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chinese chemical Letters 2008年第7期19卷 780-782页

作者： Surinder Berar Urmila Berar Satish c.Gupta ramesh c.kamboj Department of chemistry Kurukshetra UniversityKurukshetra 136119India

Photocyclisation of substituted （E）-3-hydroxy-2-（V-methyl-2＇-phenylvinyl）-4-oxo-4H-1-benzopyrans to yield linear novel tricyclic 9H-furo[3,2-b]chromen-9-ones and angular fused tetracyclic xanthenones is described.

关键词： 9H-Furo(3,2-b)chromen-9-one Photocyclisation Xanthenones

Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu Vinod Kumar Kajal kamboj Ashok Kumar Pannu Ashok Kumar Yadav Mandip Bhatia Atul Saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of Experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and c reactive protein(cRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and cRP in cases compared to the control group(ferritin:P=0.006 and cRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue cytokine Doxycycline Serum ferritin c reactive protein

Photochemical Transformations of Some 2-（5-Methylthiophen-2-yl）-3-[（naphthalen-2-yl）methoxy]-4H-chromen-4-ones Involving Type-II Process

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chinese Journal of chemistry 2011年第4期29卷 745-750页

作者： kamboj, ramesh c Kumar, Dinesh Sharma, Geeta Arora, Rita Department of chemistry Kurukshetra University Kurukshetra 136119 India

Photo-irradiation of 2-（5-methylthiophen-2-yl）-3-[（naphthalen-2-yl）methoxy]-4H-chromen-4-ones yielded the fascinating angular tetracyclic products via cyclization involving both 2-thienyl ring and naphthylmethoxy group via 1,4-biradical generated in the Norrish type-II process. The stereochemical dispositions of the products were determined by MM2 energy minimized programme and spectroscopic analysis.

关键词： type-II reaction radicals thienylchromone sigmatropic rearrangement substituent effects

*** model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement

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Genes & Diseases 2024年第4期11卷 120-123页

作者： ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes Marina L.Kennerson Northcott Neuroscience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia Sydney Medical School University of SydneySydneyNSw 2050Australia ANZAc Research Institute-Sydney Local Health District SydneyNSW 2139Australia Neuroscience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nelson Department of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics and child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,optic atrophy,and respiratory *** in SLc52A2 and SLc52A3,solute carrier family members that encode riboflavin(RF)transporters RFVT2 and RFVT3,are known to cause RTD types 2 and 3,respectively.

关键词： RTD degeneration TD

Disorders of potassium homeostasis after kidney transplantation

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World Journal of Transplantation 2024年第3期14卷 40-51页

作者： Abdelhamid Aboghanem G V ramesh Prasad School of Medicine University of TorontoToronto M5C 2T2OntarioCanada Kidney Transplant Program St.Michael's HospitalToronto M5C 2T2OntarioCanada

Disturbances of potassium balance are often encountered when managing kidney transplant recipients(KTR).Both hyperkalemia and hypokalemia may present either as medical emergencies or chronic outpatient *** the high incidence of hyperkalemia and its potential life-threatening implications,consensus on its management in KTR is *** in KTR is also well-described,although it is given less attention by clinicians compared to *** article discusses the etiology,pathophysiology and management of both types of potassium disorders in *** any emergent situation has been corrected,treatment approaches include correcting insulin deficiency if present,adjusting non-immunosuppressive and immunosuppressive medications,elimi-nating or supplementing potassium as needed,and dietary *** commonly of multifactorial etiology,ascertaining the specific cause in a particular patient will help guide successful *** KTR through regular laboratory testing is essential to detect serious disturbances in potassium balance since patients are often asymptomatic.

关键词： Balance Dialysis Hyperkalemia Hypokalemia Kidney Metabolism Potassium

Interfacial engineering through lead binding using crown ethers in perovskite solar cells

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Journal of Energy chemistry 2024年第5期92卷 263-270页

作者： Sun-Ju Kim YeonJu Kim ramesh Kumar chitumalla Gayoung Ham Thanh-Danh Nguyen Joonkyung Jang Hyojung cha Jovana Milić Jun-Ho Yum Kevin Sivula Ji-Youn Seo Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and EngineeringÉcole Polytechnique Fédérale de Lausanne(EPFL)1015 LausanneSwitzerland Department of Energy convergence and climate change Kyungpook National UniversityDaegu 41566Republic of Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 41566Republic of Korea Adolphe Merkle Institute University of FribourgCH-1700 FribourgSwitzerland

