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Apoptotic and cytostatic actions of maslinic acid in colorectal cancer cells through possible IKK-β inhibition

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 122-131页

作者： Kai Xin Ooi Menaga subramaniam Lai Yen Fong Hoe Han Goh Soo Beng Alan Khoo Yang Mooi Lim Centre for Cancer Research Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanLOT PT 21144.Jalan Sungai LongBandar Sungai LongCheras 43000 KajangSelangorMalaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanLOT PT 21144.Jalan Sungai LongBandar Sungai LongCheras 43000 KajangSelangorMalaysia Institute of Systems Biology Universiti Kebangsaan Malaysia43600 BangiSelangor Darul EhsanMalaysia Molecular Pathology Unit Cancer Research CentreInstitute for Medical ResearchKuala LumpurMalaysia

Objective:To explore the anti-cancer activity of maslinic acid against colorectal cancer(CRC)cell lines and its possible ***:The inhibitory effect of maslinic acid was screened against five CRC cell lines(HT-29,HCT 116,SW480,SW48,and LS 174 T)via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** and cell cycle analyses were carried out using annexinⅤ-FITC/propidium iodide staining and propidium iodide staining,respectively and subjected to fluorescence-activated cell sorting *** expression studies of inhibitor ofκB kinase-β(IKK-β),checkpoint kinase 1(Chk1)and cyclin D1 were conducted using the JESS ***:Maslinic acid exhibited growth inhibitory effect in a doseand time-dependent manner in HT-29 and HCT 116 cell lines.A more prominent apoptosis induced by maslinic acid was observed in HCT 116 cell ***,in HT-29 cell line,maslinic acid induced cell cycle arrest by inhibiting the G1-S transition,which was accompanied by the downregulation of cyclin *** expression of unphosphorylated IKK-βprotein was increased in both(HT-29 and HCT 116)cell lines after maslinic acid ***:Maslinic acid inhibits the growth of HT-29 and HCT 116 cells in a different manner,induces cell cycle arrest in HT-29 cells and causes apoptosis in HCT 116 cells partially via NF-κB pathway inhibition.

关键词： Maslinic acid Colorectal cancer Apoptosis Cell cycle arrest NF-κB pathway IKK-β

Testing for Sources of Irreversible Consumer Demand

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Economics World 2015年第1期3卷 1-17页

作者： Leigh Maynard Vijay subramaniam University of Kentucky Lexington USA Morehead State University Morehead USA

The existence of irreversible demand is tested, whereby price increases induce a different absolute magnitude of quantity change than price decreases. Irreversibility is potentially likely in retail food settings for storable products that are consumed regularly and can affect pricing strategy performance. If irreversibility exists, the subsequent research question for storable product demand is whether loss aversion effects dominate stockpiling effects, or vice versa. A two-period theoretical model is developed, which predicts more elastic responses to downward price movements via stockpiling, but empirical tests on secondary data are needed to evaluate offsetting loss aversion effects. A variant of the Rotterdam demand model is developed to allow differential response to price increases and decreases. The model is applied to scanner data of short periodicity （weekly in this case）, which are necessary to measure meaningful demand responses to food price changes. The products selected are U.S. cheeses and table spreads that are storable over multiple weeks. The results suggest that stockpiling dominates loss aversion. One potential cause of this behavior may be that marketers asymmetrically provide consumers with more reference price information when lowering prices, but not when raising prices. When stockpiling effects dominate, given the typically price-elastic store-level demand for food products, high-low pricing strategies should produce higher revenue. Regarding measurement of average demand response, reversible demand models applied to weekly data may overestimate own-price elasticities.

关键词： consumer demand irreversible functions scanner data loss aversion reference prices dairy products

Optical/IR studies of Be stars in NGC 6834 with emphasis on two specific stars

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Research in Astronomy and Astrophysics 2014年第9期14卷 1173-1192页

作者： Blesson Mathew Watson P. Varricatt Annapurni subramaniam N. M. Ashok D. P. K. Banerjee Centre for Astrophysics & Supercomputing Swinburne University Hawthorn VIC 3122Australia Astronomy and Astrophysics Division Physical Research Laboratory NavrangapuraAhmedabad - 380 009 Gujarat India Joint Astronomy Centre 660 N. Aohoku Pl. Hilo HI 96720 USA Indian Institute of Astrophysics Bangalore - 560 034 India

