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Evaluation of sodium borocaptate(BSH)and boronophenylalanine(BPA)as boron delivery agents for neutron capture therapy(NCT)of cancer:an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

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Cancer Communications 2024年第8期44卷 893-909页

作者： Rolf F.Barth Nilendu gupta Shinji kawabata Department of Pathology The Ohio State UniversityColumbusOhioUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA Department of Neurosurgery Osaka Medical and Pharmaceutical UniversityTakatsukiOsakaJapan

Boron neutron capture therapy(BNCT)is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron-10,a stable isotope,is irradiated with neutrons of the appropriate energy to produce boron-11 in an unstable form,which undergoes instantaneous nuclear fission to produce high-energy,tumoricidal alpha *** primary purpose of this review is to provide an update on the first drug used clinically,sodium borocaptate(BSH),by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug,boronophenylalanine(BPA),which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous ***,BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers,specifically brain tumors and recurrent tumors of the head and neck *** focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with highgrade ***,wewill summarize the studies thatwere carried out in Japan with BSH and subsequently at our own institution,The Ohio State University,and those of several other ***,we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for ***,although there have been intense efforts to develop new and better boron delivery agents for BNCT,none of these have yet been evaluated *** present reportwill provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.

关键词： Boron neutron capture therapy(BNCT) boronophenylalanine(BPA) brain tumors head and neck cancer sodium borocaptate(BSH)

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Techno-economic and environmental impact analysis of electric two-wheeler batteries in India

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Clean Energy 2024年第3期8卷 147-156页

作者： Aman gupta Ditipriya Bose Sandeep Tiwari Vikrant Sharma Jai Prakash Department of Green Energy and Sustainable Development Zakir Husain College of Engineering and Technology Aligarh Muslim UniversityUttar Pradesh-202002India Battery Testing Facility National Institute of Solar EnergyGurugram-Faridabad RoadGwal PahariGurugram-122003HaryanaIndia

This paper presents a comprehensive techno-economic and environmental impact analysis of electric two-wheeler batteries in *** technical comparison reveals that sodium-ion(Na-ion)and lithium-ion(Li-ion)batteries outperform lead-acid batteries in various parameters,with Na-ion and Li-ion batteries exhibiting higher energy densities,higher power densities,longer cycle lives,faster charge rates,better compactness,lighter weight and lower self-discharge *** economic comparison,Na-ion batteries were found to be~12-14%more expensive than Li-ion ***,the longer lifespans and higher energy densities of Na-ion and Li-ion batteries can offset their higher costs through improved performance and long-term ***-acid batteries have the highest environmental impact,while Li-ion batteries demonstrate better environmental performance and potential for ***-ion batteries offer promising environmental advantages with their abundance,lower cost and lower toxic and hazardous material *** recycling processes can further enhance the environmental benefits of Na-ion ***,this research examines the potential of Na-ion batteries as a cheaper alternative to Li-ion batteries,considering India’s abundant sodium resources in regions such as Rajasthan,Chhattisgarh,Jharkhand and others.

关键词： electric two-wheelers environmental impact assessment lead-acid batteries lithium-ion batteries sodium-ion batteries techno-economic analysis

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Investigating the Evolution of Amati Parameters with Redshift

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Research in Astronomy and Astrophysics 2024年第1期24卷 188-200页

作者： Meghendra Singh Darshan Singh kanhaiya Lal Pandey Dinkar Verma Shashikant gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka University Gurugram 122103India Department of Physics Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Physics School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray bursts(GRBs) are among the brightest objects in the Universe and, hence, can be observed up to a very high redshift. Properly calibrated empirical correlations between intensity and spectral correlations of GRBs can be used to estimate the cosmological parameters. However, the possibility of the evolution of GRBs with redshift is a long-standing puzzle. In this work, we used 162 long-duration GRBs to determine whether GRBs below and above a certain redshift have different properties. The GRBs are split into two groups, and we fit the Amati relation for each group separately. Our findings demonstrate that estimations of the Amati parameters for the two groups are substantially dissimilar. We perform simulations to investigate whether the selection effects could cause the difference. Our analysis shows that the differences may be either intrinsic or due to systematic errors in the data, and the selection effects are not their true origin. However, in-depth analysis with a new data set comprised of 119 long GRBs shows that intrinsic scatter may partly be responsible for such effects.

