检索结果-南通市图书馆

Comprehensive Assessment of Anxiolytic Properties in 4-HPAA Derivatives: Bridging in Vivo Validation and Molecular Docking Analyses

引用

Open Journal of Medicinal Chemistry 2024年第3期14卷 29-44页

作者： Kawthar Alhussieni rami ayoub Jamal Jilani Qais Jarrar Othman Alhussinei Vetriselvan Subramaniyan Esra Nasraldin Khalil Sharafaldin Harshini Muruganantham Jureerat Kijsomporn Ling Shing Wong Department of Applied Pharmaceutical Sciences and Clinical Pharmacy Faculty of Pharmacy Isra University Amman Jordan Department of Pharmaceutical Chemistry Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Department of Medicinal Chemistry and Pharmacognosy Faculty of Pharmacy Jordan University of Science and Technology Irbid Jordan Department of Allied Medical Sciences Zarqa Private University Zarqa Jordan Department of Medical Sciences School of Medical and Life Sciences Sunway University Bandar Sunway Malaysia Department of Clinical Pharmacy and Pharmacy Practice Faculty of Pharmacy Universiti Malaya Kuala Lumpur Malaysia Center for Global Research Saveetha Medical College Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India School of Nursing Metharath University Bangtoey Thailand Faculty of Health and Life Sciences INTI International University Nilai Malaysia

Anxiety is a significant mental health issue that substantially affects an individual’s quality of life. Feelings of uneasiness, irritability, and sleep disturbances characterize it. 4-Hydroxyphenyl acetic acid (4-HPAA) is identified in brain cells as a physiological byproduct of tyramine. This study hypothesizes that 4-HPAA may regulate anxiety due to its anxiolytic properties, acting as a modulator of the GABAergic system, which plays a crucial role in the pathophysiology of anxiety disorders. Our study aims to enhance the anxiolytic effects of 4-HPAA through chemical modification to improve its pharmacokinetic properties. Three derivatives, namely Isopropyl-4-hydroxy-[phenyl] acetate (IHPA), Isopropyl-4-hydroxy-[phenyl] acetate (MPAA), and 4-methoxyphenyl acetate (MPHA), have been synthesized from 4-HPAA. This assessment will use well-established animal models, specifically the Elevated Plus-Maze (EPM) and Zero Maze (EZM) tests, selected for their validity in replicating anxiety-like symptoms in animals. Chronic caffeine administration via drinking water (0.3 g/l for 14 days) was employed to induce an anxiety state for testing purposes. IHPA and MPAA demonstrated significant anxiolyticactivity when tested in the EPM and EZM experiments. Molecular docking simulations using AutoDock Vina indicated that 4-HPAA derivatives had docking scores ranging from −5.8 to −4.8 kcal/mol, compared to the standard anxiolytic medication Diazepam, which scored −7.1 kcal/mol. These scores suggest a potential for 4-HPAA derivatives to interact effectively with the Gamma-aminobutyric acid (GABA_A) receptor. In conclusion, our in vivo and in silico analyses indicate a promising anxiolytic potential for 4-HPAA derivatives.

关键词： Anxiolytics 4-HPAA Molecular Docking Elevated Plus-Maze Zero Maze Tests

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing the Decomposition of Paper Cups Using Galleria Mellonella and Eisenia Fetida

引用

Journal of Renewable Materials 2024年第2期12卷 349-367页

作者： Shadi Moqbel Habib Al-Ghoul Abd Al-Majeed Al-Ghzawi rami Mukbel Civil Engineering Department The University of JordanAmman11942Jordan Department of Chemistry Technical University of MunichMunichGermany Plant Production Jordan University of Science and TechnologyIrbid22110Jordan Basic Medical Veterinary Sciences Jordan University of Science and TechnologyIrbid22110Jordan

The composition of paper cups creates a challenge for the recycling industry,as the paperboard–plastic film composite is hard to ***,paper cups are sent to landfills or waste *** study explores the combined use of red worms(Eisenia fetida)and Greater wax moth(Galleria mellonella)in the biodegradation of paper *** study investigates the conditions and combinations that promote using Eisenia fetida and Galleria mellonella for degrading paper *** study considered the influence of environmental temperature,the presence of food waste,varying the number of Eisenia fetida worms,and the presence of a Galleria mellonella growth-slowing agent on the degradation *** achieve the study objectives,the study followed a quantitative *** study monitored the degradation of paper cup cuts that were placed in jars containing different combinations of Eisenia fetida worms,Galleria mellonella larvae,food waste,bedding material,and Galleria mellonella growth-slowing *** study found that the best operating temperature is *** study found that using food waste improves the performance of Eisenia fetida worms and Galleria mellonella larvae *** study found that adding a Galleria mellonella growth-slowing agent slightly enhances the degradation of the paper ***,a numerical model was obtained to simulate the paper cup degradation efficiency.