We present optical and infrared photometric and spectroscopic studies of two Be stars in the 70-80-Myr-old open cluster NGC 6834. NGC 6834（1） has been reported as a binary from speckle interferometric studies whereas NGC 6834（2） may possibly be a γ Cas-like variable. Infrared photometry and spectroscopy from the United Kingdom Infrared Telescope （UKIRT）, and optical data from various facilities are combined with archival data to understand the nature of these candidates. High signal-to-noise near-IR spectra obtained from UKIRT have enabled us to study the optical depth effects in the hydrogen emission lines of these stars. We have explored the spectral classification scheme based on the intensity of emission lines in the H and K bands and contrasted it with the conventional classification based on the intensity of hydrogen and helium absorption lines. This work also presents hitherto unavailable UBV CCD photometry of NGC 6834, from which the evolutionary state of the Be stars is identified.

关键词： stars: emission-line Be -- circumstellar matter -- infrared: stars -- line profiles -- (Galaxy:) open clusters and associations: individual (NGC 6834)

Knowledge and attitudes towards the use of histological assessments in ulcerative colitis by gastroenterologists vs pathologists

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World Journal of Gastroenterology 2023年第2期29卷 378-389页

作者： Aviv Pudipeddi Caroline Fung Britt Christensen Robert V Bryant Kavitha subramaniam John Chetwood Sudarshan Paramsothy Rupert W Leong Gastroenterology and Liver Services Concord Repatriation General HospitalSydney 2139Australia Faculty of Medicine and Health Concord Clinical SchoolUniversity of SydneySydney 2138Australia Department of Anatomical Pathology Concord Repatriation General HospitalSydney 2139Australia Department of Gastroenterology Royal Melbourne HospitalMelbourne 3050Australia Department of Medicine University of MelbourneMelbourne 3052Australia Department of Gastroenterology and Hepatology The Queen Elizabeth HospitalAdelaide 5011Australia Gastroenterology and Hepatology Unit Canberra HospitalCanberra 2605Australia Australian National University Medical School Australian National UniversityCanberra 2601Australia Faculty of Medicine and Health Sciences Macquarie University HospitalSydney 2109Australia

BACKGROUND Histological remission is increasingly accepted as a treatment endpoint in the management of ulcerative colitis(UC).However,the knowledge of histology guidelines and the attitudes towards their use in clinical practice by gastroenterologists and pathologists is *** To evaluate the knowledge of histology guidelines and attitudes towards the use of histology in UC by gastroenterologists and *** A prospective,cross-sectional nationwide survey of gastroenterologists and pathologists who analyse UC specimens was *** survey consisted of 34 questions to assess gastroenterologists’and pathologists’knowledge(score out of 19)and attitudes towards histological assessment in *** questions were formulated using the European Crohn’s and Colitis position paper on histopathology and the British Society of Gastroenterology biopsy reporting *** included knowledge of histological assessment of disease activity and dysplasia,knowledge of histological scoring systems for ulcerative colitis,uptake of histology scoring systems in routine practice,attitudes towards the role of histological activity,and the use of histological activity in clinical *** Of 89 responders(77 gastroenterologists,12 pathologists),there was almost universal acceptance that histological assessment should form part of UC evaluation[95%gastroenterologists,92%pathologists].However,gastroenterologists reported that 92%of their pathologists do not use a histological scoring *** of a formal histological scoring system was preferred by 77%of gastroenterologists and 58%of *** groups lacked awareness of the Geboes Score,Nancy Index and Robarts Histopathological Index scoring systems with 91%,87%,and 92%of gastroenterologists respectively;and 83%,83%,and 92%pathologists respectively,being uncertain of scoring systems’remission *** knowledge score was not significantly different between gastroenterologist

关键词： Histology Scoring system Ulcerative colitis Survey

Larvicidal efficacy of Catharanthus roseus Linn.(Family:Apocynaceae)leaf extract and bacterial insecticide Bacillus thuringiensis against Anopheles stephensi Liston.