关键词： Cosmology gamma rays:general (cosmology:)large-scale structure of universe galaxies:high-redshift

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SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

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World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep k Dabla Dharmsheel Shrivastav Swapan gupta Manisha Yadav Subhash Yadav Bidhan Chandra koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACkGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

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The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay k.gupta Neil C.Molony keshav k.gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis skull base osteomyelitis temporal bone osteomyelitis

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Hepatocellular carcinoma immune microenvironment and check point inhibitors-current status

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World Journal of Hepatology 2024年第3期16卷 353-365页

作者： Tarana gupta Nikhil Sai Jarpula Division of Hepatology Department of MedicinePandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Hepatocellular carcinoma(HCC)is the most common primary tumor of the liver and has a high mortality *** Barcelona Clinic Liver Cancer staging system in addition to tumor staging also links the modality of treatment available to a particular *** recent description of the tumor microenvironment(TME)in HCC has provided a new concept of immunogenicity within the *** HCC has been shown to be more immunogenic with higher expression of cytotoxic T lymphocytes and decreased elements for immunosuppression such as regulatory T *** immunogenic milieu provides a better response to immunotherapy especially immune checkpoint inhibitors(ICIs).In addition,the recent data on combining locoregional therapies and other strategies may convert the less immunogenic state of the TME towards higher ***,data are emerging on the use of combinations of locoregional therapy and ICIs in unresectable or advanced HCC and has shown better survival outcomes in this difficult population.

关键词： Hepatocellular carcinoma Tumor immune microenvironment Immune checkpoint inhibitor Atezolizumab Bevacizumab Pembrolizumab

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Bibliographic survey and comprehensive review on mechanical and durability properties of microorganism based self-healing concrete

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1445-1465页

作者： Md Marghoobul HAQUE kunal M.SHELOTE Namrata SINGH Supratic gupta Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Concrete is the most widely utilized material for construction purposes,second only to water,in the ever-increasing need for construction *** is a brittle material and possesses a high risk of crack formation and consequent ***,which allows chemicals to enter and can cause concrete structures to lose their physico-mechanical and durability *** and rehabilitating concrete structures involves high costs and leads to various repair methods including coating,adhesives,polymers,supplementary cementitious materials(SCMs),and *** of the latest technologies is the use of microorganisms in *** added microorganisms lead to calcite precipitation and thereby heal the cracks *** study presents a comprehensive literature survey on bacteria-included concrete,before which a bibliographic survey is performed using VOSViewer *** addition to regular bacterial concrete,this study focuses on also using SCMs and fibers in bacterial concrete.A detailed literature review with data representation for various mechanical properties including compressive strength(CS),split tensile strength(SS),and flexure strength(FS),along with durability properties including carbonation,water absorption,resistance against chloride ion penetration,gas permeation,and resistance against cyclic freeze-and-thaw is presented.A study on the use of X-ray computed tomography(XCT)in bacterial concrete is highlighted,and the scope for future research,along with identification of the research gap,is presented.