关键词： Paper cups resource recovery recycling circular economy Galleria mellonella Eisenia fetida

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SNR and RSSI Based an Optimized Machine Learning Based Indoor Localization Approach:Multistory Round Building Scenario over LoRa Network

引用

Computers, Materials & Continua 2024年第8期80卷 1927-1945页

作者： Muhammad ayoub Kamal Muhammad Mansoor Alam Aznida Abu Bakar Sajak Mazliham Mohd Su’ud Malaysian Institute of Information Technology(MIIT) Universiti Kuala LumpurKuala Lumpur50250Malaysia Faculty of Computing and Informatics Multimedia UniversityCyberjaya63100Malaysia Depertment of Computer Science DHA Suffa UniversityKarachiSindh75500Pakistan Riphah Institute of System Engineering(RISE) Faculty of ComputingRiphah International UniversityIslamabad46000Pakistan Malaysian France Institute(MFI) Universiti Kuala LumpurKuala Lumpur50250Malaysia Faculty of Engineering and Information Technology School of Computer ScienceUniversity of Technology SydneyUltimoNSW 2007Australia

In situations when the precise position of a machine is unknown,localization becomes *** research focuses on improving the position prediction accuracy over long-range(LoRa)network using an optimized machine learning-based *** order to increase the prediction accuracy of the reference point position on the data collected using the fingerprinting method over LoRa technology,this study proposed an optimized machine learning(ML)based *** signal strength indicator(RSSI)data from the sensors at different positions was first gathered via an experiment through the LoRa network in a multistory round layout *** noise factor is also taken into account,and the signal-to-noise ratio(SNR)value is recorded for every RSSI *** study concludes the examination of reference point accuracy with the modified KNN method(MKNN).MKNN was created to more precisely anticipate the position of the reference *** findings showed that MKNN outperformed other algorithms in terms of accuracy and complexity.

关键词： Indoor localization MKNN LoRa machine learning classification RSSI SNR localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-Uniform Pion Tetrahedron Aether and Electron Tetrahedron Model

引用

Journal of High Energy Physics, Gravitation and Cosmology 2024年第2期10卷 810-824页

作者： rami Rom Independent Researcher Zikhron-Yaakov Israel

We propose that the QCD vacuum pion tetrahedron condensate density vary in space and drops to extremely low values in the Kennan, Barger and Cowie (KBC) void in analogy to earth’s atmospheric density drop with elevation from earth. We propose a formula for the gravitation acceleration based on the non-uniform pion tetrahedron condensate. Gravity may be due to the underlying microscopic attraction between quarks and antiquarks, which are part of the vacuum pion tetrahedron condensate. We propose an electron tetrahedron model, where electrons are comprised of tetraquark tetrahedrons, and . The quarks determine the negative electron charge and the or quarks determine the electron two spin states. The electron tetrahedron may perform a high frequency quark exchange reactions with the pion tetrahedron condensate by tunneling through the condensation gap creating a delocalized electron cloud with a fixed spin. The pion tetrahedron may act as a QCD glue bonding electron pairs in atoms and molecules and protons to neutrons in the nuclei. Conservation of valence quarks and antiquarks is proposed.

关键词： Standard Model (SM) QCD Vacuum Condensate Electric Dipole Moment (EDM) KBC Void Antimatter MOND Theory Aether

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Pionic Deuterium and the Pion Tetrahedron Vacuum Polarization

引用

Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 329-345页

作者： rami Rom Zikhron-Ya’akov Israel

A double-well potential model is proposed for the pionic deuterium that enables to calculate the energy split, the potential barrier height and estimate the pion tetrahedron edge length. We propose that pion tetrahedrons, πTd = ud~dũ, play a central role in the Yukawa interaction by enabling quark exchange reactions between protons and neutrons by tunneling through a potential barrier. A vacuum polarization Feynman diagram is proposed for the πTd having chains of fermion loops for the two valence quarks and anti-quarks connected by gluons. With a higher order vacuum polarization diagram, the d and u quark loops are interleaved and the chiral symmetry is broken dynamically. The proposed πTd vacuum polarization integral does not diverge in both the IR and UV limits and vanishes in the limit of an infinite pion tetrahedron condensate. We propose a new Delbruck scattering Feynman diagram that includes d and u quark and anti-quark interleaved loops. We further propose that conversion of gravitons to photons may occur via quark and anti-quark loops that describe the pion tetrahedrons dynamics in the vacuum and may also transfer gravitational waves.