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 847-853页

作者： Chellasamy Panneerselvam Kadarkarai Murugan Kalimuthu Kovendan Palanisamy Mahesh Kumar Sekar Ponarulselvam Duraisamy Amerasan Jayapal subramaniam Jiang-Shiou Hwang DRDO-BU Center for Life Sciences Bharathiar UniversityCoimhatore 641046Tamil NaduIndia Division of Entomology Department of ZoologySchool of Life SciencesBharathiar UniversityCoimbatore 641046Tamil NaduIndia Institute of Marine Biology National Taiwan Ocean UniversityKeelung 202-24Taiwan

Objective:To explore the larvicidal activity of Catharanthus roseus(***) leaf extract and Raeillus thuringiensis(***) against the malarial vector Anopheles stephensi(An. stephensi),when being used alone or ***:The larvicidal activity was assayed at various concentrations under the laboratory and field *** LC_(50) and LC_(90) values of the *** leaf extract were determined by probit ***:The plant extract showed larvicidal effects after 24 h of exposure;however,the highest larval mortality was found in the petroleum ether extract of *** against the first to fourth instars larvae with LC_(50)=3.34,4.48, 5.90 and 8.17 g/L,respectively;*** against the first to fourth instars larvae with LC_(50)=1.***.1.93.2.17 and 2.42 g/***:and the combined treatment with LC_(50)=2.***.2.41. 2.76 and 3.22 g/L,*** mortality was observed in the ***:The petroleum ether extract of *** extract and *** have potential to be used as ideal eco-friendly agents for the control of *** in vector control *** combined treatment with this plant crude extract and bacterial toxin has better larvicidal efficacy against ***.

关键词： Catharanthus roseus Bacillus thuringiensis Anopheles stephensi Larvicidal activity

Finite Element Modelling of Car Seat with Hyperelastic and Viscoelastic Foam Material Properties to Assess Vertical Vibration in Terms of Acceleration

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Engineering（科研） 2020年第3期12卷 177-193页

作者： Purnendu Mondal subramaniam Arunachalam School of Architecture Computing and Engineering University of East London (Docklands Campus) London UK

Primary objective of automobile seats is to offer adequate level of safety and comfort to the seated human occupant, primarily against vibration. Ideally, any sort of automotive seat is constructed by mechanical framework, cushion, backrest and headrest. The frame structures are made of metallic alloys, while the cushion, backrest and headrest are made of polyurethane foam material. During the design phase of automotive seat, the greatest challenge is to assign realistic material properties to foam material;as it is non-linear in nature and exhibit hysteresis at low level stress. In this research paper, a car seat has been modelled in finite element environment by implementing both hyperelastic and viscoelastic material properties to polyurethane foam. The car seat has been excited with the loads due to car acceleration and human object and the effects of vibration in terms of vertical acceleration at different locations have been measured. The aims of this simulation study are to establish a car seat with the foam material properties as accurately as possible and provide a finite element set up of car seat to monitor the vertical acceleration responses in a reasonable way. The RMS acceleration values for headrest, backrest and cushion have been found to be 0.91 mm/sec2, 0.54 mm/sec2 and 0.47 mm/sec2, respectively, which showed that the car seat foam can effectively be modelled through combined hyperelastic and viscoelastic material formulations. The simulation outputs have been validated through real life testing data, which clearly indicates that this computerized simulation technique is capable of anticipating the acceleration responses at different car seat segments in a justified way.

关键词： Car Seat Hyperelastic Material Viscoelastic Material Finite Element Vertical Acceleration Vertical Vibration

Development of milk powder containing Lactobacillus plantarum NCIMB 8826 immobilized with prebiotic hi-maize starch and survival under simulated gastric and intestinal conditions

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食物生产加工与营养(英文) 2019年第1期1卷 36-43页

作者： Author detais Ronamae Bradford Vondel Reyes Franklin Bonilla Federico Bueno Bennett Dzandu Chen Liu Alexander Chouljenko subramaniam Sathivel Department of Chemistry University of the West IndiesMonaJamaica School of Nutrition and Food Sciences 220 H.D.Wilson LaboratoriesLouisiana State University Agricultural CenterBaton RougeLA 70803USA Department of Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA

The objectives of this study were to develop a probiotic milk powder containing Lactobacillus plantarum NCIMB 8826 immobilized with prebiotic Hi-maize starch and to analyze cell viability after spray drying and exposure to simulated gastric and intestinal *** powders containing free *** and cells immobilized with Hi-maize starch were *** were evaluated during storage at 4°C for 15 *** spray drying,at 0 and 15 days of storage both treatments had over 8 log CFU/g of viable cells and there were higher viable counts found for immobilized cells compared to free cells after 120 min in simulated gastric *** 15 days of storage,immobilized cells had higher viable counts than free cells after exposure to simulated intestinal fluid for 120 *** combined probiotic and prebiotic milk powder had stable viable cell counts at refrigerated storage conditions and under simulated gastric and intestinal transit.

