016年第3期27卷 365-369页

作者： Nagabhushana Nayak Jurupula ramprasad Udayakumar Dalimba Perumal Yogeeswari Dharmarajan Sriram Organic Chemistry Laboratory Department of ChemistryNational Institute of Technology Karnataka Medicinal Chemistry and Drug Discovery Research Laboratory Pharmacy GroupBirla Institute of Technology and Science-PilaniHyderabad Campus

This article demonstrates the synthesis, characterization and the study of in vitro antitubercular activities of twenty four new N-（4-（5-aryl-3-（5-methyl-1,3,4-oxadiazol-2-yl）-1H-pyrazol-1-yl）phenyl）-4-amide derivatives（8a–x）. The antitubercular activity of the compounds against Mycobacterium tuberculosis H37Rv（MTB） revealed that 2-chloro-N-（4-（5-（4-chlorophenyl）-3-（5-methyl-1,3,4-oxadiazol-2-yl）-1H-pyrazol-1-yl）phenyl）benzamide（8n） is the most promising lead molecule with a MIC of1.56 mg/m L, while the corresponding unsubstituted benzamide derivative（8o） is the next most active molecule with a MIC of 3.13 mg/m L. Interestingly, the pyrazole intermediate 5b containing chlorophenyl and N-acylcarbohydrazide substituents also showed significant activity（MIC = 3.13 mg/m L）. Further, the active molecules did not show toxicity against a normal NIH 3T3 cell line, signifying their suitability for further drug development.

关键词： Pyrazole-oxadiazole hybrids Antitubercular activity SC-XRD analysis In vitro cytotoxicity

Solving the electronic structure problem with machine learning

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npj Computational Materials 2019年第1期5卷 959-965页

作者： Anand Chandrasekaran Deepak Kamal Rohit Batra Chiho Kim Lihua Chen Rampi ramprasad School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Dr.NWAtlantaGA 30332USA

Simulations based on solving the Kohn-Sham(KS)equation of density functional theory(DFT)have become a vital component of modern materials and chemical sciences research and development *** its versatility,routine DFT calculations are usually limited to a few hundred atoms due to the computational bottleneck posed by the KS *** we introduce a machine-learning-based scheme to efficiently assimilate the function of the KS equation,and by-pass it to directly,rapidly,and accurately predict the electronic structure of a material or a molecule,given just its atomic configuration.A new rotationally invariant representation is utilized to map the atomic environment around a grid-point to the electron density and local density of states at that *** mapping is learned using a neural network trained on previously generated reference DFT results at millions of *** proposed paradigm allows for the high-fidelity emulation of KS DFT,but orders of magnitude faster than the direct ***,the machine learning prediction scheme is strictly linear-scaling with system size.

关键词： solution. equation. structure