关键词： Pionic Deuterium (πD) Yukawa Interaction QCD Vacuum Double-Well Potential Chiral Perturbation Theory Vacuum Polarization Gravitational Waves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A gated recurrent unit model to predict Poisson’s ratio using deep learning

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 123-135页

作者： Fahd Saeed Alakbari Mysara Eissa Mohyaldinn Mohammed Abdalla ayoub Ibnelwaleed A.Hussein Ali Samer Muhsan Syahrir Ridha Abdullah Abduljabbar Salih Petroleum Engineering Department Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia Institute of Hydrocarbon Recovery Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia Gas Processing Center College of EngineeringQatar UniversityP.O.Box 2713DohaQatar Department of Chemical Engineering College of EngineeringQatar UniversityP.O.Box 2713DohaQatar Mechanical Engineering Department Universiti Teknologi PETRONAS32610Bandar Seri IskandarPerakMalaysia

Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand *** models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical *** this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error *** GRU model showed the proper trends,and the model data ranges were wider than previous *** GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other *** GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,*** group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs.

关键词： Static Poisson’s ratio Deep learning Gated recurrent unit(GRU) Sand control Trend analysis Geomechanical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study of the Effectiveness of Papaver Sp. Alkaloids as Future Therapeutic Alternatives against Enterococcus Sp. Causing Hospital-Acquired Septicemic Infections

引用

Journal of Biosciences and Medicines 2024年第8期12卷 107-127页

作者： Lama Mohammed ayoub Shbibe Georgette Antranik Babojian Department of Plant Biology Faculty of Science Damascus University Damascus Syria

Background and Objective: In recent years, control of Enterococcus sp. It has been proven in the local medical environment to be a cause of acquired septicemia in various age groups, and medical instruments are considered an effective means of transmitting enterococcal septicemia, and catheters are at the forefront in terms of danger. Based on this risk, this study aimed to monitor the spread of Enterococcus sp., which causes blood poisoning acquired from catheters, and to compare its response to antibiotics with that of those isolated from clinical samples in children, as a first study locally. The effectiveness of alkaloids of different types of Papaver sp. In Syrian plants, they were tested against infection with this bacteria. Materials and Methods: The study dealt with two parts: The first part included collecting clinical samples from the University Children’s Hospital in Damascus/bacterial diagnostic laboratories/then isolating and diagnosing the bacteria by following a set of tests to identify the most prevalent genera and species and comparing their prevalence rate with Enterococcus. The second part;It included collecting plant samples, confirming the species taxonomically, then extracting alkaloids from plant parts (fruit, stem, Flowers), then comparing the extent of resistance of bacterial strains to antibiotics compared to the Enterococcus sp., and then confirming the antibacterial activity of the Papaver sp. alkaloids against Enterococcus sp. Result:In its first part, the study confirmed the significant contribution of the Enterococcus sp. to infections acquired from various sources, largely in catheter tip infections (9.09%) and to a lesser extent in other sources (3.7%), The second part was to confirm the effective-ness of the alkaloid extract of the Papaver sp., especially the two species Papaver syriacum, and Papaver dubium, against Enterococcus sp. with areole diameters that ranged between (15 - 26 mm) for the fruit extract and at a minimum inhibit

关键词： Catheters Skin Ulcers Acquired Infection Multi-Resistant Enterococcus Sp. Papaver Sp. Alkaloids Minimum Inhibitory and Lethal Concentration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Dependence between Solar Flare Emergence and the Average Background Solar X-Ray Flux Emission

引用

International Journal of Astronomy and Astrophysics 2024年第3期14卷 149-161页

作者： Yael Peleg rami Babayew Itzhak Orion Nuclear Engineering Unit Ben Gurion University of the Negev Beer Sheva Israel

Solar flares, sudden bursts of intense electromagnetic radiation from the Sun, can significantly disrupt technological infrastructure, including communication and navigation satellites. To mitigate these risks, accurate forecasting of solar activity is crucial. This study investigates the potential of the Sun’s background X-ray flux as a tool for predicting solar flares. We analyzed data collected by solar telescopes and satellites between the years 2013 and 2023, focusing on the duration, frequency, and intensity of solar flares. We compared these characteristics with the background X-ray flux at the time of each flare event. Our analysis employed statistical methods to identify potential correlations between these solar phenomena. The key finding of this study reveals a significant positive correlation between solar flare activity and the Sun’s background X-ray flux. This suggests that these phenomena are interconnected within the framework of overall solar activity. We observed a clear trend: periods with increased occurrences of solar flares coincided with elevated background flux levels. This finding has the potential to improve solar activity forecasting. By monitoring background flux variations, we may be able to develop a more effective early warning system for potentially disruptive solar flares. This research contributes to a deeper understanding of the complex relationship between solar flares and the Sun’s overall radiative output. These findings indicate that lower-resolution X-ray sensors can be a valuable tool for identifying periods of increased solar activity by allowing us to monitor background flux variations. A more affordable approach to solar activity monitoring is advised.

