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Effect of the Orientation on the Comfort of a Building Made with Compressed Earth Block

Smart Grid and Renewable Energy 2021年第7期12卷 99-112页

作者： Fati Amadou Oumarou Adama Ouedraogo Sikoudouin Maurice Thierry Ky ramchandra bhandari Amadou Konfe Ramatou Konate Rabani Adamou Dieudonné Joseph Bathiebo Sié Kam Laboratory of Renewable Thermal Energies University Joseph KI-ZERBO: UFR/SEA Ouagadougou Burkina Faso Faculty of Science and Technologies Department of Chemistry University Abdou Moumouni Niamey Niger Centre Universitaire Polytechnique de Kaya (CUP-Kaya) University Joseph KI-ZERBO Ouagadougou Burkina Faso Institute for Technology and Resources Management in the Tropics and Subtropics: ITT Cologne Germany

Thermal comfort is one of the most important requirements that scientists and building designers must meet to ensure the indoor air quality knowing its importance on productivity and the health of occupants. However, it has never been of great concern for architects and architectural historians and seldom explores it. Buildings are the large consumer of the most energy consumption (around 40% worldwide) and generate around 35% of GHGs like CO2 that leads to extreme climate change. Hence, general and specific eco-friendly solutions in the field of building construction are required. Analysis of this study shows that air conditioning consumption can be significantly reduced thanks to the compressed earth bricks and by taking into account the climate and the orientation of the facades. However, this paper establishes viable low-cost option of building energy consumption while maintaining the thermal comfort and good indoor air quality. This work explains the effect of a single residential room orientation, by reducing the thermal amplitude, and improving the thermal phase shift in Ouagadougou climate conditions in April. Internal temperature was modelled with 8 cardinal orientations. The result corresponds to a decrease of thermal amplitude damping greater than 4°C between East-West and North-South sides and, with a thermal phase shift of 4 hours 30 minutes between the Nord and West walls.

关键词： Thermal Comfort Building Optimal Orientation Thermal Amplitude Thermal Phase Shift Energy Consumption Optimal Orientation

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Effect of Inclined Tension Crack on Rock Slope Stability by SSR Technique

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Intelligent Automation & Soft Computing 2023年第4期36卷 1205-1214页

作者： Ch.Venkat Ramana Niranjan ramchandra Thote Arun Kumar Singh Visvesvaraya National Institute of Technology Nagpur440010India

The tension cracks and joints in rock or soil slopes affect their failure *** of rock or soil slope failure is one of the most challenging tasks in the earth *** actual slopes consist of inhomogeneous materials,complex morphology,and erratic *** studies concerning the failure of rock slopes primarily focused on determining Factor of Safety(FoS)and Critical Slip Surface(CSS).In this article,the effect of inclined tension crack on a rock slope failure is studied numerically with Shear Strength Reduction Factor(SRF)*** inclined Tension Crack(TC)inﬂuences the magnitude and location of the rock slope’s Critical Shear Strength Reduction Factor(CSRF).Certainly,inclined cracks are more prone to cause the failure of the slope than the vertical ***,all tension cracks do not lead to failure of the slope *** effect of the crest distance of the tension crack is also *** numerical results do not show any signiﬁcant change in the magnitude of CSRF unless the tip of the TC is very near to the crest of the *** is also replaced with a joint,and the results differ from the corresponding *** results are discussed regarding shear stress and Critical Slip Surface(CSS).

关键词： Crest distance critical shear strength reduction factor critical slip surface inclined tension crack joint

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Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer

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World Journal of Gastroenterology 2020年第6期26卷 598-613页

作者： ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta Epigenetics and Chromatin Biology Group Gupta LaboratoryCancer Research InstituteAdvanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Homi Bhabha National Institute Training School ComplexAnushakti NagarMumbaiMaharashtra 400085India Department of Developmental Biology School of MedicineWashington University in St.LouisSaint LouisMO 63130United States Animal House Facility Cancer Research InstituteAdvanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Biorepository Lab Advanced Centre for Treatment Research and Education in CancerTata Memorial CentreKhargharNavi MumbaiMaharashtra 410210India Gastrointestinal and Hepato-Pancreato-Biliary Service Department of Surgical OncologyTata Memorial HospitalParelMumbai 400012India Department of Medicine Meharry Medical CenterNashvilleTN 37208United States Department of Medicine and Cancer Center College of MedicineHoward UniversityWashington DCWA 20060United States

BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic ***,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective *** study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug *** The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and *** potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell *** In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric *** data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle ***-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell *** Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient ***,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis.

关键词： Chemotherapy Combinatorial index Gastric cancer Histone acetylation Histone deacetylase inhibitor Patient stratification

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Foot-and-Mouth Disease Outbreak at Bageshwori Gaushala,Chitwan,Nepal

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Journal of Agricultural Science and Technology(A) 2018年第6期8卷 406-411页

作者： Milan Kandel Sachin Regmi Bablu Thakur ramchandra Acharya Krishna Kaphle Faculty of Animal Science Veterinary Science and FisheriesAgriculture and Forestry UniversityBharatpur Metropolitan-15ChitwanNepal Department of Theriogenology Institute of Agriculture and Animal SciencesTribhuvan UniversityKhairehani Municipality-1ChitwanNepal

