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Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives

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World Journal of Gastroenterology 2013年第44期19卷 7955-7971页

作者： Inês Marques António Araújo ramon andrade de mello Faculty of Medicine University of Porto 4200-319 Porto Portugal Molecular Oncology Group Research CenterPortuguese Oncology Institute 4200-072 Porto Portugal department of Medical Oncology Portuguese Oncology Institute 4200-072 Porto Portugal The Royal Marsden NHS Foundation Trust London SW3 6JJ United Kingdom

Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United States,with about 142820 new cases and 50830 deaths expected in *** disease(mCRC)remains a challenge for oncologists worldwide due to its potential ***,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic ***,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient ***,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC *** review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard.

关键词： Colorectal cancer Bevacizumab Cetuximab Aflibercept FOLFOX FOLFIRI

Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies

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World Journal of Gastroenterology 2013年第38期19卷 6383-6397页

作者： Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo ramon andrade de mello Gastrointestinal Unit Service of Medical OncologyPortuguese Oncology Institute4200-072 PortoPortugal Gastrointestinal Unit Experimental Pathology and Therapeutics GroupResearch Center-Portuguese Oncology Institute4200-072 PortoPortugal department of Pharmacology and Therapeutics Faculty of MedicineUniversity of Porto4200-319 PortoPortugal Institute of Cellular and Molecular Biology 4150-180 PortoPortugal Gastrointestinal Unit Section of Surgical OncologyPortuguese Oncology Institute4200-072 PortoPortugal department of Medicine Faculty of MedicineUniversity of Porto4200-319 PortoPortugal

Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in *** the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong ***,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)***,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based ***,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this ***,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved.

关键词： Gastric cancer Human epidermal growth factor receptor 2 Biomarkers Target therapies Trastuzumab Lapatinib Pertuzumab Trastuzumab-DM1 Afatinib

HER2 therapies and gastric cancer:A step forward

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World Journal of Gastroenterology 2013年第37期19卷 6165-6169页

作者： ramon andrade de mello Andrea Marin Marques António Araújo department of Medical Oncology Gastrointestinal UnitPortuguese Oncology Institute department of Medicine FMUP-Faculty of MedicineUniversity of Porto Centro Hospitalar Médio Ave Unidade Santo Tirso

Gastric cancer usually is diagnosed in advanced stages and thus current medical practice affords limited therapeutic ***,recent studies established the role of human epidermal growth factor receptor 2(HER2)in clinical ***,an antiHER2 monoclonal antibody,acquired a main role in advanced gastric cancer harboring HER2 overexpression and/or amplification improving survival to 17.1 mo according to trastuzumab for gastric cancer phaseⅢtrial ***,new promising drugs,such as c-Met inhibitors,are in development and assessment for this ***,novel drugs will emerge in the next feel years for help oncologists improve clinical management of advanced gastric cancer providing higher survival and quality of *** this mini-review we will discuss some issues in this regard and provide an actual overview of this setting.

关键词： Gastric cancer Trastuzumab c-Met Human epidermal growth factor receptor 2 Lapatinib Pertuzumab

Epidermal growth factor receptor and metastatic colorectal cancer:Insights into target therapies

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World Journal of Gastroenterology 2013年第38期19卷 6315-6318页

作者： ramon andrade de mello Andrea Marin Marques António Araújo department of Medical Oncology Portuguese Oncology Institute4200-072 PortoPortugal department of Medicine FMUP-Faculty of MedicineUniversity of Porto4200-319 PortoPortugal department of Medicine Centro Hospitalar Médio Ave4780 PortoPortugal

Colorectal cancer(CRC)has high incidence and mortality *** 2012,CRC was the second most prevalent cancer among males(9%)and the third among females(8%).In recent decades,standard chemotherapies protocols combining 5-fluorouracil,leucovorin,irinotecan and oxaliplatin were important for improve survival in this set of ***,biological drugs throughout epidermal growth factor receptor(EGFR)pathways showed interesting results in metastatic disease(mCRC)control when in association to standard chemotherapy *** and panitumumab are two cornerstones for mCRC treatment and are both approved in Europe and United States based on previous results phaseⅢ*** paper will briefly summarize those anti-EGFR therapies framework in mCRC and discusses some issues in this regard.

关键词： Colorectal cancer Epidermal growth factor receptor KRAS mutation Chemotherapy Cetuximab Panitumumab

Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies

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World Journal of Clinical Oncology 2011年第11期2卷 367-376页

作者： ramon andrade de mello Dania Sofia Marques Rui Medeiros António MF Araújo department of Medical Oncology Portuguese Oncology InstitutePorto 4200-072Portugal 2nd department of Medicine Discipline of Clinical SemioticsFaculty of MedicineUniversity of PortoPorto 4200-319Portugal Molecular Oncology Unit CI IPOPFGPorto 4200-072Portugal 2nd departament of Molecular Immunology and Pathology Instituto de Ciências Biomédicas Abel Salazar(ICBAS)University of PortoPorto 4099-003Portugal Head of Lung Clinic of the department of Medical Oncology Portuguese Oncology InstitutePorto 4200-072Portugal

Lung cancer is currently the leading cause of cancer death in Western ***-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological *** the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful *** studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these *** article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior.