关键词： Space Weather Solar Flare Solar Activity Sunspots Solar Cycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Outcomes of endoscopic submucosal dissection in cirrhotic patients: First American cohort

引用

World Journal of Hepatology 2024年第5期16卷 784-790页

作者： Robert Luke Pecha Fares ayoub Ankur Patel Abdullah Muftah Michael W Wright Mai A Khalaf Mohamed O Othman Department of Gastroenterology and Hepatology UC DavisSacramentoCA 95817United States Department of Gastroenterology and Hepatology Baylor College of MedicineHoustonTX 77030United States Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Gastroenterology and Hepatology University of Texas Medical Branch at GalvestonGalvestonTX 77550United States Medical School Baylor College of MedicineHoustonTX 77030United States Department of Tropical Medicine Tanta UniversityTanta 31527Egypt

BACKGROUND Among patients with cirrhosis and pre-malignant or early malignant mucosal lesions,surgical intervention carries a much higher bleeding *** such lesions are discovered,endoscopic submucosal dissection(ESD)may offer curative therapy with lower risks than surgery and improved outcomes compared to traditional endoscopic *** To evaluate the outcomes of ESD in patients with *** Patients with cirrhosis undergoing ESD between July 2015 and August 2022 were retrospectively matched in 1:2 fashion to controls based on lesion location,size,and anticoagulation *** outcomes were compared between *** A total of 64 Lesions from 59 patients were included(16 cirrhosis,43 control).There were no differences in patient or lesion characteristics between *** bloc and curative resection was achieved in 84.21%,78.94%of the cirrhosis group and 88.89%,68.89%of controls,respectively,with no significant *** patients had significantly higher rates of intra-procedural coagulation grasper use for control of bleeding(47.37%vs 20%;P=0.02).There were otherwise no significant differences in adverse event *** the 29 patients with follow up,we found higher rates of recurrence in the cirrhosis group compared to controls(40%vs 5.26%;P=0.019),however this effect did not persist on multivariable analysis controlling for known *** ESD may be safe and effective in patients with *** procedure related outcomes were not significantly different between ***-procedural bleeding requiring use of the coagulation grasper use was expectedly higher in the cirrhosis group given the known effects of liver disease on hemostasis.

关键词： Endoscopic aubmucosal dissection Cirrhosis Advanced polypectomy Intraprocedural bleeding Colon cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advancing Type II Diabetes Predictions with a Hybrid LSTM-XGBoost Approach

引用

Journal of Data Analysis and Information Processing 2024年第2期12卷 163-188页

作者： ayoub Djama Waberi Ronald Waweru Mwangi Richard Maina Rimiru Department of Mathematics Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Department of Computing Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya School of Computing and Information Technology (SCIT) Jomo Kenyatta University of Agriculture and Technology (JKUAT) Nairobi Kenya

In this paper, we explore the ability of a hybrid model integrating Long Short-Term Memory (LSTM) networks and eXtreme Gradient Boosting (XGBoost) to enhance the prediction accuracy of Type II Diabetes Mellitus, which is caused by a combination of genetic, behavioral, and environmental factors. Utilizing comprehensive datasets from the Women in Data Science (WiDS) Datathon for the years 2020 and 2021, which provide a wide range of patient information required for reliable prediction. The research employs a novel approach by combining LSTM’s ability to analyze sequential data with XGBoost’s strength in handling structured datasets. To prepare this data for analysis, the methodology includes preparing it and implementing the hybrid model. The LSTM model, which excels at processing sequential data, detects temporal patterns and trends in patient history, while XGBoost, known for its classification effectiveness, converts these patterns into predictive insights. Our results demonstrate that the LSTM-XGBoost model can operate effectively with a prediction accuracy achieving 0.99. This study not only shows the usefulness of the hybrid LSTM-XGBoost model in predicting diabetes but it also provides the path for future research. This progress in machine learning applications represents a significant step forward in healthcare, with the potential to alter the treatment of chronic diseases such as diabetes and lead to better patient outcomes.

关键词： LSTM XGBoost Hybrid Models Machine Learning. Deep Learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：