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Antileishmanial assessment of leaf extracts from Pluchea carolinensis,Pluchea odorata and Pluchea rosea

Asian Pacific Journal of Tropical Medicine 2011年第10期4卷 836-840页

作者： Marley Garcia Wilmer H Perera ramon scull Lianet Monzote Parasitology Department Institute of Medicine Tropical "Pedro Kourl"Havana CityCuba Institute of Ecology and Systematic Havana CityCuba Institute of Pharmacy and Food Havana CityCuba Parasitology Department Institute of Medicine Tropical "Pedro Kouri"Havana CityCuba

Objective:To evaluate the antileishmanial activity of different extracts from three Cuban Pluchea ***:In in vitro assays the IC50was calculated in the promastigotes and amastigotes forms as cytotoxicity in murine *** leishmaniasis cutanea experiment,mortality, weight loss,lesion size and burden parasite were ***:Extracts evaluated showed inhibitive effect on growing of promastigote form;however,active extracts caused a high toxicity. Ethanol and n-hexane extracts demonstrated specific antileishmanial *** and n-hexane extracts from Pluchea carolinensis（***） caused similar inhibition against amastigote *** intraperitoneal administration of the ethanol extract of *** at 100 mg/kg prevented lesion development compared with control ***:The antileishmanial experiment suggests that ethanol extracts from *** is the most *** studies are still needed to evaluate the polential of this plant as a source of new antileishmanial agents.

关键词： Pluchea carolinensis Pluchea odorata Pluchea rosea Medicinal plants Leishmania amazonensis

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Bioassay-guided in vitro study of the antileishmanial and cytotoxic properties of Bixa orellana seed extract

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Journal of Coastal Life Medicine 2014年第6期 484-489页

作者： Marley García Ramón scull Osmany Cuesta Gaëlle Boulet Louis Maes Paul Cos Lianet Monzote Department of Parasitology Institute of Tropical Medicine“Pedro Kourí”HavanaCuba Department of Chemistry Institute of Pharmacy and FoodHavana UniversityHavanaCuba Laboratory of Microbiology Parasitology and Hygiene(LMPH)Faculty of PharmaceuticalBiomedical and Veterinary SciencesAntwerp UniversityAntwerpBelgium

Objective:To investigate the leishmanicidal effect of the Bixa orellana crude seed extract and its fractions against Leishmania ***:Four main fractions(BO-A,BO-B,BO-C and BO-D)were obtained by exhaustion with solvent with increased polarity from the Bixa orellana crude seed extract and 28 *** antileishmanial activity was evaluated in intracellular amastigotes and the cytotoxicity was assessed in murine intraperitoneal ***:The BO-A and BO-B fractions showed a good antileishmanial activity with IC50 values of(12.9±4.1)and(12.4±0.3)μg/mL,*** sub-fractions BO-B1(IC_(50)=(11.8±3.8)μg/mL)and BO-B3[IC_(50)=(13.6±4.7)μg/mL]also proved to have a good leishmanicidal *** general,the sub-fractions showed a lower toxicity than the crude extract.A selectivity index of 9 indicated a moderate selectivity of the BO-A,BO-B and BO-C fractions and BO-B1 ***:Potential of this plant against cutaneous leishmaniasis should be further investigated.

关键词： Bixa orellana Traditional medicine Bioassay-guided fractionation Leishmania amazonensis

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