关键词： Probiotics Prebiotics Simulated gastrointestinal conditions Milk powder Spray drying Immobilization

Isolation and identification of Salmonella from curry samples and its sensitivity to commercial antibiotics and aqueous extracts of Camelia sinensis(L.) and Trachyspermum ammi(L.)

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Asian Pacific Journal of Tropical Biomedicine 2011年第4期1卷 266-269页

作者： Thanes Gunasegaran Xavier Rathinam Marimuthu Kasi Kathiresan Sathasivam Sasidharan Sreenivasan Sreeramanan subramaniam Department of Biotechnology Faculty of Applied SciencesAIMST UniversitySemeling08100 BedongKedah Darul AmanMalaysia Institute for Research in Molecular Medicine(INFORMM) Universiti Sains Malaysia 11800 PenangMalaysia School of Biological Sciences Universiti Sains Malaysia11800 PenangMalaysia

Objective:To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant ***:Salmonella was isolated from the curry samples by standard microbiological methods and was confirmed by biochemical *** antibiotic susceptibility test was conducted by disc diffusion method using commercially available antibiotics such as ampicillin,tetracycline,chloramphenicol,kanamycin,and *** addition,the susceptibility of the food-borne Salmonella was also evaluated against the aqueous extracts of Camelia sinensis(L.) Theaceae(tea leaves) and the Trachyspermum ammi(L.) Apiaceae(ajwain or omum seeds).Results:Out of fifty curry samples,only seven samples were identified to have Salmonella *** Salmonella isolates showed a significant drug resistance pattern except for *** plant extracts showed a considerable antibacterial activity against the isolates,indicating the presence of antimicrobial principle which can be exploited after complete pharmacological ***:The present study demonstrates the occurrence of Salmonella in the curry samples,and shows significant drug resistance against most of the commercially available antibiotics,except *** effect of the plant extracts against the food-bone Salmonella suggests that dietary including medicinal herbs would be one strategy to manage food borne pathogens.

关键词： Food-borne Salmonella Drug resistance Plant extracts Curry samples Camelia sinensis Trachyspermum ammi Commercial antibiotics

VLSI Implementation of Optimized 2D SIMM Chaotic Map for Image Encryption

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Intelligent Automation & Soft Computing 2023年第3期35卷 3155-3168页

作者： M.Sundar Prakash Balaji V.R.Vijaykumar Kamalraj subramaniam M.Kannan V.Ayyem Pillai Department of Electronics and Communication Engineering RVS College of Engineering and TechnologyCoimbatore641402India Department of Electronics and Communication Engineering Anna University Regional CampusCoimbatore641046India Department of Biomedical Engineering Karpagam Academy of Higher EducationCoimbatore641021India Department of Electronics MIT CampusChennai600044India Department of Electronics and Communication Engineering Gokaraju Rangaraju Institute of Engineering and TechnologyHyderabad500090India

The current research work proposed a novel optimization-based 2D-SIMM(Two-Dimensional Sine Iterative chaotic map with inﬁnite collapse Mod-ulation Map)model for image *** proposed 2D-SIMM model is derived out of sine map and Iterative Chaotic Map with Inﬁnite Collapse(ICMIC).In this technique,scrambling effect is achieved with the help of Chaotic Shift Transform(CST).Chaotic Shift Transform is used to change the value of pixels in the input image while the substituted value is cyclically shifted according to the chaotic sequence generated by 2D-SIMM *** chaotic sequences,generated using 2D-SIMM model,are sensitive to initial *** the proposed algorithm,these initial conditions are optimized using JAYA optimization *** coefﬁcient and entropy are considered asﬁtness functions in this study to evaluate the best solution for initial *** simulation results clearly shows that the proposed algorithm achieved a better performance over existing *** addition,the VLSI implementation of the proposed algorithm was also carried out using Xilinx system *** optimization,the correlation coefﬁcient was-0.014096 and without optimization,it was 0.002585.

关键词： Chaotic mapping 2D-SIMM encryption decryption jaya optimization