In the domain of perovskite solar cells(PScs),the imperative to reconcile impressive photovoltaic performance with lead-related issue and environmental stability has driven innovative *** study pioneers an approach that not only rectifies lead leakage but also places paramount importance on the attainment of rigorous interfacial *** ethers,notably benzo-18-crown-6-ether(B18c6),were strategically integrated at the perovskite-hole transport material *** ethers exhibit a dual role:efficiently sequestering and immobilizing Pb^(2+)ions through host-guest complexation and simultaneously establishing a robust interfacial passivation *** crown ether candidates,guided by density functional theory(DFT)calculations,demonstrated proficiency in binding Pb2+ions and optimizing interfacial *** devices incorporating these materials achieved exceptional power conversion efficiency(PcE),notably 21.7%for B18c6,underscoring their efficacy in lead binding and interfacial *** techniques,including time-of-flight secondary ion mass spectrometry(ToF-SIMS),ultraviolet photoelectron spectroscopy(UPS),time-resolved photoluminescence(TRPL),and transient absorption spectroscopy(TAS),unequivocally affirmed Pb^(2+)ion capture and suppression of non-radiative ***,these PScs maintained efficiency even after enduring 300 h of exposure to 85%relative *** research underscores the transformative potential of crown ethers,simultaneously addressing lead binding and stringent interfacial passivation for sustainable PScs poised to commercialize and advance renewable energy applications.

关键词： Perovskite solar cells Interfacial passivation crown ether materials Stability

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo conan Juan Alec c.Bancroft Ji Hae choi chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of chemical Biology and Medicinal chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(EcM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPcs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen EcM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-creER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-creER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPcs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPcssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPc *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Determining the checkpoint of Transition from Thin to Thick Periodontal Phenotypes in the Maxillary and Mandibular Anterior Regions of South Indian Population

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Journal of Forensic Science and Medicine 2024年第1期10卷 55-61页

作者： Mohan Kumar Pasupuleti Rasagna chowdary G Gautami SPenmetsa Vivek Bypalli ramesh S.V.Konathala Sruthima N.V.S.Gottumukkala Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia2Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Aim:The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incisors utilizing the probe visibility method and traditional way of measuring gingival thickness(GT)by endodontic ***:In 200 selected patients,the GT was measured at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival *** checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups:Group A:21-30 years;Group B:31-40 years;Group c:41-50 years;and Group D:51-60 ***:GT varied from 0.3 to 1.9 *** translucency was observed up to the thickness of 0.7 *** 0.8 mm of GT,there was no probe ***:According to the present research,the gingiva appears transparent up to a thickness of around 0.7 *** checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.

关键词： Gingiva periodontal phenotype probe visibility

clinical profile and outcomes of hepatocellular carcinoma in primary Budd-chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BAcKGROUND There is scant literature on hepatocellular carcinoma(Hcc)in patients with Budd-chiari syndrome(BcS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BcS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of Hcc were determined,and among patients with BcS-Hcc,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BcS-Hcc patients,18 had Hcc at index presentation(prevalence 1.99%),and 17 developed Hcc over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BcS-Hcc patients were older when compared to patients with BcS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BcS-Hcc at first presentation than those who developed Hcc at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BcS-Hcc,26(74.3%)underwent radiological interventions for BcS,and 22(62.8%)patients underwent treatment for Hcc[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for Hcc compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BcS-Hcc patients were predominantly males,presented with a more advanced Hcc[Barcelona clinic Liver cancer c and D],and 2 patients underwent liver *** Hcc is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BcS-Hcc patients and may improve outcomes.

关键词： Budd chiari syndrome cancer cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

A novel mathematical morphology based algorithm for shoreline extraction from satellite images

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Geo-Spatial Information Science 2017年第4期20卷 345-352页

作者： c.A.Rishikeshan H.ramesh National Institute of Technology Karnataka Surathkal India

Shoreline extraction is fundamental and inevitable for several *** the precise spatial location of the shoreline is ***,the need for using remote sensing data to accomplish the complex task of automatic extraction of features,such as shoreline,has considerably *** feature extraction can drastically minimize the time and cost of data acquisition and database *** and fast approaches are essential to monitor coastline retreat and update shoreline ***,we present a flexible mathematical morphology-driven approach for shoreline extraction algorithm from satellite *** salient features of this work are the preservation of actual size and shape of the shorelines,run-time structuring element definition,semi-automation,faster processing,and single band *** proposed approach is tested with various sensor-driven images with low to high *** of the developed methodology has been assessed with manually prepared ground truths of the study area and compared with an existing shoreline classification *** proposed approach is found successful in shoreline extraction from the wide variety of satellite images based on the results drawn from visual and quantitative assessments.

关键词： Feature extraction shoreline detection satellite image processing remote sensing mathematical morphology