关键词： Epidermal growth factor receptor K-Ras Nonsmall-cell lung carcinoma Pharmacogenomics p21ras proto-oncogene proteins

Personalizing medicine for metastatic colorectal cancer:Current developments

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World Journal of Gastroenterology 2014年第30期20卷 10425-10431页

作者： rea Marin Marques Alice Turner ramon rade de mello Centro Hospitalar do Médio Ave Unidade de Santo Tirso4780-371 Santo Tirso4200-072 PortoPortugal School of Medicine University of Otago2 Riccarton AveChristchurch Central8011 ChristchurchNew Zealand department of Medical Oncology Portuguese Oncology Institute (IPO PORTO)4200-072 PortoPortugal department of Biomedical Sciences and Medicine School of MedicineUniversity of Algarve8005-139 FaroPortugal

Metastatic colorectal cancer(mCRC)is still one of the tumor types with the highest incidence and *** 2012,colorectal cancer was the second most prevalence cancer among males(9%)and the third among females(8%).In this disease,early diagnosis is important to improve treatment ***,at the time of diagnosis,about one quarter of patients already have metastases,and overall survival of these patients at 5-years survival is very *** of these poor statistics,the development of new drugs against specific targets,including the pathway of angiogenesis,has witnessed a remarkable ***,targets therapies through epidermal growth factor and its receptor and also KRAS pathways modulation acquired a main role whether in association with standard chemotherapy and *** the current knowledge in the field of molecular biology,including genetic mutations and polymorphisms,we know better why patients respond so differently to the same ***,in the future we can develop increasingly personalized treatments to the patient and not the *** review aims to summarize some molecular pathways and their relation to tumor growth,as well as novel targeted developing drugs and recently approved for mCRC.

关键词： Metastatic colorectal cancer Angiogenesis Vascular endothelial growth factor Epidermal growth factor Target therapy

Anterior transhepatic approach for total caudate lobectomy including spigelian lobe,paracaval portion and caudate process:A Brazilian experience

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 371-373页

作者： Eduardo de Souza Martins Fernandes Carlo Alberto Pacilio Felipe Pedreira Tavares de mello Ronaldo de Oliveira andrade Leandro Moreira Savattone Pimentel Camila Liberato Girão Hepato-Pancreato-Biliary and Transplant Surgery Hospital Adventista SilvestreRio de JaneiroBrazil Hospital Universitario Clementino Fraga Filho Universidade Federal do Rio De Janeiro(UFRJ)Rio de JaneiroBrazil

To the Editor:Nowadays,because of the infiltration of cholangiocarcinoma to the parenchyma and/or bile ducts of the caudate lobe,the inclusion of caudate lobe combined with a major hepatectomy remains the gold standard approach for a resectable hilar *** the last years of the 20th century,some authors have begun to report isolated caudate lobe resection for hepatocellular

关键词： HCC Anterior transhepatic approach for total caudate lobectomy including spigelian lobe paracaval portion and caudate process:A Brazilian experience

Acute Appendicitis after Liver Transplant: A Case Report and Review of the Literature

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Open Journal of Organ Transplant Surgery 2014年第4期4卷 29-32页

作者： Ronaldo de Oliveira andrade Rodrigo da Silva Pires Raul évora Silva Felipe Pedreira Tavares de mello Cláudia Cristina Tavares de Sousa Samanta Teixeira Basto Eduardo de Souza Martins Fernandes department of Surgery and Liver Transplant Hospital Adventista Silvestre Rio de Janeiro Brazil

Acute appendicitis is rare in the postoperative period of liver transplantation;only 23 cases were described in the literature to date, including late and immediate postoperative. Our case reports a patient who was presented with acute appendicitis in the immediate post-transplant and died in the subsequent postoperative period. The article reviews the available literature and all cases known until now, commenting on incidence, casual factors, symptoms, diagnostic and management.

关键词： Appendicitis Complications Early Postoperative Liver Transplantation

Evaluation of Total and Faecal Coliforms and Salmonella spp. in Irradiated Mussels from Brazil

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Journal of Agricultural Science and Technology(A) 2012年第4期2卷 511-519页

作者： Flaivia Aline andrade Calixto Eliana de Faitima Marques de Mesquita Robson Maia Franco Cynthia Annes Rubiao Neila mello dos Santos Cortez Mauro Carlos Lopes Souza Licinio Esmeraldo da Silva Higiene Veterinaria e Processamento Tecnologico de Produtos de Origem Animal （HVPTPOA） UFF Fundacao Instituto dePesca do Estado do Rio de Janeiro （FIPERJ） Niteroi 24120191 Brazil Universidade Federal Fluminense （UFF） Niteroi 24230340 Brazil Biosafe Food Consulting Rio de Janeiro 22640101 Brazil Doctorate Student in HVPTPOA UFF Niter6i 24230340 Brazil Centro Universitario Estadual da Zona Oeste （UEZO） Rio de Janeiro 23070200 Brazil

Ilha Grande Bay is one of the biggest producers of bivalves of Rio de Janeiro State. Statistics reports of foodborne diseases are quite low in Brazil, however, this fact is a matter of Public Health. In their majority concerning consumption of bivalves meat, the availability of safe products requires the use of technology as food irradiation. The objective of this paper was to evaluate the presence of bacteria resulting from the environmental contamination and epidemiological importance, Salmonella spp., total and faecal coliforms of mussel （Perna perna） from that region and the use of irradiation on the product in natura. Fifteen indicative samples of mussel were collected from five gr owing points in Ilha Grande Bay. A sample of each point was irradiated with doses of 1.0 and 1.5 kGy. The bacteriological analysis followed the instructions of the Brazilian legislation. The samples presented irregularities in relation to Salmonella spp. and faecal coliforms, the latter for the control group. The control group was noticed as not appropriate for consumption. The dose of 1.0 kGy was effective for the reduction of faecal coliforms, but ineffective for the extinction of Salmonella spp.

关键词： Mussel bacteriological evaluation Ilha Grande Bay food irradiation