关键词： bacterial concrete bibliographic survey biomineralization carbonation fibers

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Modularly assembled multiplex prime editors for simultaneous editing of agronomically important genes in rice

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Plant Communications 2024年第2期5卷 67-78页

作者： Ajay gupta Bo Liu Saad Raza Qi-Jun Chen Bing Yang Division of Plant Science and Technology Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA State key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China Donald Danforth Plant Science Center St.LouisMO 63132USA

Prime editing(PE)technology enables precise alterations in the genetic code of a genome of *** offers great potential for identifying major agronomically important genes in plants and editing them into superior variants,ideally targeting multiple loci simultaneously to realize the collective effects of the ***,we report the development of a modular assembly-based multiplex PE system in rice and demon-strate its efficacy in editing up to four genes in a single transformation *** duplex PE(DPE)system achieved a co-editing efficiency of 46.1%in the T0 generation,converting TFIIAg5 to xa5 and xa23 to *** resulting double-mutant lines exhibited robust broad-spectrum resistance against multiple Xanthomonas oryzae pathovar oryzae(Xoo)strains in the T1 *** addition,we success-fully edited OsEPSPS1 to an herbicide-tolerant variant and OsSWEET11a to a Xoo-resistant allele,achieving a co-editing rate of 57.14%.Furthermore,with the quadruple PE(QPE)system,we edited four genes—two for herbicide tolerance(OsEPSPS1 and OsALS1)and two for Xoo resistance(TFIIAg5 and OsSWEET11a)—using one construct,with a co-editing efficiency of 43.5%for all four genes in the T0 *** performed multiplex PE usingfive more constructs,including two for triplex PE(TPE)and three for QPE,each targeting a different set of *** editing rates were dependent on the activity of pegRNA and/or *** instance,optimization of ngRNA increased the PE rates for one of the targets(OsSPL13)from 0%to 30%but did not improve editing at another target(OsGS2).Overall,our modular assembly-based system yielded high PE rates and streamlined the cloning of PE reagents,making it feasible for more labs to utilize PE for their editing *** have significant implications for advancing gene editing techniques in plants and may pave the way for future agricultural applications.

关键词： prime editing rice bacterial blight herbicide tolerance multiplex genome editing

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Energy-growth nexus for‘Renewable Energy Country Attractiveness Index’countries:Evidence from new econometric methods

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Geoscience Frontiers 2024年第3期15卷 298-311页

作者： Mandeep Mahendru Aviral kumar Tiwari Gagan Deep Sharma Solomon Nathaniel Mansi gupta Szechenyi Istvan University GyorHungary Indian Institute of Management BodhgayaIndia University School of Management Studies Guru Gobind Singh Indraprastha UniversitySector 16 CDwarkaNew DelhiIndia Department of Economics University of LagosAkokaNigeria Centre for Financial Innovation S P Jain Institute of Management and ResearchMumbaiIndia

This study explores the connections between renewable energy consumption(REC),non-renewable energy consumption(NREC),gross fixed capital formation(GFCF),the labor force(LF),and economic growth(GDP)in Renewable Energy Country Attractiveness Index(RECAI)countries for *** quantify the nexus between REC,NREC,and GDP while utilizing a production model framework and including the measures of labor and capital,for suggesting a phase-wise strategy to attain the sustainable development *** use robust methodologies including Lagrange Multiplier(LM)panel unit root tests with trend shifts,Westerlund cointegration test,LM bootstrap technique for cointegration with breaks,continuously updated fully modified(CUP-FM)and continuously updated bias-corrected(CUPBC)estimators,Augmented Mean Group(AMG)approach,fully modified ordinary least squares,dynamic ordinary least squares,Canonical Cointegrating Regression(CCR),and panel causality test proposed by Canning&*** compute non-parametric time-varying coefficients with fixed effects for seeing the impact of GFCF,LF,REC,and NREC on *** results press upon policymakers to shift toward clean energy and REC for attaining the environmental goals(SDGs 6,7,13,and 15)and the economic goals(SDGs 1,2,8,and 10).While this shift would help developed economies,which have already attained the economic goals,to progress on the front of environmental goals,it would enable developing countries to progress on both fronts in a balanced manner.

关键词： Renewable energy consumption Economic growth Non-renewable energy consumption CUP-BC CUP-FM Time-varying coefficients with fixed effects

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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEk WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH kUMAR gupta GINPREET kAUR HARDEEP SINGH TULI MADHU gupta Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

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