Cow being the national animal of Nepal has special place in the *** institutions have since prehistoric time reared and cared for cattle herds and the tradition still *** Bageshwori Gaushala(cow shelter),initiated by the Hindu Rastraguru Yogi Narhaharinath in mid-1990s is one of the largest of such nucleus indigenous cattle herds in *** cattle conservation strategy of Nepal has recognized the importance of this nucleus herd,kept by grazing in the surrounding *** approaches of managing the herd health is in practice and vaccination was never *** outbreak did happen in past but overall the herd never suffered severe *** April 2018,an outbreak of foot-and-mouth disease(FMD)occurred at Bageshwori,Gaushala,Devghat,Bharatpur Metropolitan-1,Chitwan district of *** the bovine herd studied,80(53.33%)out of 150 affected animals presented characteristics FMD symptoms as vesicular lesions,drooling salivation,foot lameness,high fever and *** prompt supportive treatment,the condition *** complete recovery of infected herd was observed after 45 *** analysis showed the presence of Aphthovirus serotype O in the clinical *** present study attempts to provide fresh insights into the recent FMD outbreak,clinical signs,their effective treatment protocol and preventive measures that must be practiced following FMD outbreak.

关键词： Aphthovirus foot-and-mouth disease outbreak serotype O.

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Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats

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The Journal of Biomedical Research 2014年第2期28卷 132-145页

作者： Venkatashivam Shiva Kumar Anuchandra ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed University

The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel dis- ease in rats. Naringin （20, 40 and 80 mg/kg） was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4% （v/v） acetic acid solution. The degree of colonic mucosal damage was analyzed by examining mucosal damage, ulcer area, ulcer index and stool consistency. Intrarectal administration of 4% acetic acid resulted in significant modulation of serum alkaline phosphatase, lactate dehydrogenase, superoxide dismutase （SOD）, glutathione （GSH）, malondialdehyde （MDA） and myeloperoxidase （MPO） content along with colonic nitric oxide （NO）, xanthine oxidase （XO） level and protein carbonyl content in the colonic tissue as well as in blood. Naringin （40 and 80 mg/kg） exerted a dose dependent （P 〈 0.05） ameliorative effect, as it significantly increased hematological parameter as well as colonic SOD and GSH. There was a significant （P 〈 0.05） and dose dependant inhibition of macroscopical score, ulcer area along with colonic MDA, MPO activity by the 7 days of pretreatment of naringin （40 and 80 mg/kg）. Biochemical studies revealed a significant （P 〈 0.05） dose dependant inhibition in serum alkaline phosphatase （ALP） and lactate dehydrogenase （LDH） levels by pretreatment of naringin. Increased levels of colonic NO, XO, protein carbonyl content and DNA damage were also sig- nificantly decreased by naringin pretreatment. The findings of the present investigation propose that naringin has an anti-inflammatory, anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA, MPO, NO and XO, thus reducing DNA damage.

关键词： acetic acid, apoptosis, fluorimetric analysis of DNA unwinding, inflammatory bowel disease, my-eloperoxidase, naringin, nitrite/nitrate, oxidative stress porotein carbonyl content, vascular permeability, xanthineoxidase

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Azathioprine-induced pancytopenia:A case report

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Rheumatology & Autoimmunity 2022年第3期2卷 179-184页

作者： Keshav Raj Sigdel Astha Thapa Agnimshwor Dahal ramchandra Panthi Krishan Adhikari Pradeep Shrestha Mipsang Lama Buddhi Poudyal Buddha Basnyat Department of Internal Medicine Rheumatology Unit LagankhelPatan Academy of Health SciencesLalitpurNepal Department of Internal Medicine Hematology Unit LagankhelPatan Academy of Health SciencesLalitpurNepal Department of Internal Medicine Oxford Clinical Research Unit(OCRU)Patan Academy of Health SciencesLalitpurNepal

Azathioprine(AZA)is commonly used as immunosuppressive therapy for autoimmune diseases,including systemic lupus erythematosus(SLE).Myelosuppression is a common side effect of *** we report a case of severe myelosuppression following AZA therapy in a 15-year-old girl despite a normal thiopurine methyltransferase(TPMT)*** had been receiving AZA for SLE and presented with neutropenic fever and *** was *** stopping AZA,her blood counts steadily *** TPMT genotyping results were normal,AZA was *** reappeared after starting AZA,despite normal TPMT *** was replaced with mycophenolate mofetil which consequently resulted in improvement of blood *** is essential to understand the temporal relationship between AZA use and pancytopenia onset in patients with normal TPMT *** case illustrates that regular monitoring of blood cell counts should be routine practice after starting AZA regardless of TPMT activity.

关键词： azathioprine systemic lupus erythematosus thiopurine methyltransferase

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纬密对精纺西服面料成形性的影响

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国际纺织导报 2020年第8期48卷 24-24,26-28页

作者： G.S.Kakad R.P.Sawant 徐宸(译) 孟粉叶(校) Jawaharlal Darda工程与技术研究所(印度) 不详

织物的低应力力学性能决定了织物的外观质量。成形性是织物外观质量的主要属性之一。探讨了纬密对精纺西服面料(WSF)低应力力学性能和成形性的影响。采用Ashanhurst法对18种WSF进行了机织物设计,并在Kawabata评估系统(KES-F)上测试了这... 详细信息

织物的低应力力学性能决定了织物的外观质量。成形性是织物外观质量的主要属性之一。探讨了纬密对精纺西服面料(WSF)低应力力学性能和成形性的影响。采用Ashanhurst法对18种WSF进行了机织物设计,并在Kawabata评估系统(KES-F)上测试了这些WSF的低应力力学性能,用以评价织物的成形性。研究结果表明,随着纬密的增大,织物的低应力力学性能(如拉伸、剪切和弯曲性能)均受到影响,并最终提高了WSF的成形性。

关键词：精纺西服面料(WSF) 纬密成形性拉伸性能剪切性能弯曲性能

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