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Evaluation of antipyretic activity of ethyl acetate extract of Adenema hyssopifolium *** in a rat model

Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 523-526页

作者： Aiyalu Rajasekaran ramasamy arivukkarasu Shanmugasundaram Murugesh KMCH College of Pharmacy Coimbatore-641 048.TamilnaduIndia S.B.College of Pharmacy Sivakasi-626130TamilnaduIndia Vivekananda College of Arts and Science TamilnaduIndia

Objective:To evaluate the effect of ethyl acetate extract of Adenema hyssopifolium(AHEAE) on normal body temperature and brewer’s yeast-induced pyrexia ***:Preliminary phytochemical tests,acute toxicity tests and antipyretic evaluation were carried out in ethyl acetate extract of Adenoma hyssopifolium,.Two doses of the extract(300 or 600 mg/kg orally) and standard antipyretic agent,paracetamol at a dose of 150 mg/kg were administered to various group of the *** rectal temperature before and after treatment was ***:The phytochemical analysis of AHEAE revealed the presence of flavonoid and iridoid glycosides as major *** administration of AHEAE at a dose of 300 or 600 mg/kg produced significant reduction(P<0.001 and P<0.01) of the body temperature in normal and pyrexia rats on a dose dependent *** antipyretic influence of AHEAE was comparable to that of standard antipyretic agent,paracetamol(150 mg/kg),and onset of action and reduction in pyrexia towards normal body temperature was delayed when compared to paracetamol *** dose of 600 mg/kg,AHEAE reduced pyrexia to normal body temperature at 4 h after its administration compared to reduction of pyrexia to normal body temperature at 2 h by standard *** reduction of fever was consistent in paracetamol group from 2 to 4 h after its administration to normal body temperature compared to AHEAE ***:Our present results corroborate with the traditional notion of Adenema hyssopifolium *** that is being used as an effective cure of fever and add authenticity to claim of indigenous healers that the taxon is a potential antipyretic agent.

关键词： Adenema hyssopifolium Acute toxicity Iiidoid glycosides Pyrexia

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