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发光学报 2001年第S1期22卷 99-102页

作者： Li S ramer j WalkerR C Fabiano P EMCORE Corporation 145 Belmont Ave.Somerset NJ08873USAEMCORE Corporation145 Belmont Ave.Somerset NJ08873USAEMCORE Corporation145 Belmont Ave.Somerset NJ08873USAEMCORE Corporation145 Belmont Ave.Somerset NJ08873USA

报道了EMCORE公司的旋转盘反应器 ,或TurboDisc反应器 ,这是一种带有旋转盘的立式反应器。衬底片放置在高速旋转的盘上并被加热到合适的生长温度。反应物在初始阶段因高速旋转盘的牵引力被竖直向下地泵入 ,然后偏斜形成一个与衬底片托... 详细信息

报道了EMCORE公司的旋转盘反应器 ,或TurboDisc反应器 ,这是一种带有旋转盘的立式反应器。衬底片放置在高速旋转的盘上并被加热到合适的生长温度。反应物在初始阶段因高速旋转盘的牵引力被竖直向下地泵入 ,然后偏斜形成一个与衬底片托盘平行的流动区域。在“GaNzilla” ,EMCORE公司的一种新型 32 5mm的GaN生产反应器中外延生长了GaN材料。为在蓝宝石衬底上得到高质量的GaN ,采用高的生长压力和高旋转速度 ,可以在这种旋转盘反应器中实现必要的生长条件。还对 p GaN ,InGaN ,InGaN多量子阱 ,以及LED器件进行了类似的实验 ,都能获得最佳的生长条件。

关键词： Ⅲ-Ⅴ族薄膜材料 MOCVD理论流体动力学方法立式旋转盘反应器

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用大面积立式旋转盘MOVPE反应器生长Ⅲ族氮化物材料(英文)

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发光学报 2001年第S1期22卷 95-98页

作者： ramer j Parekh R Ronan B Loftus C Gurary A EMCORE Corporation EMCORE CorporationEMCORE CorporationEMCORE CorporationEMCORE Corporation 394Elizabeth Ave.Somerset NJ08873USA394Elizabeth Ave.Somerset NJ08873USA394Elizabeth Ave.Somerset NJ08873USA394Elizabeth Ave.Somerset NJ08873US

为了降低Ⅲ族氮化物材料和器件的成本 ,必须开发大尺寸的Ⅲ族氮化物MOVPE生长的反应器。本文报道了EMCORE公司的一种带有旋转盘的立式反应器 ,其中的衬底片载盘直径为 32 5mm。每次沉积过程中 ,载盘上可以放置 2 1片 2英寸直径的衬底片... 详细信息

为了降低Ⅲ族氮化物材料和器件的成本 ,必须开发大尺寸的Ⅲ族氮化物MOVPE生长的反应器。本文报道了EMCORE公司的一种带有旋转盘的立式反应器 ,其中的衬底片载盘直径为 32 5mm。每次沉积过程中 ,载盘上可以放置 2 1片 2英寸直径的衬底片。反应器的内壁通过水冷 ,其温度可保持在 5 0～ 6 0℃之间。衬底片可用电热丝加热 ,沉积中衬底载盘的旋转速度可达 1 0 0 0～ 1 5 0 0rpm。本文给出了用这种 32 5mmGaN生长系统生长的未掺杂GaN ,InGaN和 p GaN外延层的相关结果。这些结果表明 ,这种旋转盘的反应器是一种很适合大尺寸载盘的系统 ,完全满足Ⅲ族氮化物材料体系生长的要求。与在小反应器中生长的材料相比 ,用这种大反应器生长的材料具有相同的质量。这种 32 5mm的GaN反应器将使制备蓝光和绿光LED所用的Ⅲ族氮化外延材料的生产成本得到显著的降低。

关键词： Ⅲ族氮化物材料 MOVPE外延生长立式旋转盘反应器

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Establishment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines

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World journal of Gastroenterology 2018年第43期24卷 4880-4892页

作者： Michael Gock Christina S Mullins Carina Bergner Friedrich Prall Robert ramer Anja Goder Oliver H Kramer Falko Lange Bernd j Krause Ernst Klar Michael Linnebacher Department of General Surgery University Medical CenterRostock 18055Germany Section of Molecular Oncology and Immunotherapy University MedicalCenterRostock 18055Germany Department of NuclearMedicine University Medical CenterRostock 18055Germany Institute of Pathology University MedicalCenterRostock 18055Germany Institute of Pharmacology University Medical CenterRostock 18055Germany Institute of Toxicology University Medical Center MainzMainz 55131Germany Oscar-Langendorff-Institute of Physiology University Medical CenterRostock 18055Germany

AIM To establish patient-individual tumor models of rectal cancer for analyses of novel biomarkers, individual response prediction and individual therapy *** Establishment of cell lines was conducted by direct in vitro culturing and in vivo xenografting with subsequent in vitro culturing. Cell lines were in-depth characterized concerning morphological features, invasive and migratory behavior, phenotype, molecular profile including mutational analysis, protein expression, and confirmation of origin by DNA fingerprint. Assessment of chemosensitivity towards an extensive range of current chemotherapeutic drugs and of radiosensitivity was performed including analysis of a combined radioand chemotherapeutic treatment. In addition, glucose metabolism was assessed with 18 F-fluorodeoxyglucose(FDG) and proliferation with 18 *** We describe the establishment of ultra-low passage rectal cancer cell lines of three patients suffering from rectal cancer. Two cell lines(HROC126, HROC284 Met) were established directly from tumor specimens while HROC239 T0 M1 was established subsequent to xenografting of the tumor. Molecular analysis classified all three cell lines as CIMP-0/non-MSI-H(sporadic standard) type. Mutational analysis revealed following mutational profiles: HROC126: APC^(wt), TP53^(wt), KRAS^(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 M1: APC^(mut), P53^(wt), KRAS^(mut), BRAF^(wt), PTEN^(mut) and HROC284 Met: APC^(wt), P53^(mut), KRAS^(mut), BRAF^(wt), PTEN^(mut). All cell lines could be characterized as epithelial(EpCAM+) tumor cells with equivalent morphologic features and comparable growth kinetics. The cell lines displayed a heterogeneous response toward chemotherapy, radiotherapy and their combined application. HROC126 showed a highly radio-resistant phenotype and HROC284 Met was more susceptible to a combined radiochemotherapy than HROC126 and HROC239 T0 M1. Analysis of 18 F-FDG uptake displayed a markedly reduced FDG uptake of all th

关键词： Patient-derived tumor model Rectal cancer ^(18)F-fluorodeoxyglucose ^(18)F-fluorothymidine FOLFOX FOLFIRI Personalized medicine

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Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice

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World journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 223-237页

作者： Kelley MK Haarberg Meghan j Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy jesse M Hostetter Amanda E ramer-Tait Michael j Wannemuehler Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University Department of Food Science and Human Nutrition Iowa State University Department of Veterinary Pathology College of Veterinary Medicine Iowa State University Department of Food Science and Technology University of Nebraska-Lincoln

AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulga

关键词： Prunella vulgaris Spontaneous colitis Inflammatory

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